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Health 2014年第10期6卷 969-974页

作者： Mitsuro chiba Hidehiko Tsuda Satoko Tsuda Masafumi Komatsu Yasuo Horie Hirohide Ohnishi Depatment of Gastroenterology Akita University School of Medicine Akita Japan Division of Gastroenterology Akita City Hospital Akita Japan Division of Gastroenterology Akita Kumiai General Hospital Akita Japan

Primary sclerosing cholangitis (PSC) is commonly associated with ulcerative colitis (UC). PSC progresses independently of UC ultimately resulting in liver failure. There is no established medical treatment to improve the natural course of PSC. Normalization of serum alkaline phosphatase (ALP) in early stage might delay the progress of PSC. A 20-year-old female, had a sudden attack of right hypochondralgia with high fever and abnormal liver function tests without elevation of bilirubin: ALP 478 IU/L, aspartate aminotransferase 360 IU/L, alanine aminotransferase 174 IU/L. Abnormal liver function tests returned to normal after the attacks. Morphological examinations initially indicated then confirmed a diagnosis of PSC. One month after displaying PSC symptoms administration of ursodeoxycholic acid was initiated. Similar attacks of cholangitis were repeated several times over the following two years. Even in the absence of these attacks, she always suffered postprandial hypochondralgia. There was no acute cholangitis in the year prior to the last hospitalization due to abdominal pain and bloody diarrhea. Findings were consistent with UC in the form of entire colitis. Sulfasalazine, metronidazole and semi-vegetarian diet (SVD) were initiated. Metronidazole is routinely used in inflammatory bowel disease (IBD) in our practice with the expectation of elimination of any potentially pathogenic bacteria. SVD was designed for IBD hoping to increase beneficial bacteria. A remission of UC was ascertained during hospitalization. Elevated ALP, in the absence of clinical cholangitis, was decreased to normal after the therapy for UC.

关键词： Primary Sclerosing Cholangitis Ulcerative Colitis Alkaline Phosphatase Metronidazole Vegetarian Diet

Ductilization of Ni_3Al by Alloying with Substitutional Elements

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Journal of Materials Science & Technology 1993年第6期9卷 391-399页

作者： Department of Metallurgy,Faculty of Engineering,Iwate University,Morioka 020,Japan A.chiba S.Hanada Institute for Materials Research,Tohoku University,Sendai 980,Japan

This paper reviews recent research on ductility improvement of B-undoped Ni_3Al ***_3Al binary alloys with hypostoichiometric compositions show appreciable ductility at room temperature when the samples are prepared by recrystallization annealing after cold pressing,although the alloys with stoichiometric and hyperstoichiometric compositions remain ***-spun ribbons with hypostoichiometric compositions contain fine anti-phase domains (APDs),while no APD can be seen in melt-spun ribbons with a hyperstoichiometric *** ductility in hypostoichiometric Ni_3Al alloys is associated with low ordering energy of the *** addition of ternary elements,which have been classified as γ formers such as Pd,Pt,Cu,Co and *** ductility of Ni_3Al ***,the microstructure of the melt-spun ribbons consists of fine *** addition of γ' formers such as Si,Ti,Zr,V,Nb and Ta leads to brittle intergranular frac- *** APD was observed in the melt-spun ribbons of these ternary alloys.

关键词： ductility Ni_3Al substitutional element

Percoll fractionation of adult mouse spermatogonia improvesgerm cell transplantation

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Asian Journal of Andrology 2004年第2期6卷 93-98页

作者： Kyu-Bom Koh Masatoshi Komiyama Yoshiro Toyama Tetsuya Adachi Chisato Mori Department of Bioenvironmental Medicine Graduate School of Medicine Chiba University Chiba 260-8670 Japan Center for Environment Health and Field Sciences Chiba University Kashiwa 277-0882 Japan 不详 Department of Genomic Drug Discovery Sciences Graduate School of Pharmaceutical Sciences Kyoto University Kyoto 606-8501 Japan Core Research for Evolutional Science and Technology Japan Science and Technology Agency Kawaguchi 332-0012 Japan

Aim: To isolate and transplant germ celis from adult mouse testes for transplantation. Methods: In order to distinguish transplanted celis from endogenous celis of recipients, donor transgenic mice expressing green fluores cent protein (GFP) were used. Germ celis were collected from the donors at 10-12 weeks of age and spermatogonia were concentrated by percoll fractionation and transplanted into recipient seminiferous tubules that had been previ ously treated with busulfan at 5 weeks of age to remove the endogenous spermatogenic celis. Results: Twenty vveeks after the transplantation, a wide spread GFP signal was observed in the recipient seminiferous tubules. The presence of spermatogenesis and spermatozoa was confirmed in sections of 12 out of 14 testes transplanted (86 %). However, when germ celis were transplanted without concentration the success rate was zero (0/9). Conclusion: Germ celis from adult mouse testes can be successfully transplanted into recipient seminiferous tubules if the cell population is rich in spermatogonia and the percoll fractionation is useful in obtaining such a cell population.

关键词： germ cell transplantation green fluorescent protein percoll fractionation spermatogenic cells mice

Hsp90 and ECM29 Are Important to Maintain the Integrity of Mammalian 26S Proteasome

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Advances in Biological Chemistry 2015年第7期5卷 255-265页

作者： Jean-Rene Q. Acquah Kousuke Haratake Randeep Rakwal Heiichiro Udono Tomoki chiba Graduate School of Life and Environmental Sciences University of Tsukuba Ibaraki Japan Organization for Educational Initiatives University of Tsukuba Ibaraki Japan Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University Okayama Japan

The proteasome is a protease complex composed of a core particle (CP) and regulatory particles (RPs) that bind to both ends of the CP. ECM29 is a protein that associates with the proteasome and is involved in the maintenance and regulation of the proteasome assembly. However, ECM29 deficient mice can form functional proteasome. In this paper we sought to identify the mechanisms and/or proteins that help and allow the maintenance of the proteasome activity in the absence of ECM29. We analyzed the proteasome components of ECM29-deficient mice and identified Hsp90 as a protein associated with the proteasome. Furthermore, the inhibition of Hsp90 led to a partial disassembly of the proteasome only in ECM29-deficient cells. Those findings attest to the importance of Hsp90 for the maintenance of the proteasome integrity in the absence of ECM29.

关键词： Mammalian Proteasome ECM29 Hsp90 Proteasome Structure

Antimicrobial therapy using sulfamethoxazole trimethoprim for Kawasaki disease patients unresponsive to intravenous immunoglobulin

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Open Journal of Pediatrics 2011年第3期1卷 27-29页

作者： Satoru Nagata Yuichiro Yamashiro Makoto Fujimori Yukihide chiba Yoshikazu Ohtsuka Toshiaki Shimizu 不详

Our previous study suggested that the production of superantigens and heat-shock protein 60 by small intestinal bacteria might play a role in Kawasaki disease (KD). We demonstrated that they were all resistant to commonly used antibiotics, except for sulamethoxazole trimethoprim (SMX-TMP). We used SMX-TMP for 7 cases of KD that were unresponsive to intravenous immunoglobulin (IVIG) and studied the antipyretic potency of this treatment. In 6 out of the 7 cases, we demonstrated that antipyretic potency was observed without side effects within 2 days of the initial administration. Antimicrobial therapy using SMX-TMP might represent a novel strategy for cases of KD that are unresponsive to IVIG.

关键词： Antimicrobial Therapy Intravenous Immunoglobulin Resistance Kawasaki Disease Sulfamethoxazole Trimethoprim

树在风中摆动的计算机实时模拟方法研究(英文)

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系统仿真学报 2008年第8期20卷 2085-2091页

作者：李占利千叶则茂安科技大学计算机系陕西西安710054 岩手大学工学部盛冈市0208550

提出了一种生成树叶和树枝在风中摆动动画的计算机方法,该方法考虑了风速、风力和噪音。根据空气动力学给出了一个能很好反映风的物理作用的计算公式,并在力学分析的基础上给出了计算树叶和树枝变形的数学公式,利用这些公式,并结合1/f... 详细信息

提出了一种生成树叶和树枝在风中摆动动画的计算机方法,该方法考虑了风速、风力和噪音。根据空气动力学给出了一个能很好反映风的物理作用的计算公式,并在力学分析的基础上给出了计算树叶和树枝变形的数学公式,利用这些公式,并结合1/fβ噪音技术,可以计算每一个树叶和树枝的变形,进而可以得到整个树的变形。利用这种方法可以很快得到树在风中摆动的效果,实现树在风中摆动的计算机模拟。

关键词：实时动画模拟树数学模型力学分析

Experimental Investigation on the Power Generation Performance of Dielectric Elastomer Wave Power Generator Mounted on a Square Type Floating Body

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材料科学与工程（中英文B版） 2017年第5期7卷 179-186页

作者： Mikio Waki Seiki A. chiba Z. Song S. Zhu K. Ohyama Wits Inc. Oshiage Sakura-City Tochigi 329-1334 Japan chiba Science Institute Muguro-ward Tokyo 152-0023 Japan Fukuoka Institute of Technology Wajiro-Higashi Higashi-ku Fukuoka Fukuoka 811-0295 Japan

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冲绳海槽中活动热液系统的地球化学研究

海洋地质动态 1997年第3期 18-20页

作者： chiba,H 姚伯初

冲绳海槽是一弧后盆地,它处于陆壳的张裂阶段.在海槽轴的南部到中部,有几个火山脊.这些脊是由年轻双峰集合的火山岩组成,包括玄武岩、安山岩、英安岩和流纹岩,自1984年以来,对该区进行了广泛的地球物理、地质和地球化学调查。1988年在Iz... 详细信息

冲绳海槽是一弧后盆地,它处于陆壳的张裂阶段.在海槽轴的南部到中部,有几个火山脊.这些脊是由年轻双峰集合的火山岩组成,包括玄武岩、安山岩、英安岩和流纹岩,自1984年以来,对该区进行了广泛的地球物理、地质和地球化学调查。1988年在Izena Cauldron和Iheya脊发现了高温活动热液系统,1990年在Minami-Ensei和1995年在Iheya脊北部的圆丘上也发现了高温活动热液。在这些高温热液系中,热液流体、活动和死的烟囱、矿石和火山岩均采集到了。

关键词：冲绳海槽热液活动系统地球化学热流体

Metallothionein Genes in the Nematode Caenorhabditis elegans and Metal Inducibility in Mammalian Culture Cells

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Biomedical and Environmental Sciences 1994年第3期7卷 222-231页

作者： FUMIHIKO KUGAWA HIROKO YAMAMOTO SHIGEHIRO OSADA MASATADA AOKI MASAYOSHI IMAGAWA AND TSUTOMU NISHIHARA (College of Pharmacy, Nihon University, 7-7-1 Narashino-dai, Funabashi,chiba 274 and Faculty of Pharmaceutical Sciences, Osaka University,1-6 Yama College of Pharmacy Nihon University Chiba Japan.

Genomic DNAs of metallothionein Ⅰ and Ⅱ in Caenorhabditis elegans (CeMT-Ⅰand CeMT-Ⅱ) were isolated by YAC library/polytene filter hybridization followed by subcloning of corresponding cosmid clones. Both genes are mapped at chromosome V. Although the similarities of 5'-flanking regions and coding regions have shown only 55-58%, the introns are split at the same position in both genes, indicating that these two genes are originally from the same gene. While several metal responsive elements are conserved among eukaryotes, only one metal responsive element was found in the promoter region in CeMT-Ⅱ and not in CeMT-Ⅰ. Indced, neither of 5'-flanking regions of CeMT-Ⅰ nor CeMT-Ⅱ connected to chloramphenicol acetyltransferase reporter gene is responsive to heavy metals in mammalian culture cells by transient transfection analysis. These results would suggest that the metal regulatory factors in *** might be different from those conserved in invertebrates and vertebrates, although the MTs in C elegans revealed the similarities to mammalian MTs in several points

关键词： MT gene Metallothionein Genes in the Nematode Caenorhabditis elegans and Metal Inducibility in Mammalian Culture Cells