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Excessive portal flow causes graft failure in extremely small-for-size liver transplantation in pigs

World Journal of Gastroenterology 2005年第44期11卷 6954-6959页

作者： Hong-Sheng Wang Nobuhiro Ohkohchi Yoshitaka Enomoto Masahiro Usuda Shigehito Miyagi Takeshi Asakura Hiroo Masuoka Takashi Aiso Keisuke Fukushima Tomohiro Narita hideyuki yamaya Atsushi Nakamura Satoshi Sekiguchi Naoki Kawagishi Akira Sato Susumu Satomi Division of Advanced Surgical Science and Technology Department of Surgery

AIM： To evaluate the effects of a portocaval shunt on the decrease of excessive portal flow for the prevention of sinusoidal microcirculatory injury in extremely smallfor-size liver transplantation in pigs. METHODS： The right lateral lobe of pigs, i.e. the 25% of the liver, was transplanted orthotopically. The pigs were divided into two groups： graft without portocaval shunt （n = 11） and graft with portocaval shunt （n = 11）. Survival rate, portal flow, hepatic arterial flow, and histological findings were investigated. RESULTS： In the group without portocaval shunt, all pigs except one died of liver dysfunction within 24 h afcer transplantation. In the group with portocaval shunt, eight pigs survived for more than 4 d. The portal flow volumes before and after transplantation in the group without portocaval shunt were 118.2±26.9 mL/min/100 g liver tissue and 270.5±72.9 ml./min/100 g liver tissue, respectively. On the other hand, in the group with portocaval shunt, those volumes were 124.2±27.8 ml./ min/100 g liver tissue and 42.7±32.3 mL/min/100 g liver tissue, respectively （P〈0.01）. As for histological findings in the group without portocaval shunt, destruction of the sinusoidal lining and bleeding in the peri-portal areas were observed afl：er reperfusion, but these findings were not recognized in the group with portocaval shunt. CONCLUSION： These results suggest that excessive portal flow is attributed to post transplant liver dysfunction after extreme small-for-size liver transplantation caused by sinusoidal microcirculatory injury.

关键词： Hyperperfusion syndrome Liver regeneration Portocaval shunt Postoperative liver dysfunction Sinusoidal microcirculatory injury Small-for-size liver transplantation

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Polyarteritis nodosa clinically mimicking nonocclusive mesenteric ischemia

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World Journal of Gastroenterology 2013年第23期19卷 3693-3698页

作者： Tsuyoshi Shirai Hiroshi Fujii Shinichiro Saito Tomonori Ishii hideyuki yamaya Shigehito Miyagi Satoshi Sekiguchi Naoki Kawagishi Masato Nose Hideo Harigae Department of Hematology and Rheumatology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Division of Advanced Surgical Science and Technology Tohoku University Graduate School of MedicineSendai 980-8574 Japan Department of Histopathology Tohoku University Graduate School of MedicineSendai 980-8574 Japan

Here, we present the case of a 74-year-old Japanese man with segmental intestinal necrosis, which developed after treatment with pulsed methylprednisolone for mononeuritis multiplex. The patient was weakly positive for myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibody (ANCA). Computed tomography and surgical findings were compatible with nonocclusive mesenteric ischemia (NOMI). He underwent small intestinal resection by emergency surgery and an intestinal fistula was made. Pathologically, necrotizing vasculitis with fibrinoid necrosis was present in medium to small-sized arteries, which was equivalent to Arkin's classification Ⅱ-Ⅳ. Most of the arteries had fibrous intimal thickening, which was considered to obstruct the arteries and thus cause segmental intestinal necrosis. A diagnosis of polyarteritis nodosa (PAN) was made, and intravenous cyclophosphamide pulse therapy was added to the therapeutic regimen. This patient was successfully treated with these multidisciplinary therapies and his stoma was finally closed. This is a very rare and indicative case of PAN weakly positive for MPO-ANCA and clinically mimicking NOMI, which occurred even after treatment with pulsed methylprednisolone.

关键词： Anti-neutrophil cytoplasmic antibody Intestinal necrosis Myeloperoxidase Nonocclusive mesenteric ischemia Polyarteritis nodosa

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Optimal calibration scheme for map-based control of diesel engines

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Science China(Information Sciences) 2018年第7期61卷 68-81页

作者： Yui NISHIO Yutaka MURATA Yukihisa yamaya Masato KIKUCHI Automobile R & D Center Honda R & D Co. Ltd.

Map-based control has the advantage of a simple control structure. However, in the case of a complex plant, calibrating the map is difficult. Calibration methodology using plant model is increasing in engine calibration industries. However, the models are for steady-state operation and cannot simulate at transient operation well. This study introduces the dynamic empirical model and applies the transient corrective function of an electronic control unit to simulate more realistic behavior. The optimization problem for calibrating maps of diesel engines is constructed, and the formulation of cost function and constraints is discussed. Consequently, the proposed calibration scheme can find an optimal map in satisfied ***, the optimized maps are validated using mass production diesel engines.

关键词： optimization Gaussian SQP Diesel engine calibration DoE

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土耳其国家铁路(TCDD)25kV晶闸管控制电力机车

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机车电传动 1989年第6期 58-61页

作者： Takatsugu yamaya 崔军

一、引言东芝公司即将交付的E43000型交流电力机车准备用在伊斯肯特伦和迪夫里伊之间的线路上,该机车为大型交流电力机车,可以进行重联运行。它采用电阻制动,当与50Hz25kV架空线接触时,其持续输出功率为3180kW。轴式为B_0-B_0-B_0,车体... 详细信息

一、引言东芝公司即将交付的E43000型交流电力机车准备用在伊斯肯特伦和迪夫里伊之间的线路上,该机车为大型交流电力机车,可以进行重联运行。它采用电阻制动,当与50Hz25kV架空线接触时,其持续输出功率为3180kW。轴式为B_0-B_0-B_0,车体为无骨架箱形结构,两头均设有司机室。二、主要参数及机车设计 1.主要特点表1给出了机车主要参数。其主要特点如下:

关键词：电力机车晶闸管 TCDD

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Pressure Effect on Charge-Density-Wave and Superconductivity in ZrTe3

Pressure Effect on Charge-Density-Wave and Superconductivity...

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18th International Conference on High Pressure Science and Technology

作者： K.yamaya M.Yoneda S.Yasuzuka Y.Okajima S.Tanda Department of Applied Physics Hokkaido UniversitySapporo 060-8623Japan

The charge-density-wave (CDW) transition temperature, TCDW of ZrTe3 is found to increase for pressures up to 0.6 GPa, while the superconducting transition temperature, Tc decreases with increasing pressure. This is contrary to pressure-induced suppression of CDW and enhancement of superconductivity, which are observed in many quasi-one dimensional conductors. ZrTe3, which is one of low-dimensional conductors, exhibits a resistance anomaly due to a CDW formation near 63 K and undergoes a superconducting transition at ca. 2 K [1]. The CDW nesting vector obtained in electron diffraction is q = (1/14, 0, 1/3), where no component of b* (the chain axis) is observed, only components perpendicular to the chain axis exist [2]. The superconductivity is not of bulk nature but filamentary [1]. These features lead us to an interest for competition and coexistence of the CDW and the superconductivity in ZrTe3 under pressure. Single crystals are prepared by the chemical transport method. The pressure was generated by use of a piston and a clamp type cylinder. The resistance was measured by a usual four-probe dc method, where a current is parallel to the a axis. Fig. 1. Temperature dependence of resistance near TCDW for various pressures. Figure 1 shows the temperature dependence of resistance near TCDW for various pressures. TCDW raises with increasing pressure and a magnitude of the resistance anomaly associated by the CDW transition also increases. Figure 2 shows the temperature dependence of resistance near the Tc for various pressures. Tc decreases with increasing pressure. We find pressure-induced enhancement of CDW and suppression of superconductivity in ZrTes. This result is inconsistent with a prediction from the calculated electronic band structure [3], suggesting that the fact is not simply explained in terms of the nesting effect of the Fermi surface under pressure. We will propose reasonable explanations for the present result, including the filamentary nature of the s

关键词： High Pressure CDW Superconductivity.

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