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Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi tanaka Hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

Treatment for superficial non-ampullary duodenal epithelial tumors

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World Journal of Gastroenterology 2014年第35期20卷 12501-12508页

作者： Naomi Kakushima hideyuki Kanemoto Masaki tanaka Kohei Takizawa Hiroyuki Ono Division of Endoscopy Shizuoka Cancer Center Division of Hepato-Biliary-Pancreatic Surgery Shizuoka Cancer CenterShizuoka Cancer Center

Because of the low prevalence of non-ampullary duodenal epithelial tumors(NADETs),standardized clinical management of sporadic superficial NADETs,including diagnosis,treatment,and follow-up,has not yet been *** studies have revealed certain endoscopic findings suggestive of *** adenoma with high-grade dysplasia and mucosal cancer are candidates for local resection by endoscopic or minimally invasive *** use of endoscopic treatment including endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD),for the treatment for superficial NADETs is *** requires multiple sessions to achieve complete remission and repetitive endoscopy is needed after *** provides an excellent complete resection rate,however it remains a challenging method,considering the high risk of intraoperative or delayed *** invasive surgery such as wedge resection and pancreas-sparing duodenectomy are beneficial for superficial NADETs that are technically difficult to remove by endoscopic *** remains a standard surgical procedure for treatment of duodenal cancer with submucosal invasion,which presents a risk of lymph node *** or surgical treatment outcomes of superficial NADETs without submucosal invasion are *** an endoscopic diagnostic tool to differentiate superficial NADETs between adenoma and cancer as well as between mucosal and submucosal cancer is required to select the most appropriate treatment.

关键词： Duodenal neoplasms Duodenal cancer Pancreaticoduodenectomy Endoscopic surgery Esophagogastroduodenoscopy

Bile duct hamartomas(von Mayenburg complexes) mimicking liver metastases from bile duct cancer:MRC findings

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World Journal of Gastroenterology 2006年第8期12卷 1321-1323页

作者： Yasuhiko Nagano Kenichi Matsuo Katsuya Gorai Kazuya Sugimori Chikara Kunisaki hideyuki Ike Katsuaki tanaka Toshio Imada Hiroshi Shimada Yokohama City University Medical Center Gastroenterological CenterYokohamaJapan Department of Gastroenterological Surgery Yokohama City UniversityGraduate School of MedicineYokohamaJapan

We present a case of a 72-year-old man with a common bile duct cancer, who was initially believed to have multiple liver metastases based on computed tomography findings, and in whom magnetic resonance cholangiography （MRC） revealed a diagnosis of bile duct hamartomas. At exploration for pancreaticoduodenectomy, liver palpation revealed disseminated nodules at the surface of the liver. These nodules showed gray-white nodular lesions of about 0.5 cm in diameter scattered on the surface of both liver lobes, which were looked like multiple liver metastases from bile duct cancer. Frozen section of the liver biopsy disclosed multiple bile ducts with slightly dilated lumens embedded in the collagenous stroma characteristics of multiple bile duct hamartomas （BDHs）. Only two reports have described the MRC features of bile duct hamartomas. Of all imaging procedures, MRC provides the most relevant features for the imaging diagnosis of bile duct hamartomas.

关键词： Bile duct hamartoma Magnetic resonance cholangiography Multiple liver metastases

Endoscopic and biopsy diagnoses of superficial, nonampullary, duodenal adenocarcinomas

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World Journal of Gastroenterology 2015年第18期21卷 5560-5567页

作者： Naomi Kakushima hideyuki Kanemoto Keiko Sasaki Noboru Kawata Masaki tanaka Kohei Takizawa Kenichiro Imai Kinichi Hotta Hiroyuki Matsubayashi Hiroyuki Ono Division of Endoscopy Shizuoka Cancer Center Division of Hepato-Biliary-Pancreatic Surgery Shizuoka Cancer Center Division of Pathology Shizuoka Cancer Center

AIM: To investigate the accuracy of endoscopic or biopsy diagnoses of superficial nonampullary duodenal epithelial tumors(NADETs).METHODS:Clinicopathological data were reviewed for84 superficial NADETs from 74 patients who underwent surgery or endoscopic resection between September2002 and August 2014 at a single prefectural cancer *** NADETs were defined as lesions confined to the mucosa or *** and clinicopathological data were retrieved from charts,endoscopic and pathologic *** reports included endoscopic diagnosis,location,gross type,diameter,color,and presence or absence of *** diagnoses were made by an endoscopist in charge of the examination before biopsy specimens were *** images were obtained using routine,front-view,high-resolution video endoscopy,and chromoendoscopy with indigocarmine was performed for all *** images were reviewed by at least two endoscopists to assess endoscopic findings indicative of *** diagnoses based on endoscopy and biopsy findings were compared with histological diagnoses of resected ***,specificity,and accuracy were assessed for endoscopic diagnosis and biopsy ***:The majority(81%)of the lesions were located in the second portion of the *** median lesion diameter was 14.5 mm according to final *** was performed for 49 lesions from 39 patients,and 35 lesions from 35 patients were endoscopically *** histology confirmed 65carcinomas,15 adenomas,and 3 hyperplasias.A finaldiagnosis of duodenal carcinoma was made for 91%(52/57)of the lesions diagnosed as carcinoma by endoscopy and 93%(42/45)of the lesions diagnosed as carcinoma by *** sensitivity,specificity,and accuracy of endoscopic diagnoses were 80%,72%,and 78%,respectively,whereas those of biopsy diagnoses were 72%,80%,and 74%,*** diagnoses of carcinomas were made in88%(57/65)of

关键词： Biopsy Endoscopic diagnosis Duodenal adenoma Duodenal carcinoma Duodenal neoplasms

The Fefferman-Stein-Type Inequality for the Kakeya Maximal Operator Ⅱ

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Acta Mathematica Sinica,English Series 2002年第3期18卷 447-454页

作者： Hitoshi tanaka Department of Mathematics Gakushuin University 1-5-1 Mejiro Toshima-ku Tokyo 171-8588 Japan

Let K, 0 ±1, be the Kakeya maximal operator defined as the supremum of averages over tubes of the eccentricity . The (so-called) Fefferman-Stein-type inequality: $|| {K_\delta f} ||_{L^d({{\rm R}^d,w})} \le C_d ({1 \over \delta})^{(d - 2)/2d}(\log ({1 \over \delta } ))^{\alpha_d} || f ||_{L^d ({\rm R}^d,K_{\delta}w})}$is shown, where Cd and d are constants depending only on the dimension d and w is a weight. The result contains the exponent (d-2)/2d which is smaller than the exponent (d-2)(d-1)/d(2d-3) obtained in [7].

关键词： Maximal functions Weighted inequalties

One-Dimensional Modeling of Multiple Scattering in the Upper Inner Core: Depth Extent of a Scattering Region in the Eastern Hemisphere

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Journal of Earth Science 2013年第5期24卷 706-715页

作者： Satoru tanaka Institute for Research on Earth Evolution Japan Agency for Marine-Earth Science and Technology

Attenuation of PKP（DF） in the Eastern Hemisphere is examined in terms of multiple scattering to simultaneously explain a puzzling relationship, a relatively fast velocity anomaly corre- sponding to strong attenuation. Reflectivity synthetics with one-dimensional random velocity fluctua- tions are compared with observations of PKP（DF）/PKP（Cdiff） amplitude ratios and differential travel times of PKP（Cdiff）-PKP（DF） for the equatorial paths. A Gaussian distribution of P-wave velocity fluctuations with the standard deviations of 5%, 6%, and 7% in the uppermost 200 km of the inner core is superimposed on the velocity structure that is slightly faster than the typical structure in the Eastern Hemisphere, which is likely to explain both the travel time and amplitude data as far as only the one-dimensional structure is considered. Further examinations of the statistic characteristic of scat- terer distribution in two and three-dimensions are required to obtain a realistic conclusion.

关键词： seismology the inner core attenuation scattering.

Tingley's Problem on Symmetric Absolute Normalized Norms on R^2

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Acta Mathematica Sinica,English Series 2014年第8期30卷 1324-1340页

作者： Ryotaro tanaka Department of Mathematical Science Graduate School of Science and TechnologyNiigata University

In this paper,we study Tingley＇s problem on symmetric absolute normalized norms on R^*** construct new methods for Tingley＇s problem on two-dimensional spaces by using isosceles orthogonality,which does not make use of the notion of natural ***,using our methods,several sufficient conditions for Tingley＇s problem on symmetric absolute normalized norms on R2 are *** applications,we present various new examples including the two-dimensional Lorentz sequence space d^（2）（ω,q） and its dual d^（2）（ω,q）＊by simple arguments.

关键词： Tingley's problem isometric extension problem isosceles orthogonality symmetric absolute normalized norm

Application of 3D Scanned Big Data of Large-scale Cultural Heritage Objects Based on Noise-robust Transparent Visualization

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系统仿真学报 2023年第8期35卷 1635-1650页

作者： tanaka Satoshi College of Information Science and Engineering Ritsumeikan UniversityShiga 525-8577Japan

Three-dimensional(3D) scanning technology has undergone remarkable developments in recent *** acquired by 3D scanning have the form of 3D point *** 3D scanned point clouds have data sizes that can be considered big *** also contain measurement noise inherent in measurement *** properties of 3D scanned point clouds make many traditional CG/visualization techniques *** paper reviewed our recent achievements in developing varieties of high-quality visualizations suitable for the visual analysis of 3D scanned point *** demonstrated the effectiveness of the method by applying the visualizations to various cultural heritage *** main visualization targets used in this paper are the floats in the Gion Festival in Kyoto(the float parade is on the UNESCO Intangible Cultural Heritage List) and Borobudur Temple in Indonesia(a UNESCO World Heritage Site).

关键词： 3D scanning point cloud transparent visualization noise transparentization cultural heritage object

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The Research Existing Condition and Application of Solid Waste Disposal in Japan

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四川大学学报（工程科学版） 2009年第S1期41卷 62-69页

作者： tanaka Reiji KITATSUJI Masafumi Faculty of Eng. Tohoku Inst.e of Technol. Miyagi Univ.

Japan lacked resources is a large import country and also a large consuming *** it is turned society structure system of consumption goods stocked in domestic,which leads to 450 millions ton waste ***,because of continuing development of intermediate handling and recycled utilization technology,finally disposed waste materials approximately 30 millions *** quantity of concrete product is consumed 300 millions ton per year unprecedented,beau case of large scope,it is expected valid and large absorption industry of recycled material. The purpose of this paper is to do a report on applied present status and future assignment of recycled material and building structure in Japan.

关键词： inorganic waste recycled aggregate circumstance security precast concrete product reinforced concrete structure