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Clearance of the liver remnant predicts short-term outcome in patients undergoing resection of hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第38期28卷 5614-5625页

作者： Atsushi Miki Yasunaru Sakuma Hideyuki Ohzawa Akira Saito Yoshiyuki Meguro Jun Watanabe Kazue Morishima Kazuhiro Endo Hideki Sasanuma Atsushi Shimizu Alan Kawarai Lefor Yoshikazu Yasuda Naohiro Sata Department of Surgery Jichi Medical UniversityShimotsuke 329-0498TochigiJapan

BACKGROUND Estimation of the functional reserve of the remnant liver is important to reduce morbidity and mortality.AIM To estimate the functional reserve of the remnant liver in patients with hepatocellular carcinoma(HCC).METHODS We reviewed the medical records of 199 patients who underwent resection of HCC.Hepatic clearance of the remnant liver was calculated using fusion images of 99mTc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography.Posthepatectomy liver failure(PHLF)was classified according to the International Study Group of Liver Surgery.Complications was classified according to Clavien–Dindo classification.We analyzed by the risk factors for PHLF,morbidity and mortality with multivariate analysis.RESULTS Twenty-seven(30%)patients had major complications and 23(12%)developed PHLF.The incidence of major complications increased with increasing albumin–bilirubin(ALBI)grade.The area under the curve values for hepatic clearance of the remnant liver,liver to heart-plus-liver radioactivity at 15 min(LHL15),and ALBI score predicting PHLF were 0.868,0.629,and 0.655,respectively.The area under the curve for hepatic clearance of the remnant liver,LHL15,and ALBI score predicting major complications were 0.758,0.594,and 0.647,respectively.The risk factors for PHLF and major complications were hepatic clearance of the remnant liver and intraoperative bleeding.CONCLUSION The measurement of hepatic clearance may predict PHLF and major complications for patients undergoing resection of HCC.

关键词： Liver function Hepatectomy Cirrhosis Fusion image Complication Mortality

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Complex-Valued Neural Networks:A Comprehensive Survey

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IEEE/CAA Journal of Automatica Sinica 2022年第8期9卷 1406-1426页

作者： ChiYan Lee hideyuki Hasegawa Shangce Gao Faculty of Engineering University of ToyamaToyama 930-8555Japan

Complex-valued neural networks(CVNNs)have shown their excellent efficiency compared to their real counterparts in speech enhancement,image and signal processing.Researchers throughout the years have made many efforts to improve the learning algorithms and activation functions of CVNNs.Since CVNNs have proven to have better performance in handling the naturally complex-valued data and signals,this area of study will grow and expect the arrival of some effective improvements in the future.Therefore,there exists an obvious reason to provide a comprehensive survey paper that systematically collects and categorizes the advancement of CVNNs.In this paper,we discuss and summarize the recent advances based on their learning algorithms,activation functions,which is the most challenging part of building a CVNN,and applications.Besides,we outline the structure and applications of complex-valued convolutional,residual and recurrent neural networks.Finally,we also present some challenges and future research directions to facilitate the exploration of the ability of CVNNs.

关键词： Complex activation function complex backpropagation algorithm complex-valued learning algorithm complex-valued neural network deep learning

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Supranormal orientation selectivity of neurons in primary visual cortex in experience-restricted animals

Supranormal orientation selectivity of neurons in primary vi...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Izumi ohzawa Graduate School of Frontier Biosciences Osaka University

＜正＞Restricted sensory experience in early life often leads to a remarkable adaptation so that animals can make maximal use of information available in a particular environment.Such restriction inevitably leaves some neurons in the brain unused or underused for an original purpose.How do cortical neurons adapt to the statistical structure of restricted environment to represent sensory signals efficiently? We addressed the question by measuring receptive field of neurons in cats reared with vertical-pass cylindrical lenses.Such lenses severely limit the range of orientation experienced by the animals essentially to vertical only,filtering out horizontal and oblique orientations.Aspect ratios of receptive fields of neurons in these animals show a marked elongation in the length dimension compared with those from normal cats.The responses of individual neurons were also examined by presenting gratings of various combinations of orientation and spatial frequency.Orientation tuning of neurons in these animals was significantly sharpened for neurons tuned to vertical and broadened for those tuned to other orientations,compared with those in normal animals.Our results indicate that limited visual experience early in life not only increases the proportion of cells tuned to the experienced parameter,but also causes changes in the shape and tuning properties of receptive fields of individual neurons.

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Dendritic Learning-Incorporated Vision Transformer for Image Recognition

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 539-541页

作者： Zhiming Zhang Zhenyu Lei Masaaki Omura hideyuki Hasegawa Shangce Gao Faculty of Engineering University of ToyamaToyama-shi 930-8555Japan IEEE

Dear Editor,This letter proposes to integrate dendritic learnable network architecture with Vision Transformer to improve the accuracy of image recognition.In this study,based on the theory of dendritic neurons in neuroscience,we design a network that is more practical for engineering to classify visual features.Based on this,we propose a dendritic learning-incorporated vision Transformer(DVT),which out-performs other state-of-the-art methods on three image recognition benchmarks.

关键词： Image network image

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Asian trends in primary androgen depletion therapy on prostate cancer

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癌症生物学与医学：英文版 2013年第4期10卷 187-191页

作者： hideyuki Akaza Department of Strategic Investigation on Comprehensive Cancer Network Research Center for Advanced Science and Technology The University of Tokyo

There are notable differences in the incidence and mortality rates for prostate cancer between Asia and Western countries.It is also recognized that there are differences in thinking with regard to treatment options.Recently it is also the case that opinions have been reported concerning the differences between Asian and Western patients with regard to their reaction to androgen depletion therapy(ADT).Given that ADT is a method of treatment that focuses on the elimination of testosterone,an inevitable symptom of its administration is testosterone losing syndrome.It is for this reason that in Western countries ADT has only been recommended in cases of advanced or metastatic cancer.On the other hand,in Asia,ADT is used in relatively many cases,including non-metastatic localized cancer and invasive localized cancer.To date,however,there has been little substantive discussion concerning this difference in utilization of ADT.ADT-related drugs for prostate cancer and the development of new drugs for castration resistant prostate cancer(CRPC)have been actively tested in recent years.It could be the case that analyzing the differences in concepts about ADT between Asia and the West could contribute to the effective use of ADT-related drugs and also help to build new treatment strategies for prostate cancer.

关键词：前列腺癌治疗方案雄激素亚洲发展趋势西方国家 ADT 睾丸激素

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Mechanophore activation enhanced by hydrogen bonding of diarylurea motifs:An efficient supramolecular force-transducing system

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Aggregate 2021年第3期2卷 9-13页

作者： Jumpei Kida Daisuke Aoki hideyuki Otsuka Department of Chemical Science and Engineering Tokyo Institute of TechnologyMeguro-kuTokyoJapan

Macromolecules are efficient as mechanical transducers for mechanically induced chemical bond cleavage reactions.Although various classes of polymers have been studied as effective mechanical-force transducers for mechanophores,alternatives to polymer chains,that is,small molecules,have rarely been studied.In this paper,the role of hydrogen bonding as small-molecule mechanical-force transducers for the activation of mechano-responsive molecular units(mechanophores)in the bulk is investigated.The introduction of diarylurea linkage motifs,which are known as strong hydrogen bonding groups,enhances the mechanochemical activation of the fluorescent mechanophore tetraarylsuccinonitrile(TASN)as effectively as the attachment of a typical macromolecular transducer.Electron paramagnetic resonance measurements of mechanically activated TASN with diphenyl urea motifs demonstrate its higher carbon–carbon bond dissociation ratio compared to that of TASN without diphenyl urea motifs.This efficient supramolecular-forcetransducing system represents a new concept in the field of mechanochemistry,namely,the enhancement of mechanochemical bond scission by simply changing the substituents of a mechanophore,even in small molecules.

关键词： hydrogen bonding mechanophore radical

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The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models

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Neural Regeneration Research 2017年第1期12卷 43-46页

作者： Syoichi Tashiro Masaya Nakamura hideyuki Okano Department of Rehabilitation Medicine Keio University School of MedicineTokyoJapan Department of Orthopaedic Surgery Keio University School of MedicineTokyoJapan Department of Physiology Keio University School of MedicineTokyoJapan

Regenerative medicine has opened a window for functional recovery in acute-to-subacute phase spinal cord injury（SCI）.By contrast,there are still only a few studies have focused on the treatment of the chronically injured spinal cord,in which cell-based regenerative medicine seems less effective.Since the majority of SCI patients are in the chronic phase,representing a major challenge for the clinical application of cellbased regenerative medicine.Although combined therapies for the treatment of chronic SCI have attracted attention of researchers and its potential importance is also widely recognized,there had been very few studies involving rehabilitative treatments to date.In a recent study,we have demonstrated for the first time that treadmill training combined with cell transplantation significantly promotes functional recovery even in chronic SCI,not only in additive but also in synergistic manner.Even though we have succeeded to outline the profiles of recovery secondary to the combination therapy,the mechanism underlying the effects remain unsolved.In this review article,we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly combined with rehabilitative approaches for chronic SCI animal models.

关键词： transplantation spinal cord injury regenerative medicine chronic phase rehabilitation treadmill training

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Regenerative medicine strategies for chronic complete spinal cord injury

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Neural Regeneration Research 2024年第4期19卷 818-824页

作者： Shogo Hashimoto Narihito Nagoshi Masaya Nakamura hideyuki Okano Department of Orthopedic Surgery Keio University School of Medicine Department of Physiology Keio University School of Medicine

Spinal cord injury is a condition in which the parenchyma of the spinal cord is damaged by trauma or various diseases.While rapid progress has been made in regenerative medicine for spinal cord injury that was previously untreatable,most research in this field has focused on the early phase of incomplete injury.However,the majority of patients have chronic severe injuries;therefore,treatments for these situations are of fundamental importance.The reason why the treatment of complete spinal cord injury has not been studied is that,unlike in the early stage of incomplete spinal cord injury,there are various inhibitors of neural regeneration.Thus,we assumed that it is difficult to address all conditions with a single treatment in chronic complete spinal cord injury and that a combination of several treatments is essential to target severe pathologies.First,we established a combination therapy of cell transplantation and drug-releasing scaffolds,which contributes to functional recovery after chronic complete transection spinal cord injury,but we found that functional recovery was limited and still needs further investigation.Here,for the further development of the treatment of chronic complete spinal cord injury,we review the necessary approaches to the different pathologies based on our findings and the many studies that have been accumulated to date and discuss,with reference to the literature,which combination of treatments is most effective in achieving functional recovery.

关键词： cell transplantation chronic phase complete transection regenerative medicine spinal cord injury

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The deterministic condition for the ground reaction force acting point on the combined knee valgus and tibial internal rotation moments in early phase of cutting maneuvers in female athletes

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Journal of Sport and Health Science 2024年第3期13卷 376-386页

作者： Issei Ogasawara Ken Ohta Gajanan S.Revankar Shoji Konda Yohei Shimokochi hideyuki Koga Ken Nakata Department of Health and Sport Sciences Graduate School of MedicineOsaka UniversityToyonaka 560-0043Japan Sports Sensing Co. LTD.Fukuoka 815-0035Japan Department of Neurology Graduate School of MedicineOsaka UniversitySuita 565-0871Japan Department of Health and Sport Management Osaka University of Health and Sport SciencesSennan-gun 590-0496Japan Department of Joint Surgery and Sports Medicine Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8519Japan

Background:Combined knee valgus and tibial internal rotation(VL+IR)moments have been shown to stress the anterior cruciate ligament(ACL)in several in vitro cadaveric studies.To utilize this knowledge for non-contact ACL injury prevention in sports,it is necessary to elucidate how the ground reaction force(GRF)acting point(center of pressure(CoP))in the stance foot produces combined knee VL+IR moments in risky maneuvers,such as cuttings.However,the effects of the GRF acting point on the development of the combined knee VL+IR moment in cutting are still unknown.Methods:We first established the deterministic mechanical condition that the CoP position relative to the tibial rotational axis differentiates the GRF vector’s directional probability for developing the combined knee VL+IR moment,and theoretically predicted that when the CoP is posterior to the tibial rotational axis,the GRF vector is more likely to produce the combined knee VL+IR moment than when the CoP is anterior to the tibial rotational axis.Then,we tested a stochastic aspect of our theory in a lab-controlled in vivo experiment.Fourteen females performed 60˚cutting under forefoot/rearfoot strike conditions(10 trials each).The positions of lower limb markers and GRF data were measured,and the knee moment due to GRF vector was calculated.The trials were divided into anterior-and posterior-CoP groups depending on the CoP position relative to the tibial rotational axis at each 10 ms interval from 0 to 100 ms after foot strike,and the occurrence rate of the combined knee VL+IR moment was compared between trial groups.Results:The posterior-CoP group showed significantly higher occurrence rates of the combined knee VL+IR moment(maximum of 82.8%)at every time point than those of the anterior-CoP trials,as theoretically predicted by the deterministic mechanical condition.Conclusion:The rearfoot strikes inducing the posterior CoP should be avoided to reduce the risk of non-contact ACL injury associated with the combined knee VL+IR stress.

关键词： Center of pressure Deterministic condition Foot strike pattern Injury mechanism Moment of ground reaction force

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Degradation behaviors of nonylphenol ethoxylates by isolated bacteria using improved isolation method

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Journal of Environmental Sciences 2008年第9期20卷 1025-1027页

作者： hideyuki Tamaki Yoichi Kamagata Institute for Biological Resources and Functions National Institute of Advanced Industrial Science and Technology

Nonylphenol ethoxylate (NPEO)-degrading bacteria were isolated from activated sludge using an improved isolation method, and the corresponding degradation behaviours were investigated. Eight NPEO-degrading strains distributed in genera Pseudomonas, Sphingomonas, Sphingobium, Cupriavidus, Ralstonia, Achromobacter, and Staphylococcus were acquired. The latter five genera have never been reported for the degradation of NPEOs. Four degradation patterns were observed for the eight pure strains. In pattern A, NPE...

关键词： nonylphenol ethoxylate （NPEO） biodegradation ssolation method

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