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Molecular phylogenetic relationships of Eastern Asian Cyprinidae(Pisces:Cypriniformes)inferred from cytochrome b sequences

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Science China(Life Sciences) 2004年第2期47卷 130-138页

作者： Masayuki kuwahara Tsuneo Nakajima Lake Biwa Museum 1091 Oroshimo Kusatsu Shiga 525 JapanLake Biwa Museum 1091 Oroshimo Kusatsu Shiga 525 Japan

Complete mitochondrial cytochrome b sequences of 54 species, including 18 newly sequenced, were analyzed to infer the phylogenetic relationships within the family Cyprinidae in East Asia. Phylogenetic trees were generated using various tree-building methods, including Neighbor-joining (NJ), Maximum Parsimony (MP) and Maximum Likelihood (ML) methods, with Myxocyprinus asiaticus (family Catostomidae) as the designated outgroup. The results from NJ and ML methods were mostly similar, supporting some existing subfamilies within Cyprinidae as monophyletic, such as Cultrinae, Xenocyprinae and Gobioninae (including Gobiobotinae). How-ever, genera within the subfamily 揇anioninae?did not form a monophyletic group. The subfamily Leuciscinae was divided into two unrelated groups: the Leuciscinae in East Asia forming as a monophyletic group together with Cultrinae and Xenocyprinae, while the Leuciscinae in Europe, Siberia, and North America as another monophyletic group. The monophyly of subfamily Cy-prininae sensu Howes was supported by NJ and ML trees and is basal in the tree. The position of Acheilognathinae, a widely accepted monophyletic group represented by Rhodeus sericeus, was not resolved.

关键词： Cyprinidae, cytochrome b, molecular phylogeny, Pisces.

Ru complex and N,P-containing polymers confined within mesoporous hollow carbon spheres for hydrogenation of CO_(2)to formate

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Nano Research 2023年第4期16卷 4515-4523页

作者： Guoxiang Yang Yasutaka kuwahara Kohsuke Mori Catherine Louis Hiromi Yamashita Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Institute for Open and Transdisciplinary Research Initiatives(OTRI) Osaka University2-1 Yamada-okaSuitaOsaka 565-0871Japan Unit of Elements Strategy Initiative for Catalysts&Batteries(ESICB) Kyoto UniversityKatsuraKyoto 615-8520Japan JST PRESTO4-1-8 HonchoKawaguchiSaitama 332-0012Japan Sorbonne Université CNRSLaboratoire de Réactivitéde SurfaceLRSF-75005 ParisFrance

The development of reliable catalysts with both excellent activity and recyclability for carbon dioxide(CO_(2))hydrogenation is ***,a ternary hybrid heterogeneous catalyst,involving mononuclear Ru complex,N,P-containing porous organic polymers(POPs),and mesoporous hollow carbon spheres(Ru^(3+)-POPs@MHCS)is reported for CO_(2)hydrogenation to *** on comprehensive structural analyses,we demonstrated that Ru^(3+)-POPs were successfully immobilized within *** optimized Ru^(3+)-0.5POPs@MHCS catalyst,which was obtained with about 5 wt.%Ru^(3+)and 0.5 mmol POPs polymers confined into 0.3 g MHCS,exhibited high catalytic activity for CO_(2)hydrogenation to formate(turnover number(TON)>1,200 for 24 h under mild reaction conditions(4.0 MPa,120℃))and improved durability,compared to Ru^(3+)catalysts without POPs polymers(Ru^(3+)-MHCS)and unencapsulated MHCS(Ru^(3+)-0.5POPs)*** improved catalytic performance is attributed to the high surface area and large pore volume of MHCS which favors dispersion and stabilization of Ru^(3+)-***,the MHCS and POPs showed high CO_(2)adsorption ***^(3+)-POPs encapsulated into MHCS reduces the activation energy barrier for CO_(2)hydrogenation to formate.

关键词： heterogeneous catalysis porous organic polymers(POPs) mesoporous hollow carbon spheres CO_(2)hydrogenation formate synthesis

A Spectral-Mode-Splitting Scheme for CSRZ and CSRZ-DPSK Signal Transmission

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光学学报 2003年第S1期23卷 595-596页

作者： Akira Hirano Yutaka Miyamoto Shoichiro kuwahara NTT Network Innovation Labs. NTT Corporation Hikarino-oka 1-1 Yokosuka Kanagawa JAPANNTT Network Innovation Labs. NTT Corporation Hikarino-oka 1-1 Yokosuka Kanagawa JAPANNTT Network Innovation Labs. NTT Corporation Hikarino-oka 1-1 Yokosuka Kanagawa JAPAN

We propose a spectral-mode-splitting scheme and how it can be applied to CSRZ and CSRZ-DPSK signal formats, and show that it provides both accurate chromatic dispersion detection in CSRZ application and robustness aga... 详细信息

关键词： CSRZ it DPSK NRZ for

On the horizon:Hedgehog signaling to heal broken bones

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Bone Research 2022年第1期10卷 20-30页

作者： Stephanie T.kuwahara Shuwan Liu Andrew Chareunsouk Maxwell Serowoky Francesca V.Mariani University of Southern California Keck School of MedicineDepartment of Stem Cell Biology and Regenerative MedicineLos AngelesCA 90033USA

Uncovering the molecular pathways that drive skeletal repair has been an ongoing challenge. Initial efforts have relied on in vitro assays to identify the key signaling pathways that drive cartilage and bone differentiation. While these assays can provide some clues, assessing specific pathways in animal models is critical. Furthermore, definitive proof that a pathway is required for skeletal repair is best provided using genetic tests. Stimulating the Hh(Hedgehog) pathway can promote cartilage and bone differentiation in cell culture assays. In addition, the application of HH protein or various pathway agonists in vivo has a positive influence on bone healing. Until recently, however, genetic proof that the Hh pathway is involved in bone repair has been lacking. Here, we consider both in vitro and in vivo studies that examine the role of Hh in repair and discuss some of the challenges inherent in their interpretation. We also identify needed areas of study considering a new appreciation for the role of cartilage during repair, the variety of cell types that may have differing roles in repair, and the recent availability of powerful lineage tracing techniques. We are optimistic that emerging genetic tools will make it possible to precisely define when and in which cells promoting Hh signaling can best promote skeletal repair, and thus, the clinical potential for targeting the Hh pathway can be realized.

关键词： healing Hedgehog horizon

Poly(ethylenimine)-assisted synthesis of hollow carbon spheres comprising multi-sized Ni species for CO_(2) electroreduction

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Chinese Journal of Catalysis 2024年第9期64卷 66-76页

作者： Kaining Li Yasutaka kuwahara Hiromi Yamashita Division of Materials and Manufacturing Science Graduate School of EngineeringOsaka University2‐1 Yamada‐okaOsaka 565‐0871Japan Innovative Catalysis Science Division Institute for Open and Transdisciplinary Research Initiatives(OTRI)Osaka University2‐1 Yamada‐okaSuitaOsaka 565‐0871Japan

Electrochemical CO_(2) reduction to produce value-added chemicals and fuels is one of the research hotspots in the field of energy *** development of efficient catalysts with high conductivity and readily accessible active sites for CO_(2) electroreduction remains challenging yet *** this work,a reliable poly(ethyleneimine)(PEI)-assisted strategy is developed to prepare a hollow carbon nanocomposite comprising a single-site Ni-modified carbon shell and confined Ni nanoparticles(NPs)(denoted as Ni@NHCS),where PEI not only functions as a mediator to induce the highly dispersed growth of Ni NPs within hollow carbon spheres,but also as a nitrogen precursor to construct highly active atomically-dispersed Ni-Nx *** from the unique structural properties of Ni@NHCS,the aggregation and exposure of Ni NPs can be effectively prevented,while the accessibility of abundant catalytically active Ni-Nx sites can be *** a result,Ni@NHCS exhibits a high CO partial current density of 26.9 mA cm^(-2) and a Faradaic efficiency of 93.0% at-1.0 V ***,outperforming those of its PEI-free *** from the excellent activity and selectivity,the shell confinement effect of the hollow carbon sphere endows this catalyst with long-term *** findings here are anticipated to help understand the structure-activity relationship in Ni-based carbon catalyst systems for electrocatalytic CO_(2) ***,the PEI-assisted synthetic concept is potentially applicable to the preparation of high-performance metal-based nanoconfined materials tailored for diverse energy conversion applications and beyond.

关键词： Hollow carbon sphere Ni nanoparticle CO_(2) reduction Electrocatalysis Single-atom catalyst

Oral administration of Lactiplantibacillus plantarum 22A-3 exerts anti-allergic activity against intestinal food allergy mouse models sensitized and challenged with ovalbumin

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Food Bioscience 2022年第3期47卷 1294-1300页

作者： Mari Enokida Ken-ichiro Minato Susumu Yoshino Nobuaki Ohto Hiroshige kuwahara Masashi Mizuno Department of Agrobioscience Graduate School of Agricultural ScienceKobe UniversityKobe657-8501Japan Department of Applied Biological Chemistry Graduate School of AgricultureMeijo UniversityNagoya468-8502Japan Research Center Maruzen Pharmaceuticals Co.Ltd.Fukuyama729-3102Japan

In recent years,researches on food components with anti-allergic effects have been gathering attention,because of the expectation for the establishment of a safe and effective treatment for food *** studies have reported that Lactiplantibacillus plantarum 22A-3 (LP22A3) inhibited degranulation of mast cells and reduced IgE *** have developed a gastrointestinal allergy system in which mice are sensitized by intraperitoneal and oral administration of OVA and then challenged by oral administration of high doses of *** a result,an increase in the amount of IgE in the blood and a decrease in the temperature of the colon were confirmed,and it was clarified that food allergy was induced by oral administration of high dose of OVA as the *** administration of LP22A3 ameliorated allergic responses significantly by reducing the amount of IgE in the blood and to recovered the decrease of rectal ***,LP22A3 did not affect the intestinal barrier *** LP22A3 significantly suppressed mRNA expression of OX40L and *** results suggested that LP22A3 suppressed Th2 differentiation and IL-4 production via downregulation of OX40L,and consequently suppressed IgE ***22A3 might provide a safe and effective treatment for allergic diseases due to ability modulating intestinal immune system.

关键词： Anti-allergic activity Food allergy Lactiplantibacillus plantarum 22A-3 Ovalbumin OX40L

Gastric adenocarcinoma arising in gastritis cystica profunda presenting with selective loss of KCNE2 expression

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World Journal of Gastroenterology 2013年第8期19卷 1314-1317页

作者： Natsumi kuwahara Riko Kitazawa Koto Fujiishi Yusa Nagai Ryuma Haraguchi Sohei Kitazawa Department of Molecular Pathology Ehime UniversityGraduate School of MedicineEhime 791-0295Japan

Gastritis cystica profunda(GCP) is a rare condition caused by ectopic entrapment of gastric glands,probably secondary to the disruption of muscularis *** is often associated with gastric adenocarcinoma,and loss of the KCNE2 subunit from potassium channel complexes is considered a common primary target molecule leads to both GCP and *** this study,we,for the first time,analyzed the expression of KCNE2 in surgically excised tissue from human gastric cancer associated with GCP and confirmed that reduced KCNE2 expression correlates with disease formation.

关键词： KCNE2 Gastritis cystica profunda Immunohistochemistry

Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice

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Animal Models and Experimental Medicine 2024年第1期7卷 77-81页

作者： Tatsushi Mutoh Ryota Tochinai Hiroaki Aono Masayoshi kuwahara Yasuyuki Taki Tatsuya Ishikawa Department of Surgical Neurology Research Institute for Brain and Blood VesselsAkita Cerebrospinal and Cardiovascular CenterAkitaJapan Department of Aging Research and Geriatric Medicine Institute of DevelopmentAging and CancerTohoku UniversitySendaiJapan Department of Veterinary Pathophysiology and Animal Health Graduate School of Agriculture and Life SciencesThe University of TokyoTokyoJapan

The murine model of subarachnoid hemorrhage(SAH)is a valuable experimental tool for investigating molecular and cellular mechanisms,and the endovascular filament perforation technique can be used to simulate prominent pathophysiological features observed after human SAH;however,current validation methods for assessing an appropriate SAH model are ***,we introduce a simple procedure for se-lecting a mouse model of diffuse *** was induced in 24 mice using a standard filament perforation *** confirming survival at 24 h,SAH was scored 0-1 based on T2*-weighted images on whole-brain magnetic resonance imaging(MRI)and visual surveillance of the cisterna magna(CM)through the dura *** CM-based SAH grading correlated well with a reference parameter defined by extracted brain(r^(2)=0.53,p<0.0001).The receiver operating characteristic curve revealed a sensi-tivity of 85%and a specificity of 91%for detecting diffuse SAH,with a similar area under the curve(0.89±0.06[standard error of the mean])as the MRI-based grading(0.72±0.10,p=0.12).Our data suggest that confirming an SAH clot in the CM is a valuable way to select a clinically relevant diffuse SAH model that can be used in future experimental studies.

关键词： cisterna magna clot distribution filament perforation mouse model subarachnoid hemorrhage

Verbal Abuse, Physical Assault, and Harassment in Pediatric Medical Settings: A Nationwide Survey in Japan

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Health 2022年第2期14卷 177-193页

作者： Rie Wakimizu Hinako kuwahara Department of Child Health and Developmental Nursing Faculty of Medicine University of Tsukuba Ibaraki Japan Department of Nursing Toranomon Hospital Tokyo Japan

Background: Verbal abuse, physical assault, and harassment of pediatric healthcare workers by patients and their families have become increasingly serious. These incidents lead to various problems, including the deterioration of staff members’ mental health and employee turnover. Methods: This study was conducted as the first Japanese nationwide survey to assess the abuse perpetrated by patients and families and experienced by medical staff in pediatric medical settings in 2018, countermeasures employed, and staff member evaluations of the countermeasures. Results: Responses from 526 facilities were received, clinics accounted for 79.8% of these facilities;88.1% of the respondents were females. Further, 10.5% of the facility staff reported having experienced verbal abuse, violence, or harassment from patients or family members. Of 1103 cases of victimizations, there were 719, 136, and 248 cases of verbal abuse, violence, and harassment, respectively. Manuals and guidelines had been created and training and drill performances were conducted as countermeasures in 10.7% and 9.0% of facilities, respectively;7.3% of staff members felt that the countermeasures were effective, corresponding to 45.6% of the affected staff. Conclusion: The findings suggest the necessity of thoroughly familiarizing staff with existing facility countermeasures as well as introducing new countermeasures such as victimization simulations.

关键词： Verbal Abuse Physical Assault Harassment Pediatric Medical Setting Countermeasures