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Gravitational wave footprints from Higgs-portal scalegenesis with multiple dark chiral scalars

Chinese Physics C 2024年第4期48卷 209-221页

作者： He-Xu Zhang Shinya Matsuzaki Hiroyuki ishida Center for Theoretical Physics and College of Physics Jilin UniversityChangchun 130012China Center for Liberal Arts and Sciences Toyama Prefectural UniversityToyama 939-0398Japan

We discuss the gravitational wave(GW)spectra predicted from the electroweak scalegenesis of the Higgs portal type with a large number of dark chiral flavors,which many flavor QCD would underlie and give the dynamical explanation of the negative Higgs portal coupling required to trigger the electroweak symmetry *** employ the linear-sigma model as the low-energy description of dark many flavor QCD and show that the model undergoes ultra-supercooling due to the produced strong first-order thermal phase transition along the(approximately realized)flat direction based on the Gildener-Weinberg *** through evaluation of the bubble nucleation/percolation,we address the reheating and relaxation processes,which are generically non-thermal and *** the reheating epoch in terms of the e-folding number,we propose proper formulae for the redshift effects on the GW frequencies and signal *** then turns out that the ultra-supercooling predicted from the Higgs-portal scalegenesis generically yields none of GW signals with the frequencies as low as nano Hz,unless the released latent heat is transported into another sector other than reheating the ***,models of this class prefer to give the higher frequency signals and still keeps the future prospected detection sensitivity,like at LISA,BBO,and DECIGO,*** also find that with large flavors in the dark sector,the GW signals are made further smaller and the peak frequencies *** phenomenological consequences related to the multiple chiral scalars include the prediction of dark pions with the mass much less than TeV scale,which is also briefly addressed.

关键词： gravitational wave electroweak scalegenesis many flavor QCD

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Z-shaped incision without epithelial resection in pterygium surgery

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1262-1266页

作者： Satoru Kase Shinki Chin Susumu ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo 060-8638Japan

AIM:To introduce a novel surgical technique using a Z-shaped incision without epithelial resection in ophthalmic ***:This was a prospective *** pterygium surgery,all proliferative tissues were separated from the cornea and conjunctiva without resection of the *** unaffected conjunctiva was incised in a *** upper(or lower)conjunctival flap was sutured to the lower(or upper)normal conjunctiva on the limbal sclera,while the proliferative tissue was sutured to the upper conjunctiva(or lower)near the ***:Ten patients with pterygia were eligible for this *** patients with primary pterygia and 2 with recurrent pterygia were *** age of patients at surgery ranged from 47 to 90y(average:71.9y).Five patients each showed right and left-sided *** postoperative follow-up periods were from 8 to 78mo(average:25.0mo).The surgery was successfully conducted and wounds were favorably reconstructed in all *** proliferative tissues sutured to the normal conjunctiva showed palor and attenuated neovessles,and never showed re-growth after *** patients did not show *** pterygium was noted in 1 patient,but additional treatments were not ***:The procedure involves the reconstruction of pterygial tissue and normal conjunctiva using a Z-shaped *** scleral limbal wound can be covered with nonaffected conjunctiva without any excision of conjunctival epithelia in patients with primary or recurrent pterygia.

关键词： pterygium surgery Z-shape non-resection

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Ornithine decarboxylase, mitogen-activated protein kinase and matrix metalloproteinase-2 expressions in human colon tumors

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World Journal of Gastroenterology 2005年第20期11卷 3065-3069页

作者： Takahiro Nemoto Shunichiro Kubota hideyuki ishida Nobuo Murata Daijo Hashimoto Department of Physiological Chemistry and Metabolism Graduate School of Medicine The University of Tokyo 7-3-1 Hongo Bunkyo-kuTokyo 113-0033 Japan Department of Physiological Chemistry and Metabolism Graduate School of Medicine The University of Tokyo 7-3-1 Hongo Bunkyo-kuTokyo 113-0033 Japan Department of Life Sciences Graduate School of Arts and Sciences The University of Tokyo 3-8-1 KomabaMeguro-ku Tokyo 153-8902 Japan Department of Surgery Saitama Medical Center Saitama Medical School 1981 Tsujido-machi Kamoda Kawagoe City Saitama 350-8550 Japan

AIM: To investigate the expressions of omithine decarboxylase (ODC), MMP-2, and Erk, and their relationship in human colon ***: ODC activity, MMP-2 expression, and mitogenactivated protein (MAP) kinase activity (Erk phosphorylation) were determined in 58 surgically removed human colon tumors and their adjacent normal tissues, using [1-14C]-ornithine as a substrate, ELISA assay, and Western blotting, ***: ODC activity, MMP-2 expression, and Erk phosphorylation were significantly elevated in colon tumors, compared to those in adjacent normal tissues. A significant correlation was observed between ODC activities and MMP-2 ***: This is the first report showing a significant correlation between ODC activities and MMP-2 levels in human colon tumors. As MMP-2 is involved in cancer invasion and metastasis, and colon cancer overexpresses ODC, suppression of ODC expression may be a rational approach to treat colon cancer which overexpresses ODC.

关键词：鸟氨酸脱羧酶分裂素活性蛋白蛋白激酶金属蛋白酶-2 结肠肿瘤

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Gravitational wave footprints from Higgs-portal scalegenesis with multiple dark chiral scalars

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Chinese Physics C 2024年第4期 213-225页

作者：张贺旭 Shinya Matsuzaki Hiroyuki ishida Center for Theoretical Physics and College of Physics Jilin University Center for Liberal Arts and Sciences Toyama Prefectural University

We discuss the gravitational wave(GW) spectra predicted from the electroweak scalegenesis of the Higgs portal type with a large number of dark chiral flavors, which many flavor QCD would underlie and give the dynamical explanation of the negative Higgs portal coupling required to trigger the electroweak symmetry *** employ the linear-sigma model as the low-energy description of dark many flavor QCD and show that the model undergoes ultra-supercooling due to the produced strong first-order thermal phase transition along the(approximately realized) flat direction based on the Gildener-Weinberg mechanism. Passing through evaluation of the bubble nucleation/percolation, we address the reheating and relaxation processes, which are generically non-thermal and nonadiabatic. Parametrizing the reheating epoch in terms of the e-folding number, we propose proper formulae for the redshift effects on the GW frequencies and signal spectra. It then turns out that the ultra-supercooling predicted from the Higgs-portal scalegenesis generically yields none of GW signals with the frequencies as low as nano Hz,unless the released latent heat is transported into another sector other than reheating the universe. Instead, models of this class prefer to give the higher frequency signals and still keeps the future prospected detection sensitivity, like at LISA, BBO, and DECIGO, etc. We also find that with large flavors in the dark sector, the GW signals are made further smaller and the peak frequencies higher. Characteristic phenomenological consequences related to the multiple chiral scalars include the prediction of dark pions with the mass much less than Te V scale, which is also briefly addressed.

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Utility of plasma D-dimer for diagnosis of venous thromboembolism after hepatectomy

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World Journal of Clinical Cases 2024年第2期12卷 276-284页

作者： Taiichiro Miyake Hiroaki Yanagimoto Daisuke Tsugawa Masayuki Akita Riki Asakura Keisuke Arai Toshihiko Yoshida Shinichi So Jun ishida Takeshi Urade Yoshihide Nanno Kenji Fukushima Hidetoshi Gon Shohei Komatsu Sadaki Asari Hirochika Toyama Masahiro Kido Tetsuo Ajiki Takumi Fukumoto Division of Hepato-Biliary-Pancreatic Surgery Department of SurgeryKobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Venous thromboembolism(VTE)is a potentially fatal complication of *** use of postoperative prophylactic anticoagulation in patients who have undergone hepatectomy is controversial because of the risk of postoperative ***,we hypothesized that monitoring plasma D-dimer could be useful in the early diagnosis of VTE after *** To evaluate the utility of monitoring plasma D-dimer levels in the early diagnosis of VTE after *** The medical records of patients who underwent hepatectomy at our institution between January 2017 and December 2020 were retrospectively *** were divided into two groups according to whether or not they developed VTE after hepatectomy,as diagnosed by contrast-enhanced computed tomography and/or ultrasonography of the lower *** factors,including demographic data and perioperative D-dimer values,were compared between the two *** operating characteristic curve analysis was performed to determine the D-dimer cutoff *** and multivariate analyses were performed using logistic regression analysis to identify significant *** In total,234 patients who underwent hepatectomy were,of whom(5.6%)were diagnosed with VTE following hepatectomy.A comparison between the two groups showed significant differences in operative time(529 vs 403 min,P=0.0274)and blood loss(530 vs 138 mL,P=0.0067).The D-dimer levels on postoperative days(POD)1,3,5,7 were significantly higher in the VTE group than in the non-VTE *** the multivariate analysis,intraoperative blood loss of>275 mL[odds ratio(OR)=5.32,95%confidence interval(CI):1.05-27.0,P=0.044]and plasma D-dimer levels on POD 5≥21μg/mL(OR=10.1,95%CI:2.04-50.1,P=0.0046)were independent risk factors for VTE after *** Monitoring of plasma D-dimer levels after hepatectomy is useful for early diagnosis of VTE and may avoid routine prophylactic anticoagulation in the

关键词： Hepatectomy Malignant tumor Postoperative complication D-dimer Early diagnosis Venous thromboembolism

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Commentary on transplant outcomes of 100 cases of living-donor ABO-incompatible kidney transplantation

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Chinese Medical Journal 2022年第19期135卷 2301-2302页

作者： Hideki ishida Department of Organ Transplant Medicine Tokyo Women's Medical University HospitalShinjuku-kuTokyo 162-8666Japan.

By the end of 1980,Japanese groups had started programs with ABO-incomparible kidney transplantation as a consequence of the very limited supply of cadaveric organs for *** then,they have done successful transplantations across the blood type barrier in combina-tion with plasmapheresis and *** Japan,the strategy for ABO-incompatible transplantation has changed with the development of the tacrolimus(FK)/mycophenolate mofetil(MMF)combination in 2000 and rituximab in 2005.1 In addition,preoperative 1-week administration of FK/MMF produced much more excellent *** graft survival(2005-2013)was almost over 90%in both ABO-incompatible at 9-year follow-up,which was comparable to ABO-compatible kidney trans-plantations.

关键词： ABO kidney organs

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A backpropagation neural network improved by a genetic algorithm for predicting the mean radiant temperature around buildings within the long-term period of the near future

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Building Simulation 2022年第3期15卷 473-492页

作者： Yuquan Xie Yasuyuki ishida Jialong Hu Akashi Mochida Department of Architecture and Building Science Graduate School of EngineeringTohoku UniversityJapan Institute of Technology Tokyu ConstructionJapan

This study aimed to develop a neural network(NN)-based method to predict the long-term mean radiant temperature(MRT)around buildings by using meteorological parameters as training *** MRT dramatically impacts building energy consumption and significantly affects outdoor thermal *** NN-based long-term MRT prediction,two main restrictions must be overcome to achieve precise results:first,the difficulty of preparing numerous training datasets;second,the challenge of developing an accurate NN *** overcome these restrictions,a combination of principal component analysis(PCA)and K-means clustering was employed to reduce the training data while maintaining high prediction ***,three widely used NN models(feedforward NN(FFNN),backpropagation NN(BPNN),and BPNN optimized using a genetic algorithm(GA-BPNN))were compared to identify the NN with the best long-term MRT prediction *** performances of the tested NNs were evaluated using the mean absolute percentage error(MAPE),which was≤3%in each *** findings indicate that the training dataset was reduced effectively by the PCA and *** the three NNs,the GA-BPNN produced the most accurate results,with its MAPE being below 1%.This study will contribute to the development of fast and feasible outdoor thermal environment prediction.

关键词： backpropagation neural network principal component analysis mean radiant temperature K-means clustering genetic algorithm long-term prediction

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Factors other than fibrosis that increase measured shear wave velocity

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World Journal of Gastroenterology 2022年第46期28卷 6512-6521页

作者： Hiroko Naganuma Hideaki ishida Department of Gastroenterology Yokote Municipal HospitalYokote 013-8602Japan Department of Gastroenterology Akita Red Cross HospitalAkita 010-1495Japan

Shear wave elastography(SWE)is now becoming an indispensable diagnostic tool in the routine examination of liver *** particular,accuracy is required for shear wave propagation velocity measurement,which is directly related to diagnostic *** is generally accepted that the liver shear wave propagation velocity reflects the degree of fibrosis,but there are still few reports on other factors that increase the shear wave propagation *** this study,we reviewed such factors in the literature and examined their *** SWE measures propagation velocity based on the assumption that the medium has a homogeneous structure,uniform density,and is purely ***,the measurement is subject to *** other(confounding)factors that we routinely experience are primarily:(1)Conditions that appear to increase the viscous component;and(2)Conditions that appear to increase tissue ***,the former includes acute hepatitis,congested liver,biliary obstruction,etc,and the latter includes diffuse infiltration of malignant cells,various storage diseases,tissue necrosis,*** any case,it is important to evaluate SWE in the context of the entire clinical picture.

关键词： Liver Shear wave elastography Propagation velocity Viscoelasticity Artifact Ultrasound

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Pneumonia and seizures due to hypereosinophilic syndrome—organ damage and eosinophilia without synchronisation:A case report

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World Journal of Clinical Cases 2022年第18期10卷 6325-6332页

作者： Tetsuro ishida Tomonori Murayama Seiju Kobayashi Department of Psychiatry Hokujinkai Ishibashi HospitalOtaru 047-8585Japan Department of Psychiatry Kushiro Red Cross HospitalKushiro 085-8512Japan Department of Psychiatry Shinyukai Nakae HospitalSapporo 001-0022Japan

BACKGROUND Hypereosinophilic syndrome(HES)is a condition characterized by increased eosinophil proliferation in the bone marrow,as well as tissue eosinophilia,often causing organ *** cause of the disease is *** symptoms include fatigue,cough,shortness of breath,myalgia,angioedema,fever,and *** addition to the respiratory symptoms,damage to the central nervous system can lead to severe ***,we report a case with pneumonia and complex partial seizures secondary to *** SUMMARY A 94-year-old woman was admitted to our hospital for heart failure and bloody *** admission,she also showed symptoms of ***-contrast computed tomography of the chest showed pleural effusion and infiltrative *** gastrointestinal endoscopy showed multiple ulcers in the sigmoid *** analyses showed marked eosinophilia(eosinophils 1760/mm3,total leukocytes 6850/mm3).Initial treatment with furosemide 20 mg/d and prednisolone 25 mg/d relieved these ***,the patient subsequently experienced localised epileptic seizures characterized by bilateral eyelid twitching and eyes rolling upwards,without generalized convulsions,and respiratory arrest *** showed spikes and ***-contrast magnetic resonance imaging of the brain showed extensive periventricular *** administration of levetiracetam 1000 mg/d the epileptic seizures ***,the patient’s consciousness remained impaired,and her pneumonia worsened *** weeks later,she died of *** HES symptoms are variable and atypical,and the level and timing of eosinophilia and organ damage are often discordant.

关键词： Case report Hypereosinophilic syndrome Pneumonia Seizures Prednisolone Levetiracetam

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Current research of idiopathic normal pressure hydrocephalus:Pathogenesis,diagnosis and treatment

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World Journal of Clinical Cases 2023年第16期11卷 3706-3713页

作者： Tetsuro ishida Tomonori Murayama Seiju Kobayashi Department of Psychiatry Japan Health Care CollegeSapporo 062-0053HokkaidoJapan Department of Psychiatry Asahikawa Keisenkai HospitalAsahikawa 078-8208HokkaidoJapan Department of Psychiatry Shinyukai Nakae HospitalSapporo 001-0022HokkaidoJapan

Idiopathic normal pressure hydrocephalus(iNPH)is caused by impaired cerebrospinal fluid absorption in the elderly;it is a surgically treatable form of *** disturbance,dementia,and urinary incontinence are the triad of signs for *** addition to these clinical findings,imaging studies show characteristic ventricular *** Evans Index and‘disproportionately enlarged subarachnoid hydrocephalus’are other well-known imaging findings of *** the tap test shows improved symptoms,shunt surgery is *** disease was first described by Hakim and Adams in 1965,followed by the publication of the first,second,and third editions of the guidelines in 2004,2012,and 2020,*** studies signal the glymphatic system and classical cerebrospinal fluid(CSF)absorption from the dural lymphatics as aetiological mechanisms of CSF *** is also underway on imaging test and biomarker developments for more precise diagnosis,shunting technique options with fewer sequelae and complications,and the influence of ***,the newly introduced‘suspected iNPH’in the third edition of the guidelines may be useful for earlier ***,less well-studied areas remain,such as pharmacotherapy in non-operative indications and neurological findings other than the triadic *** review briefly presents previous research on these and future issues.

关键词： Review Idiopathic normal pressure hydrocephalus Treatable dementia Shunt surgery Drug therapy

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