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Invasive group B streptococcal infection in a patient with post splenectomy for hypersplenism secondary to liver cirrhosis and portal hypertension

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World Journal of Emergency Medicine 2016年第1期7卷 68-70页

作者： Tomoya Okazaki Toru Hifumi Arisa Manabe Hikari Matsumura Satoshi Egawa hideyuki hamaya Nastuyo Shinohara Koshiro Takano Hajime Shishido Yuko Abe Kenya Kawakita Masanobu Hagiike Yasuhiro Kuroda Emergency Medical Center Kagawa University Hospital Kita Kagawa 761-0793 Japan

BACKGROUND:Splenectomy in patients with liver cirrhosis(LC)is expected to become more common owing to its efficacy on portal *** this report we describe an alarming case of group B streptococcus(GBS)infection after splenectomy in a patient with ***:A 72-year-old woman with a history of LC was admitted to our emergency department because of respiratory *** patient had received left lateral segmentectomy of the liver and splenectomy three months before *** examination revealed significant wheezing during inspiration and expiration,but no crackles and *** radiography and CT showed no infiltrates.A presumptive diagnosis of bronchial asthma caused by upper respiratory infection was *** days after admission,GBS infection was confirmed by blood culture and penicillin G was *** were given intravenously for a total of 12 ***:The patient was discharged on the 12th day after ***:Although efficacy of splenectomy in patients with LC has been reported,immune status should be evaluated for a longer *** who have undergone splenectomy are highly susceptible to bacteria;moreover,LC itself is an independent risk factor for mortality in patients with *** prophylaxis against GBS has not been established,immediate action should be *** physicians should be aware of invasive GBS infection in the context of the critical risk factors related to splenectomy and LC,particularly the expected increase of splenectomy performed in LC patients.

关键词： Group B streptococcal infection Splenectomy Liver cirrhosis

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Existence and Stability Property of Almost Periodic Solutions in Discrete Almost Periodic Systems

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Advances in Pure Mathematics 2018年第5期8卷 463-484页

作者： Yoshihiro hamaya Department of Information Science Okayama University of Science 1-1 Ridai-cho Okayama Japan

In this paper, we consider an almost periodic system which includes a system of the type , where k is a positive integer, aij are almost periodic in n and satisfy aij(n)≥0 for i≠j,? for 1≤j≤m. In the special case where aij(n) are constant functions, above system is a mathematical model of gas dynamics and was treated by T. Carleman and R. D. Jenks for differential systems. In the main theorem, we show that if the m X m matrix (aij(n)) is irreducible, then there exists a positive almost periodic solution which is unique and has some stability. Moreover, we can see that this result gives R. D. Jenks’ result for differential model in the case where aij(n) are constant functions. In Section 3, we consider the linear system with variable cofficients . Even in nonlinear problems, this linear system plays an important role, as their variational equations, and it is requested to determine the uniform asymptotically stability of the zero solution from the information about A(n). In order to obtain the existence of almost periodic solutions of both linear and nonlinear almost periodic discrete systems: above linear system and? for 1≤i≤m, respectively, we shall consider between certain stability properties, which are referred to as uniformly asymptotically stable, and the diagonal dominance matrix condition.

关键词： Almost Periodic Solutions Linear and Nonlinear Almost Periodic Discrete Systems Uniformly Asymptotically Stable Diagonal Dominance Matrix Condition

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Global Asymptotically Stable of a Generalized Discrete Ricker Competition System

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Journal of Mathematics and System Science 2013年第6期3卷 282-288页

作者： Yoshihiro hamaya Department of Information Science Okayama University of Science Okayama 7000005 Japan

The purpose of this article is to investigate the sufficient conditions for the global asymptotic stability of one equilibrium point of a generalized Ricker competition system,……which appears as a model for dynamics with one extinct species, by applying the technique of average functions and the new principle of competitive exclusion.

关键词： Generalized discrete ricker competition systems average functions new principle of competitive exclusion.

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On the Asymptotic Stability of Discrete Crocodilians Model

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Advances in Pure Mathematics 2023年第5期13卷 211-225页

作者： Kaori Saito Yoshihiro hamaya Meise University Tokyo Japan Okayama University of Science Okayama Japan

The sex ratio of crocodiles is strongly biased towards females, often as high as 10 females to 1 male. In crocodilians, the temperature of egg incubation is the environmental factor determining sex. If the temperature is low, around 30˚C, the hatchlings are all females. Higher temperature, around 34˚C, hatch all males. This study was made to consider the asymptotic stability of a positive equilibrium point in a nonlinear discrete model of the basic nesting population model, which is described in three-region depending on the temperature of egg incubation. This model is based on key life-historical data and Murray’s research. To study above, we have applied the classical linearization method and P. Cull’s method and moreover, we employ non-standard discretization methods for later our Equations (6)-(8) and (15).

关键词： Asymptotic Stability Crocodilians Population Model Positive Equilibrium Point

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Detecting Bank Conflict of GPU Programs Using Symbolic Execution—Case Study

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Journal of Software Engineering and Applications 2017年第2期10卷 159-167页

作者： Koki hamaya Satoshi Yamane Graduate School of Natural Science and Technology Kanazawa University Kanazawa Japan

GPU (Graphics Processing Unit) is used in various areas. Therefore, the demand for the verification of GPU programs is increasing. In this paper, we suggest the method to detect bank conflict by using symbolic execution. Bank conflict is one of the bugs happening in GPU and it leads the performance of programs lower. Bank conflict happens when some processing units in GPU access the same shared memory. Symbolic execution is the method to analysis programs with symbolic values. By using it, we can detect bank conflict on GPU programs which use many threads. We implement a prototype of the detector for bank conflict and evaluate it with some GPU programs. The result states that we can detect bank conflict on the programs with no loop regardless of the number of threads.

关键词： Graphics Processing Units GPU Bank Conflict Symbolic Execution Model Checking

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Early serum albumin changes in patients with ulcerative colitis treated with tacrolimus will predict clinical outcome

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World Journal of Gastroenterology 2021年第22期27卷 3109-3120页

作者： Natsuki Ishida Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto First Department of Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Laboratory Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Department of Endoscopic and Photodynamic Medicine Hamamatsu University of School of MedicineHamamatsu 431-3192Japan Center for Clinical Research Hamamatsu University of School of MedicineHamamatsu 43131Japan

BACKGROUND Oral tacrolimus is a therapeutic agent for moderate to severe steroid-dependent or resistant ulcerative colitis(UC),but remission induction is difficult,and it is necessary to treat the patient while considering the next *** To examine serum albumin(Alb)level as a prognostic factor for the therapeutic effect of tacrolimus in clinical *** Forty-seven patients with UC treated with tacrolimus at our institution were divided into remission and failure groups(colectomy or switch to biologics),and the biological data at the start of observation and at weeks 1 and 2 were retrospectively ***-Meier and multivariate analyses were performed using Alb as a prognostic factor in UC *** During the three months observed,17(36.2%)patients failed treatment with tacrolimus.A comparison between the failure and remission groups showed a significant difference only in Alb in week 2,and in the week 2/week 0 Alb ratio,which showed the rate of change in *** cut-off value of the week 2/week 0 Alb ratio that predicted failure was 1,and its area under the curve was 0.751(95%CI:0.604-0.898).In the Kaplan-Meier analysis,a week 2/week 0 Alb ratio≤1 had a significantly higher failure rate than that of>1;Cox proportional hazard regression analysis also showed that a week 2/week 0 Alb ratio≤1 was an independent prognostic factor for failure within 3 mo after the start of tacrolimus *** A week 2/week 0 Alb ratio≤1 predicts failure within 3 mo of tacrolimus administration for *** failure risk exists with week 2 Alb values≤1 on admission.

关键词： Ulcerative colitis Tacrolimus Albumin

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Love Dynamical Models with Delay

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Advances in Pure Mathematics 2020年第5期10卷 297-311页

作者： Kaori Saito Shiho Takagi Yoshihiro hamaya Department of Industrial Information Iwate Prefectural University Miyako College Miyako Japan Global Education Development Center Okayama University of Science 1-1 Ridai-Cho Okayama Japan Department of Information Science Okayama University of Science 1-1 Ridai-Cho Okayama Japan

A sufficient condition for the asymptotic stability of the equilibrium point of a system, which appears as a model for couple of the love affair with time delay, is obtained by applying the technique of linearized met... 详细信息

关键词： Love Affairs Asymptotic Stability Linearized Method Hop-Bifurcation Delay Dynamical Model

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Inverted Meckel's diverticulum preoperatively diagnosed using double-balloon enteroscopy

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World Journal of Gastroenterology 2016年第17期22卷 4416-4420页

作者： Kosuke Takagaki Satoshi Osawa Tatsuhiro Ito Moriya Iwaizumi Yasushi hamaya Hiroe Tsukui Takahisa Furuta Hidetoshi Wada Satoshi Baba Ken Sugimoto First Department of Medicine Hamamatsu University School of Medicine Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of Medicine Department of Diagnostic Pathology Hamamatsu University School of Medicine Center for Clinical Research Hamamatsu University School of Medicine First Department of Surgery Hamamatsu University School of Medicine

An inverted Meckel’s diverticulum is a rare gastrointestinal congenital anomaly that is difficult to diagnose prior to surgery and presents with anemia, abdominal pain, or intussusception. Here, we report the case of 57-year-old men with an inverted Meckel’s diverticulum, who was preoperatively diagnosed using double-balloon enteroscopy. He had repeatedly experienced epigastric pain for 2 mo. Ultrasonography and computed tomography showed intestinal wall thickening in the pelvis. Double-balloon enteroscopy via the anal route was performed for further examination, which demonstrated an approximately 8-cm, sausage-shaped, submucosal tumor located approximately 80 cm proximal to the ileocecal valve. A small depressed erosion was observed at the tip of this lesion. Forceps biopsy revealed heterotopic gastric mucosa. Thus, the patient was diagnosed with an inverted Meckel’s diverticulum, and single-incision laparoscopic surgery was performed. This case suggests that an inverted Meckel’s diverticulum should be considered as a differential diagnosis for a submucosal tumor in the ileum. Balloon-assisted enteroscopy with forceps biopsy facilitate a precise diagnosis of this condition.

关键词： Inverted Meckel’ s diverticulum Double-balloon enteroscopy Small bowel tumor Epigastric pain Heterotopic gastric mucosa

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Lymphocyte-to-monocyte ratio is a short-term predictive marker of ulcerative colitis after induction of advanced therapy

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Gastroenterology Report 2022年第1期10卷 370-376页

作者： Natsuki Ishida Yusuke Asai Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto First Department of Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Center for Clinical Research Hamamatsu University School of MedicineHamamatsuShizuokaJapan

Advanced therapies for patients with mild-to-severe ulcerative colitis(UC)may result in treatment *** examined whether the lymphocyte-to-monocyte ratio(L/M ratio)could predict the failure of advanced *** retrospective,observational,cohort study included 73 patients who were treated with advanced therapies at the Hamamatsu University School of Medicine(Shizuoka,Japan)between February 2011 and November *** patients were divided into the nonfailure and failure groups,and their leukocyte counts and ratios before induction were *** and multivariate analyses were performed to identify the prognostic *** therapies failed within 3 months in 15(20.5%)*** the L/M ratio was significantly lower in the failure group than in the non-failure group(P=0.004).Receiveroperating characteristic(ROC)curve analysis revealed that an L/M ratio of ≤3.417 was predictive of treatment failure;the area under the curve(AUC)was 0.747(95%CI,0.620–0.874).Kaplan–Meier analysis revealed that the failure-free rate was significantly lower in the group with an L/M ratio of≤3.417 than in the group with an L/M ratio of>3.417(log-rank test P=0.002).Cox proportional hazard regression analysis identified an L/M ratio of≤3.417 as an independent risk factor for failure within 3 months after the induction of advanced ***,ROC analysis of patients who did not receive immunomodulators also revealed that the cut-off L/M ratio was 3.417 and the AUC was 0.796(95%CI,0.666–0.925).In patients receiving advanced therapies for active UC,the L/M ratio can predict treatment failure within 3 months.L/M ratios could facilitate the transition from advanced therapies to subsequent treatments.

关键词： advanced therapy failure lymphocyte-to-monocyte ratio ulcerative colitis

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Evaluating mucosal healing using colon capsule endoscopy predicts outcome in patients with ulcerative colitis in clinical remission

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World Journal of Clinical Cases 2018年第15期6卷 952-960页

作者： Ryosuke Takano Satoshi Osawa Takahiro Uotani Shinya Tani Natsuki Ishida Satoshi Tamura Mihoko Yamade Moriya Iwaizumi Yasushi hamaya Takahisa Furuta Hiroaki Miyajima Ken Sugimoto First Department of Medicine Hamamatsu University School of Medicine Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of Medicine Department of Laboratory Medicine Hamamatsu University School of Medicine Center for Clinical Research Hamamatsu University School of Medicine

AIM To examine whether second generation of colon capsule endoscopy(CCE-2) is acceptable for assessing the severity of mucosal inflammation and evaluating mucosal healing using CCE-2 is able to predict outcome in ulcerative colitis(UC) patients, especially in clinical *** A total of 30 consecutive UC patients in clinical remission were enrolled to undergo CCE-2. Clinical remission was defined as clinical activity index(CAI) ≤ 4 according to Rachmilewitz index. The rate of total colon observation and colon cleansing level were evaluated. Severity of mucosal inflammation in UC was assessed according to the Mayo endoscopic subscore(MES) and Ulcerative Colitis Endoscopic Index of Severity(UCEIS). Relapsefree survival was assessed. Acceptability of CCE-2 was assessed using a questionnaire *** The rate of total colon observation within its battery life was 93.3%. The proportion of "excellent" plus "good" cleansing level was 73.3%. The rate of mucosal healing(MES 0, 1) assessed by CCE-2 was 77.0%. The relapse-free survival rate was significantly higher in MES 0, 1 than in MES 2, 3(P = 0.0435), and in UCEIS 0-3 than in UCEIS 4-8(P = 0.0211), whereas there was no significant difference between CAI 0 and CAI 1-4 groups. A questionnaire survey revealed an overall acceptability of *** CCE-2 is acceptable for assessing the severity of mucosal inflammation in UC patients, especially in clinical remission. Evaluating mucosal healing using CCE-2 was able to predict outcome.

关键词： Colon capsule endoscopy Ulcerative colitis Mucosal healing Mayo endoscopic subscore Ulcerative Colitis Endoscopic Index of Severity

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