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Molecular pathogenesis of sporadiccolorectal cancers

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Chinese Journal of Cancer 2016年第1期35卷 12-19页

作者： Hidetsugu Yamagishi Hajime Kuroda Yasuo Imai hideyuki Hiraishi Department of Diagnostic Pathology Dokkyo Medical University880 Kita‑KobayashiMibuShimotsugaTochigi 321‑0293Japan Department of Pathology International University of Health and Welfare Hospital537‑3 IguchiNasushiobaraTochigi 329‑2763Japan Department of Diagnostic Pathology Ota Memorial HospitalFuji Heavy Industries Health Insurance Society455‑1 OshimaOtaGunma 373‑8585Japan Department of Gastroenterology Dokkyo Medical University880 Kita‑KobayashiMibuShimotsugaTochigi 321‑0293Japan.

Colorectal cancer(CRC)results from the progressive accumulation of genetic and epigenetic alterations that lead to the transformation of normal colonic mucosa to *** 75%of CRCs are sporadic and occur in people without genetic predisposition or family history of *** the past two decades,sporadic CRCs were classified into three major groups according to frequently altered/mutated *** genes have been identified by linkage analyses of cancer-prone families and by individual mutation analyses of candidate genes selected on the basis of functional *** the first half of this review,we describe the genetic pathways of sporadic CRCs and their clinicopathologic ***,large-scale genome analyses have detected many infrequently mutated genes as well as a small number of frequently mutated *** infrequently mutated genes are likely described in a limited number of ***-oriented models of CRC progression are being replaced by pathway-oriented *** the second half of this review,we summarize the present knowledge of this research field and discuss its prospects.

关键词： Sporadic colorectal cancer, Pathogenesis, Morphology, Large-scale genome analysis, Genetic pathway

Impact of thermal history of spherical silicon crystal on its crystal quality

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Rare Metals 2006年第Z1期25卷 127-132页

作者： TSUJIYA Kaoru MINEMOTO Takashi MUROZONO Mikio TAKAKURA hideyuki HAMAKAWA Yoshihiro College of Science and Engineering Ritsumeikan University 1-1-1 Nojihigashi Kusatsu Shiga 525-8577 Japan Clean Venture 21 Co. Ltd. 35 Kamitoba Daimotsu-chou Minami-ku Kyoto 601-8121 Japan

Spherical Si solar cells were fabricated based on multicrystalline Si spheres produced by a dropping method. The thermal history of Si spheres were calculated by numerical simulation. The simulation result reveals that heat transfered by convection is greater than heat transfered by radiation. Considering the calculation results, Si spheres were dropped in the free-fall tower at low pressure state (0.2×105-0.5×105 Pa) to slow heat transfer by convection. After dash etching for 60 min, low pressure Si spheres have less etch pits, i.e., 80% for etch pit density and 8% for etch pit-area ratio compared to normal one. Furthermore, the conversion efficiency was improved from 6.57% (normal pressure spherical Si solar cell) to 9.56% (low one), which is 45% relative increase. The improvement is due to decrease of undercooling and increase of crystal growth duration. These results demonstrate that the dropping method at low pressure state is useful for fabricating high performance spherical Si solar cells.

关键词： solar cell sphere silicon undercooling low pressure thermal history etch pit

Degradation of Reactive Yellow 86 with photo-Fenton process driven by solar light

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Journal of Environmental Sciences 2010年第9期22卷 1455-1461页

作者： hideyuki Katsumata Syunya Koike Satoshi Kaneco Tohru Suzuki Kiyohisa Ohta Department of Chemistry for Materials Graduate School of EngineeringMie UniversityTsu Environmental Preservation Center Mie UniversityTsu

The decolorization of Reactive Yellow 86 （RY 86）, one of reactive azo dyes, was investigated in the presence of Fenton reagent under solar light irradiation. The decolorization rate was strongly influenced by pH, initial concentrations of H202 and Fe（II）, and so on. An initial concentration of 40 mg/L was decolored more than 90% after 20 min under optimum conditions. The activation energy of the solar photo-Fenton reaction was 1.50 kJ/mol for RY 86 in the temperature range of 10-60℃. In the kinetic study, the rate constant of RY 86 with OH- radicals could be estimated to be 1.7 × 10^10 L/（***）. The decolorization efficiency of RY 86 under solar light irradiation was comparable to the artificial light irradiation. The decrease of TOC as a result of mineralization of RY 86 was observed during photo-Fenton process. The rate of RY 86 mineralization was about 83% under UV irradiation after 24 hr. The formation of chloride, sulfate, nitrate and ammonium ions as end-products was observed during the photocatalytic process. The decomposition of RY 86 gave two kinds of intermediate products. The degradation mechanism of RY 86 was proposed on the base of the identified intermediates.

关键词： reactive azo dye photo-Fenton reaction solar light irradiation decolorization mineralization

Numerical Simulations of Rarefied Gases in Curved Channels: Thermal Creep, Circulating Flow, and Pumping Effect

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Communications in Computational Physics 2009年第10期6卷 919-954页

作者： Kazuo aoki Pierre Degond Luc Mieussens Department of Mechanical Engineering and Science Graduate School of EngineeringKyoto UniversityKyoto 606-8501Japan Universite de Toulouse UPSINSAUT1UTMInstitut de Mathematiques de ToulouseF-31062 ToulouseFrance CNRS Institut de Mathematiques de Toulouse UMR 5219F-31062 ToulouseFrance Universite de Bordeaux Institut de Mathematiques de Bordeaux351cours de la Liberation33405 Talence cedexFrance

We present numerical simulations of a new system of micro-pump based on the thermal creep effect described by the kinetic theory of *** device is made of a simple smooth and curved channel with a periodic temperature *** the Boltzmann-BGK model as the governing equation for the gas flow,we develop a numerical method based on a deterministic finite volume scheme,implicit in time,with an implicit treatment of the boundary *** method is comparatively less sensitive to the slow flow velocity than the usual Direct Simulation Monte Carlo method in case of long devices,and turns out to be accurate enough to compute macroscopic quantities like the pressure field in the *** simulations show the ability of the device to produce a one-way flow that has a pumping effect.

关键词： Knudsen compressor thermal creep flow transpiration flow BGK model implicit scheme

Synchrotron X-ray diffraction techniques for in situ measurement of hydride formation under several gigapascals of hydrogen pressure

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Chinese Science Bulletin 2014年第36期59卷 5290-5301页

作者： Hiroyuki Saitoh Akihiko Machida Katsutoshi aoki Quantum Beam Science Directorate Japan Atomic Energy Agency Sayo-cho Sayo-gun Hyogo 679-5148 Japan Institute for Materials Research Tohoku University Aoba-kuSendai 980-8577 Japan

The high-pressure technique is a fundamental tool for realizing novel phase transitions, chemical reactions, and other exotic phenomena. Hydrogenation is one example of a high-pressure reaction; at high pressures of several gigapascals, hydrogen becomes chemically active and reacts with metals and alloys to form hydrides. This paper covers a high-pressure study of the hydrogenation process and the synthesis of hydrides using a cubic-type multi-anvil apparatus. The experimental details of a hydrogenation cell assembly, high-temperature and highpressure generation, and an in situ observation technique are presented. These experiments are conducted with the aid of in situ synchrotron radiation X-ray diffraction measurements operated in an energy-dispersive mode in the conventional manner for time-resolved measurements and a newly developed angle-dispersive mode for observation of the crystal growth process during formation of metal hydrides. Two successful cases of high-pressure hydrogenation are presented: aluminum hydride, Al H3, and an aluminum-based alloy hydride, Al2 Cu Hx, which are potential candidates for hydrogen storage materials.

关键词： X射线衍射技术金属氢化物原位测量氢气压力同步加速器同步辐射X射线衍射高压技术晶体生长过程

Photodimerization and photooxygenation of 9-vinylcarbazole catalyzed by titanium dioxide and magnesium perchlorate

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Chinese Chemical Letters 2010年第3期21卷 365-368页

作者： Hajime Maeda Mio Yamamoto hideyuki Nakagawa Kazuhiko Mizuno Division of Material Sciences Graduate School of Natural Science and TechnologyKanazawa University Department of Applied Chemistry Graduate School of EngineeringOsaka Prefecture University

Photoreaction of 9-vinylcarbazole in acetonitrile in the presence of titanium dioxide and a catalytic amount of magnesium perchlorate gave 3,6-di(9-carbazolyl)-1,2-dioxane as a photooxygenated product via photodimerization of *** photoreaction proceeds via an electron transfer mechanism,where magnesium perchlorate accelerated formation of the photo-oxygenated product.

关键词： Titanium dioxide Magnesium perchlorate 9-Vinylcarbazole Photooxygenation Photodimerization

Moxibustion Promotes Formation of Granulation in Wound Healing Process through Induction of Transforming Growth Factor-β in Rats

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Chinese Journal of Integrative Medicine 2020年第1期26卷 26-32页

作者： Hiroshi Kawanami Hirohisa Kawahata Hiroko-Miyuki Mori Motokuni aoki Graduate School of Health Sciences Morinomiya University of Medical Sciences

Objective:To examine the effect of moxibustion on the wound healing process and its mechanism using a rat wound ***:Sixty male Sprague-Dawley rats were randomly divided into a sham-treated group(n=30,wound surgery only)and a moxibustion group(n=30,wound treated with moxibustion).Circular fullthick ness skin wounds were produced in *** was applied to the edge of wound and was continued on alternating days till 14 days after surgery,followed by measurement of wound *** of collagens,prolyl-4-hydroxylase(P4H)and transtorming growth factor-β(TGF-β)were evaluated by histochemical study and real-time polymerase chain ***:The size of the wound lesion was significantly reduced in rats treated with moxibustion as compared to that in sham-treated rats at 4-10 days after wounding(P<0.01).Moxibusti on stimulated mRNA expressi on of collage ns at 4 days(P<0.01),but not at 7 days,accompa nied by enhanced proliferation of P4H-positive *** importanee,expression of TGF-β in tissue from the wound lesio n treated with moxibusti on was sign ifica ntly in creased as compared to that in sham-treated rats at 4 days(P<0.01 or P<0.05),but not at 7 ***:The treatment with moxibustion promoted the wound healing process in the early phase through proliferation of fibroblasts and rapid formation of granulation,possibly mediated by induction of TGF-β which is a key molecule in the physiological process of wound *** can be expected to be effective as complementary treatment for intractable ulcers.

关键词： compleme ntary and alter native medicine moxibusti on wound healing granulation tran storming growth factor-β collagen

Enhanced hydrogen production from aqueous methanol solution using TiO2/Cu as photocatalysts

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Frontiers of Chemical Science and Engineering 2014年第2期8卷 197-202页

作者： Paramasivan GOMATHISANKAR Tomoko NODA hideyuki KATSUMATA Tohru SUZUKI Satoshi KANECO Department of Chemistry for Materials Graduate School of Engineering Mie University Mie 514-8507 Japan Environmental Preservation Center Mie University Mie 514-8507 Japan

The photocatalytic hydrogen production from aqueous methanol solution using titanium dioxide （TiO2） was investigated in the addition of metal particles including copper, lead, tin, and zinc. The results show that only the addition of copper particles enhances the hydrogen production. The copper usage and reaction temperature were further optimized for TiO2/Cu photocatalyts. Under the optimal conditions, the hydrogen production using TiO2/Cu as photocatalysts is approxi- mately 68 times higher than that obtained with only TiO2.

关键词： photocatalytic hydrogen generation metha-nol copper particles TiO2 metal-semiconductor interface

NANOMECHANICAL MAPPING OF CARBON BLACK REINFORCED NATURAL RUBBER BY ATOMIC FORCE MICROSCOPY

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Chinese Journal of Polymer Science 2007年第1期25卷 35-41页

作者： Toshio Nishi hideyuki Nukaga So Fujinami Ken Nakajima Department of Organic and Polymeric Materials Graduate School of Science and EngineeringTokyo Institute of Technology2-12-1 O-okayamaMeguro-kuTokyo 152-8552Japan

Atomic force microscopy （AFM） has the advantage of obtaining mechanical properties as well as topographic information at the same time. By analyzing force-distance curves measured over two-dimensional area using Hertzian contact mechanics, Young＇s modulus mapping was obtained with nanometer-scale resolution. Furthermore, the sample deformation by the force exerted was also estimated from the force-distance curve analyses. We could thus reconstruct a real topographic image by incorporating apparent topographic image with deformation image. We applied this method to carbon black reinforced natural rubber to obtain Young＇s modulus distribution image together with reconstructed real topographic image. Then we were able to recognize three regions; rubber matrix, carbon black （or bound rubber） and intermediate regions. Though the existence of these regions had been investigated by pulsed nuclear magnetic resonance, this paper would be the first to report on the quantitative evaluation of the interfacial region in real space.

关键词： AFM, Natural rubber Carbon black Young's modulus Force-distance curve.