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长期重度溃疡性结肠炎患者肠道非肿瘤上皮的雌激素受体基因甲基化可预示结肠直肠癌肿瘤的发生

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世界核心医学期刊文摘（胃肠病学分册） 2006年第1期2卷 38-38页

作者： Fujii S. tominaga K. Kitajima K. T. Fujimori 廖新华 Department of Surgical and Molecular Pathology Dokkyo University School of Medicine 880 Kitakobayashi Mibu Shimotsuga Tochigi 321-0293 Japan Dr.

Background: Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectalneoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia. There is a great need for sensitive markers to identify individuals at increased risk of neoplasia. The oestrogen receptor (OR) gene shows age related methylation in the colorectal epithelium and is methylated frequently in sporadic colorectal neoplasia, suggesting that OR methylation may predispose to colorectal neoplasia. Aim: To clarify whether analysis of methylation of the OR gene in non-neoplastic epithelium can contribute to prediction of increased neoplasia risk in UC patients. Materials and methods: Atotal of 165 non-neoplastic colorectal epithelia from 30 patients with longstanding and extensive UC, including 13 UC patients with neoplasia and 17 patients without, were evaluated. Methylation specific polymerase chain reaction was performed to determine the methylation status of the OR gene. Results: Methylation of the OR gene was detected in 54 of 70 (77.1% ) non-neoplastic colorectal epithelia in UC with neoplasia but in only 23 of 95 (24.2% ) without neoplasia. Methylation of the OR gene was significantly more frequent in non-neoplastic epithelium from UC with neoplasia than in chronic colitic epithelium from UC without neoplasia. Furthermore, in UC with neoplasia, the OR gene was extensively methylated in non-neoplastic epithelia throughout the colorectum compared with those in UC without neoplasia. Conclusion: These results suggest that analysis of OR gene methylation may have potential as a useful marker for identifying individuals at increased risk of neoplasia among those with longstanding and extensive UC.

关键词：溃疡性结肠炎结肠直肠癌雌激素受体基因甲基化纤维结肠镜早期癌变非肿瘤患者

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十二指肠原发低度恶性黏膜相关性淋巴组织淋巴瘤在长期克拉霉素治疗之后消退

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世界核心医学期刊文摘（胃肠病学分册） 2006年第9期2卷 62-62页

作者： Ochi M. tominaga K. Okazaki H. 张欣(译) 王晓君(校) Department of Gastroenterology Osaka City UniversityGraduate School of Medicine 1-4-3 AsahimachiAbeno-ku Osaka 545-8585 Japan 不详

A 74-year-old woman was referred to our department because of *** findings revealed yellowish bumpy mucosa from the bulbus to the second portion of the *** patient was admitted to our hospital for further examinations and treatment for this *** mucosal resection(EMR)was performed on part of the lesion to obtain the final diagnosis,and then mucosa-associated lymphoid tissue(MALT)lymphoma of the duodenum was diagnosed using this *** this case,no evidence of Helicobacter pylori infection in the patient’s stomach was detected by any of the diagnostic examinations used,such as the urea breath test,histological study,culture,and serological *** this reason,the patient’s duodenal MALT lymphoma was treated solely with long-term clarithromycin,which had an inhibitory action on lymphocyte *** lesion showed slight improved during the first 12 days of treatment,and complete regression was reached after 6 months of *** is suggested that the long-term use of clarithromycin may be effective for diseases of the gastrointestinal tract associated with the lymphocyte proliferation.

关键词：淋巴组织淋巴瘤十二指肠球部黏膜相关性克拉霉素治疗后低度恶性消退淋巴细胞增殖性疾病

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肝细胞期延迟时间缩短在减少肝脏GD-EOB-DTPA增强MRI检查时间的可行性研究

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国际医学放射学杂志 2010年第1期 90-90页

作者： U.Motosugi T.Ichikawa L.tominaga H.Sou K.Sano S.Ichikawa 王大丽 Department of Radiology University of Yamanashi

探索在局灶性肝脏病变检出中,是否能够通过省略延迟20min的时间的肝细胞期(Im-20)来缩短Gd-EOB-DTPA增强MRI的检查时间。本研究共包括265例病人,在Im-20上检出了495个恶性的局灶性肝病灶。肝细胞期在注射Gd-EOB后10min和20min获得。肝... 详细信息

探索在局灶性肝脏病变检出中,是否能够通过省略延迟20min的时间的肝细胞期(Im-20)来缩短Gd-EOB-DTPA增强MRI的检查时间。本研究共包括265例病人,在Im-20上检出了495个恶性的局灶性肝病灶。肝细胞期在注射Gd-EOB后10min和20min获得。肝脏强化程度的评估采用4点分级法[优秀、良好、差

关键词： GD-EOB-DTPA MRI 肝脏细胞期

应用MR参数ADC值检测乳腺导管原位癌是否具有侵袭性

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国际医学放射学杂志 2013年第6期 605-605页

作者： N.Mori H.Ota S.Mugikura C.Takasawa J.tominaga T.Ishida 时代刘倩 Department of Diagnostic Radiology Tohoku University Graduate School of Medicine Seiryo 1-1Sendai 980-8574 Japan

摘要目的评估表观扩散系数(ADC)能否检出乳腺导管原位癌(DCIS)具有侵袭性。方法本回顾性研究得到机构审查委员会的许可,并免除签署知情同意书。69例可连续性

关键词：乳腺癌导管原位癌侵袭性癌扩散加权成像升级

Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)

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中国神经肿瘤杂志 2013年第1期11卷 21-21页

作者： Shibui S Narita Y Mizusawa J Beppu T Ogasawara K Sawamura Y Kobayashi H Nishikawa R Mishima K Muragaki Y Maruyama T Kuratsu J Nakamura H Kochi M Minamida Y Yamaki T Kumabe T tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T Yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi J Takano S Fujimaki T Sumi M Miyakita Y Nakazato Y Sato A Fukuda H Nomura K Department of Neurosurgery and Neuro-Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of *** therapy consists of resection with concomitant *** to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT *** study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + *** primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR ***: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in *** median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,*** median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,*** 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse ***: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM.

关键词：星形细胞母细胞随机试验放疗胶质变性化疗 MGMT