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Mucinous phenotype and CD10 expression of primary adenocarcinoma of the small intestine

World Journal of Gastroenterology 2015年第9期21卷 2700-2710页

作者： Reiko Kumagai Kenichi Kohashi Shunsuke Takahashi hidetaka yamamoto Minako Hirahashi Kenichi Taguchi Kenichi Nishiyama Yoshinao Oda Department of Anatomic Pathology Pathological SciencesGraduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Pathology National Hospital Organization Kyushu Cancer CenterFukuoka 811-1395Japan Division of Pathology Japanese Red Cross Fukuoka HospitalFukuoka 815-8555Japan

AIM:To clarify the correlation with phenotypic expression,clinicopathological features,genetic alteration and microsatellite-instability status in small intestinal adenocarcinoma(SIA).METHODS:The cases of 47 patients diagnosed with primary SIAs that were surgically resected at our institution in 1975-2005 were *** reviewed clinicopathological findings(age,gender,tumor size,gross appearance,histological morphologic type,invasion depth,lymphatic permeation,venous invasion,and lymph node metastasis),and the immunohistochemical expression of MUC5 AC,MUC6,MUC2,CD10,and mismatch-repair(MMR) proteins(MLH1 and MSH2).We analyzed KRAS and BRAF gene mutations,and the microsatellite instability(MSI) *** immunohistochemical staining of CD10,MUC2,MUC5 AC and MUC6 was considered positive when distinct staining in > 5% of the adenocarcinoma cells was *** evaluate of MMR protein expression,we used adjacent normal tissue including lymphoid follicles,inflammatory cells,and stromal cells as an internal positive *** without nuclear staining in the tumor cells were considered to have lost the expression of the respective MMR ***:There were 29 males and 18 females patients(mean age 59.9 years,range:23-87 years).Tumors were located in the duodenum in 14 cases(30%),the jejunum in 21 cases(45%),and the ileumin 12 cases(25%).A phenotypic expression analysis revealed 20 MUC2-positive tumors(42.6%),11 MUC5AC-positive(23.4%),4 MUC6-positive(8.5%),and 7 CD10-positive(14.9%).The tumor sizes of the MUC2(+) tumors were significantly larger than those of the MUC2(-) tumors(mean,5.7 ± 1.4 cm vs 4.7 ± 2.1 cm,P < 0.05).All three tumors with adenomatous component were positive for MUC2(P < 0.05).Polypoid appearance was seen significantly more frequently in the CD10(+) group than in the CD10(-) group(P < 0.05).The tumor size was significantly larger in the CD10(+) group than in the CD10(-) group(mean,5.9 ± 1.4 cm vs 5.0 ± 2.1 cm,P < 0.05).Of 34 SIAs with succ

关键词： Small intestine Adenocarcinoma Mucin CD10 Microsat

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