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Nutrition status and Helicobacter pylori infection in patients receiving hemodialysis

World Journal of Gastroenterology 2018年第15期24卷 1591-1600页

作者： Mitsushige Sugimoto hideo yasuda Akira Andoh Division of Digestive Endoscopy Shiga University of Medical Science Hospital First Department of Medicine Hamamatsu University School of Medicine Department of Gastroenterology Shiga University of Medical Science Hospital

Chronic kidney disease(CKD) patients receiving hemodialysis(HD) often develop gastrointestinal abnormalities over their long treatment period. In general, prognosis in such patients is poor due to the development of protein-energy wasting(PEW). Therefore, it is important to clarify the etiology of PEW and to establish better strategies to deal with this condition. Chronic Helicobacter pylori(H. pylori) infection in the gastric mucosa has a close association with not only the development of peptic ulcer disease and gastric cancer, but is also associated with abnormal plasma and gastric mucosal ghrelin levels that are seen in malnutrition. It is unclear whether H. pylori infection of the gastric mucosa is directly associated with prognosis in HD patients by affecting ghrelin levels. Recent studies show that the prevalence of H. pylori infection in HD patients is significantly lower than in subjects with normal renal function. In the natural history of H. pylori infection in HD patients, the prevalence of infection decreases as the length of time on HD increases. The severity of gastric mucosal atrophy has been suggested as the major determinant of ghrelin levels in these patients, and eradication therapy of H. pylori improves nutritional status by increasing serum cholinesterase and cholesterol levels, especially in patients with mildto-moderate gastric mucosal atrophy. Prompt H. pylori eradication to inhibit the progress of gastric atrophy may be required to prevent this decrease in ghrelin levels and subsequent PEW and improve the prognosis of HD patients by improving their nutritional status.

关键词： Helicobacter pylori Hemodialysis Ghrelin Gastric mucosa Anti-bacterial agents

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Relationship between ghrelin, Helicobacter pylori and gastric mucosal atrophy in hemodialysis patients

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World Journal of Gastroenterology 2016年第47期22卷 10440-10449页

作者： Hitomi Ichikawa Mitsushige Sugimoto Yukitoshi Sakao Shu Sahara Naro Ohashi Akihiko Kato Ken Sugimoto Takahisa Furuta Akira Andoh Tadashi Sakao hideo yasuda First Department of Medicine Hamamatsu University School of Medicine Hamamastsu Shizuoka 431-3192 Japan Division of Digestive Endoscopy Shiga University of Medical Science Hospital Otsu Shiga 520-2192 Japan Hamana Clinic Hamana Clinic Hamamatsu Shizuoka 434-0037 Japan Blood Purification Unit Hamamatsu University School of Medicine Hamamastsu Shizuoka 431-3192 Japan Center for Clinical Research Hamamatsu University School of Medicine Hamamastsu Shizuoka 431-3192 Japan Department of Gastroenterology Shiga University of Medical Science HospitalOtsu Shiga 520-2192 Japan

AIM To investigate the relationship between plasma ghrelin level, Helicobacter pylori(H. pylori) infection status and the severity of atrophy in hemodialysis *** One hundred eights patients who received hemodialysis and 13 non-hemodialysis H. pylori-negative controlsunderwent gastroduodenoscopy to evaluate the severity of gastric atrophy. Serum levels of pepsinogen(PG) were measured as serum markers of gastric atrophy. H. pylori infection was evaluated by anti-H. pylori IgG antibody, rapid urease test and culture test. We classified H. pylori infection status as non-infection, present infection and past infection. In addition, plasma acyl-ghrelin and desacyl-ghrelin levels were measured by enzyme-linked immunosorbent assay. RESULTS Infection rate of H. pylori was 45.4%(49/108). Acylghrelin level in the non-infection group(39.4 ± 23.0 fmol/ml) was significantly higher than in the past(23.4 ± 19.9 fmol/ml, P = 0.005) and present infection groups(19.5 ± 14.0 fmol/ml, P < 0.001). Furthermore, desacyl-ghrelin level in the non-infection group(353.2 ± 190.2 fmol/ml) was significantly higher than those in the past(234.9 ± 137.5 fmol/ml, P = 0.008) and present infection groups(211.8 ± 124.2 fmol/ml, P < 0.001). Acyl-ghrelin was positively correlated with the PG Ⅰ level and PG Ⅰ/Ⅱ ratio(|R| = 0.484, P < 0.001 and |R| = 0.403, P < 0.001, respectively). Both ghrelins were significantly decreased in accordance with the progress of endoscopic atrophy(both P < 0.001) and acyl-ghrelin was significantly lower in patients with mild, moderate and severe atrophy(24.5 ± 23.1 fmol/ml, 20.2 ± 14.9 fmol/ml and 18.3 ± 11.8 fmol/ml) than in those with non-atrophy(39.4 ± 22.2 fmol/ml, P = 0.039, P = 0.002 and P < 0.001, respectively).CONCLUSION In hemodialysis patients, plasma ghrelin level was associated with the endoscopic and serological severity of atrophy related to H. pylori infection.

关键词： Acyl-ghrelin Desacyl-ghrelin Helicobacter pylori Hemodialysis Pepsinogen

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NiCoZn/C@melamine sponge-derived carbon composites with highperformance electromagnetic wave absorption

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International Journal of Minerals,Metallurgy and Materials 2024年第10期31卷 2274-2286页

作者： Xiubo Xie Heshan Wang hideo Kimura Cui Ni Wei Du Guanglei Wu School of Environmental and Material Engineering Yantai UniversityYantai 264005China Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of AeronauticsBinzhou 256603China Institute of Materials for Energy and Environment State Key Laboratory of Bio-fibers and Eco-textilesCollege of Materials Science and EngineeringQingdao UniversityQingdao 266071China

NiMZn/C@melamine sponge-derived carbon(MSDC)composites(M=Co,Fe,and Mn)were prepared by a vacuum pump-ing solution method followed by carbonization.A large number of carbon nanotubes(CNTs)homogeneously attached to the surfaces of the three-dimensional cross-linked of the sponge-derived carbon in the NiCoZn/C@MSDC composite,and CNTs were detected in the NiFeZn/C@MSDC and NiMnZn/C@MSDC ***_(3)ZnC_(0.7),Ni_(3)Fe,and MnO in-situ formed in the NiFeZn/C@MSDC and NiMnZn/C@MSDC *** CNTs in the NiCoZn/C@MSDC composite efficiently modulated its complex ***,the composite exhibited the best performance among the composites,with the minimum reflection loss(RL_(min))of-33.1 dB at 18 GHz and thickness of 1.4 *** bandwidth for RL of≤-10 dB was up to 5.04 GHz at the thickness of 1.7 mm and loading of 25wt%.The op-timized impedance matching,enhanced interfacial and dipole polarization,remarkable conduction loss,and multiple reflections and scat-tering of the incident microwaves improved the microwave absorption *** effects of Co,Ni,and Fe on the phase and mor-phology provided an alternative way for developing highly efficient and broadband microwave absorbers.

关键词： microwave absorption carbon nanotube element substitution melamine sponge-derived carbon

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电磁场辅助绿色氨合成

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Science Bulletin 2024年第1期69卷 7-8页

作者： hideo Hosono Tokyo Institute of Technology Yokohama 226-8503Japan National Institute for Materials Science Tsukuba 305-0047Japan

Nitrogen is an indispensable element for life because it is a constituent of amino acids and a key constituent for various materials,as well as fine *** molecules occupy~80%of the atmosphere but are chemically inert due to the strength of the NN triple bond and absence of *** nonpolar nature makes N_(2)totally different from CO with an isoelectronic diatomic structure in ***,it was a challenge in chemistry to activate N_(2)to transform it into chemically usable molecules,such as NH_(3)and NO_(x).The Haber-Bosch(HB)process for the synthesis of NH_(3)from N_(2)and H_(2),which was established in 1913,marked the first practical chemical process of nitrogen fixation through extensive fundamental chemical research and much engineering ingenuity[1,2].This success of the industrial process saves human civilization from a hunger *** then,the HB process has been the predominant method for industrial NH_(3)*** annual NH_(3)production has reached180 million tons globally,which makes it the most mass-produced chemical comparable to methanol.

关键词：氨合成 occupy totally

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Case of human immunodeficiency virus infection presenting as a tip variant of focal segmental glomerulosclerosis: A case report and review of the literature

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World Journal of Nephrology 2018年第4期7卷 90-95页

作者： Daiki Goto Naro Ohashi Asumi Takeda Yoshihide Fujigaki Akira Shimizu hideo yasuda Kazuhisa Ohishi Internal Medicine 1 Hamamatsu University School of Medicine Division of Nephrology Hamamatsu Medical Center Department of Internal Medicine Teikyo University School of Medicine Department of Pathology Nihon University School of Medicine

The incidence of the collapsing variant of focal segmental glomerulosclerosis(FSGS) as a human immunodeficiency virus(HIV)-associated nephropathy has reduced since the introduction of antiretroviral therapy(ART). However, the incidence of other variants of FSGS, except for the collapsing variant, is increasing, and its therapeutic strategies remain uncertain. A 60-year-old HIV infected man in remission with ART was admitted for progressive renal insufficiency and nephrotic-ranged proteinuria. Renal biopsy revealed a tip variant of FSGS and his clinical manifestations resolved with corticosteroid therapy. HIV infected patients might develop non-collapsing FSGS, including tip variant of FSGS and corticosteroid therapy might be effective for them. A renal biopsy might be essential to determine the renal histology and to decide on corticosteroid therapy.

关键词： Focal segmental glomerulosclerosis Tip variant Antiretroviral therapy Corticosteroid therapy Human immunodeficiency virus

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Expression levels of K_(ATP)channel subunits and morphological changes in the mouse liver after exposure to radiation

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World Journal of Experimental Medicine 2024年第2期14卷 103-113页

作者： Ming Zhou Tao-Sheng Li Hiroshi Abe hideo Akashi Ryoji Suzuki Yoshio Bando Department of Anatomy Akita University Graduate School of MedicineAkita 010-8543Japan Department of Stem Cell Biology Atomic Bomb Disease InstituteNagasaki UniversityNagasaki 852-8523Japan Sendai Old Age Refresh Station A Long-term Care Health FacilitySendai 981-1105Japan

BACKGROUND ATP sensitive K+(K_(ATP))channels are ubiquitously distributed in various of cells and tissues,including the *** play a role in the pathogenesis of myocardial and liver *** To evaluate the radiation-induced changes in the expression of K_(ATP)channel subunits in the mouse liver to understand the potential role of K_(ATP)channels in radiation *** Adult C57BL/6 mice were randomly exposed toγ-rays at 0 Gy(control,n=2),0.2 Gy(n=6),1 Gy(n=6),or 5 Gy(n=6).The livers were removed 3 and 24 h after radiation *** and eosin staining was used for morphological observation;immunohistochemical staining was applied to determine the expression of K_(ATP)channel subunits in the liver *** Compared with the control group,the livers exposed to 0.2 Gyγ-ray showed an initial increase in the expression of Kir6.1 at 3 h,followed by recovery at 24 h after *** to a high dose of 5.0 Gy resulted in decreased expression of Kir6.1 and increased expression of SUR2B at 24 ***,the expression of Kir6.2,SUR1,or SUR2A had no remarkable changes at 3 and 24 h after exposure to any of these *** The expression levels of Kir6.1 and SUR2B in mouse liver changed differently in response to different radiation doses,suggesting a potential role for them in radiation-induced liver injury.

关键词： Radiation exposure ATP-sensitive K^(+)channel Mouse Liver

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N-乙酰半胱氨酸影响p38有丝分裂原活化蛋白激酶对顺铂诱导急性肾损伤的保护作用

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中国药理学通报 2011年第2期27卷 229-233页

作者：罗景慧杨迎暴安田日出夫菱田明南方医院药学部广东广州510515 南方医科大学药学院临床药理学系广东广州510515 浜松医科大学附属医院第一内科日本浜松431-3192

目的研究N-乙酰半胱氨酸(N-acetylcysteine,NAC)对顺铂(cisplatin,CDDP)诱导大鼠急性肾损伤(acute kidney in-jury,AKI)后组织细胞凋亡的影响和与p38有丝分裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)的关系。方法静脉注射CDDP制备大鼠AKI模型。大鼠随机分为正常对照组、AKI模型对照组、NAC低剂量组(50 ***-1)、NAC中剂量组(100 ***-1)、NAC高剂量组(200 ***-1)、特异性p38MAPK抑制剂SB203580组(***-1)。大鼠预先连续给药3 d,给予CDDP,再继续给药5 d。TUNEL法进行细胞凋亡检查。试剂盒测定肾脏组织caspase-3。Western blot测定caspase-3、Bax、Bcl-2、磷酸化p38MAPK(phosphorylated p38MAPK,p-p38MAPK)表达。结果与正常对照组相比,CDDP诱导AKI模型组肾组织凋亡细胞增加,caspase-3、Bax、p-p38MAPK表达升高,Bcl-2表达降低(P<0.01)。与AKI模型组相比,NAC与SB203580减少凋亡细胞、降低肾脏组织caspase-3、Bax、p-p38MAPK表达和增加Bcl-2表达(P<0.01)。结论 NAC可有效防治CD-DP诱导大鼠AKI,并与p38MAPK相关。

关键词： N-乙酰半胱氨酸 p38有丝分裂原活化蛋白激酶顺铂急性肾损伤凋亡大鼠

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Optimal consumption–investment under partial information in conditionally log-Gaussian models

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Probability, Uncertainty and Quantitative Risk 2023年第1期8卷 95-120页

作者： hideo Nagai MMDS Osaka UniversityToyonaka 560-8531OsakaJapan

Certain Merton type consumption−investment problems under partial information are reduced to the ones of full information and within the framework of a complete market ***,specializing to conditionally log−Gaussian diffusion models,concrete analysis about the optimal values and optimal strategies is performed by using analytical tools like Feynman−Kac formula,or HJB *** explicit solutions to the related forward-backward equations are also given.

关键词： Optimal consumption-investment problem Conditionally log−Gaussian models HJB equations Feynman−Kac formula Forward-backward equations

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Calcitriol-induced hypercalcemia in a patient with granulomatous mycosis fungoides and end-stage renal disease

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World Journal of Nephrology 2013年第2期2卷 44-48页

作者： Takamasa Iwakura Naro Ohashi Naoko Tsuji Yoshitaka Naito Shinsuke Isobe Masafumi Ono Tomoyuki Fujikura Takayuki Tsuji Yukitoshi Sakao hideo yasuda Akihiko Kato Toshiharu Fujiyama Yoshiki Tokura Yoshihide Fujigaki First Department of Medicine Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan Blood Purification Unit Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan Department of Dermatology Hamamatsu University School of Medicine Higashi-ku Hamamatsu 431-3192 Japan

An 86-year-old man, diagnosed as having mycosis fungoides in May 2008 and treated with repeated radiation therapy, was admitted to our hospital for initiation of hemodialysis due to end-stage renal disease(ESRD) in April 2012. On admission, his corrected serum calcium level was 9.3 mg/d L, and his intact parathyroid hormone level was 121.9 pg/mL(normal range 13.9-78.5pg/mL), indicating secondary hyperparathyroidism due to ESRD. After starting hemodialysis, urinary volume diminished rapidly. The serum calcium level increased(12.7 mg/dL), and the intact parathyroid hormone level was suppressed(< 5 pg/m L), while the 1,25-dihy-droxyvitamin D3(calcitriol) level increased(114 pg/mL, normal range: 20.0-60.0 pg/m L) in June 2012. The possibilities of sarcoidosis and tuberculosis were ruled out. Skin biopsies from tumorous lesions revealed a diagnosis of granulomatous mycosis fungoides. The serum soluble interleukin-2 receptor levels and the degrees of skin lesions went in parallel with the increased serum calcium and calcitriol levels. Therefore, the patient was diagnosed as having calcitriol-induced hypercalcemia possibly associated with granulomatous mycosis fungoides. Granulomatous mycosis fungoides is rare, and its association with calcitriol-induced hypercalcemia has not been reported. Careful attention to calcium metabolism is needed in patients with granulomatous mycosis fungoides, especially in patients with ESRD.

关键词：血液透析肾病治疗方法临床分析

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Crystal structure,chemical bond characteristics,infrared reflection spectrum,and microwave dielectric properties of Nd_(2)(Zr_(1−x)Ti_(x))_(3)(MoO_(4))_(9) ceramics

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Journal of Advanced Ceramics 2023年第1期12卷 82-92页

作者： Jian BAO Yuping ZHANG hideo KIMURA Haitao WU Zhenxing YUE School of Environmental and Material Engineering Yantai UniversityYantai 264005China State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

Microwave dielectric ceramics(MWDCs)with low dielectric constant and low dielectric loss are desired in contemporary society,where the communication frequency is developing to high frequency(sub-6G).Herein,Nd_(2)(Zr_(1−x)Ti_(x))_(3)(MoO_(4))_(9)(NZ_(1−x)T_(x)M,x=0.02-0.10)ceramics were prepared through a solid-phase *** to X-ray diffraction(XRD)patterns,the ceramics could form a pure crystal structure with the R3c(167)space *** internal parameters affecting the properties of the ceramics were calculated and analyzed by employing Clausius-Mossotti relationship,Shannon’s rule,and Phillips-van Vechten-Levine(P-V-L)***,theoretical dielectric loss of the ceramics was measured and analyzed by a Fourier transform infrared(IR)radiation ***,when x=0.08 and sintered at 700℃,optimal microwave dielectric properties of the ceramics were obtained,including a dielectric constant(ε_(r))=10.94,Q·f=82,525 GHz(at 9.62 GHz),and near-zero resonant frequency temperature coefficient(τ_(f))=−12.99 ppm/℃.This study not only obtained an MWDC with excellent properties but also deeply analyzed the effects of Ti^(4+)on the microwave dielectric properties and chemical bond characteristics of Nd_(2)Zr_(3)(MoO_(4))_(9)(NZM),which laid a solid foundation for the development of rare-earth molybdate MWDC system.

关键词： microwave dielectric ceramics(MWDCs) Nd_(2)(Zr_(1−x)Ti_(x))_(3)(MoO_(4))_(9)(NZ_(1−x)T_(x)M) Phillips-van Vechten-Levine(P-V-L)theory theoretical dielectric loss

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