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The Treatment Strategy of Patients with Sleep Apnea Syndrome in Our Department and Subsequent Course

International Journal of Otolaryngology and Head & Neck Surgery 2014年第4期3卷 179-183页

作者： Takanori Fujioka hideo yamane Department of Otorhinolaryngology Graduate School of Medicine Osaka City University Osaka Japan

It is known that acute or chronic heart failure can develop in patients with grave sleep apnea syndrome (SAS), and known to have the social problem including an accident and the decrease of the labor will. Several medical treatments are now available for SAS. We considered problems of the treatment based on the practice situation of our department about the present conditions and subsequent treatment. The subjects consisted of 306 patients. We measured Epworth Sleepiness Scale (ESS) and apnea hypopnea index (AHI) after polysomnography in all patients at the first time and 6 months later. So, it was found that AHI and ESS decreased when we could be treated in the SAS patients appropriately. It was confirmed that the choice of the appropriate regimen was important.

关键词： Sleep Apnea Syndrome Apnea Hypopnea Index Epworth Sleepiness Scale

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梅尼埃病的影像学评估:球囊耳石可能是病因?

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临床耳鼻咽喉头颈外科杂志 2013年第15期27卷 839-843页

作者： hideo yamane KISHIKO SUNAMI HIROYOSHI IGUCHI HIRAMORI SAKAMOTO TOSHIO IMOTO HELGE RASK-ANDERSEN 张甦琳孔维佳 Department of Otorhinolaryngology Osaka City University Graduate School of MedicineOsakaJapan Department of Otorhinolaryngology Uppsala University HospitalUppsalaSweden 华中科技大学同济医学院附属协和医院耳鼻咽喉科武汉430022

目的:本研究拟采用3DCT来评估梅尼埃病(MD)患者的连合管(RD)、球囊管(SD)和内淋巴囊(ES)的显影情况。方法:根据美国耳鼻咽喉头颈外科学会听力与平衡委员会的诊断标准,我们采用3DCT对62例确诊为单侧MD的患者进行影像学评估,并与其对侧耳... 详细信息

目的:本研究拟采用3DCT来评估梅尼埃病(MD)患者的连合管(RD)、球囊管(SD)和内淋巴囊(ES)的显影情况。方法:根据美国耳鼻咽喉头颈外科学会听力与平衡委员会的诊断标准,我们采用3DCT对62例确诊为单侧MD的患者进行影像学评估,并与其对侧耳及正常对照组(26耳)进行比较,观察它们在3DCT影像中RD、SD和ES的通畅性。结果:MD患耳在3DCT影像中表现为连续性中断,与对照组比较差异有统计学意义(P<0.01)。结论:3DCT成像中,MD耳与对照耳相比,RD、SD和ES的显影明显减弱,提示内淋巴流动可能被致密物质阻断,该物质可能为球囊上脱落的耳石。RD、SD和ES可能参与MD的发病。

关键词：球囊管球囊内淋巴积水内淋巴管 CT成像双侧

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Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

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International Journal of Ophthalmology(English edition) 2015年第1期8卷 1-10页

作者： Junmi Tanaka hideo Tanaka Nobuhisa Mizuki Eiichi Nomura Norihiko Ito Naoko Nomura Masayuki yamane Tomonobu Hida Yoshio Goshima Hiroshi Hatano Hisashi Nakagawa Department of Ophthalmology and Visual Science Graduate School of MedicineYokohama City University Department of Ophthalmology Graduate School of MedicineUniversity of Tokyo Department of Obstetrics and Gynecology School of MedicineKeio University Department of Environmental Immuno-Dermatology Graduate School of MedicineYokohama City University Hatano Eye Clinic 438-1 FujisawaFujisawa Kanagawaken 251-0052Japan Tokushima Eye Clinic 1-2-14 Fujimi-choHigashimurayamaTokyo 189-0024Japan

AIM: To assess the efficacy of topical Semaphorin 3A(SEMA3A) in the treatment of allergic ***: Experimental allergic conjunctivitis(EAC)mice model induced by short ragweed pollen(SRW) in 4-week-old of BALB/c mice, mice were evaluated using haematoxylin and eosin(H&E) staining, immunofluor-escence and light microscope photographs. Early phase took the samples in 24 h after instillation and late phase took the samples between 4 to 14 d after the start of treatment. The study use of topical SEMA3A(10 U, 100 U,1000 U) eye drops and subconjunctival injection of SEMA3 A with same concentration. For comparison, five types of allergy eyedrops were quantified using clinical characteristics.· RESULTS: Clinical score of composite ocular symptoms of the mice treated with SEMA3 A were significantly decreased both in the immediate phase and the late phase compared to those treated with commercial ophthalmic formulations and non-treatment mice. SEMA3 A treatment attenuates infiltration of eosinophils entering into conjunctiva in EAC mice. The score of eosinophil infiltration in the conjunctiva of SEMA3 A 1000 U-treated group were significantly lower than low-concentration of SEMA3 A treated groups and non-treated group. SEMA3 A treatment also suppressed T-cell proliferation in vitro and decreased serum total Ig E levels in EAC mice. Moreover, treatment of SEMA3 A suppressed Th2-related cytokines(IL-5, IL-13 and IL-4)and pro-inflammatory cytokines(IFN-γ, IL-17 and TNF-α)release, but increased regulatory cytokine IL-10 concentration in the conjunctiva of EAC ***: SEMA3 A as a biological agent, showed the beneficial activity in ocular allergic processes with the less damage to the intraocular tissue. It is expected that SEMA3 A may be contributed in patients with a more severe spectrum of refractory ocular allergic diseases including allergic conjunctivitis in the near future.

关键词： Semaphorin 3A experimental allergic conjunctivitis eosinophil infiltration serum total Ig E cytokines instillation subconjunctival administration

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Expression of Fab fragment of catalytic antibody 6D9 in an Escherichia coli in vitro coupled transcription/translation system

Expression of Fab fragment of catalytic antibody 6D9 in an E...

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The Eighth China-Japan-Korea Joint Symposium on Enzyme Engineering

作者： XiuPing Jiang Muhamad Ali Yuji Ookubo Ikuo Fujii hideo Nakano Tsuneo yamane Laboratory of Molecular Biotechnology Graduate School of Biological and Agricultural SciencesNagoya University

＜正＞*** Since a complete antibody such as IgG is a large molecule,much smaller functional domains（Fv,Fab fragments）retaining antigen-binding activity can be applied for a number of practical uses（1）.Because of the small size and useful properties,single-chain Fv（scFv）,which is composed of the variable heavy chain（VH）,a

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