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Glutathione as a Prognostic Biomarker and a Potential Therapeutic Target for Ovarian Cancer

Open Journal of Obstetrics and Gynecology 2022年第1期12卷 56-66页

作者： Motoki Takenaka Tatsuro Furui Noriko Suzuki Tiger Koike Hitomi aoki Ken-Ichirou Morishige Department of Obstetrics and Gynecology Gifu University School of Medicine Gifu Japan Department of Tissue and Organ Development Gifu University Graduate School of Medicine Gifu Japan

Aim: Glutathione (GSH) is an antioxidant, protecting cell against toxicity of reactive oxygen species (ROS). Data showed that GSH might play roles in malignancy including ovarian cancer (OC), and, thus, we attempted to determine the clinical significance of GSH and effects of erastin (an inhibitor of GSH synthesis) in OC. Methods: OC tissues were taken from 41 OC patients, and cancer-tissue GSH level was measured with GSH Assay Kit. Survival curves were carried out by the Kaplan-Meier method and evaluated using the log-rank test. Multivariable Cox proportional hazard risk regression model was performed to screen the independent factor affecting the prognosis of OC patients. In vitro effect of erastin was studied using OC cell lines. Cell viability, GSH levels and whole (cytosolic and lipid) ROS production were assessed. Results: Patients with high OC-tissue-GSH levels had an apparently lower progression free survival (PFS) and overall survival (OS) compared with those with low GSH levels. The GSH levels were independent factors for predicting the PFS and OS. The basal ROS level was inversely proportional to GSH levels in OC cell lines. The basal GSH levels were important for estimating the sensitivity to erastin. Reduction of intracellular GSH levels increased whole ROS, which caused cell deaths. Conclusions: Data suggested that the GSH levels could be a candidate of prognostic biomarkers and that erastin might be worth studying as a new therapeutic drug in OC.

关键词： Glutathione Reactive Oxygen Species Ovarian Cancer Erastin

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Involvement of Dectin-2 in the Innate Inflammatory Response Triggered by Influenza Virus Hemagglutinin

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Advances in Infectious Diseases 2023年第3期13卷 478-497页

作者： hideki Yamamoto Chikako Tomiyama Sho Yamasaki Shinobu Saijo Yoichiro Iwakura Kazuyoshi Kawakami Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Department of Molecular Immunology Research Institute for Microbial Diseases Osaka University Osaka Japan Laboratory of Molecular Immunology Immunology Frontier Research Center Osaka University Osaka Japan Project for Cytokine Research Division of Molecular Immunology Medical Mycology Research Center Chiba University Chiba Japan Center for Animal Disease Models Research Institute for Biomedical Sciences Tokyo University of Science Chiba Japan Department of Medical Microbiology Mycology and Immunology Tohoku University Miyagi Japan Department of Internal Medicine Hirose Hospital Miyagi Japan

C-type lectin receptors (CLRs) are representative pattern recognition receptors that recognize microbial polysaccharides expressed on antigen-presenting cells. In the present study, we carried out further detailed analysis on the involvement of Dectin-2, a CLR that senses high mannose polysaccharide, in innate immune responses induced by influenza virus hemagglutinin (HA). Treatment of HA with periodate or PNGase F induced lower interleukin (IL)-12p40 secretion by conventional dendritic cells (DCs) compared with the untreated group. In contrast, treatment with O-glycosidase did not affect cytokine production. Green fluorescent protein expression in canonical Dectin-2-transducing cells was approximately 3% - 12% following HA stimulation, except with the A/H1N1pdm09 subtype HA. This expression was markedly reduced in cells possessing mutated amino acids in the carbohydrate recognition domain of Dectin-2, especially following stimulation with HA derived from the A/H3N2 subtype. Interferon (IFN)-α production from CD11c+Siglec-H+PDCA-1+ plasmacytoid DCs was significantly increased in Dectin-2 knockout mice compared with wild-type mice upon stimulation with HA except for the B/Yamagata lineage HA. These results suggested that Dectin-2 is involved in initiating inflammatory responses via mannose polysaccharide on HA. However, other mechanisms may function in the antiviral response, including the type I IFN axis.

关键词： C-Type Lectin Receptors Influenza Virus Innate Immunity Type I Interferon

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Time effect and prediction of broken rock bulking coefficient on the base of particle discrete element method

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International Journal of Mining Science and Technology 2021年第4期31卷 643-651页

作者： Fanfei Meng Hai Pu Takashi Sasaoka hideki Shimada Sifei Liu Tumelo KM Dintwe Ziheng Sha Department of Earth Resources Engineering Faculty of EngineeringKyushu UniversityFukuoka 819-0395Japan State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China College of Mining Engineering and Geology Xinjiang Institute of EngineeringUrumqi 830023China

Bulking characteristics of gangue are of great significance for the stability of goafs in mining overburden in the caving *** this paper,a particle discrete element method with clusters to represent gangue was adopted to explore the bulking coefficient time effect of the broken rock in the caving zone under three-dimensional triaxial compression *** phenomena of stress corrosion,deformation,and failure of rock blocks were simulated in the numerical ***,a new criterion of rock fragments damage was put *** was found that the broken rock has obvious viscoelastic properties.A new equation based on the Burgers creep model was proposed to predict the bulking coefficient of broken rock.A deformation characteristic parameter of the prediction equation was analyzed,which can be set as a fixed value in the mid-and long-term prediction of the bulking *** are quadratic function relationships between the deformation characteristic parameter value and Talbot gradation index,axial pressure and confining pressure.

关键词： Bulking coefficient Time effect Deformation prediction Broken rock Particle discrete element model

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Patient experience of residents with restricted primary care access during the COVID-19 pandemic

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Family Medicine and Community Health 2022年第2期10卷 20-25页

作者： Takuya aoki Yasuki Fujinuma Masato Matsushima Division of Clinical Epidemiology Research Center for Medical SciencesThe Jikei University School of MedicineTokyoJapan Section of Clinical Epidemiology Department of Community MedicineGraduate School of MedicineKyoto UniversityKyotoJapan Centre for Family Medicine Development Japanese Health and Welfare Co-operative FederationTokyoJapan

Objectives To evaluate primary care access for COVID-19 consultation among residents who have a usual source of care(USC)and to examine their associations with patient experience during the pandemic in *** Nationwide cross-sectional *** Japanese general adult *** 1004 adult residents who have a *** outcome measures Patient experience assessed by the Japanese version of Primary Care Assessment Tool Short Form(JPCAT-SF).Results A total of 198(19.7%)reported restricted primary care access for COVID-19 consultation despite having a *** adjustment for possible confounders,restricted primary care access for COVID-19 consultation was negatively associated with the JPCAT-SF total score(adjusted mean difference=−8.61,95%CI−11.11 to−6.10).In addition,restricted primary care access was significantly associated with a decrease in all JPCAT-SF domain *** Approximately one-fifth of adult residents who had a USC reported restricted primary care access for COVID-19 consultation during the pandemic in *** study also found that restricted primary care access for COVID-19 consultation was negatively associated with a wide range of patient experience including first ***,financial and educational support to primary care facilities,the spread of telemedicine and the application of a patient registration system might be necessary to improve access to primary care during a pandemic.

关键词： COV restricted sectional

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A prolonged granitoid formation in Saglek Block,Labrador:Zonal growth and crustal reworking of continental crust in the Eoarchean

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Geoscience Frontiers 2017年第2期8卷 355-385页

作者： Tsuyoshi Komiya Shinji Yamamoto Shogo aoki Keiko Koshida Masanori Shimojo Yusuke Sawaki Kazumasa aoki Shuhei Sakata Takaomi D.Yokoyama Kenshi Maki Akira Ishikawa Takafumi Hirata Kenneth D.Collerson Department of Earth Science and Astronomy Graduate School of Arts and SciencesThe University of TokyoTokyo 153-8902Japan Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 OokayamaMeguroTokyo 152-8551Japan Laboratory for Planetary Sciences Kyoto UniversityKitashirakawa OiwakechoKyoto 606-8502Japan School of Earth Sciences The University of QueenslandBrisbaneQueenslandAustralia KDC Consulting 33 Cramond StWitstonQld 4051Australia

The Archean continental crusts account for ca.20% of the present volume,but the thermal history of the Earths＇ mantle suggests much more continental crusts were formed in the early *** the Archean continental crust underwent severe metamorphism,it is important to avoid influence by the later thermal *** carried out a comprehensive geochronological work of Cathodoluminescence（CL） observation and U-Pb dating of zircons from orthogneisses and supracrustal rocks over the Saglek Block to obtain their protolith *** zircons were classified into three domains of core,mantle and rims,and the cores were further classified into three groups of inherited,altered and zoned cores based on the zonation on the CL *** estimated the protolith ages from Pb-Pb ages of the zoned-cores of zircons with low U *** made a detailed sketch of a small outcrop in ***＇s Harbour South（SJHS） area,and classified the orthogneisses and mafic enclaves into seven generations based on the geologic *** first and second generations comprise mafic rocks and lack magmatic *** conducted CL imaging and U-Pb dating of zircons from the third,sixth and seventh generation of the orthogneisses to estimate the protolith ages at 3902 L 25,3892 ± 33 and 3897 ± 33 Ma for each,supporting the presence of the over 3.9 Ca Iqaluk *** geological occurrence that the mafic rocks occur as enclaves within the 3.9 Ga Iqaluk Gneiss indicates that they are the oldest supracrustal rocks in the *** geochronological and geological studies show the Uivak Gneiss is quite varied in lithology and age from 3.6 to 〉3.9 Ga,and tentatively classified into six groups based on their *** oldest Uivak Gneiss components including the Iqaluk Gneiss are present around the SJHS area,and the orthogneisses become young as it is *** lines of evidence of overprinting of younger granitoid on older granitoid in small outcrops and geological-map scale as well as presence of in

关键词： Eoarchean Geochronology Uivak Gneiss Iqaluk Gneiss Continental recycling The oldest rocks

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An Advanced Oscillation Mixing Method for Improving the Cooling Uniformity in Quenching

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材料热处理学报 2004年第5期25卷 475-479页

作者： Hiroyuki Hoshino Hiromitsu Murakami Hideo Yokota Satoshi Suda hideki Tsuge Koichi Terasaka Toshiaki Wakabayashi Nippon Oil Processing CO. LTD Niigata JapanOriental engineering CO. LTD Tokyo JapanNippon Oil Corp. Yokohama JapanNippon Oil Processing CO. LTD Niigata JapanKeio Univ. Yokohama Japan Keio Univ. Yokohama Japan Kagawa Univ. Takamatsu Japan

In quenching, the cooling uniformity is most important to diminish distortion occurring on work pieces. As a trial to accomplish uniform cooling, therefore, there exist various mixing methods of a quenchant and the quenchant circulation with an external pump has so far been the well accepted mixing method. However, this study proposes an advanced oscillation mixing method that can improve more the cooling uniformity in quenching. The proposed method includes a stirrer in oscillating motion, so that the simultaneous oscillating and mixing movements of the stirrer are considered to provide effectively the uniform cooling characteristics for the quenchant. In comparison with the case of the circulation pump mixing, the investigation using the oscillation mixing method has demonstrated the following two experimental facts: (1) the short vapor blanket stage caused by the quick breakage of the oil vapor blanket and (2) the reduced variation of the quenching distortion.

关键词：淬火剂冷却能力变形振动混合

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Modeling three-dimensional forest structures to drive canopy radiative transfer simulations of bidirectional reflectance factor

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International Journal of Digital Earth 2018年第10期11卷 981-1000页

作者： Wei Yang hideki Kobayashi Xuehong Chen Kenlo Nishida Nasahara Rikie Suzuki Akihiko Kondoh Center for Environmental Remote Sensing Chiba UniversityChibaJapan Department of Environmental Geochemical Cycle Research Japan Agency for Marine-Earth Science and TechnologyYokohamaJapan State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijingPeople’s Republic of China Faculty of Life and Environmental Sciences University of TsukubaTsukubaJapan

Three-dimensional(3-D)Monte Carlo-based radiative transfer(MCRT)models are usually used for benchmarking in intercomparisons of the canopy radiative transfer(RT)***,the 3-D MCRT models are rarely applied to develop remote sensing algorithms to estimate essential climate variables of forests,due mainly to the difficulties in obtaining realistic stand structures for different forest biomes over regional to global ***,some of important tree structure parameters such as canopy height and tree density distribution have been available *** enables to run the intermediate complexities of the 3-D MCRT *** consequently developed a statistical approach to generate forest structures with intermediate complexities depending on the inputs of canopy height and tree *** aims at facilitating applications of the 3-D MCRT models to develop remote sensing retrieval *** proposed approach was evaluated using field measurements of two boreal forest stands at Estonia and USA,*** demonstrated that the simulations of bidirectional reflectance factor(BRF)based on the measured forest structures agreed well with the BRF based on the generated structures from the proposed approach with the root mean square error(RMSE)and relative RMSE(rRMSE)ranging from 0.002 to 0.006 and from 0.7%to 19.8%,*** of the computed BRF with corresponding MODIS reflectance data yielded RMSE and rRMSE lower than 0.03 and 20%,*** the results from the current study are limited in two boreal forest stands,our approach has the potential to generate stand structures for different forest biomes.

关键词： Bidirectional reflectance factor remote sensing forest structure radiative transfer model

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Production and Accumulation of Xylooligosaccharides with Long Chains by Growing Culture and Xylanase of a Mutant Strain of Bacillus pumilus X-6-19

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生物工程学报 2008年第7期24卷 1221-1227页

作者： Qingzhu Yuan Tsuyoshi Adachi Shinji Takenaka Shuichiro Murakami Machiko Tanaka Kenji aoki Division of Life Science Graduate School of Science and Technology Kobe University Rokko Kobe 657-8501 Japan Department of Applied Biological Chemistry Graduate school of Agricultural Science Kobe University Rokko Kobe 657-8501 Japan Research ＆ Development Department Bunsen Co. Ltd. Shingu-cho Tatsuno 679-4393 Japan

Bacillus pumilus X-6-9 isolated from soil and subsequently identified, produced xylooligosaccharides with long chains from xylan and accumulated them in the culture. By improving the culture conditions and mutating the bacterium, a 3.2-fold increase in the production of the xylooligosaccharides was established, when compared to the original culture conditions of B. pumilus X-6-19. The addition of D-glucose to the culture of the mutant strain U-3 of B. pumilus X-6-9 repressed the synthesis of β-xylosidase, but not xylanase. Thus, it was revealed that strain U-3 was a good organism for the production and accumulation of xylooligosaccharides with long chains from xylan by a microbial culture. Xylanase produced by strain U-3 was purified to homogeneity and characterized. The hydrolyzates generated by the purified xylanase contained xylobiose, xylotriose, xylotetraose, and xylopentaose, but not xylose.

关键词：木聚糖酶菌株细菌堆积作用

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Evaluating Rock Mass Properties of Vipingo Coral Limestone Quarry Based on a Modified Geological Strength Index (GSI) and State of Karstification

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Open Journal of Geology 2022年第1期12卷 57-79页

作者： Joan Atieno Onyango Takashi Sasaoka hideki Shimada Akihiro Hamanaka Dyson Moses Dintwe Tumelo Earth Resources Engineering Department Kyushu University Fukuoka Japan Mining Materials and Petroleum Engineering Department Jomo Kenyatta University of Agriculture and Technology Nairobi Kenya

The process of evaluating rock mass strength requires that major structural features such as joints that influence rock strength are considered. In carbonate rock masses, however, the strength of the rock mass is largely dependent on intact rock strength and structural features play a secondary role. Laboratory experiments on porous rock have shown that intact rock strength reduces with increasing porosity, which has a direct effect on the rock mass strength. Rock porosity has however not been well accounted for in rock mass characterization methods currently in use. This research applies the modified GSI method for carbonate rock masses which is based on a combination of GSI and total porosity. The main aim is to quantify the GSI with respect to rock porosity which is a direct indicator of the state of karstification, as an inherent feature that affects rock mass strength. An empirical equation is proposed whereby the GSI as observed in the field is modified by a natural log of the value of porosity, giving rise to a modified GSI (GSIm). The GSIm together with laboratory properties of rock is used to determine the properties of Vipingo coral limestone from RocLab software. A deterministic parametric slope stability analysis is done using the finite element software Phase 2 with the rock mass properties as input parameters. The analysis results point to a direct dependence of the slope stability on slope angle, slope height and rock mass strength of the lithological unit. The graphs make a useful design guide for slopes engineered in this type of rock mass.

关键词： Carbonates Karstification Porosity Rock Mass Strength Slope Stability Weak Rock

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Reciprocal costimulatory molecules control the activation of mucosal type 3 innate lymphoid cells during engagement with B cells

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Cellular & Molecular Immunology 2023年第7期20卷 808-819页

作者： Xinping Lv Shan Zhu Jing Wu Jinfeng Shi Qiuyu Wei Tete Li Ning Yang Chunyan Liu Lingli Qi Guoxia Zang Hang Cheng Zhiguang Yang Chengyan Jin Yusheng Wang Jiuwei Cui hideki Ueno Yong-Jun Liu Jingtao Chen Cancer Center First Hospital of Jilin UniversityChangchunJilin 130021China Laboratory for Tumor Immunology First Hospital of Jilin UniversityChangchunJilin 130061China Department of Otolaryngology Head and Neck Surgery First Hospital of Jilin UniversityChangchunJilin 130021China Department of Translational Medicine Changchun GeneScience Pharmaceuticals Co.Ltd.ChangchunJilin 130012China Department of Gynecology First Hospital of Jilin UniversityChangchunJilin 130021China Department of Pediatric Gastroenterology First Hospital of Jilin UniversityChangchunJilin 130021China Department of Pediatrics First Hospital of Jilin UniversityChangchunJilin 130021China Department of Thoracic Surgery First Hospital of Jilin UniversityChangchunJilin 130021China Department of Thoracic Surgery Second Hospital of Jilin UniversityChangchunJilin 130041China Department of Immunology Graduate School of MedicineKyoto UniversityKyotoJapan ASHBi Institute for the Advanced Study of Human Biology Kyoto UniversityKyotoJapan

Innate lymphoid cells(ILCs)are the counterpart of T helper cells in the innate immune system and share multiple phenotypes with T helper *** T-cell costimulator(ICOS)is recognized on T cells and participates in T-cell activation and T and B-cell engagement in lymphoid ***,the role of ICOS in ILC3s and ILC3-involved interactions with the immune microenvironment remains ***,we found that ICOS expression on human ILC3s was correlated with the activated state of *** costimulation enhanced the survival,proliferation,and capacity of ILC3s to produce cytokines(IL-22,IL-17A,IFN-γ,TNF,and GM-CSF).Via synergistic effects of ICOS and CD40 signaling,B cells promoted ILC3 functions,and ILC3-induced T-cellindependent B-cell IgA and IgM secretion primarily required CD40 ***,ICOS is essential for the nonredundant role of ILC3s and their interaction with adjacent B cells.

关键词： Innate lymphoid cell B cell Tonsil ICOS Costimulatory molecule

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