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A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

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Bone Research 2020年第4期8卷 429-438页

作者： Junichi Kushioka Takashi Kaito Rintaro Okada Hiroyuki Ishiguro Zeynep Bal Joe Kodama Ryota Chijimatsu Melanie Pye Masahiro Narimatsu Jeffrey LWrana Yasumichi Inoue Hiroko Ninomiya Shin Yamamoto Takashi Saitou hideki yoshikawa Takeshi Imamura Department of Orthopaedic Surgery Osaka University Graduate School of Medicine2-2 YamadaokaSuitaOsaka 565-0871Japan Bone and Cartilage Regenerative Medicine The University of Tokyo7-3-1HongoBunkyo-kuTokyo 113-8655Japan Centre for Systems Biology Lunenfeld-Tanenbaum Research InstituteMount Sinai Hospital600 University AveTorontoON M5G 1X5Canada Department of Cell Signaling Graduate School of Pharmaceutical SciencesNagoya City University3-1 Tanabe-doriMizuho-kuNagoyaAichi 467-8603Japan Department of Molecular Medicine for Pathogenesis Ehime University Graduate School of Medicine454 ShitsukawaToonEhime 791-0295Japan Department of Gastroenterology and Metabology Ehime University Graduate School of Medicine454 ShitsukawaToonEhime 791-0295Japan Translational Research Center Ehime University Hospital454 ShitsukawaToonEhime 791-0295Japan

Transforming growth factor-β(TGF-β)and bone morphogenetic protein(BMP)play important roles in bone metabolism.Smad ubiquitination regulatory factors(Smurfs)regulate TGF-β/BMP signaling via ubiquitination,resulting in degradation of signaling molecules to prevent excessive activation of TGF-β/BMP signaling.Though Smurf2 has been shown to negatively regulate TGF-β/Smad signaling,its involvement in BMP/Smad signaling in bone metabolism has not been thoroughly investigated.In the present study,we sought to evaluate the role of Smurf2 in BMP/Smad signaling in bone metabolism.Absorbable collagen sponges containing 3μg of recombinant human BMP2(rhBMP2)were implanted in the dorsal muscle pouches of wild type(WT)and Smurf2−/−mice.The rhBMP2-induced ectopic bone in Smurf2−/−mice showed greater bone mass,higher mineral apposition and bone formation rates,and greater osteoblast numbers than the ectopic bone in WT mice.In WT mice,the ectopic bone consisted of a thin discontinuous outer cortical shell and scant inner trabecular bone.In contrast,in Smurf2−/−mice,the induced bone consisted of a thick,continuous outer cortical shell and abundant inner trabecular bone.Additionally,rhBMP2-stimulated bone marrow stromal cells(BMSCs)from Smurf2−/−mice showed increased osteogenic differentiation.Smurf2 induced the ubiquitination of Smad1/5.BMP/Smad signaling was enhanced in Smurf2−/−BMSCs stimulated with rhBMP2,and the inhibition of BMP/Smad signaling suppressed osteogenic differentiation of these BMSCs.These findings demonstrate that Smurf2 negatively regulates BMP/Smad signaling,thereby identifying a new regulatory mechanism in bone metabolism.

关键词： Smurf2 metabolism involvement

Macro-structural effect of metal surfaces treated using computer-assisted yttrium-aluminum-garnet laser scanning on bone-implant fixation.

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Macro-structural effect of metal surfaces treated using comp...

Cavitation assisted HIFU with phase-change nano droplet

第六届国际骨质疏松及骨矿盐疾病学术会议

作者： Yusuke Mori Kazuomi Sugamoto hideki yoshikawa Tetsuo Ogawa Division of Electrical Electronic and information EngineeringGraduate School of EngineeringOsaka University Osaka Univ.Graduate School of Med.Orthopedic Biomaterial Science Osaka Univ.Graduate School of Med.Orthopedic department Department of Physics Osaka University

＜正＞Porous coatings have been applied to the surface of prosthetic devices to foster stable device fixation.The coating serves as a source of mechanical interlocking and may stimulate healthy bone growth through osseointegrated load transfer in cementless arthroplasty.Joint arthroplasty by porous-coated prostheses is one of the most common surgical treatments,and has provided painless and successful joint mobility.However,long-term success is often impaired by the loss of fixation between the prosthesis and bone.Porouscoated prostheses are associated with several disadvantages.

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Cavitation assisted HIFU with phase-change nano droplet

2-D/3-D registration for Kinematics analysis of Total Knee Arthroplasty

2008 IEEE International Ultrasonics Symposium

作者： Ken-ichi Kawabata Rei Asami Takashi Azuma hideki yoshikawa Shin-ichiro Umemura Central Research Laboratory HitachiLtd. Tohoku University

＜正＞Background,Motivation and Objective Although HIFU therapy is well established as a minimally invasive cancer treatment,there is a great demand for an improved throughput on total operation time.One of approaches...

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2-D/3-D registration for Kinematics analysis of Total Knee A...

Freeze-thaw cycles and associated geomorphology in a post-glacial environment:current glacial,paraglacial,periglacial and proglacial scenarios at Pico de Orizaba volcano,Mexico

The 6th International Conference on Biomedical Engineering and Rehabilitation Engineering

作者： Takaharu Yamazaki Tetsu Watanabe Yoshikazu Nakajima Yoshinobu Sato Tetsuya Tomita KazuomiSugamoto hideki yoshikawa Takahiro Ochi Shinichi Tamura Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan Osaka University Medical School Yamadaoka 2-2SuitaOsaka 565-0871Japan

＜正＞ In the domain of orthopaedic surgery, a knowledge of three-dimensional （3-D） kneeprosthesis kinematics after Total Knee Arthroplasty （TKA） is highly important to validateinnovative prosthesis designs and different surgical strategies. In general, X-ray fluoroscopyis suitable for observing dynamic movement of knee prosthesis. Recently, a model-based

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Journal of Mountain Science 2024年第6期21卷 1954-1977页

作者： Víctor SOTO Carlos M.WELSH R. Kenji yoshikawa Hugo DELGADO GRANADOS Centro de Ciencias de la Tierra Universidad VeracruzanaCircuito Gonzalo Aguirre BeltránS/NZona Universitaria91090XalapaMéxico Water and Environmental Research Center University of Alaska FairbanksFairbanksAlaska 99775USA Instituto de Geofísica Universidad Nacional Autónoma de MéxicoCiudad de México 04150México Department of Earth and Environmental Sciences Ludwig Maximilians UniversitätMunich 80333Germany

The glacial history of Pico de Orizaba indicates that during the Last Glacial Maximum,its icecap covered up to~3000 m asl;due to the air temperature increasing,its main glacier has retreated to 5050 m asl.The retraction of the glacier has left behind an intense climatic instability that causes a high frequency of freeze-thaw cycles of great intensity;the resulting geomorphological processes are represented by the fragmentation of the bedrock that occupies the upper parts of the mountain.There is a notable lack of studies regarding the fragmentation and erosion occurring in tropical high mountains,and the associated geomorphological risks;for this reason,as a first stage of future continuous research,this study analyzes the freezing and thawing cycles that occur above 4000 m asl,through continuous monitoring of surface ground temperature.The results allow us to identify and characterize four zones:glacial,paraglacial,periglacial and proglacial.It was found that the paraglacial zone presents an intense drop of temperature,of up to~9℃ in only sixty minutes.The rock fatigue and intense freeze-thaw cycles that occur in this area are responsible for the high rate of rock disintegration and represent the main factor of the constant slope dynamics that occur at the site.This activity decreases,both in frequency and intensity,according to the distance to the glacier,which is where the temperature presents a certain degree of stability,until reaching the proglacial zone,where cycles are almost non-existent,and therefore there is no gelifraction activity.The geomorphological processes have resulted in significant alterations to the mountain slopes,which can have severe consequences in terms of risk and water.

关键词： Freeze-Thaw Gelifraction Mountain mechanical erosion Periglacial geomorphology Postglacial scenarios

Acta Biomat:开发出可促进机体神经组织再生的新型网格纤维结构

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现代生物医学进展 2017年第18期17卷 I0002-I0003页

作者： Koji Suzuki[a] Hiroyuki Tanaka[a] Mitsuhiro Ebara[b] Koichiro Uto[b] Hozo Matsuoka[a] Shunsuke Nishimoto[a] Kiyoshi Okada[a][c] Tsuyoshi Murase[a] hideki yoshikawa[a] [a] Department of Orthopaedic Surgery Osaka University Graduate School of Medicine 2-2 Yamadaoka Suita Osaka 565-0871 Japan[b] International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science (NIMS) 1-1 Namiki Tsukuba Ibaraki 304-0044 Japan[c] Medical Center for Translational and Clinical Research Osaka University Hospital 2-15 Yamadaoka Suita Osaka 565-0871 Japan

近日。一项刊登在国际杂志Acta Biomaterialia上的研究报告中。来自日本大阪大学的研究人员通过研究开发出了一种网格结构。其能够被缠绕在损伤的周围神经组织上来帮助促进损伤神经的再生并且恢复其功能。

关键词：损伤神经组织再生网格结构研究开发纤维结构机体日本大阪大学研究人员

Challenges of Bioethics Education in Pediatric Basic Nursing Education: A Faculty Perspective

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Health 2024年第2期16卷 105-117页

作者： Junko Nemoto Chikage Kubota Yukiko yoshikawa Faculty of Nursing Hyogo University Kakogawa Japan Department of Emergency Medical Science Suzuka University of Medical Science Suzuka Japan

In the field of pediatric nursing, in the perinatal period, numerous ethical issues arise alongside the advancement of medical technology. However, sufficient education on bioethics is not provided in the pediatric nursing domain of basic nursing education. The purpose of this research is to examine the current status of bioethics education in the pediatric nursing domain of basic nursing education and explore the challenges perceived by the pediatric nursing faculty regarding bioethics education. The research method was a questionnaire survey on 100 randomly selected pediatric nursing faculty members from nursing universities across Japan. The results revealed that although bioethics issues were considered important, the emphasis remained primarily on addressing bioethics as part of nursing that respects children’s rights. Furthermore, respondents expressed difficulties regarding teaching methods and content related to bioethics.

关键词： Basic Nursing Education Bioethics Education Pediatric Nursing

An Experimental Study on Aerodynamic Sound Generated from Wake Interaction of Circular Cylinder and Airfoil with Attack Angle in Tandem

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Journal of Thermal Science 2008年第3期17卷 212-217页

作者： Mizue MUNEKATA Ryuta KOSHIISHI Hiroyuki yoshikawa hideki OHBA Department of Mechanical System Engineering

在我们的以前的学习，在空气动力学的声音上的柱体和机翼之间的间隔的效果被调查并且与单个圆形、单个的机翼的案例相比。在这研究，机翼的攻击角度的效果在空气动力学的声音的特征上定位了 downstream， wake 结构在在柱体和机翼之间... 详细信息

在我们的以前的学习，在空气动力学的声音上的柱体和机翼之间的间隔的效果被调查并且与单个圆形、单个的机翼的案例相比。在这研究，机翼的攻击角度的效果在空气动力学的声音的特征上定位了 downstream， wake 结构在在柱体和机翼之间的给定的间隔被调查。DFN 和山峰频率的健全压力水平与因为，增加机翼的攻击角度减少，这被发现散开由于圆形的柱体的增加的反应弄醒结构，它被机翼的堵住的效果引起。健全来源被通信到流旋涡形式的攻击点，这被显示出在上游的圆形的柱体到下游的机翼。我们断定在机翼表面的压力变化在健全压力水平上完成，从流动可视化和健全来源的探索测试。

关键词：空气动力学尾流圆柱机翼

Effects of Pulsation on Separated Flow and Heat Transfer in Enlarged Channel

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Journal of Thermal Science 2011年第1期20卷 70-75页

作者： Hiroyuki yoshikawa Tomonori KAI Mizue MUNEKATA hideki OHBA Dept.of Mechanical System Engineering Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Kikuyo KikuchiKumamoto 869-1101Japan

Numerical results of three-dimensional separated flow and heat transfer in an enlarged rectangular channel are presented in this paper.The expansion ratio and aspect ratio of the channel are 2.0 and 16.0,respectively.Reynolds number of the flow is 200 and it is over the critical Reynolds number.Over the critical Reynolds number,the flow in the symmetric channel becomes asymmetric and deflects to one side of the walls.Effects of the pulsating fluctuation at the inlet upon the flow in the channel are investigated.It is clarified that the inlet flow with a pulsating fluctuation of Strouhal number 0.05 and 0.10 strongly affects on the flow in the channel,and heat transfer on the walls is enhanced,especially on the wall surface covered with long separation bubble.On the other hand,the pulsation of St=0.0125 oscillates the shear layer more weakly than that of St=0.05,0.10 and the enhancement of heat transfer is smaller,though some vortices are shed from the vicinity of the side wall near the reattachment region.The oscillation of the main flow calms down gradually as the Strouhal number of the pulsation increases over 0.10.The influence of pulsation of St=0.20 on the flow is restricted in the near downstream of the step,and heat transfer on the walls is almost similar to that of the steady flow in the channel.

关键词：分离流动强化传热脉动流 Strouhal数临界雷诺数矩形通道频道斯特劳哈尔数