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Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion

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World Journal of Gastroenterology 2017年第4期23卷 735-739页

作者： Muneji Yasuda hideki sato Yuki Koyama Tomoki Sakakida Takumi Kawakami Takeshi Nishimura hideki Fujii Yoshikazu Nakatsugawa Shinya Yamada Naoya Tomatsuri Yusuke Okuyama Hiroyuki Kimura Takaaki Ito Hiroyuki Morishita Norimasa Yoshida Department of Gastroenterology and Hepatology Japanese Red Cross Kyoto Daiichi Hospital Department of Radiology Japanese Red Cross Kyoto Daiichi Hospital

Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage(ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization(TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fatal complication in patients with long-term placement of ERBD. TAE is a minimally invasive procedure that offers effective treatment for biliary bleeding.

关键词： Biliary stent Plastic stent Biliary bleeding Pseudoaneurysm Pigtail stent

Factors Predicting Late Rectal Disorders after Radiation Therapy for Prostate Cancer

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Chinese Medical Journal 2017年第20期130卷 2441-2446页

作者： Toshiya Maebayashi Naoya Ishibashi Takuya Aizawa Masakuni Sakaguchi hideki sato Katsuhiko sato Tsuyoshi Matsui Kenya Yamaguchi satoru Takahashi Department of Radiology Nihon University School of Medicine Tokyo 173-8610 Japan Department of Gastroenterology and Hepatology Nihon University School of Medicine Tokyo 173-8610 Japan Department of Urology Nihon University School of Medicine Tokyo 173-8610 Japan

Background： Although various studies have been conducted on the effects of radiation therapy for prostate cancer, rectal toxicity after radiation therapy for prostate cancer, which is an important late adverse event associated with radiation therapy, has not been sufficiently examined. This study aimed to assess the associations of late rectal disorder （LRD） with dosimetric, anatomic, and clinical factors in patients with prostate cancer who underwent three-dimensional conformal radiation therapy （3D-CRT）. Methods： We retrospectively analyzed 104 patients undergoing 3D-CRT between January 2009 and October 2011. Thirty patients were administered anticoagulation/antiplatelet （AC/AP） agents. The standard dose was 74 Gy. Uni- and multi-va,iate analyses we,e performed to identify factors predictive of LRD after 3D-CRT. Results： The median follow-up period was 66 （range： 14 87） months. LRD occurred in 10.6% （11/104） of patients. The median time fi＇om RT to LRD was 15 months （range： 7MI months）. Sixty-four percent of those with LRD （7/11 patients） had been given AC/AP agents. Fitly-five （6/11 ） patients had severe internal iliac artery calcification. By univariate analysis, significant predictors of LRD were internal iliac artery calcification, administration of AC/AP agents, and age. Being very elderly was the significant predictor identified by multivariate analysis （P = 0.0276）. For patients receiving AC/AP agents and those with severe internal iliac artery calcification, the LRD incidences were 23.3% （7/30 patients） and 23.1% （6/26 patients）, respectively, and being 75 years of age or older was a significant predictor in these subsets. Conclusions： Our results suggest advanced age, administration of AC/AP agents, and severe internal iliac artery calcification to be risk factors tbr LRD in patients undergoing standard RT. Therefore, it is necessary to administer radiation with particular caution in the very elderly, especially those receiving AC/AP agents and/or with se

关键词： Anticoagulation/Antiplatelet Agents Late Rectal Disorder Prostate Cancer Radiation Therapy Severe Internal lliac Artery Calcification

A Twin Unidirectional Impulse Turbine for Wave Energy Conversion—Effect of Fluidic Diode on the Performance

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Open Journal of Fluid Dynamics 2014年第5期4卷 433-439页

作者： Shinya Okuhara Manabu Takao hideki sato Akiyasu Takami Toshiaki Setoguchi Support Center for Practical Education National Institute of Technology Matsue College Matsue Japan Department of Mechanical Engineering National Institute of Technology Matsue College Matsue Japan Advanced Engineering Faculty National Institute of Technology Matsue College Matsue Japan Institute of Ocean Energy Saga University Saga Japan

As a system using a conventional unidirectional air turbine in oscillating water column (OWC) based on a wave energy plant, a twin unidirectional impulse turbine topology has been suggested in previous studies. However, the average efficiency of the suggested twin turbine is considerably lower than that of a conventional unidirectional turbine in this topology because reciprocating air flow can’t be rectified adequately by a unidirectional turbine. In order to improve the efficiency, using fluidic diode is discussed. In this study, two different fluidic diodes were discussed by computational fluid dynamics (CFD) and a wind tunnel test. Further, its usefulness is discussed from a view point of the turbine efficiency. The fluidic diode was shown to improve rectification of the topology. However, it needs more improvement in regards to its energy loss in order to enhance the turbine efficiency.

关键词： Fluidic Diode Twin Unidirectional Turbine Wave Energy Conversion Oscillating Water Column

Analysis of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor-Induced Left Ventricular Dysfunction

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Journal of Biophysical Chemistry 2023年第2期14卷 67-78页

作者： Yasuhisa Hashino Kengo Umehara Shinya Takada Kuninori Iwayama Koichi Ohtaki hideki sato Faculty of Pharmaceutical Sciences Hokkaido University of Science Sapporo Japan Department of Pharmacy National Hospital Organization Hokkaido Cancer Center Sapporo Japan

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor (VEGFR-TKI), an oral molecular targeted drug, reportedly causes serious adverse cardiovascular events such as hypertension and left ventricular failure. The association between VEGFR-TKI-induced hypertension and heart failure with preserved left ventricular ejection fraction (LVEF) (HFpEF) has been previously studied. Therefore, we investigated the relationship between hypertension onset and associated cardiac diastolic dysfunction due to VEGFR-TKI use. Patients who used VEGFR-TKIs (target drugs: sunitinib, axitinib, sorafenib, pazopanib, and cabozantinib) at the Department of Urology, Hokkaido Cancer Center were recruited between May 2009 and October 2021 and were divided into two groups based on whether their blood pressure was elevated during VEGFR-TKI use. The markers of left ventricular diastolic function (E/A, Dct (ms), mean E/e, septal e') and left ventricular systolic function (LVEF, LVDd, and LVDs) were evaluated. LVEF and mean E/e in the elevated blood pressure group (n = 41) showed significant changes before and after treatment. LVEF values (contractile function markers) in the TKI-HT (+) group significantly decreased from 70.7% ± 6.8% before treatment to 68.3% ± 7.8% after treatment (p = 0.03). Conversely, no significant difference was observed for any ventricular systolic function marker in the TKI-HT (−) group. E/e (diastolic function marker) in the TKI-HT (+) group significantly decreased from 11.9% ± 3.6% before treatment to 10.3% ± 3.0% after treatment (p = 0.02). However, no change was observed in any ventricular diastolic function marker in the TKI-HT (−) group. The results of this study suggest that cardiac function may be affected in patients using VEGFR-TKI. Furthermore, appropriate antihypertensive treatment and early monitoring with regular echocardiography, even in asymptomatic patients, may help prevent VEGFR-TKI-induced deterioration of systolic and diastolic func

关键词： VEGFR-TKI Left Ventricular Dysfunction Cardio-Oncology HFrEF HFpEF CTRCD

Usefulness of vonoprazan,a potassium ion-competitive acid blocker,for primary eradication of Helicobacter pylori

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 550-555页

作者： Shinya Yamada Takumi Kawakami Yoshikazu Nakatsugawa Takahiro Suzuki hideki Fujii Naoya Tomatsuri hideki Nakamura hideki sato Yusuke Okuyama Hiroyuki Kimura Norimasa Yoshida Department of Gastroenterology Japanese Red Cross Kyoto Daiichi Hospital

AIM To investigate usefulness of triple therapy with vonoprazan,a potassium ion-competitive acid blocker and antibiotics,for Helicobacter pylori(***) *** The *** eradication rate was examined in 2507 patients(2055 undergoing primary eradication and 452 undergoing secondary eradication,excluding patients with subtotal gastrectomy) at the Japanese Red Cross Kyoto Daiichi Hospital from March 2013 to September *** patients treated from March 2013 to February 2015,a proton pump inhibitor(PPI) was used to reduce acid secretion,while vonoprazan was used after March *** success rates of the 2 regimens(PPI + amoxicillin + clarithromycin/metronidazole,or vonoprazan + amoxicillin + clarithromycin/metronidazole) were *** The success rate of primary *** eradication was significantly higher in the vonoprazan *** stratified by the underlying disease,a significant increase of the *** eradication rate was observed in patients with chronic gastritis.A significantly lower *** eradication rate was observed in younger patients compared to older patients in the PPI group,but there was no difference according to age in the vonoprazan *** the otherhand,the success rate of secondary eradication was similar at approximately 90% in both *** Vonoprazan is very useful for primary eradication of ***,and may become a first-line acid secretion inhibitor instead of PPIs.

关键词： Helicobacter pylori Eradication Vonoprazan Chronic gastritis Potassium ion-competitive acid blocker

Phytoremediation of Cd contaminated arable soil and postphytoremediation

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Phytoremediation of Cd contaminated arable soil and postphyt...

人体醛缩酶C cDNA的克隆及其在家蚕体内的表达(英文)

International Symposium on Phytoremediation and Ecosystem Health

作者： hideki sato Shou Shindo Hiroyuki Hattori Mitsuo Chino Akita Prefectural University

＜正＞We have tried to decrease Cd concentration of soil by phytoremediation in northern part of *** of plant species and utilization of biomass of plant grown on Cd polluted farm land are important for the success of... 详细信息

关键词： Arable soil Cd phytoremediation Lactobacillus casei

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蚕业科学 2005年第4期31卷 449-453页

作者：段家龙佐藤秀对原三郎安徽农业大学合肥230036 日本京都工艺纤维大学

利用人体醛缩酶C cNDA的一对特异性引物A ld-5′(5′-ggatcccctcactcgtaccca-3′)和A ld-3′(5′g-gatcctcag-taggcatggtt-3′),从人脑cDNA文库中PCR扩增出人体醛缩酶C cDNA,并依次被克隆进克隆载体pCR2.1、转移载体pAcGP67B以及来源于AcNPV和BmNPV的杂交重组病毒HyNPV。通过对家蚕血液的SDS-PAGE电泳和酶活力测定,证明人体醛缩酶C cDNA在家蚕体内成功得到表达。

关键词：人体醛缩酶C 基因表达杂交重组病毒家蚕

New aspects of a small GTPase RAB35 in brain development and function

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Neural Regeneration Research 2025年第7期20卷 1971-1980页

作者： Ikuko Maejima Ken sato Laboratory of Molecular Traffic Institute for Molecular and Cellular RegulationGunma UniversityMaebashiJapan

In eukaryotic cells,organelles in the secretory,lysosomal,and endocytic pathways actively exchange biological materials with each other through intracellular membrane trafficking,which is the process of transporting the cargo of proteins,lipids,and other molecules to appropriate compartments via transport vesicles or *** processes are strictly regulated by various small GTPases such as the RAS-like in rat brain(RAB)protein family,which is the largest subfamily of the RAS *** of membrane trafficking affects tissue homeostasis and leads to a wide range of diseases,including neurological disorders and neurodegenerative ***,it is important to understand the physiological and pathological roles of RAB proteins in brain ***35,a member of the RAB family,is an evolutionarily conserved protein in metazoans.A wide range of studies using cultured mammalian cells and model organisms have revealed that RAB35 mediates various processes such as cytokinesis,endocytic recycling,actin bundling,and cell ***35 is also involved in neurite outgrowth and turnover of synaptic *** generated brain-specific Rab35 knockout mice to study the physiological roles of RAB35 in brain development and *** mice exhibited defects in anxiety-related behaviors and spatial ***,RAB35 is required for the precise positioning of pyramidal neurons during hippocampal development,and thereby for normal hippocampal *** contrast,layer formation in the cerebral cortex occurred superficially,even in the absence of RAB35,suggesting a predominant role for RAB35 in hippocampal development rather than in cerebral cortex *** studies have suggested an association between RAB35 and neurodegenerative diseases,including Parkinson's disease and Alzheimer's *** this review,we provide an overview of the current understanding of subcellular functions of *** also provide insights into the phys

关键词： endocytosis endosomes hippocampal development neurodegenerative diseases RAB35

Analysis of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor-Induced Left Ventricular Dysfunction

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