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Relationship between testicular volume and testicular function： comparison of the Prader orchidometric and ultrasonographic measurements in patients with infertility

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Asian Journal of Andrology 2008年第2期10卷 319-324页

作者： Hideo Sakamoto Yoshio Ogawa hideki Yoshida Department of Urology Showa University School of Medicine Tokyo 142-8666 Japan

Aim： To evaluate the relationship between testicular function and testicular volume measured by using Prader orchidometry and ultrasonography （US） to determine the critical testicular volume indicating normal testicular function by each method. Methods： Total testicular volume （right plus left testicular volume） was measured in 794 testes in 397 men with infertility （mean age, 35.6 years） using a Prader orchidometer and also by ultrasonography. Ultrasonographic testicular volumes were calculated as length x width x height x 0.71. To evaluate volume-function relationships, patients were divided into 10 groups representing 5-mL increments of total testicular volume by each method from below 10 mL to 50 mL or more. Results： Mean total testicular volume based on Prader orchidometry and US were 36.8 mL and 26.3 mL, respectively. Semen volume, sperm density, total sperm count, total motile sperm count, and serum FSH, LH, and testosterone all correlated significantly with total testicular volume measured by either method. Mean sperm density was in the oligozoospermic range in patients with total testicular volume below 35 mL by orchidometry or below 20 mL by ultrasonography. Mean total sperm count was subnormal in patients with total testicular volume below 30 mL by orchidometry or under 20 mL by ultrasonography. Conclusion： Testicular volume measured by either ultrasonography or Prader orchidometry correlated significantly with testicular function. However, critical total testicular volume indicating normal or nearly normal testicular function was 30 mL to 35 mL using Prader orchidometer and 20 mL using ultrasonography. Prader orchidometry morphometrically and functionally overestimated the testicular volume in comparison to US. （Asian JAndro12008 Mar; 10： 319-324）

关键词： orchidometer ultrasonography testicular volume testicular function

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Efficient Origin-Destination Estimation Using Microscopic Traffic Simulation with Restricted Rerouting

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Computer Modeling in Engineering & Sciences 2023年第5期135卷 1091-1109页

作者： Kazuki Abe hideki Fujii Shinobu Yoshimura Vector Research Institute Inc.Shibuya-kuTokyo150-0002Japan School of Engineering The University of TokyoBunkyo-kuTokyo113-8656Japan

Traffic simulators are utilized to solve a variety of traffic-related *** such simulators,origin-destination(OD)traffic volumes as mobility demands are required to input,and we need to estimate *** authors regard an OD estimation as a bi-level programming problem,and apply a microscopic traffic simulation model to ***,the simulation trials can be computationally expensive if full dynamic rerouting is allowed,when employing multi-agent-based models in the estimation *** paper proposes an efficient OD estimation method using a multi-agent-based simulator with restricted dynamic rerouting to reduce the computational *** though,in the case of large traffic demand,the restriction on dynamic rerouting can result in heavier *** authors resolve this problem by introducing constraints of the bi-level programming problem depending on link *** results show that the accuracy of the link traffic volume reproduced with the proposed method is virtually identical to that of existing methods but that the proposed method is more computationally efficient in a wide-range or high-demand context.

关键词： ODestimation microscopic traffic simulation dynamic rerouting bi-level programming multi-agent basedmodel

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Medaka factor in the germline alpha(figα)is indispensable for oogenesis but not for gonadal sex differentiation

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Aquaculture and Fisheries 2024年第3期9卷 347-354页

作者： Katsuyasu Kamimura Masato kinoshita Akira Kanamori Division of Biological Science Graduate School of ScienceNagoya UniversityNagoyaAichi464-8602Japan Division of Applied Biosciences Graduate School of AgricultureKyoto UniversityKyoto606-8502Japan

A basic helix-loop-helix transcription factor,figα,is one of the earliest marker genes of oocyte differentiation in *** the present study,we made figαknockout medaka by CRISPR/Cas9,expecting aborted progress of oogenesis,to see if differentiation of somatic ovarian tissues is ***αknockout male gonads differentiated normally into testes with functional *** females,on the other hand,were sterile;there are oocytes only up to *** growing oocytes in diplotene were *** phenotype was already apparent at 10 days after hatching,when diplotene oocytes start to develop in the ***,several putative target genes of figαwere not expressed in the mutant female *** studies showed that medaka lacking germ cells have morphologically abnormal gonads and female to male sex reversal ***αknockout female gonads differentiated morphologically into ovaries,suggesting that in medaka,figαknockout prevents oogenesis progress into diplotene stage,and ovarian differentiation do not need developed oocytes beyond pachytene *** ovarian phenotype reminded us of"pachytene checkpoint",which blocks meiotic progress into diplotene when chromosomal abnormalities are ***,we further analyzed phenotype of oocytes in the mutant *** number of oocytes at each meiotic stage suggested that oogenesis normally proceeded up to pachytene *** number of apoptotic oocytes in the knockout ovaries was ***,we did not detect any abnormal pairings or unrepaired double-strand breaks by *** together,figαknockout likely stop oocyte growth at or around pachytene via unknown mechanisms other than"pachytene checkpoint"and arrested oocytes remained in the *** is in contrast to figαknockout mice where all oocytes underwent apoptosis quickly after birth.

关键词： bHLH transcription factor CRISPR/Cas9 Pachytene checkpoint Oocyte growth Medaka

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A Study on Viscoelastic Fluid Flow in a Square-Section 90-Degrees Bend

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Journal of Thermal Science 2003年第4期12卷 337-343页

作者： Mizue Munekata Kazuyoshi Matsuzaki hideki Ohba Dept. of Mechanical Engineering and Materials Science Kumamoto University Kurokami 2-39-1 Kumamoto JapanDept. of Mechanical Engineering and Materials Science Kumamoto University Kurokami 2-39-1 Kumamoto JapanDept. of Mechanical Engineering and Materials Science Kumamoto University Kurokami 2-39-1 Kumamoto Japan

It is well known that the drag-reducing effect is obtained in a surfactant solution flow in a straight pipe. We investigate about a viscoelastic fluid flow such as a surfactant solution flow in a square-section 90° bend. In the experimental study, drag-reducing effect and velocity field in a surfactant solution flow are investigated by measurements of wall pressure loss and LDV measurements. For the numerical method, LES with FENE-P model is used in the viscoelastic fluid flow in the bend. The flow characteristics of viscoelastic fluid are discussed compared with that of a Newtonian fluid.

关键词： non-Newtonian flow viscoelastic fluid drag reduction bend flow LES LDV.

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Effect of Non-Newtonian Viscosity for Surfactant Solutions on Vortex Characteristics in a Swirling Pipe Flow

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Journal of Thermal Science 2005年第4期14卷 357-361,356页

作者： Mizue MUNEKATA Hidefumi TAKAKI hideki OHBA Kazuyoshi MATSUZAKI Kumamoto University 2-39-1 KurokamiKumamoto 860-8555Japan Tokyo Electron LTD. 650 Mitsuzawa Hosaka-cho NirasakiYamanashi 407-0192Japan

Effects of non-Newtonian viscosity for surfactant solution on the vortex characteristics and drag-reducing rate in a swirling pipe flow are investigated by pressure drop measurements, velocity profile measurements and viscosity measurements. Non-Newtonian viscosity is represented by power-law model （t= kD^π）. Surfactant solution used has shear-thinning viscosity with n 〈 1.0. The swirling flow in this study has decay of swirl and vortex-type change from Rankin＇s combined vortex to forced vortex. It is shown that the effect of shear-thinning viscosity on the decay of swirl intensity is different by vortex category and the critical swirl number with the vortex-type change depends on shear-thinning viscosity.

关键词： swirling flow drag reduction surfactant solution non-Newtonian fluid vortex LDV.

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An Experimental Study on Aerodynamic Sound Generated from Wake Interaction of Circular Cylinder and Airfoil with Attack Angle in Tandem

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Journal of Thermal Science 2008年第3期17卷 212-217页

作者： Mizue MUNEKATA Ryuta KOSHIISHI Hiroyuki YOSHIKAWA hideki OHBA Department of Mechanical System Engineering

In our previous study, the effects of the interval between the cylinder and the airfoil on the aerodynamic sound were investigated and compared with the cases of single circular and single airfoil. In this study, the effects of the attack angle of the airfoil located downstream on the characteristics of aerodynamic sound and the wake structure are investigated at a given interval between the cylinder and the airfoil. It is found that the sound pressure level of DFN and the peak frequency decrease with increasing attack angle of airfoil because of the diffusive wake structure due to the increased back pressure of circular cylinder, which is caused by the blocking effect of airfoil. It is shown that the sound sources are corresponded to the attack points of shedding vortex form the upstream circular cylinder to the downstream airfoil. We conclude that the pressure fluctuation at the airfoil surface effects on the sound pressure level, from the flow visualizations and the exploration test of sound source.

关键词： aerodynamic sound wake interaction circular cylinder airfoil Karman's vortex flow visualization

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Contributions of the Secondary Jet to the Tangential Velocity Distribution and to the Collection Efficiency of the Fixed Guide Vane Type Axial Flow Cyclone Dust Collector

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Journal of Thermal Science 2015年第6期24卷 503-509页

作者： Akira Ogawa hideki Anzou So Yamamoto Mituru Shimagaki Tokyo Japan

In order to control the maximum tangential velocity V?m(m/s)of the turbulent rotational air flow and the collection efficiencyηc(%)using the fly ash of the mean diameter X R50=5.57?m,two secondary jet nozzles were installed to the body of the axial flow cyclone dust collector with the body diameter D1=*** in order to estimate V?m(m/s),the conservation theory of the angular momentum flux with Ogawa combined vortex model was *** comparisons of the estimated results of V?m(m/s)with the measured results by the cylindrical Pitot-tube were shown in good *** also the estimated collection efficienciesηcth(%)basing upon the cut-size Xc(?m)which was calculated by using the estimated V?m(m/s)and also the particle size distribution R(Xp)were shown a little higher values than the experimental results due to the re-entrainment of the collected *** best method for adjustment ofηc(%)related to the contribution of the secondary jet flow is principally to apply the centrifugal effect?c(1).Above stated results are described in detail.

关键词： Axial Flow Cyclone Dust Collector Maximum Tangential Velocity Cut-Size Particle Size Distribution Collection Efficiency Reynolds number Centrifugal Effect

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Effects of Pulsation on Separated Flow and Heat Transfer in Enlarged Channel

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Journal of Thermal Science 2011年第1期20卷 70-75页

作者： Hiroyuki YOSHIKAWA Tomonori KAI Mizue MUNEKATA hideki OHBA Dept.of Mechanical System Engineering Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Graduate School of Science and Technology Kumamoto University2-39-1 KurokamiKumamoto 860-8555Japan Kikuyo KikuchiKumamoto 869-1101Japan

Numerical results of three-dimensional separated flow and heat transfer in an enlarged rectangular channel are presented in this *** expansion ratio and aspect ratio of the channel are 2.0 and 16.0,*** number of the flow is 200 and it is over the critical Reynolds *** the critical Reynolds number,the flow in the symmetric channel becomes asymmetric and deflects to one side of the *** of the pulsating fluctuation at the inlet upon the flow in the channel are *** is clarified that the inlet flow with a pulsating fluctuation of Strouhal number 0.05 and 0.10 strongly affects on the flow in the channel,and heat transfer on the walls is enhanced,especially on the wall surface covered with long separation *** the other hand,the pulsation of St=0.0125 oscillates the shear layer more weakly than that of St=0.05,0.10 and the enhancement of heat transfer is smaller,though some vortices are shed from the vicinity of the side wall near the reattachment *** oscillation of the main flow calms down gradually as the Strouhal number of the pulsation increases over *** influence of pulsation of St=0.20 on the flow is restricted in the near downstream of the step,and heat transfer on the walls is almost similar to that of the steady flow in the channel.

关键词： Pulsating Fluctuation Symmetric Enlarged Channel Separated Flow Heat Transfer

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On Using Physico-Chemical Properties of Amino Acids in String Kernels for Protein Classification via Support Vector Machines

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Journal of Systems Science & Complexity 2015年第2期28卷 504-516页

作者： LI Limin AOKI-kinoshita Kiyoko F CHING Wai-Ki JIANG Hao Institute of Information and System Science Xi'an Jiaotong University Department of Bioinformatics Faculty of EngineeringSoka University Advanced Modeling and Applied Computing Laboratory Department of MathematicsThe University of Hong Kong Department of Mathematics School of InformationRenmin University of China

String kernels are popular tools for analyzing protein sequence data and they have been successfully applied to many computational biology problems. The traditional string kernels assume that different substrings are independent. However, substrings can be highly correlated due to their substructure relationship or common physico-chemical properties. This paper proposes two kinds of weighted spectrum kernels： The correlation spectrum kernel and the AA spectrum kernel. We evMuate their performances by predicting glycan-binding proteins of 12 glycans. The results show that the correlation spectrum kernel and the AA spectrum kernel perform significantly better than the spectrum kernel for nearly all the 12 glycans. By comparing the predictive power of AA spectrum kernels constructed by different physico-chemical properties, the authors can also identify the physico- chemical properties which contributes the most to the glycan-protein binding. The results indicate that physico-chemical properties of amino acids in proteins play an important role in the mechanism of glycamprotein binding.

关键词： AAindex AA spectrum kernel correlation spectrum kernel physico-chemical properties string kernel weighted spectrum kernel.

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Control of Slave EDFA with Master EDFA

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光学学报 2003年第S1期23卷 423-424页

作者： Cechan Tian Susumu kinoshita Photonics Networking Laboratory Fujitsu Laboratories of America Inc. 2801 Telecom Parkway Richardson TX 75082Photonics Networking Laboratory Fujitsu Laboratories of America Inc. 2801 Telecom Parkway Richardson TX 75082

We have demonstrated that the AGC signals generated in a master EDFA can be used to drive a slave EDFA, thus to make the slave EDFA work in AGC mode without its own AGC control electronics. This idea can be used to re... 详细信息

关键词： Control of Slave EDFA with Master EDFA on in of AGC with

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