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Journal of Cancer Therapy 2013年第9期4卷 1-5页

作者： hideki bou Hideyuki Suzuki Kentaro Maejima Hidetsugu Hanawa Masanori Watanabe Eiji Uchida Department of Surgery Nippon Medical School Tokyo Japan Institute of Gastroenterology Nippon Medical School Musashi-kosugi Hospital Kawasaki Japan

Laparoscopy-assisted distal gastrectomy (LADG) has been widely used to treat early gastric cancer (EGC). The Estimation of Physiologic Ability and Surgical Stress (E-PASS) scoring system predicts the risk of fatal postoperative complications by quantifying the patient’s reserve and degree of surgical stress, but there have been a few reports of use of the E-PASS scoring system to assess the risk of mortality following special types of surgical procedures such as LADG. In this study we assessed the feasibility of LADG versus open distal gastrectomy (ODG) by the E-PASS scoring system. The subjects of this study consisted of 69 stage IA gastric cancer patients who underwent LADG (LADG group) and 69 stage IA gastric cancer patients who underwent ODG (ODG group). The mean age of the patients in the LADG group was 68.6 years, which was significantly higher than the mean age of 63.4 years in the ODG group. There were no statistically significant differences between the groups in operation time or preoperative risk score, but there were statistically significant differences in blood loss, surgical stress score, comprehensive risk score, and duration of postoperative hospital stay. We conclude that using the E-PASS scoring system, LADG appreciates a more beneficial procedure for the treatment of EGC than ODG.

关键词： E-PASS LADG ODG

Advancing critical care recovery:The pivotal role of machine learning in early detection of intensive care unit-acquired weakness

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World Journal of Clinical Cases 2024年第21期12卷 4455-4459页

作者： Georges Khattar Elie bou Sanayeh Department of Medicine Staten Island University HospitalStaten IslandNY 10305United States

This editorial explores the significant challenge of intensive care unit-acquiredweakness(ICU-AW),a prevalent condition affecting critically ill patients,characterizedby profound muscle weakness and complicating patient *** paradox of modern medical advances,it emphasizes the urgent needfor early identification and intervention to mitigate ICU-AW's ***,the study by Wang et al is showcased for employing a multilayer perceptronneural network model,achieving high accuracy in predicting *** advancement underscores the potential of neural network models inenhancing patient care but also calls for continued research to address limitationsand improve model *** editorial advocates for the developmentand validation of sophisticated predictive tools,aiming for personalized carestrategies to reduce ICU-AW incidence and severity,ultimately improving patientoutcomes in critical care settings.

关键词： Critical illness myopathy Critical illness polyneuropathy Early detection Intensive care unit-acquired weakness Neural network models Patient outcomes Personalized intervention strategies Predictive modeling

Phase II Study of Irinotecan plus S-1 in Treatment of Advanced Gastric Cancer

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Journal of Cancer Therapy 2013年第2期4卷 578-583页

作者： hideki bou Akira Tokunaga Hideyuki Suzuki Nobuo Murata Yasuyuki Sugiyama Naoto Fukuda Masahiro Ishimaru Hiroyuki Suzuki Department of Surgery Kanto Rosai Hospital Kawasaki Japan Department of Surgery University Hospital of Mizonokuchi Teikyo University School of Medicine Kawasaki Japan Institute of Gastroenterology Nippon Medical School Musashi Kosugi Hospital Kawasaki Japan

Objective: The efficacy and safety of irinotecan hydrochloride (CPT-11) plus oral fluoropyrimidine S-1 combination therapy in patients with previously untreated advanced gastric cancer was evaluated. Methods: The regimen comprised CPT-11 plus S-1: CPT-11, 60 mg/m2 (days 1, 15);S-1, 40 - 60 mg/body twice daily (days 1 - 21) followed by a 1-week rest, every 4 weeks. Primary endpoint was response rate. Secondary endpoints were tumor control rate, adverse events, relative dose intensity, and overall survival. Results: Twenty-five patients were enrolled;median age was 66 years. Response rate was 40% (95% confidence interval, 21.1% - 61.3%;complete response in 1;partial response in 9). Tumor control rate was 56.0%, median survival time was 436 days and relative dose intensities were 0.83 for CPT-11 and 0.85 for S-1. Incidence of grade 3 or greater neutropenia, anemia and diarrhea was 16%, 12%, and 12%, ***: The present results indicate that CPT-11 plus S-1 offers lower treatment-related toxicity than regimens including cisplatin and is effective in patients with advanced gastric cancer.

关键词： Advanced Gastric Cancer Systemic Chemotherapy Irinotecan S-1

Will artificial intelligence reach any limit in gastroenterology?

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Artificial Intelligence in Gastroenterology 2024年第2期5卷 1-9页

作者： Joseph bou Jaoude Rose Al Bacha Bassam Abboud Department of Gastroenterology Levant HospitalBeirut 166830Lebanon Department of General Surgery Geitaoui HospitalFaculty of MedicineLebanese UniversityLebanonBeirut 166830Lebanon

Endoscopy is the cornerstone in the management of digestive *** the last few decades,technology has played an important role in the development of this field,helping endoscopists in better detecting and characterizing luminal ***,despite ongoing advancements in endoscopic technology,the incidence of missed pre-neoplastic and neoplastic lesions remains high due to the operator-dependent nature of endoscopy and the challenging learning curve associated with new *** intelligence(AI),an operator-independent field,could be an invaluable *** can serve as a“second observer”,enhancing the performance of endoscopists in detecting and characterizing luminal *** utilizing deep learning(DL),an innovation within machine learning,AI automatically extracts input features from targeted endoscopic *** encompasses both computer-aided detection and computer-aided diagnosis,assisting endoscopists in reducing missed detection rates and predicting the histology of luminal digestive *** applications in clinical gastrointestinal diseases are continuously expanding and evolving the entire digestive *** all published studies,real-time AI assists endoscopists in improving the performance of non-expert gastroenterologists,bringing it to a level comparable to that of *** development of DL may be affected by selection *** have utilized different AI-assisted models,which are *** the future,algorithms need validation through large,randomized ***,AI has no limit to assist endoscopists in increasing the accuracy and the quality of endoscopic ***,practically,we still have a long way to go before standardizing our AI models to be accepted and applied by all gastroenterologists.

关键词： Artificial intelligence Digestive tract Gastroenterology Gastroscopy Coloscopy

Geochemical and Petrological Insights into the Neoproterozoic Moumba Metabasites: Implications for Crustal Processes in the West Congo Belt (Republic of Congo)

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Journal of Geoscience and Environment Protection 2024年第2期12卷 1-29页

作者： Ulrich Verne Matiaba-Bazika Nelson Lekeba Makamba Vicky Tendresse Télange bouénitéla Nicy Carmelle Bazebizonza Tchiguina Timothée Miyouna Florent boudzoumou Laboratory of Geosciences Faculty of Sciences and Technics Marien NGOUABI University Brazzaville Republic of Congo National Institute for Research in Exact and Natural Sciences (IRSEN) Brazzaville Republic of Congo Geographid Research and Cartographic Production Center (CERGEC) Brazzaville Republic of Congo

The West Congo Belt contains in its rocks of Neoproterozoic age from Nemba complex outcropping in the Moumba River. This West Congo belt is made up of a crustal segment of the Arcuaï-West Congo orogen which extends from southwest Gabon to the northeast of Angola. This study aims to constrain the geochemical signature Nemba complex of West Congo belt from the petrograhic and geochemical study on the whole rock. The petrographic data from this study show the Moumba metabasites are made up of amphibolites, metagabbros, epidotites and greenschists interstratified in the Eburnean metasediments and affected by mesozonal to epizonal metamorphism characterized by the retromorphosis of intermediate amphibolite facies minerals into greenschist facies. Whole-rock geochemical data indicate that these metabasites are continental flood basalts (CFB) of basic nature and transitional affinity emplaced in intraplate context. These continental flood basalts are generated from magma originating from a significantly enriched shallow mantle plume and this magma then contaminated by the continental crust during their ascent. The reconstruction of tectonic signature suggests that West Congo belt would result from closure of an ocean basin with subduction phenomena. This collision would be marked by the establishment of ophiolite complex. We show that this model is incompatible with the CFB nature of metabasites and the orogenic evolution of Neoproterozoic. It does not seem that we can evoke a genetic link with a subduction of oceanic crust, because the paleogeography of Neoproterozoic (Rodinia) is marked by intracontinental rifts linked to opening of Rodinia. We therefore suggest the non-existence of ophiolitic complex in western Congo belt and reject the collisional model published by certain authors. We confirm the currently available intracontinental orogen model.

关键词： Mayombe Metabasites Moumba Mantle Plume Continental Rifting Basalts Flood Continental

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动物精子的发生研究进展

中国畜牧杂志 2024年第1期60卷 36-43页

作者：杜明刘源壹李昕俞张磊格日乐其木格芒来内蒙古农业大学动物科学学院内蒙古自治区马属动物遗传育种与繁殖学重点实验室内蒙古呼和浩特010018

精子发生主要在动物睾丸组织的曲细精管中进行,是由多种生殖细胞、体细胞共同参与的生殖进程之一。在精子发生过程中,细胞受到关键分子的影响,阶段性连续发生着独特的关键变化(有丝分裂、减数分裂、细胞变形及成熟精子形成),贯穿着精原... 详细信息

精子发生主要在动物睾丸组织的曲细精管中进行,是由多种生殖细胞、体细胞共同参与的生殖进程之一。在精子发生过程中,细胞受到关键分子的影响,阶段性连续发生着独特的关键变化(有丝分裂、减数分裂、细胞变形及成熟精子形成),贯穿着精原细胞到精子的生命起始全过程。对精子发生过程中睾丸及相关细胞、分子进行研究对于动物繁殖、物种保护以及生产力提高具有重要意义。随着测序技术的发展、多技术手段的广泛联合应用,一些新型技术手段也被应用于动物精子发生的研究当中。本文主要对精子发生关键场所、关键细胞及关键分子的研究进展进行综述,以期为动物繁殖相关科学问题的深入研究提供参考。

关键词：精子发生动物繁殖细胞睾丸分子

Outpatient insulin use in type 2 diabetes mellitus and acute respiratory distress syndrome outcomes:A retrospective cohort study

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World Journal of Clinical Cases 2024年第17期12卷 2966-2975页

作者： Georges Khattar Samer Asmar Laurence Aoun Fares Saliba Shaza Almardini Saif Abu Baker Catherine Hong Carolla El Chamieh Fadi Haddadin Toni Habib Omar Mourad Zeina Morcos Fatema Arafa Jonathan Mina Khalil El Gharib Mohammad Aldalahmeh Salman Khan Elie bou Sanayeh Department of Medicine Holy Spirit University of KaslikJounieh 00000Lebanon Department of Internal Medicine Staten Island University HospitalStaten IslandNY 10305United States Public Heath and Biostatistics Independent ResearchBeirut 0000Lebanon Department of Medicine Lebanese UniversityBeirut 00000Lebanon Department of Medicine University of BalamandBeirut 00000Lebanon Department of Medicine Lebanese American UniversityBeirut 00000Lebanon Department of Medicine Northwell Health Staten Island University HospitalNew YorkNY 10305United States

BACKGROUND The impact of type 2 diabetes mellitus(T2DM)on acute respiratory distress syndrome(ARDS)is debatable.T2DM was suspected to reduce the risk and complications of ***,during coronavirus disease 2019(COVID-19),T2DM predisposed patients to ARDS,especially those who were on insulin at *** evaluate the impact of outpatient insulin use in T2DM patients on non-COVID-19 ARDS *** We conducted a retrospective cohort analysis using the Nationwide Inpatient Sample *** patients diagnosed with ARDS were stratified into insulin-dependent diabetes mellitus(DM)(IDDM)and non-insulindependent DM(NIDDM)*** applying exclusion criteria and matching over 20 variables,we compared cohorts for mortality,duration of mechanical ventilation,incidence of acute kidney injury(AKI),length of stay(LOS),hospitalization costs,and other clinical *** Following 1:1 propensity score matching,the analysis included 274 patients in each ***,no statistically significant differences emerged between the IDDM and NIDDM groups in terms of mortality rates(32.8%vs 31.0%,P=0.520),median hospital LOS(10 d,P=0.537),requirement for mechanical ventilation,incidence rates of sepsis,pneumonia or AKI,median total hospitalization costs,or patient disposition upon *** Compared to alternative anti-diabetic medications,outpatient insulin treatment does not appear to exert an independent influence on in-hospital morbidity or mortality in diabetic patients with non-COVID-19 ARDS.

关键词： Acute respiratory distress syndrome Type 2 diabetes mellitus Insulin Length of stay Mortality Endotracheal intubation Acute kidney injury Coronavirus disease 2019

Antioxidant and anti-diabetic activities in commercial and homemade pomegranate molasses in Lebanon

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Food Bioscience 2022年第2期46卷 338-345页

作者： Mira bou Dargham Jocelyne Matar boumosleh Antoine Farhat Salwa Abdelkhalek Elias bou-Maroun Leina El Hosry Department of Nursing and Health Sciences Notre Dame University-LouaizeZouk MosbehLebanon Department of Rehabilitation and Health Services University of North TexasDentonTexasUSA Department of Health and Medical Sciences Khawarizmi International College Univ.bourgogne Franche-Comt´e AgroSup DijonUMR A 02.102Proc´ed´es Alimentaires et MicrobiologiquesF-21000DijonFrance

Pomegranate fruit and its derived products are rich sources of bioactive *** have many biological *** molasses(PM)is a thick,traditional Middle Eastern syrup used in many recipes for Lebanese and international *** is a highly nutritious product which makes it of great *** purpose of this study was to assess the phytochemical composition,antioxidant and anti-diabetic properties of homemade and commercial PM consumed in Lebanon using samples collected from households in rural areas(n=4)and the market(n=28).The objectives of this study were to determine their total phenolic content using the Follin-Ciocalteu method,their total flavonoid content using aluminum chloride method,their antioxidant activity using DPPH radical scavenging as well as ferrous ion chelating assays and their anti-diabetic activity usingα-amylase andα-glucosidase inhibitory activities with acarbose,a known anti-diabetic drug,used as the standard *** PM samples exhibited a higher antioxidant activity than commercial samples,with the most active homemade PM sample having IC_(50)values of 0.09 mg/mL(DPPH radical scavenging assay)and 46.78%ferrous ion chelating assay).Homemade PM samples also showed higher anti-diabetic activity than commercial samples,with the most active homemade PM sample having an IC_(50)values of 0.63 mg/mL(α-amylase inhibitory activity)and of 0.41 mg/mL(α-glucosidase inhibitory activity)and being almost as active as acarbose with both enzymes(1.5 times).Significant inverse strong/moderate correlations were observed between total phenolic content/total flavonoid content and the IC_(50)value of DPPH radical scavenging assay,indicating positive associations between total phenolic and flavonoid contents and antioxidant *** addition,significant negative moderate correlations were observed between total phenolic/flavonoid contents andα-amylase inhibitory activity,indicating positive associations between total phenoli

关键词： Pomegranate molasses Antioxidant activity Ferrous ion chelating assay Anti-diabetic activity α-amylase inhibitory assay α-glucosidase inhibitory assay

Screening, Treatment and Control of High Blood Pressure on Five Sites in Mali

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World Journal of Cardiovascular Diseases 2024年第5期14卷 322-332页

作者： Mamadou Touré Sagara Ibrahima Youssouf Camara Hamidou Oumar Bâ Ibrahima Sangaré Djénébou Traoré Noumou Sidibé Fousseyni Samassékou Massama Konaté Coumba Thiam Doumbia Asmaou Maiga Réné-Marie Dakouo Hamidou Camara Sako Mariam Sidibé Samba Adama Sogodogo boubacar Diarra boubacar Sonfo Aladji Traoré Mamadou Diakité Ilo Bella Diall Ichaka Menta Departement of Cardiology University Hospital Gabriel Tour&#233 Bamako Mali Departement of Cardiology Cardiology University Hospital Sidy Bocar Sall Kati Mali Internal Medecine University Hospital Point G Bamako Mali Departement of Cardiology Cardiology University Hospital &#8220H&#244pital du Mali&#8221 Bamako Mali Departement of Cardiology Cardiology University Hospital Mother-Children Bamako Mali

Introduction: High blood pressure is defined as blood pressure greater than or equal to 140 mm Hg for systolic and or 90 mm Hg for diastolic. It constitutes a major public health problem, the leading chronic disease in the world. The objective was to determine the prevalence, treatment rate and control of hypertension. Methods: This was a cross-sectional and descriptive study which took place over a period of 6 months in a hospital environment and in the general population. Results: Of the 1000 participants, 637 had hypertension, giving a prevalence of 63.70% with a female predominance. Thirty-three percent (33%) were unaware of their high blood pressure. The age group 60 and more was the most represented (44%). A proportion of 33 and 23.20 were overweight and obese participants, respectively. Male subjects were more overweight than female, unlike obesity which was more common among female subjects. Sixty-two percent (62%) of hypertensives were treated, of whom 44% were non-compliant. The excessively high cost and consumption of medications as needed were the main factors in therapeutic non-compliance. Twenty-two percent (22%) of all hypertensive patients and 35% of treated hypertensive patients were controlled. Women were more treated but less observant and less controlled than men. Therapeutic coverage and combination therapy rates were lower in rural areas. Hypertensives who had a high level of education were better treated and controlled than those who had no level. Conclusion: High blood pressure remains a real public health problem in Mali. It is more common in people aged 60 and over and in females. One in three hypertensives were unaware of their hypertension. The majority received antihypertensive treatments, but only a minority of them had their hypertension controlled.

关键词： High Blood Pressure Screening Control Rate Mali

COVID-19 and the Vascular Elderly Subject: Illustration of Therapeutic Management with Corticosteroids in an Elderly Diabetic Patient with COVID-19

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Open Journal of Clinical Diagnostics 2024年第1期14卷 1-6页

作者： Ibrahima Amadou Dembele Abrar-Ahmad Zulfiqar Romuald Nounga Nyanke Sékou Landoure Stéphane Loique Djeugoue Adama Sinayoko Nouhoum Kone Paul Antoni Amadou Nouroudine Rosunee Ahsveen Yacouba Koné Aoua Diarra Tania Mekuiko Ngeupi Mamadou Cissoko Mamadou Mallé Keïta Kaly Djibril Sy Djénébou Traoré Didier Mukéba Tshialala Assétou Soukho Kaya Emmanuel Andres Internal Medicine Department Medical Clinic B University Hospital Center of Strasbourg Strasbourg France Internal Medicine Department University Hospital Center Point G Bamako Mali Faculty of Medicine and Odontostomatology University of Sciences Techniques and Technologies of Bamako Bamako Mali Faculty of Medicine Pharmacy and Public Health University of Mbuji-Mayi Democratic Republic of Congo

Introduction: The severity of Sars-Cov-2 infection is associated with the development of acute respiratory distress syndrome (ARDS). The progression to ARDS appears to be driven by a major inflammatory mechanism potentially sensitive to corticosteroids. Observation: This article describes the case of an elderly patient was admitted to emergency departments for intense asthenia, accompanied by motor diarrhoea, dyspnoea with desaturation in ambient air, in a context of strong suspicion of infection linked to COVID-19. The article also reviews the existing literature on the diagnosis and treatment of this severe form of the disease. Conclusion: Corticosteroids, and in particular dexamethasone, have been shown to be effective in the management of patients with COVID-19, an oxygen-releasing disease.

关键词： COVID-19 Diabetes Mellitus Elderly person Corticosteroids Internal Medicine