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Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto Shinji Oe Koichiro Miyagawa Yuichi honma Masaru Harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

Enzyme-linked immunosorbent assay of 3 Screen Islet Cell Autoantibody in patients with autoimmune thyroid disease

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World Journal of Diabetes 2024年第5期15卷 935-944页

作者： Eiji Kawasaki hidekazu Tamai Takahiro Fukuyama Yoko Sagara Ryutaro Hidaka Aira Uchida Masayuki Tojikubo Narihito Tatsumoto Yuko Akehi Yuji Hiromatsu The Diabetes Thyroid and Endocrine CenterShin-Koga HospitalKurume 830-8577Japan

BACKGROUND In recent years,the emergence of multiplex technology that can simultaneously measure multiple anti-islet autoantibodies has become particularly valuable for the staging and early diagnosis of immune-mediated type 1 diabetes(T1D).While it has been established that 20%-30%of T1D patients suffer from autoimmune thyroid disease(AITD),there is limited available data regarding the presence of anti-islet autoantibodies in AITD *** commercially available anti-islet autoantibodies,glutamic acid decarboxylase 65 autoantibodies(GADAs)are often the first marker measured in general clinical *** To investigate the frequency of anti-islet autoantibodies in AITD *** Our study involved four hundred ninety-five AITD patients,categorized into three distinct groups:AITD with T1D(n=18),AITD with phenotypic type 2 diabetes(T2D)(n=81),and AITD without diabetes(n=396),and the enzyme-linked immunosorbent assay(ELISA)was employed to determine the frequencies of 3 Screen Islet Cell Autoantibody(3 Screen ICA),GADA,insulinoma-associated antigen-2 autoantibodies(IA-2As),and zinc transporter 8 autoantibodies(ZnT8As)within these *** The frequency of 3 Screen ICA in AITD patients with T1D,T2D,and those without diabetes were 88.9%,6.2%,and 5.1%,respectively,with no significant difference seen between the latter two ***,the frequency of 3 Screen ICA was 11.1%higher in AITD patients with T1D,1.3%higher in AITD patients with T2D,and 1.1%higher in AITD patients without diabetes compared to GADA,***,12.5%,20.0%,and 20.0%of the 3 Screen ICA-positive patients were negative for ***,1.3%of the AITD patients who tested negative for 3 Screen ICA in both the AITD with T2D and non-diabetic AITD groups were found to be positive for individual *** the 3 Screen ICA-positive patients,there was a significantly higher proportion of individuals with multiple autoantibodies in AITD patients with T1D com

关键词： Anti-islet autoantibodies Autoimmune thyroid disease Real-world practice Retrospective study Type 1 diabetes

Study of visualized simulation and analysis of nuclear fuel cycle system based on multilevel flow model

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Nuclear Science and Techniques 2005年第6期16卷 358-370页

作者： YOSHIKAWA hidekazu Graduate School of Energy Science Kyoto University Engineering Building 2 Room 123Kyoto University Yoshida Honmachi Sakyoku Kyoto Japan 606-8501

Complex energy and environment system, especially nuclear fuel cycle system recently raised socialconcerns about the issues of economic competitiveness, environmental effect and nuclear proliferation. Only underthe condition that those conflicting issues are gotten a consensus between stakeholders with different knowledgebackground, can nuclear power industry be continuingly developed. In this paper, a new analysis platform has beendeveloped to help stakeholders to recognize and analyze various socio-technical issues in the nuclear fuel cycle systembased on the functional modeling method named Multilevel Flow Models (MFM) according to the cognition theoryof human being. Its character is that MFM models define a set of mass, energy and information flow structures onmultiple levels of abstraction to describe the functional structure of a process system and its graphical symbol representationand the means-end and part-whole hierarchical flow structure to make the represented process easy to beunderstood. Based upon this methodology, a micro-process and a macro-process of nuclear fuel cycle system wereselected to be simulated and some analysis processes such as economics analysis, environmental analysis and energybalance analysis related to those flows were also integrated to help stakeholders to understand the process of decision-making with the introduction of some new functions for the improved Multilevel Flow Models Studio, and finallythe simple simulation such as spent fuel management process simulation and money flow of nuclear fuel cycleand its levelised cost analysis will be represented as feasible examples.

关键词：核燃料功能模型能源工业核能环境友好性核电厂

Activities of nicotinic acetylcholine receptors modulate neurotransmission and synaptic architecture

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Neural Regeneration Research 2014年第24期9卷 2128-2131页

作者： Akira Oda hidekazu Tanaka CNS Drug Discovery Unit Pharmaceutical Research Division Takeda Pharmaceutical Company Limited Laboratory of Pharmacology Department of Biomedical Sciences College of Life Sciences Ritsumeikan University

The cholinergic system is involved in a broad spectrum of brain function, and its failure has been implicated in Alzheimer＇s disease. Acetylcholine transduces signals through muscarinic and nicotinic acetylcholine receptors, both of which influence synaptic plasticity and cognition. However, the mechanisms that relate the rapid gating of nicotinic acetylcholine receptors to persistent changes in brain function have remained elusive. Recent evidence indicates that nicotinic acetylcholine receptors activities affect synaptic morphology and density, which result in persistent rearrangements of neural connectivity. Further investigations of the relationships between nicotinic acetylcholine receptors and rearrangements of neural circuitry in the central nervous system may help understand the pathogenesis of Alzheimer＇s disease.

关键词： cholinergic system nicotinic acetylcholine receptors (nAChRs) Alzheimer's disease (AD) synaptic transmission synaptic plasticity synaptic morphology dendritic spine remodeling cognition

Research on welding simulation methods and software development

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China Welding 2014年第1期23卷 19-26页

作者： hidekazu Murakawa Ninshu Ma Osaka University Japan

To develop highly efficient and useful software, we need to understand the essential feature of the welding phenomenon. From the mechanical point view, welding is a transient nonlinear problem in which small but strongly nonlinear region is moving with the welding torch. Noting this characteristic, ISM （Iterative Substructure Method） was developed for the thermal-elastic-plastic analysis of large scale structures. It is also known that the welding distortion and the residual stress are produced by inherent strain. The inherent strain is the sum of irreversible strains such as plastic strain due to welding thermal cycles or phase transformation and creep strain. In addition to the inherent strain, the mismatch produced by cutting error and fitting is also an important cause of the welding distortions and residual stresses. Based on this understanding, an elastic FEM introducing the inherent strain and mismatch is developed. The potential capabilities of these methods are demonstrated through some examples.

关键词： welding distortion residual stress FEM large structure practical method

Update on quinolone-containing rescue therapies for Helicobacter pylori infection

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World Journal of Gastroenterology 2020年第15期26卷 1733-1744页

作者： Hideki Mori hidekazu Suzuki Department of Clinical and Experimental Medicine Translational Research Center for Gastrointestinal DisordersUniversity of LeuvenLeuven 3000Belgium Division of Gastroenterology and Hepatology Department of Internal MedicineTokai University School of MedicineIsehara 259-1193Japan

Third generation of quinolones,such as levofloxacin and moxifloxacin,-containing regimens are often used in second-line or rescue treatment of Helicobacter pylori ***,the increasing antibiotic resistance to quinolones affects the efficacies of quinolones-containing therapies in recent ***,there is a need to enhance the effectiveness of quinolonescontaining ***,a fourth-generation quinolone,and vonoprazan,a novel potassium-competitive acid blocker,are now available as more effective treatment *** aim of this paper is to summarize the current evidence of quinolone-containing therapies in rescue treatments,and to discuss the importance of drug sensitivity tests or analysis of gyrA mutation before treatments.

关键词： Helicobacter pylori Levofloxacin Sitafloxacin Moxifloxacin gyrA Vonoprazan

Feature-aware regularization for sparse online learning

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Science China(Information Sciences) 2014年第5期57卷 65-85页

作者： OIWA hidekazu MATSUSHIMA Shin NAKAGAWA Hiroshi Graduate School of Information Science and Technology The University of Tokyo Information Technology Center The University of Tokyo

Learning a compact predictive model in an online setting has recently gained a great deal of *** combination of online learning with sparsity-inducing regularization enables faster learning with a smaller memory space than the previous learning *** optimization methods and learning algorithms have been developed on the basis of online learning with L1-regularization.L1-regularization tends to truncate some types of parameters,such as those that rarely occur or have a small range of values,unless they are emphasized in ***,the inclusion of a pre-processing step would make it very difficult to preserve the advantages of online *** propose a new regularization framework for sparse online *** focus on regularization terms,and we enhance the state-of-the-art regularization approach by integrating information on all previous subgradients of the loss function into a regularization *** resulting algorithms enable online learning to adjust the intensity of each feature’s truncations without pre-processing and eventually eliminate the bias of *** show theoretical properties of our framework,the computational complexity and upper bound of *** demonstrated that our algorithms outperformed previous methods in many classification tasks.

关键词： online learning supervised learning sparsity-inducing regularization feature selection sentiment analysis

Prediction of the Residual Welding Stress in 2.25Cr-1Mo Steel by Taking into Account the Effect of the Solid-State Phase Transformations

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Acta Metallurgica Sinica(English Letters) 2013年第3期26卷 333-339页

作者： Dean DENG Yangang TONG Ninshu MA hidekazu MURAKAWA College of Materials Science and Engineering Chongqing University State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology JWRI Osaka University11-1 MihogaokaIbaraki Osaka 567-0047 Japan

A computational approach based on the thermal elastic plastic finite element method was developed for predicting welding residual stress in low carbon alloyed steel welds by taking into account the effect of the solid-state phase transformations. The kinetics of phase transformations was described by Johnson Mehl Avrami Kolmogrov （JMAK） equation for bainitic transition and by Koistinen-Marburger （K-M） relationship for martensitic transition. Moreover, an additive rule depending on volumetric phase fraction was adopted to represent the material property changes during heating and cooling. Consequently, the residual welding stresses in a 2.25Cr1Mo steel TIG welded plate were computed. Early calculation results suggest that the bainitic and martensitic transformations took place in the weld the heat-affected zone drastically reduce the residual longitudinal tensile stress in the region.

关键词： Computational approach Numerical simulation Phase transformation Welding residual stress

Formation Mechanism of MgO·Al_(2)O_(3) Spinel Inclusions in Stainless Steelmaking Processes

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Journal of Iron and Steel Research International 2011年第S2期18卷 320-330页

作者： PARK Joo Hyun TODOROKI hidekazu School of Materials Science and Engineering University of UlsanUlsan 680-749Korea Technical Research Center Nippon Yakin Kogyo Co.Ltd.KawasakishiKanagawa 210-8558Japan

The latest publications regarding the development of technology to control inclusion compositions focusing on MgO?Al2O3 spinel inclusions were summarized in this review article. The problems caused by spinel inclusions, which affect practice as well as products were shown. The formation mechanism of MgO?Al2O3 spinel inclusions is secondly explained thermodynamically from the view points of chemistries of molten steels and slag compositions. Furthermore, crystallization behaviour of spinel was introduced. Countermeasures conducted in practices and laboratories were shown along with some problems still left that should be solved in the future.

关键词： inclusion MgO?Al2O3 spinel thermodynamics crystallization stability deoxidation slag basicity