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中华口腔医学杂志 2007年第1期42卷 34-36页

作者：和璐长泽敏行石川烈北京大学口腔医学院.口腔医院牙周科 100081 东京医科齿科大学齿周病分野

目的观察牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)、伴放线放线杆菌(Actinobacillus actinomycetemcomitans,Aa)、大肠杆菌(Escherichia coli,Ec)的脂多糖(lipopolysacchrides,LPS)刺激人牙龈成纤维细胞(human gingival fibroblasts,HGF)合成白细胞介素(interleukin,IL)-11和IL-6的能力,并了解内源性前列腺素是否介导 IL-11和 IL-6的产生。方法将3种浓度的 LPS(0.1、1、10 mg/L)分别作用于体外培养的 HGF 24 h,另外在10 mg/L 的 LPS 中加入10^(-6)mol/L 的吲哚美辛后再分别刺激 HGF 24 h,ELISA 法检测 HGF 上清液中 IL-11和 IL-6含量的变化。结果 Aa-,Ec-LPS(10 mg/L)和 Pg-LPS(1、10 mg/L)刺激 HGF 后 IL-11水平显著提高;Pg-,Ec-LPS(0.1、1、10 mg/L)和Aa-LPS(1、10 mg/L)刺激 HGF 产生 IL-6的水平明显增高;这些作用均受到吲哚美辛的抑制作用。结论 LPS 使 HGF 产生 IL-11和 IL-6的水平明显增加,并受到内源性前列腺素的正向调控。

关键词：脂多糖类白细胞介素11 白细胞介素6 紫单胞菌龈

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Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein:A New Food Function of Proso Millet

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Biomedical and Environmental Sciences 1996年第2期9卷 209-212页

作者： N. NISHIZAWA S. SHIMANUKI H. FUJIHASHI H. WATANABE Y. FUDAMOTO AND T. nagasawa (Department of Bioscience and Technology, Faculty of Agriculture, Iwate University Morioka, Iwate 020, Japan Research Laboratory,Nitto Best Co., Ltd, Sagae, Yamagata 991 Ka Department of Bioscience and Technology Faculty of Agriculture Iwate University Morioka Japan.

We examined the effects of dietary proso-millet protein on plasma levels of high-density lipoprotein (HDL) cholesterol in different rats from animals reported in our previous studies. The results showed also, in this animal, that the ingestion of the millet protein elevates plasma levels of HDL-cholesterol like our earlier works. Taking into account the anti-atherogenic function of HDL, therefore, the millet protein would be useful as a new food ingredient which has the function that regulates cholesterol metabolism

关键词： HDL Proso Millet Protein Elevates Plasma Level of High-Density Lipoprotein

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年龄为3.5Ga 的翁弗瓦赫特群燧石的稀土元素浓度—早前寒武纪地壳环境的一个指示标志

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地球与环境 1988年第6期 47-50页

作者： Iliroshi.nagasawa ,Kanenori.Suwa ,刘康怀广西桂林地质学院

引言沉积岩中一直很好地保留着在过去地壳中稀土元素(REE)的相对丰度。沉积岩的REE研究结果表明,在最近的3Ga中。地壳中REE的相对丰度没有发生明显的改变,只是观测到太古代后的沉积岩中的Eu相对亏损(Wil-deman和Haskin,1973;McLennan和T... 详细信息

引言沉积岩中一直很好地保留着在过去地壳中稀土元素(REE)的相对丰度。沉积岩的REE研究结果表明,在最近的3Ga中。地壳中REE的相对丰度没有发生明显的改变,只是观测到太古代后的沉积岩中的Eu相对亏损(Wil-deman和Haskin,1973;McLennan和Taylor,

关键词：稀土元素相对丰度 ⅢB族元素基峰早前寒武纪 REE 隧石瓦赫地球外壳地球内部地壳 Ga

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铁-钼-硫合金在真空中的自润滑性

固体润滑 1985年第2期 120-128页

作者： Mizutani Y.Shimura Y.nagasawa Y. 张国威日本爱知县丰田公司丰田研究和发展中心实验室

我们制备了含钼15％～20％、含硫3％的铁基三元合金,並将其作为一种自润滑材料,在栓-盘式试验机上进行了检验,评价了它们在低真空中的摩擦磨损性能。实验的滑动速度在0.1～0.9米/秒的范围内。我们发现,在这种合金的基体中,生成了一种... 详细信息

我们制备了含钼15％～20％、含硫3％的铁基三元合金,並将其作为一种自润滑材料,在栓-盘式试验机上进行了检验,评价了它们在低真空中的摩擦磨损性能。实验的滑动速度在0.1～0.9米/秒的范围内。我们发现,在这种合金的基体中,生成了一种原子比不定的钼的硫化物—MoSx（x≈1.8）,其结构类似于MoS2。这种合金的摩擦性能要受到周围气压的影响,它在空气中滑动摩擦时,界面上会发生氧化,生成α-Fe2O3,使摩擦系数增大到0.7。但是,在气压低于103帕的真空中（1帕=1牛顿/米2—译者）,该合金却呈现出良好的润滑性,其摩擦系数之低可与MoS2相比。在实验所用的各种气压条件下,该合金的磨损率都明显地小于S45℃碳钢（AISI1045）。

关键词：碳钢空气工业气体摩擦系数气压

暴雨径流期间前次洪水对悬移质传输影响的研究

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中国水土保持 2002年第7期 17-17页

作者： OkazawaHiromu nagasawa Tetuaki Inoue Takashi Yamamo toTadao Graduate School of Agriculture Hokkaido UniversityGraduate School of AgricultureHokkaido UniversityGraduate School of AgricultureHokkaido UniversityGraduate School of AgricultureHokkaido University Kita-9Nishi-9Kita-kuSapporo060-8589JapanKit

暴雨径流期间前次洪水对悬移质传输影响的研究

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中国水土保持 2002年第7期 21-21页

作者： Okazawa Hiromu,nagasawa Tetuaki,Inoue Takashi,Yamamo toTadao Graduate School of Agriculture Hokkaido University Graduate School of Agriculture Hokkaido University Graduate School of Agriculture Hokkaido University Graduate School of Agriculture Hokkaido University Kita-9 Nishi-9 Kita-ku Sapporo060-8589 Japan Kit

Global Wheat Head Detection 2021:An Improved Dataset for Benchmarking Wheat Head Detection Methods

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Plant Phenomics 2021年第1期3卷 277-285页

作者： Etienne David Mario Serouart Daniel Smith Simon Madec Kaaviya Velumani Shouyang Liu Xu Wang Francisco Pinto Shahameh Shafiee Izzat SATahir Hisashi Tsujimoto Shuhei Nasuda Bangyou Zheng Norbert Kirchgessner Helge Aasen Andreas Hund Pouria Sadhegi-Tehran Koichi nagasawa Goro Ishikawa Sébastien Dandrifosse Alexis Carlier Benjamin Dumont Benoit Mercatoris Byron Evers Ken Kuroki Haozhou Wang Masanori Ishii Minhajul ABadhon Curtis Pozniak David Shaner LeBauer Morten Lillemo Jesse Poland Scott Chapman Benoit de Solan Frédéric Baret Ian Stavness Wei Guo Arvalis Institut du Végétal3 Rue Joseph et Marie Hackin75116 ParisFrance UMR1114 EMMAH INRAECentre PACABâtiment ClimatDomaine Saint-Paul228 Route de l’AérodromeCS 4050984914 Avignon CedexFrance School of Food and Agricultural Sciences The University of QueenslandGatton4343 QLDAustralia Hiphen SAS 120 Rue Jean DaussetAgroparcBâtiment Technicité84140 AvignonFrance Plant Phenomics Research Center Nanjing Agricultural UniversityNanjingChina Wheat Genetics Resource Center Dep.of Plant PathologyKansas State Univ.4024 Throckmorton Plant Sciences CenterManhattanKansasUSA Global Wheat Program International Maize and Wheat Improvement Centre(CIMMYT)MexicoD.F.Mexico Faculty of Biosciences Norwegian University of Life SciencesP.O.Box 5003NO-1432ÅsNorway Agricultural Research Corporation Wheat Research ProgramP.O.Box 126Wad MedaniSudan Arid Land Research Center Tottori UniversityTottori 680-0001Japan Laboratories of Plant Genetics and Plant Breeding Graduate School of AgricultureKyoto UniversityJapan CSIRO Agriculture and Food Queensland Biosciences Precinct306 Carmody RoadSt Lucia4067 QLDAustralia Institute of Agricultural Sciences ETH ZurichUniversitätstrasse 28092 ZurichSwitzerland Plant Sciences Department Rothamsted ResearchHarpendenUK Institute of Crop Science National Agriculture and Food Research OrganizationJapan Hokkaido Agricultural Research Center National Agriculture and Food Research OrganizationJapan Biosystems Dynamics and Exchanges TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Plant Sciences TERRA Teaching and Research CenterGembloux Agro-Bio TechUniversity of Liège5030 GemblouxBelgium Graduate School of Agricultural and Life Sciences The University of Tokyo1-1-1 Midori-choNishitokyo CityTokyoJapan Department of Computer Science University of SaskatchewanCanada Department of Plant Sciences University of SaskatchewanCanada College of Agriculture and Life Sciences University of ArizonaTucsonArizona

The Global Wheat Head Detection(GWHD)dataset was created in 2020 and has assembled 193,634 labelled wheat heads from 4700 RGB images acquired from various acquisition platforms and 7 countries/*** an associated competition hosted in Kaggle,GWHD_2020 has successfully attracted attention from both the computer vision and agricultural science *** this first experience,a few avenues for improvements have been identified regarding data size,head diversity,and label *** address these issues,the 2020 dataset has been reexamined,relabeled,and complemented by adding 1722 images from 5 additional countries,allowing for 81,553 additional wheat *** now release in 2021 a new version of the Global Wheat Head Detection dataset,which is bigger,more diverse,and less noisy than the GWHD_2020 version.

关键词： Wheat adding release

Prion Protein Binds to Aldolase A Produced by Bovine Intestinal M Cells

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Open Journal of Veterinary Medicine 2015年第3期5卷 43-60页

作者： Yuya nagasawa Yu Takahashi Wataru Itani Hitoshi Watanabe Yusuke Hidaka Shotaro Morita Kei Suzuki Kouichi Watanabe Shyuichi Ohwada Haruki Kitazawa Morikazu Imamura Takashi Yokoyama Motohiro Horiuchi Suehiro Sakaguchi Shirou Mohri Michael T. Rose Tomonori Nochi Hisashi Aso Cellular Biology Laboratory Tohoku University Sendai Japan Food Immunology Group Tohoku University Sendai Japan Prion Disease Research Center National Institute of Animal Health Tsukuba Japan Laboratory of Veterinary Hygiene Hokkaido University Sapporo Japan Institute for Enzyme Research The University of Tokushima Tokushima Japan Institute of Biological Environmental and Rural Sciences Aberystwyth University Aberystwyth UK

Microfold (M) cells are a kind of intestinal epithelial cell in the follicle-associated epithelium (FAE) of Peyer’s patches. They can transport antigens and microorganisms to lymphoid tissues. Bovine spongiform encephalopathy (BSE) is a fatal neurodegenerative disorder in cattle. It is linked to variant Creutzfeldt-Jakob disease in humans. Although it is thought that M cells transport the BSE agent, the exact mechanism by which it crosses the intestinal barrier is not clear. We have bovine intestinal epithelial cell line (BIE cells), which can differentiate into the M cell type in vitro after stimulation, and which is able to transport the BSE agent. We show here that M cells are able to incorporate large numbers of PrP coated magnetic particles into intracellular vesicles, which we collected. The results of 2-DE show a specific protein associated with the PrP-coated particles, compared with non-coated particles. This protein was identified as aldolase A, a glycolytic pathway enzyme, using LC-MS/MS analysis. Aldolase A was synthesized and secreted by BIE cells, and increased during M cell differentiation. In the villi of the bovine intestine, aldolase A was detected on the surface of the epithelium and in the mucus droplet of goblet cells. In the FAE of bovine jejunal and ileal Peyer’s patches, aldolase A was localized on the surface and the apical part of the M cells. The binding of rbPrP to aldolase A was clearly detected and inhibited by pre-treatment of anti-aldolase A antibody. Aldolase A was co-stained with incorporated PrPSc in M-BIE cells. These results suggest that bovine M cells and goblet cells synthesize aldolase A, and that aldolase A may have the ability to bind PrP and associate with PrP in cellular vesicles. Therefore, aldolase A-positive M cells may play a key role in the invasion of BSE into the body.

关键词： Peyer’s Patch M Cell BIE Cells Aldolase A PrP Binding Protein

多层螺旋CT基于模型的迭代重建对Adamkiewicz动脉的显示

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国际医学放射学杂志 2014年第2期 168-169页

作者： J.Nishida K.Kitagawa M.Nagata A.Yamazaki N.nagasawa H.Sakuma 张倩 Department of Radiology Mie University School of Medicine 2-174 Edobashi Tsu Mie 514-8507 Japan

目的相对于自适应统计迭代重建(ASIR)和滤过反投影重建(FBP),判断基于模型的迭代重建(MBIR)技术在多层螺旋CT影像上显示Adamkiewicz动脉的效果是否更

关键词：迭代重建 Adamkiewicz 螺旋动脉基于模型 CT