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Development and Practical Applications of Blue Light-Emitting Diodes

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Engineering 2015年第2期1卷 167-168页

作者： hideaki Koizumi Hitachi Ltd. Engineering Academy of Japan(EAJ)

The practical application of semiconductor-based high-efficiency white-light sources, also known as light-emitting diodes, or LEDs, is a recent development of Japanese engineering. This development could be a game-changer for lighting worldwide, given that current power consumption for lighting accounts for 16% of the total electricity consumption in Japan.

关键词： salinity gradient energy pressure-retarded osmosis reverses electrodialysis

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Cardiac biomarkers in children with congenital heart disease

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World Journal of Pediatrics 2015年第4期11卷 309-315页

作者： Masaya Sugimoto Seiko Kuwata Clara Kurishima Jeong Hye Kim Yoich Iwamoto hideaki Senzaki Department of Pediatrics Asahikawa Medical UniversityAsahikawaJapan Department of Pediatric Cardiology Saitama Medical CenterSaitama Medical UniversityKawagoeJapan

Background:Most congenital heart diseases(CHDs)have specific hemodynamics,including volume and pressure overload,as well as cyanosis and pulmonary hypertension,associated with anatomical *** hemodynamic abnormalities can cause activation of neurohormones,inflammatory cytokines,fibroblasts,and vascular endothelial cells,which in turn contribute to the development of pathologic conditions such as cardiac hypertrophy,fi brosis,and cardiac cell damages and *** biomarker levels facilitates the prediction of these pathological changes,and provides information about the stress placed on the myocardial cells,the severity of the damage,the responses of neurohumoral factors,and the remodeling of the *** to the ample information on cardiac biomarkers in adult heart diseases,data from children with CHD are still *** sources:We reviewed cardiac biomarkers-specifi cally focusing on troponin as a biomarker of myocardial damage,amino-terminal procollagen type III peptide(PIIIP)as a biomarker of myocardialfi brosis and stromal remodeling,and B-type natriuretic peptide(BNP)/N-terminal proBNP as biomarkers of cardiac load and heart failure,by introducing relevant publications,including our own,on pediatric CHD patients as well as ***:Levels of highly sensitive troponin I are elevated in patients with atrial septal defects(ASDs)and ventricular septal defects(VSDs).PIIIP levels are also elevated in patients with ASD,VSD,pulmonary stenosis,and Tetralogy of *** of BNP and N-terminal proBNP levels shows good correlation with heart failure score in ***:In the treatment of children with CHD requiring delicate care,it is vital to know the specifi c degree of myocardial damage and severity of heart *** biomarkers are useful tools for ascertaining the condition of CHDs with ease and are likely to be useful in determining the appropriate care of pediatric cardiology patients.

关键词： biomarker B-type natriuretic peptide congenital heart disease procollagen type III peptide troponin

Complete response to an anti-programmed cell death 1 antibody following a combination therapy of an anti-programmed cell death ligand 1 antibody and a tyrosine kinase inhibitor for metastatic renal cell carcinoma

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Asian Journal of Urology 2023年第1期10卷 103-105页

作者： Masayuki Kurokawa Sei Naito Tomoyuki Kato Masaki ushijima Atsushi Yamagishi Toshihiko Sakurai Hayato Nishida Norihiko Tsuchiya Department of Urology Yamagata University Faculty of MedicineYamagataJapan

Dear Editor,Several Phase 3 trials have demonstrated the efficacy of immune checkpoint inhibitor(ICI)-based combination therapies in the treatment of advanced clear cell renal cell carcinoma(RCC)[1-5].However,there is still no well-defined adequate treatment for patients who experience disease progression after initial ICI-based combination therapy.

关键词： death carcinoma treatment

Improved Transfer Process for the Fully Additive Manufacturing of a Conductive Layer-Stacked Polymeric Cantilever

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Materials Sciences and Applications 2019年第1期10卷 45-52页

作者： Shusuke Kanazawa Yasuyuki Kusaka Noritaka Yamamoto Hirobumi ushijima Flexible Electronics Research Center National Institute of Advanced Industrial Science and Technology Tsukuba Japan

This paper reports on an efficient fabrication process for a polymeric cantilever covered with conductive nano silver. The entire structure can be constructed additively using a printing process, without the use of an etching process or a sacrificial layer. The fabricated cantilever exhibits good linearity and forms a submillimeter-ordered air gap between itself and the substrate surface. Fine operation of a capacitive force gauge was obtained using the capacitance between the conductive cantilever and an electrode on the substrate. This process is expected to make possible the efficient manufacturing of various types of sensors that measure mechanical strain in a cantilever structure.

关键词： Additive Manufacturing MEMS Screen Printing Polymer Sensor

Engineering for Human Security and Well-Being

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Engineering 2015年第3期1卷 282-287页

作者： hideaki Koizumi Hitachi Ltd. Engineering Academy of Japan(EAJ)

For some time,I have been studying the combined concept of'human security and well-being,'which addresses people’s daily lives as a top priority,as well as the concept of'societal innovation.'The concept of'human sec... 详细信息

关键词：人类安全工程健康全球变暖流行病

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Leaf-meridian bio-inspired nanofibrous electronics with uniform distributed microgrid and 3D multi-level structure for wearable applications

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npj Flexible Electronics 2022年第1期6卷 372-381页

作者： Mingxu Wang Li Dong Jiajia Wu Jian Shi Qiang Gao Chunhong Zhu hideaki Morikawa Graduate School of Medicine Science and TechnologyShinshu University3-15-1 TokidaUedaNaganoJapan Institute for Fiber Engineering(IFES) Interdisciplinary Cluster for Cutting Edge Research(ICCER)Shinshu University3-15-1 TokidaUedaNaganoJapan Faculty of Systems Science and Technology Akita Prefectural University84-4 Aza EbinokuchiTsuchiyaYurihonjoAkitaJapan School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouChina Faculty of Textile Science and Technology Shinshu University3-15-1 TokidaUedaNaganoJapan

The interface between the active electronic and its osculatory target dominates the sensing response of high-sensitivity ***,the interface properties are difficult to be adjusted and preserved owing to the limited strategies for surface *** this work,inspired by nature frond leaf,a spatial multi-level nanofibrous membrane with grid-like microstructure of uniform distribution was fabricated,in which carboxylated carbon nanotubes(CCNTs)/poly(3,4-ethylenedioxythiophene)(PEDOT)was modified onto the surface of grid-like polyurethane(PU)nanofiber via the combination of metal mesh template,in situ polymerization and ultrasonic *** membrane enables a pressure sensor with high sensitivities(5.13 kPa−1),fast response/recovery time(80 ms and 120 ms),and ultralow detection limit of 1 *** addition,as a scalable and integrable platform,we also demonstrate its multifunctional applications for electro-thermal conversion and energy *** these results indicate the proposed nanofibrous membrane may potentially be applied to next-generation wearable devices.

关键词： treatment. template polyurethane

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用于旋翼飞机开发研究的多分野解析框架

Transactions of Nanjing University of Aeronautics and Astronautics 2024年第1期41卷 43-52页

作者： TANABE Yasutada SUGAWARA hideaki KIMURA Keita 日本宇宙航空研究开发机构航空技术部日本东京181-0015

介绍了日本宇宙航空研究开发机构研发的用于旋翼飞机的多分野解析框架。Heli Design是在各种旋翼飞机初期概念设计时使用的软件;rFlight可以提供在各种飞行条件下的平衡解析和线性化飞行模型;rBET/RMT是基于叶片要素理论的低保真度空力... 详细信息

介绍了日本宇宙航空研究开发机构研发的用于旋翼飞机的多分野解析框架。Heli Design是在各种旋翼飞机初期概念设计时使用的软件;rFlight可以提供在各种飞行条件下的平衡解析和线性化飞行模型;rBET/RMT是基于叶片要素理论的低保真度空力解析软件,和rMode提供的结构模型结合,可以推测旋转翼的弹性变形和各种飞行条件下的空力负载;rFlow3D是基于CFD计算的高保真度数值模拟软件;rGrid系列自动网格构造工具为其提供简单的网格生成;基于rFlow3D的计算结果,r Noise可以预测在任何观测点的噪声。这些软件已经广泛地被应用在各种新型旋翼飞机的开发研究中,其计算精度也已被各种实验结果所应证。

关键词：旋翼飞机多分野解析高保真模拟设计工具

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Effect of branched-chain amino acids in patients receiving intervention for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第10期20卷 2673-2680页

作者： Tomoaki Ishihara Motoh Iwasa hideaki Tanaka Masahiko Kaito Jiro Ikoma Toshiya Shibata Yoshiyuki Takei Department of Gastroenterology and Hepatology Yokkaichi Digestive Disease Center Komono Mie 510-1232 Japan Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine Tsu Mie 514-8507 Japan Department of Gastroenterology and Hepatology Mie Shokakinaika Tsu Mie 514-0062 Japan Department of Diagnostic Imaging and Nuclear Medicine Kyoto University Graduate School of MedicineKyoto 606-8507 Japan

AIM: To investigate the usefulness of branched-chain amino acids (BCAA) before transarterial chemoembolization (TACE) or radiofrequency ablation (RFA).

关键词： Branched-chain amino acids Cirrhosis Hepatocellular carcinoma Transarterial chemoembolization Radiofrequency ablation Hypoalbuminemia

Crystal Structures of Human Dipeptidyl Peptidase Ⅳ in its Apo and Diprotin B-complexed Forms

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Acta Biochimica et Biophysica Sinica 2007年第5期39卷 335-343页

作者： Hajime H1RAMATSU Kiyoshi KYONO Atsushi YAMAMOTO Kazuhiko SAEKI hideaki SHIMA Shigeru SUGIYAMA Koji INAKA Ryo SHIMIZU Tanabe Seiyaku Co. Ltd Osaka 532-8505 Japan Aphoenix Inc. Tokyo 150-0002 Japan Maruwa Food Industries Inc. Nara 639-1123 Japan Mol Logics Inc. Kyoto 619-0237 Japan Maruwa Food Industries Inc. Nara 639-1123 Japan

Dipeptidyl peptidase Ⅳ (DPPIV), which belongs to the prolyl oligopeptidase family of serine proteases, is known to have a variety of regulatory biological functions and has been shown to be implicated in type 2 diabetes. It is therefore important to develop selective human DPPIV (hDPPIV) inhibitors. In this study, we determined the crystal structure of apo hDPPIV at 1.9 A resolution. Our high-resolution crystal structure of apo hDPPIV revealed the presence of sodium ion and glycerol molecules at the active site. In order to elucidate the hDPPIV binding mode and substrate specificity, we determined the crystal structure of hDPPIV-diprotin B (Val-Pro-Leu) complex at 2.1 A resolution, and clarified the difference in binding mode between diprotin B and diprotin A (Ile-Pro-Ile) into the active site of hDPPIV. Comparison between our crystal structures and the reported apo hDPPIV structures revealed that positively charged functional groups and conserved water molecules contributed to the interaction of ligands with hDPPIV. These results are useful for the design of potent hDPPIV inhibitors.

关键词： dipeptidyl peptidase Ⅳ diprotin B serine protease crystal structure water molecule