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A novel equation and nomogram including body weight for estimating prostate volumes in men with biopsy-proven benign prostatic hyperplasia

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Asian Journal of Andrology 2012年第5期14卷 703-707页

作者： Yasukazu Nakanishi Hitoshi Masuda Satoru Kawakami Mizuaki Sakura Yasuhisa Fujii Kazutaka Saito Fumitaka koga Masaya Ito lunji Yonese Iwao Fukui Kazunori Kihara Department of Urology Tokyo Medical and Dental University Tokyo 113-8519 Japan Department of Urology Cancer institute Hospital Tokyo 135-8550 Japan

Anthropometric measurements, e.g., body weight （BW）, body mass index （BMI）, as well as serum prostate-specific antigen （PSA） and percent-free PSA （%fPSA） have been shown to have positive correlations with total prostate volume （TPV）. We developed an equation and nomogram for estimating TPV, incorporating these predictors in men with benign prostatic hyperplasia （BPH）. A total of 1852 men, including 1113 at Tokyo Medical and Dental University （TMDU） Hospital as a training set and 739 at Cancer Institute Hospital （CIH） as a validation set, with PSA levels of up to 20 ng m1-1, who underwent extended prostate biopsy and were proved to have BPH, were enrolled in this study. We developed an equation for continuously coded TPV and a logistic regression-based nomogram for estimating a TPV grater than 40 mh Predictive accuracy and performance characteristics were assessed using an area under the receiver operating characteristics curve （AUC） and calibration plots. The final linear regression model indicated age, PSA, %fPSA and BW as independent predictors of continuously coded TPV. For predictions in the training set, the multiple correlation coefficient was increased from 0.38 for PSA alone to 0.60 in the final model. We developed a novel nomogram incorporating age, PSA, %fPSA and BW for estimating TPV greater than 40 mh External validation confirmed its predictive accuracy, with AUC value of 0.764. Calibration plots showed good agreement between predicted probability and observed proportion. In conclusion, TPV can be easily estimated using these four independent predictors.

关键词： body weight equation nomogram prediction prostate-specific antigen prostate volume

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Efficacy of omarigliptin,once-weekly dipeptidyl peptidase-4 inhibitor,in patients with type 2 diabetes

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World Journal of Diabetes 2021年第12期12卷 2087-2095页

作者： Eiji Kawasaki Yuko Nakano Takahiro Fukuyama Aira Uchida Yoko Sagara Hidekazu Tamai Masayuki Tojikubo Yuji Hiromatsu Nobuhiko koga Department of Diabetes and Endocrinology Shin-Koga HospitalKurume 830-8577Japan

BACKGROUND Omarigliptin is one of several once-weekly dipeptidyl peptidase-4 inhibitors(DPP-4is).Despite the high frequency of switching from various daily DPP-4is to omarigliptin in actual clinical practice,data regarding its efficacy in patients with type 2 diabetes(T2D)after switching are *** To analyze the efficacy of omarigliptin in Japanese patients with T2D who had previously received treatment with other glucose-lowering *** Forty-nine T2D patients treated for the first time with omarigliptin were recruited retrospectively and divided into four groups defined as either add-on or switched from daily DPP-4is:switched from linagliptin,switched from sitagliptin,and switched from *** a 3-mo follow-up,the clinical parameters among these groups were assessed and compared,with the impact of the switch on glycemic variability as measured by continuous glucose monitoring also being evaluated in the switched *** Hemoglobin A1c levels saw a significant decrease of-0.32%±0.41%in the add-on group(P=0.002).However,the other groups’variables depended on the preswitch daily DPP-4i:switched from linagliptin,-0.05%±0.22%;switched from sitagliptin,-0.17%±0.33%;and switched from vildagliptin,0.45%±0.42%,which saw significant worsening(P=0.0007).Multivariate logistic regression analysis revealed that switching from vildagliptin to omarigliptin was independently associated with worsening glycemic control(P=0.0013).The mean and standard deviation of sensor glucose value,the mean amplitude of glycemic excursions,and the mean of daily difference significantly improved when switching the patient from either linagliptin or sitagliptin to ***,in patients switched from vildagliptin,not only did the glucose variability indices see no improvements,the mean of daily difference even underwent significant *** Administering omarigliptin as add-on therapy or switching to it from sitagliptin and linagliptin,but not v

关键词： Omarigliptin Once-weekly dipeptidyl peptidase-4 inhibitor Real-world practice Retrospective study Type 2 diabetes

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Co-Chairman’s Message

Co-Chairman’s Message

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The Fourth Asia-Pacific Conference on Environmental Electromagnetics

作者： Ryuji koga/Cochair Okayama University Japan Professor

＜正＞Electronics is a facet of the modern civilization and the dominant part of it, focused on consumer electronics, is carried in pan-pacific area now centered in far-east districts. Engineers who develop a new product, with better performance, easier to treat and with new function which had never claimed, will inevitably confront to EMC problems when they put their products to the market. They are young and enthusiastic to resolve the difficult subjects. CEEM’06 is the opportunity for the embarrassed engineers to find hints to untie entangled subject or lend other engineers an

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Occult hepatitis B virus infection and surgical outcomes in non-B, non-C patients with curative resection for hepatocellular carcinoma

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World Journal of Hepatology 2017年第35期9卷 1286-1295页

作者： Hiroki koga Keita Kai Shinichi Aishima Atsushi Kawaguchi Koutaro Yamaji Takao Ide Junji Ueda Hirokazu Noshiro Department of Surgery Saga University Faculty of Medicine Department of Pathology Saga University Hospital Department of Pathology and Microbiology Saga University Faculty of Medicine Center for Comprehensive Community Medicine Saga University Faculty of Medicine

AIM To investigate the prevalence, clinicopathological characteristics and surgical outcomes of occult hepatitis B virus(HBV) infection(OBI) in patients with non-B, non-C(NBNC) hepatocellular carcinoma(HCC).METHODS This study retrospectively examined the cases of 78 NBNC patients with curative resection for HCC for whom DNA could be extracted from formalin-fixed paraffin-embedded tissue. OBI was determined by the HBV-DNA amplification of at least two different sets of primers by TaqM an realtime polymerase chain reaction. Possibly carcinogenetic factors such as alcohol abuse, diabetes mellitus, obesity and non-alcoholic steatohepatitis(NASH) were examined. Surgical outcomes were evaluated according to diseasefree survival(DFS), overall survival(OS) and diseasespecific survival(DSS).RESULTS OBI was found in 27/78 patients(34.6%) with NBNC HCC. The OBI patients were significantly younger than the non-OBI cases at the time of surgery(average age 63.0 vs 68.1, P = 0.0334) and the OBI cases overlapped with other etiologies significantly more frequently compared to the non-OBI cases(P = 0.0057). OBI had no impact on the DFS, OS or DSS. Only tumorrelated factors affected these surgical *** Our findings indicate that OBI had no impact on surgical outcomes. The surgical outcomes of NBNC HCC depend on early tumor detection; this reconfirms the importance of a periodic medical examination for individuals who have NBNC HCC risk factors.

关键词： Hepatocellular carcinoma Non-B non-C Occult hepatitis B virus infection Surgery Surgical outcome

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Probing and possible application of the QED vacuum with micro-bubble implosions induced by ultra-intense laser pulses

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Matter and Radiation at Extremes 2019年第3期4卷 18-24页

作者： James K.koga Masakatsu Murakami Alexey V.Arefiev Yoshihide Nakamiya Kansai Photon Science Institute National Institutes for Quantum and Radiological Science and TechnologyKizugawaKyoto 619-0215Japan Institute of Laser Engineering Osaka UniversityOsaka 565-0871Japan Department of Mechanical and Aerospace Engineering University of California at San DiegoLa JollaCalifornia 92093USA Extreme Light Infrastructure-Nuclear Physics(ELI-NP)/Horia Hulubei National Institute forR&Din PhysicsandNuclear Engineering(IFIN-HH) 30 Reactorului St.P.O.Box MG-6Bucharest-MagureleJudet¸ul Ilfov RO-077125Romania

The interaction of micro-bubbles with ultra-intense laser pulses has been shown to generate ultra-high proton densities and correspondingly high electric *** the possibility of using such a combination to study the fundamental physical phenomenon of vacuum *** current or near-future laser systems,measurement of vacuum polarization via the bending of gamma rays that pass near imploded microbubbles may be *** it is independent of photon energy to within the leading-order solution of the Heisenberg–Euler Lagrangian and the geometric optics approximation,the corresponding index of refraction can dominate the indices of refraction due to other effects at sufficiently high photon *** consider the possibility of its application to a transient gamma-ray lens.

关键词： laser polarization vacuum

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Development and Evaluation of an All Weather-Type Solar Drying House to Make for Wood Pellet Material

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Open Journal of Applied Sciences 2012年第3期2卷 153-162页

作者： Kimio Kanayama Shinya koga Hiromu Baba Tomoyoshi Sugawara Kitami Institute of Technology Kitami Japan Kyushu University Fukuoka Japan Marusho-Giken Co. Ltd. Ashoro Japan

To suppress the global environment pollutions, we tried to develop a new-type solar drying house by improving a typical agricultural green-house, so that an all weather-type solar drying house was invented ultimately. This house is capable to dry raw wood materials (Ogako) into suitable moisture content (Mc) to make a wood pellet. The all weather-type solar Ogako drying house is covered with a triple transparent film, and an open/close free-type shield sheet is spread along with house’s inner surface with a small space, which is opened when solar radiation is incident on the house in daytime and closed to prevent heat loss from the house while out of sun shining in night. Inside of the all weather-type solar Ogako drying house, there are four belt-conveyors over which four top radiation panels are hanged, and on which four Ogako agitators are touched, a turn-table, two hoppers, four small fans, and besides, a floor heating is molded in concrete floor. Also on the north wall outside the house, two insulated cylinders (chimney) are stood up vertically to exhaust inside moist air passively. Then, to make clearly the operation performance of the house, the drying tests for the proof examination were conducted nineteen times at first test site in Ashoro where is located east-central part of Hokkaido, Japan. As a result of the drying test for the proof examination, it was made clear that the all weather-type solar Ogako drying house is practically useful as a supplementary apparatus to produce the dried Ogako, and consequently to suppress CO2 exhaustion.

关键词： Solar Energy and Biomass Energy Agricultural Green-House Ogako Drying House Wood Powder (Ogako) Wood Pellet Moisture Content (Mc) Decrease of Oil Consumption Suppression of CO2 Exhaustion

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Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel

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World Journal of Gastroenterology 2018年第35期24卷 4036-4053页

作者： Keizo Hiraishi Lin-Hai Kurahara Miho Sumiyoshi Yao-Peng Hu Kaori koga Miki Onitsuka Daibo Kojima Lixia Yue Hidetoshi Takedatsu Yu-Wen Jian Ryuji Inoue Department of Physiology Graduate School of Medical Sciences Fukuoka University Department of Pathology Faculty of Medicine Fukuoka University Department of Gastroenterological Surgery Faculty of Medicine Fukuoka University Department of Cell Biology University of Connecticut Health Center Department of Gastroenterology and Medicine Faculty of Medicine Fukuoka University College of Letters and Science University of CaliforniaDavis

AIM To investigate the anti-fibrotic effects of the traditional oriental herbal medicine Daikenchuto(DKT) associated with transient receptor potential ankyrin 1(TRPA1) channels in intestinal myofibroblasts. METHODS Inflammatory and fibrotic changes were detected in a2,4,6-trinitrobenzenesulfonic acid(TNBS) chronic colitis model of wild-type and TRPA1-knockout(TRPA1-KO) mice via pathological staining and immunoblotting ***^(2+) imaging experiments examined the effects of DKT and its components/ingredients on intestinal myofibroblast(In Myo Fib) cell TRPA1 channel *** factors and transforming growth factor (TGF) -β1-associated signaling were tested in an In Myo Fib cell line by q PCR and immunoblotting *** from non-stenotic and stenotic regions of the intestines of patients with Crohn’s disease (CD) were used for pathological analysis. RESULTS Chronic treatment with TNBS caused more severe inflammation and fibrotic changes in TRPA1-KO than in wild-type mice.A one-week enema administration of DKT reduced fibrotic lesions in wild-type but not in TRPA1-KO *** active ingredients of DKT,i.e.,hydroxyα-sanshool and 6-shogaol,induced Ca^(2+) influxes in In Myo Fib,and this was antagonized by co-treatment with a selective TRPA1 channel blocker,*** counteracted TGF-β1-induced expression of TypeⅠcollagen andα-smooth muscle actin (α-SMA) ,which were accompanied by a reduction in the phosphorylation of Smad-2 and p38-mitogen-activated protein kinase (p38-MAPK) and the expression of ***,24-h incubation with a DKT active component Japanese Pepper increased the m RNA and protein expression levels of TRPA1 in In Myo Fibs,which in turn negatively regulated collagen *** the stenotic regions of the intestines of CD patients,TRPA1 expression was significantly *** The effects of DKT on the expression and activation of the TRPA1 channel could be advantageous for suppressing intestinal fibrosis

关键词： Intestinal fibrosis Myofibroblast Transient receptor potential ankyrin 1 Crohn’s disease Collagen α-smooth muscle actin

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Molecular Characterization of Peruvian Fowl Adenovirus (FAdV) Isolates

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Advances in Microbiology 2014年第10期4卷 595-603页

作者： Jorge Rodríguez Ysabel koga Arnaldo Alvarado Robert Tinoco Bioservice SRL Lima Peru

Forty seven clinical samples of Fowl adenovirus (FAdV) associated with Inclusion Body Hepatitis (IBH) from Peruvian broilers received between July 2006 and April 2013 were genotyped using sequencing of L1 Loop of Hexon gene. All 47 clinical samples presented macroscopic and histopathology lesions consistent with IBH, and amplified a specific fragment of Hexon gene by Polymerase Chain Reaction (PCR). A unique nucleotide sequence of 789 base pairs of Hexon gene (position 273 to 1061) was obtained in all 47 clinical samples analyzed. This sequence showed a high level of conservation in amino acid and nucleotide sequence (>99%) with a Fowl Adenovirus C serotype 4 previously identified. Sequence and phylogenetic analysis indicate no genotypic variation in Peruvian isolates. The presence of a unique genotype very closely related with genotype C1 previously reported in Peru and Ecuador (>99%), suggests the presence of FAdV C serotype 4 genotype C1 in clinical cases of IBH from Peruvian broilers.

关键词： Fowl Adenovirus C Molecular Characterization Inclusion Body Hepatitis Peru

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Liquid Chromatography-Tandem Mass Spectrometry Methods for Determination of Delamanid in Mouse Plasma and Lung

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American Journal of Analytical Chemistry 2015年第2期6卷 98-105页

作者： Yukihiro Hirao Toshihisa koga Noriyuki Koyama Yoshihiko Shimokawa Ken Umehara Tokushima Research Institute Otsuka Pharmaceutical Co. Ltd. Tokushima-shi Japan

Sensitive and selective liquid chromatography-tandem mass spectrometry methods have been developed and validated for the determination of delamanid in mouse plasma and lung. Sample preparation involved liquid-liquid extraction with diethyl ether for plasma, or protein precipitation followed by liquid-liquid extraction with tert-butyl methyl ether for lung homogenate. Chromatographic separation was performed on a reversed phase column with a linear gradient elution using purified water-formic acid (1000:2, v/v) and methanol-formic acid (1000:2, v/v) at a flow rate of 0.2 mL/min. Detection was performed on a triple-quadrupole tandem mass spectrometer using positive ion electrospray ionization in the selected reaction monitoring mode. The analytical methods were successfully validated for selectivity, calibration curve, accuracy, precision, extraction recovery, and stability over a range of 6 - 1000 ng/mL for plasma and 10 - 1000 ng/mL for lung homogenate. The validated methods were successfully applied for evaluation of pharmacokinetics of delamanid in male mice.

关键词： Delamanid LC-MS/MS Mouse Plasma Mouse Lung Pharmacokinetics

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Clinical outcomes of Clutch Cutter endoscopic submucosal dissection for older patients with early gastric cancer

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World Journal of Gastrointestinal Oncology 2017年第10期9卷 416-422页

作者： Yoshihiro Otsuka Kazuya Akahoshi Kayoko Yasunaga Masaru Kubokawa Junya Gibo Shigeki Osada Kayo Tokumaru Kazuaki Miyamoto Takao Sato Yuki Shiratsuchi Masafumi Oya Hidenobu koga Eikichi Ihara Kazuhiko Nakamura Department of Gastroenterology Aso Iizuka Hospital Diagnosis Procedure Combination Coding Management Office Aso Iizuka Hospital Department of Pathology Aso Iizuka Hospital Clinical Research Supportive Office Aso Iizuka Hospital Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu University

AIM To evaluate the clinical outcome of endoscopic submucosal dissection using the Clutch Cutter(ESDCC) in older patients. METHODS We reviewed 232 consecutive patients with early gastric cancer who underwent ESDCC between June 2010 and February 2014 at Aso Iizuka Hospital. We divided patients into two groups according to age: Older patients(> 80 years, n = 64) and non-older patients(≤ 80 years, n = 168). We retrospectively compared the prevalence rates of pre-existing comorbidities, anticoagulant therapy, en bloc resection, mean duration of hospitalization, incidence of ESDCC-related complications, change in performance status(PS) before and after ESDCC, and financial cost of admission. RESULTS The older group comprised 64 patients with a mean age of 84.1 years, and the non-older group comprised 168 patients with a mean age of 69.5 years. Older patients had significantly more pre-existing comorbidities than did non-older patients, specifically heart disease(P < 0.05). The en bloc resection rate in non-older patients was significantly higher than that in older patients(100% vs 95.3%, P = 0.02). There were no significant differences between the older and non-older groups in the incidence of ESDCC-related complications(i.e., postoperative bleeding and perforation) and the post-ESDCC change in PS. There were also no significant differences between the older and non-older groups in the mean duration of hospitalization(11.4 and 10.7 d, respectively) and financial cost of admission(657040 JPY and 574890 JPY, respectively).CONCLUSION ESDCC has a good clinical outcome in older patients.

关键词： Older patients Clutch Cutter Endoscopic submucosal dissection Early gastric cancer Financial cost Duration of hospitalization

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