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The deterministic condition for the ground reaction force acting point on the combined knee valgus and tibial internal rotation moments in early phase of cutting maneuvers in female athletes

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Journal of Sport and Health Science 2024年第3期13卷 376-386页

作者： Issei Ogasawara Ken Ohta Gajanan S.Revankar Shoji Konda Yohei Shimokochi Hideyuki koga Ken Nakata Department of Health and Sport Sciences Graduate School of MedicineOsaka UniversityToyonaka 560-0043Japan Sports Sensing Co. LTD.Fukuoka 815-0035Japan Department of Neurology Graduate School of MedicineOsaka UniversitySuita 565-0871Japan Department of Health and Sport Management Osaka University of Health and Sport SciencesSennan-gun 590-0496Japan Department of Joint Surgery and Sports Medicine Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8519Japan

Background:Combined knee valgus and tibial internal rotation(VL+IR)moments have been shown to stress the anterior cruciate ligament(ACL)in several in vitro cadaveric *** utilize this knowledge for non-contact ACL injury prevention in sports,it is necessary to elucidate how the ground reaction force(GRF)acting point(center of pressure(CoP))in the stance foot produces combined knee VL+IR moments in risky maneuvers,such as ***,the effects of the GRF acting point on the development of the combined knee VL+IR moment in cutting are still ***:We first established the deterministic mechanical condition that the CoP position relative to the tibial rotational axis differentiates the GRF vector’s directional probability for developing the combined knee VL+IR moment,and theoretically predicted that when the CoP is posterior to the tibial rotational axis,the GRF vector is more likely to produce the combined knee VL+IR moment than when the CoP is anterior to the tibial rotational ***,we tested a stochastic aspect of our theory in a lab-controlled in vivo *** females performed 60˚cutting under forefoot/rearfoot strike conditions(10 trials each).The positions of lower limb markers and GRF data were measured,and the knee moment due to GRF vector was *** trials were divided into anterior-and posterior-CoP groups depending on the CoP position relative to the tibial rotational axis at each 10 ms interval from 0 to 100 ms after foot strike,and the occurrence rate of the combined knee VL+IR moment was compared between trial ***:The posterior-CoP group showed significantly higher occurrence rates of the combined knee VL+IR moment(maximum of 82.8%)at every time point than those of the anterior-CoP trials,as theoretically predicted by the deterministic mechanical ***:The rearfoot strikes inducing the posterior CoP should be avoided to reduce the risk of non-contact ACL injury associated with the com

关键词： Center of pressure Deterministic condition Foot strike pattern Injury mechanism Moment of ground reaction force

Pulmonary artery diameter ratio as a prognostic indicator of congenital diaphragmatic hernia

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World Journal of Pediatric Surgery 2024年第1期7卷 20-25页

作者： Yuichiro Miyake Hiroyuki koga Shuko Nojiri Shunsuke Yamada Takanori Ochi Go Miyano Geoffrey J Lane Atsuyuki Yamataka Tadaharu Okazaki Department of Pediatric General and Urogenital Surgery Juntendo University School of MedicineBunkyo-kuTokyoJapan Department of Medical Technology Innovation Center Juntendo UniversityBunkyo-ku TokyoJapan Department of Pediatric Surgery Juntendo University Urayasu HospitalUrayasuChibaJapan

Background Following on from an earlier study published in 2008 about left pulmonary artery(LPA)flow measured on serial echocardiography being strongly prognostic in left-sided congenital diaphragmatic hernia(CDH)and the ratio of LPA to right pulmonary artery(RPA)diameters being a simple and reliable indicator for commencing nitric oxide(NO)therapy,the ratio of LPA:RPA diameters(PA ratio orPAR)was hypothesized to possibly reflect cardiopulmonary stresses accompanying CDH *** Subjects with isolated left-sided CDH treated between 2007 and 2020 at a single pediatric surgical center were recruited and classified according to *** obtained retrospectively for subject demographics,clinical course,LPA/RPA diameters,and PAR were compared between survivors and *** value of PAR for optimizing the prognostic value of PA diameter data in CDH were analyzed with receiver operating characteristic(ROC)curve *** Of 65 subjects,there were 54 survivors(82.3%)and 11 non-survivors(17.7%);7 of 11 non-survivors died before surgical repair could be *** PAR for survivors(0.851±0.152)was significantly higher than for non-survivors(0.672±0.108)(p=0.0003).Mean PAR for non-survivors was not affected by surgical *** of survivors were:LPA≥2 mm(n=52 of 54;mean PAR=0.866±0.146)and RPA≥3mm(n=46 of 54;mean PAR=0.857±0.152).Non-survivors with similar LPA and RPA diameters to survivors had significantly lower mean *** curve cut-off for PAR was *** with high PAR(≥0.762)required high-frequency oscillatory ventilation/NO less than subjects with low PAR(<0.762)(p=0.0244 and p=0.0485,respectively)and subjects with high PAR stabilized significantly earlier than subjects with low PAR(1.71±0.68 days vs 3.20±0.87 days)(p<0.0001).Conclusions PAR would appear to be strongly correlated with clinical outcome in CDH and be useful for planning management of cardiopulmonary instability in CDH.

关键词： hernia congenital diameters

Microbiota in the stomach and application of probiotics to gastroduodenal diseases

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World Journal of Gastroenterology 2022年第47期28卷 6702-6715页

作者： Yasuhiro koga Japanese Society for Probiotic Science Isehara 259-1143Japan

The stomach is a hostile environment for most microbes because strong gastric acid kills indigenous ***,the mass of indigenous microbes detected by traditional culturing method in a highly acidic stomach is reported to be very ***,in a stomach with less acidity due to atrophic changes of the gastric mucosa,the number of live gastric microbiota dramatically increases and their composition changes.A probiotic is defined as a live microorganism that,when administered in adequate amounts,confers a health benefit on the *** administration of probiotics to the stomach has thus far been considered impractical,mainly due to the strong acidity in the *** identification of candidate probiotic strains with sufficient resistance to acidity and the ability to achieve close proximity to the gastric mucosa could enable the application of probiotics to the *** utilization of probiotics alone for Helicobacter pylori(***)infection significantly improves gastric mucosal inflammation and decreases the density of *** on the mucosa,although complete eradication of *** has not yet been *** use of probiotics in combination with antimicrobial agents significantly increases the *** eradication rate,especially when the *** strains are resistant to antimicrobial *** *** has been considered the most important pathogenic bacterium for the development of gastric cancer,bacteria other than *** are also suggested to be causative pathogens that promote the development of gastric cancer,even after the eradication of *** *** Gram-negative bacteria in the stomach with weak acidity accompanying atrophic gastritis may perpetuate gastric mucosal inflammation and accelerate carcinogenic progression,even after *** *** restore the acidity in this stomach environment and may therefore prevent the development of gastric cancer by termination of Gram-negative ba

关键词： Stomach Microbiota Probiotics Helicobacter pylori Post-eradication gastric cancers Functional dyspepsia

Beyond management to conquer life-threatening tumor thrombosis in hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 773-774页

作者： Hironori koga Division of Gastroenterology Department of MedicineKurume University School of MedicineKurumeJapan

Hepatic vein tumor thrombus(HVTT),together with portal vein tumor thrombus(PVTT),is a major determinant of survival outcome in patients with advanced hepatocellular carcinoma(HCC).HVTT can be an oncologic emergency,especially when it invades beyond IVC into the right atrium,where it can cause sudden death from pulmonary *** studies using large numbers of patients are generally difficult in this relatively rare and urgent *** this context,the multicenter study conducted by Chen et *** significant,albeit retrospective(1).

关键词： hepatocellular thrombus al.

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大型锻造炉的若干改进节约了40％的能耗

大型铸锻件 1986年第2期 13-13页

作者： Hiroshi Ogawa Masami Kanda Chikayuki Matsumoto hideaki koga 有仪（译）日本不详

通过改进8000tf（78400MN）水压机锻造车间的大型锻造加热炉，我们已能节约40％能耗（如油和电力）。1．改造内容 1）增加锻造炉的负荷量。稍微改变侧墙结构，把炉中台车宽度从5.5m扩大到7.0m。其结果负荷量从300t增加到400t。

关键词：锻造炉能耗锻造加热炉锻造车间侧墙结构负荷量水压机

Does time taken to achieve jaundice-clearance influence survival of the native liver in post-Kasai biliary atresia?

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World Journal of Pediatrics 2018年第2期14卷 191-196页

作者： hideaki Nakajima Hiroyuki koga Manabu Okawada Hiroki Nakamura Geoffrey James Lane Atsuyuki Yamataka Department of Pediatric General and Urogenital Surgery Juntendo University School of MedicineTokyo 113-8421Japan

Background We reviewed the time taken for post-portoenterostomy(PE)biliary atresia(BA)patients to obtain jaundice-clearance(total bilirubin≤1.2 mg/dL;JC)post-PE to determine if JC time(JCT)is prognostic for survival of the native liver(SNL).Methods The subjects were 66 BA patients treated with PE at our institute between 1989,the year when liver transplan-tation(LTx)became available in Japan,and *** was used to create three groups(≤30 days:n=14;31-60 days:n=31;≥61 days:n=21).Medical records were reviewed retrospectively to evaluate:age at onset of symptoms,duration of symptoms pre-PE,age and weight at PE,serum liver function tests,incidence of cholangitis,and micro-bile duct size at *** Age at onset of symptoms,age and weight at PE,duration of symptoms pre-PE,and micro-bile duct size were similar for all patients in all three *** and SNL appeared to correlate because preoperative total bilirubin(7.1,9.6,10.2 mg/dL;P<0.05)was significantly lower in the JCT≤30 days group(P<0.05)while there was a significant decrease in SNL(P<0.03)and a significant increase in LTx(P<0.01)in the JCT≥61 days *** LTx subjects who achieved JC were found to have developed cholangitis within 3 months of *** During the follow-up of post-PE subjects,longer JCT and cholangitis occurrence within 3 months of PE would appear to be negative prognostic factors for SNL while preoperative total bilirubin would appear to be a positive prognostic factor for SNL.

关键词： Biliary atresia Jaundice free Liver transplantation Native liver survival Portoenterostomy

Molecules with a TEMPO-based head group as high-performance organic friction modifiers

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Friction 2023年第2期11卷 316-332页

作者： Jinchi HOU Masaki TSUKAMOTO Seanghai HOR Xingyu CHEN Juntao YANG Hedong ZHANG Nobuaki koga Koji YASUDA Kenji FUKUZAWA Shintaro ITOH Naoki AZUMA Department of Complex Systems Science Graduate School of InformaticsNagoya UniversityNagoya 464-8601Japan Institute of Materials and Systems for Sustainability Nagoya UniversityNagoya 464-8601Japan Department of Micro-Nano Systems Engineering Graduate School of EngineeringNagoya UniversityNagoya 464-8603Japan

High-performance organic friction modifiers(OFMs)added to lubricating oils are crucial for reducing energy loss and carbon *** establish a new class of OFMs,we measured the friction and wear properties of N-(2,2,6,6-tetramethyl-1-oxyl-4-piperidinyl)dodecaneamide referred to as *** effect of its head group chemistry,which is characterized by a rigid six-membered ring sandwiched by an amide group and a terminal free oxygen radical,was also investigated with both experiments and quantum mechanical(QM)*** measurement results show that C12Amide-TEMPO outperforms the conventional OFMs of glyceryl monooleate(GMO)and stearic acid,particularly for load-carrying capacity,wear reduction,and stability of friction over *** friction and wear reduction effect of C12Amide-TEMPO is also greatly superior to those of C12Ester-TEMPO and C12Amino-TEMPO,in which ester and amino groups replace the amide group,highlighting the critical role of the amide *** QM calculation results suggest that,in contrast to C12Ester-TEMPO,C12Amino-TEMPO,and the conventional OFMs of GMO and stearic acid,C12Amide-TEMPO can form effective boundary films on iron oxide surfaces with a unique double-layer structure:a strong surface adsorption layer owing to the chemical interactions of the amide oxygen and free radical with iron oxide surfaces,and an upper layer owing to the interlayer hydrogen-bonding between the amide hydrogen and free radical or between the amide hydrogen and ***,the intralayer hydrogen-bonding in each of the two layers is also *** suggest that in addition to strong surface adsorption,the interlayer and intralayer hydrogen-bonding also increases the strength of the boundary films by enhancing the cohesion strength,thereby resulting in the high tribological performance of *** findings in this study are expected to provide new hints for the optimal molecular design of OFMs.

关键词： organic friction modifiers(OFMs) TEMPO friction and wear surface adsorption molecular reactivity boundary lubrication

HYDRATION AND PHASE SEPARATION OF TEMPERATURE-SENSITIVE WATER-SOLUBLE POLYMERS

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Chinese Journal of Polymer Science 2011年第1期29卷 13-21页

作者： Fumihiko Tanaka Tsuyoshi koga Hiroyuki Kojima Francoise M.Winnik Department of Polymer Chemistry Graduate School of EngineeringKyoto University Department of Chemistry and Faculty of Pharmacy University of Montréal

Collapse of a poly（N-isopropylacrylamide）（PNIPAM） chain upon heating and phase diagrams of aqueous PNIPAM solutions with very fiat LCST phase separation line are theoretically studied on the basis of cooperative dehydration （simultaneous dissociation of bound water molecules in a group of correlated sequence）, and compared with the experimental observation of temperature-induced coil-globule transition by light scattering methods. The transition becomes sharper with the cooperativity parameter σ of hydration. Reentrant coil-globule-coil transition in mixed solvent of water and methanol is also studied from the viewpoint of competitive hydrogen bonds between polymer-water and polymer-methanol. The downward shift of the cloud-point curves （LCST cononsolvency） with the mole fraction of methanol due to the competition is calculated and compared with the experimental data. Aqueous solutions of hydophobically-modified PNIPAM carrying short alkyl chains at both chain ends （telechelic PNIPAM） are theoretically and experimentally studied. The LCST of these solutions is found to shift downward along the sol-gel transition curve as a result of end-chain association （association-induced phase separation）, and separate from the coil-globule transition line. Associated structures in the solution, such as flower micelles, mesoglobules and higher fractal assembly, are studied by USANS with theoretical modeling of the scattering function.

关键词： Cooperative dehydration LCST phase separation Poly(N-isopropylacrylamide) Cononsolvency Coil-globule transition Flower micelle.

Spin Interference in Rectangle Loop Based on Rashba and Dresselhaus Spin-Orbit Interactions

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Chinese Physics Letters 2009年第12期26卷 210-212页

作者：倪佳婷梁小婉陈斌 T.koga Department of Physics Hangzhou Normal University Hangzhou 310018 Department of Physics Oklahoma State University Stillwater 74075 USA Zhejiang Economic and Trade Polytechnic Hangzhou 310036 Division of Electronics for Informatics Graduate School of Information Science and Technology Hokkaido University N-14 W-9 Kita-ku Sapporo Hokkaido 060-0814 Japan CREST Japan Science and Technology Agency 4-1-8 Honchou Kawaguchi Saitama 332-0012 Japan

We demonstrate the amplitude and spin polarization of AAS oscillation changing with Rashba spin-orbit interaction （SOI） and Dresselhaus SOI. The amplitude and spin polarization of AB oscillation changing with Rashba SOI and Dresselhaus SOI are demonstrated as well. The ideal quasi-one-dimensional square loop does not exist in reality, therefore to match the experiment better we should consider the shape of the rectangle loop in theory.

关键词： Chinese climate network complex systems small world community