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一位难以捉摸的建筑师

城市环境设计 2023年第1期141卷 28-31页

作者：原田麻鱼王惠波韩莹 MOUNT FUJI ARCHITECTS STUDIO 早稻田大学建筑系

古谷老师是个很难捉摸的人。不拘于世俗，性格开朗，关怀备至。虽然偶尔会发出尖锐的评论，但却被温和的面容所融化而不会感到会伤害任何人。总是英姿飒爽地走着，本以为上去搭话会被无情地忽视，但是，对突然主动来向我搭话的这一行为...

古谷老师是个很难捉摸的人。不拘于世俗，性格开朗，关怀备至。虽然偶尔会发出尖锐的评论，但却被温和的面容所融化而不会感到会伤害任何人。总是英姿飒爽地走着，本以为上去搭话会被无情地忽视，但是，对突然主动来向我搭话的这一行为，令我很惊讶。这样的行为方式姑且不谈。说到建筑作品，就会关于用地、历史、经验、景观等侃侃而谈，并作以详细的解答。只是见一面的话，很难清晰地看出他作为建筑师的个性和特征。

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来源：博看期刊

PP242诱导多囊肾大鼠胆管上皮细胞自噬和凋亡的机制研究

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中国药理学通报 2018年第9期34卷 1218-1225页

作者：闫文帝李珍玲刘特思李玉姬原田宪一任香善延边大学肿瘤研究中心吉林延边133002 金泽大学医学部病理学教研室日本金泽9208640 延边大学医学院病理学教研室吉林延边133002

目的探讨mTORC1/2抑制剂PP242诱导多囊肾(polycystic kidney,PCK)大鼠胆管上皮细胞凋亡和自噬、抑制细胞增殖及胆管囊性扩张的分子机制。方法免疫组织化学染色法检测PCK大鼠胆管上皮细胞中p-mTOR和p-Akt的表达;WST-1比色法检测雷帕霉素... 详细信息

目的探讨mTORC1/2抑制剂PP242诱导多囊肾(polycystic kidney,PCK)大鼠胆管上皮细胞凋亡和自噬、抑制细胞增殖及胆管囊性扩张的分子机制。方法免疫组织化学染色法检测PCK大鼠胆管上皮细胞中p-mTOR和p-Akt的表达;WST-1比色法检测雷帕霉素和PP242对胆管上皮细胞增殖活性的抑制作用,以及LC3、Beclin-1基因沉默和自噬特异性抑制剂3-甲基腺嘌呤(3-methyladenine,3-MA)对细胞增殖的影响;蛋白免疫印迹法检测PP242对PI3K/Akt信号通路相关蛋白、自噬标识蛋白LC3和Beclin-1、cleaved caspase-3表达的影响;流式细胞术和ELISA法检测PP242对细胞凋亡的影响;免疫荧光染色法检测LC3在细胞质中的表达情况;3D细胞培养检测Rictor基因沉默和雷帕霉素联用及雷帕霉素单独应用时对大鼠胆管上皮细胞成球能力的影响。结果 p-mTOR和p-Akt在PCK大鼠胆管上皮细胞中呈过表达,PP242比雷帕霉素抑制胆管上皮细胞增殖效果更为明显,且呈浓度和时间依赖性改变(P <0. 05); PP242明显抑制PI3K/Akt信号通路相关蛋白的表达; PP242可诱导细胞凋亡和自噬,上调cleaved caspase-3、Beclin-1和LC3-Ⅱ/LC3-Ⅰ比值。Rictor基因沉默和雷帕霉素联用比雷帕霉素单独应用对大鼠胆管上皮细胞的抑制作用更为明显; LC3、Beclin-1基因沉默和3-MA均可明显减弱PP242对细胞增殖的抑制作用(P <0. 05)。结论 PP242可通过PI3K/Akt/mTOR信号通路抑制PCK大鼠胆管上皮细胞的增殖,其机制与细胞凋亡和自噬密切相关。

关键词：自噬凋亡 PI3K/Akt/mTOR信号通路多囊肾大鼠 PP242 Caroli病

Research on Treatment Technology for the Industrial Wastewaters with High Concentrationin China

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Engineering Sciences 2005年第4期 70-75页

作者： Sun Peishi~1,Qian Biao~2,Hong Pinjie~1,harada Yoshiaki~3,Yang Ying~2,Hao Yukun~2(1.Yunnan University, Kunming 650091 2. Environmental Engineering Technology Research Center of Kunming City, Kunming 650032 3.Osaka Gas Co. Ltd, Osaka 554, Japan.)

By using the introduced CWO technology and its 200 L/d plant, more than 10 kinds of industrial wastewaters with high concentration in China, such as the waste liquor of coking, the black liquor of paper making, the waste mother liquor of bio-pharmacy and so on, were treated in this test research. The results showed that the CWO technology and its equipment had a good applicability for treating the industrial wastewaters with high concentration in China. One set of CWO-20 m3/d industrial plant, as a demonstration engineering installation of CWO technology, was independently designed, made and operated in Kunming city. During the running test, the CWO-20 m3/d plant displayed a favorable treatment capability for the bio-degradedly difficult industrial wastewaters with high concentration. For the treatment of the waste liquor from coking and the black liquor of paper making, more than 99% of CODcr and NH3-N in the wastewater could be removed. The CWO-20 m3/d plant could be run continuously and stably. The treated wastewater could meet the discharge standard and the treatment process with CWO technology shown up a good economic advantage.

关键词： catalytic wet oxidation process (CWO) industrial wastewaters with high concentration technology process

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中国蝙蝠核型研究的现状

广州大学学报（自然科学版） 2004年第6期3卷 504-509页

作者：吴毅杨俊慧原田正史广州大学生物与化学工程学院广东广州510405 大阪市立大学医学部动物实验中心

对中国蝙蝠核型研究的现状进行了分析和研究,在已发表的22篇研究论文中,报道了39种蝙蝠的核型,中国尚有约60％以上的蝙蝠种类未进行核型分析.针对已发表研究论文中存在部分种类鉴定有误、图表欠准确合理和研究方法待改进等问题,提出... 详细信息

对中国蝙蝠核型研究的现状进行了分析和研究,在已发表的22篇研究论文中,报道了39种蝙蝠的核型,中国尚有约60％以上的蝙蝠种类未进行核型分析.针对已发表研究论文中存在部分种类鉴定有误、图表欠准确合理和研究方法待改进等问题,提出了改进研究方法等建议,对提高我国蝙蝠研究水平和核型研究论文的质量有较重要的意义.

关键词：蝙蝠核型染色体

BENEFICIAL EFFECT OF A CONTROLLED HERBAL REMEDY, K-17.22, IN CCL4-INDUCED LIVER TOXICITY

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BENEFICIAL EFFECT OF A CONTROLLED HERBAL REMEDY, K-17.22, IN...

The Second International Symposium on Natural Antioxidants: Molecular Mechanisms and Health Effects

作者： F.Marotta A.Rouge H.Anzulovic M.harada G.M.IdéoGI Dept., S. G. Hosp. K.Kajikawa N.Yanaihara G.Princess G.Idéo. GI Dept. S. G. Hosp. α-Ω Tech α-Ω Tech MCH Hosp. MCK Hosp. Yanaihara Institute. α-Ω Tech GI Dept. S. G. Hosp.

Recently, it has been devised an herbal formula (Yojyo-Henshiko: K-17.22, Kyotsu Inc., Tokyo, Japan), obtained from selective control of the processing preparation and which has been shown in preliminary clinical tests to significantly decrease transaminases level in HCV-positive chronic liver disease patients. The aim of this study was to test K-17.22 in

关键词： CCL BENEFICIAL EFFECT OF A CONTROLLED HERBAL REMEDY IN CCL4-INDUCED LIVER TOXICITY K-17.22

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曲线长椅

设计 2013年第1期26卷 33-33页

作者： Jacob Chikako harada

这款由Lincoln Kayiwa所设计的JOKI长椅不只是有性感的弧度，同时也完全符合人体工学。长椅材质为桦木板，“JOKI”是芬兰语中河流的意思，也是Kayiwa的灵感来源。JOKI长凳的外形，充满女性身体的曲线美，但这种设计并非是为了外形，而... 详细信息

这款由Lincoln Kayiwa所设计的JOKI长椅不只是有性感的弧度，同时也完全符合人体工学。长椅材质为桦木板，“JOKI”是芬兰语中河流的意思，也是Kayiwa的灵感来源。JOKI长凳的外形，充满女性身体的曲线美，但这种设计并非是为了外形，而是从功能性出发。

关键词：曲线长人体工学曲线美设计外形

广东省南岭新纪录种中管鼻蝠的形态测量、核型及超声波数据

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动物学杂志 2011年第1期46卷 109-114,112-114页

作者：周全张燕均本川雅治原田正史龚粤宁李玉春吴毅广州大学华南生物多样性保护与利用重点实验室广州510006 京都大学综合博物馆大阪市立大学医学部动物实验中心南岭国家级自然保护区广东韶关512700 山东大学威海分校海洋学院威海264209

2009年9月在广东省南岭采集到5只森林型蝙蝠,其鼻孔突出成短管状,背部毛棕褐色,前臂长34.3～36.8 mm;核型为2n=44,FN=50。经鉴定为蝙蝠科管鼻蝠亚科的中管鼻蝠(Murina huttonii),为广东省翼手类分布新纪录。用蝙蝠超声波接收器(AnabatⅡ... 详细信息

2009年9月在广东省南岭采集到5只森林型蝙蝠,其鼻孔突出成短管状,背部毛棕褐色,前臂长34.3～36.8 mm;核型为2n=44,FN=50。经鉴定为蝙蝠科管鼻蝠亚科的中管鼻蝠(Murina huttonii),为广东省翼手类分布新纪录。用蝙蝠超声波接收器(AnabatⅡ)录制并分析其回声定位声波,为FM型。中管鼻蝠的染色体核型和回声定位声波均为首次报道。

关键词：蝙蝠中管鼻蝠新纪录广东南岭

G－CSF对化疗后外周血干细胞动员作用的影响

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中华血液学杂志 1994年第8期15卷 414-416页

作者：刘开彦原田实根新疆医学院第一附属医院

通过对１１例急性白血病患者单独化疗与化疗后加用粒细胞集落刺激因子（Ｇ－ＣＳＦ）的对比，动态观察了Ｇ－ＣＳＦ对外周血造血干细胞（ＰＢＳＣ）的动员作用。发现化疗后加用Ｇ－ＣＳＦ比单用化疗的粒－巨噬细胞集落形成单位（ＣＦＵ... 详细信息

通过对１１例急性白血病患者单独化疗与化疗后加用粒细胞集落刺激因子（Ｇ－ＣＳＦ）的对比，动态观察了Ｇ－ＣＳＦ对外周血造血干细胞（ＰＢＳＣ）的动员作用。发现化疗后加用Ｇ－ＣＳＦ比单用化疗的粒－巨噬细胞集落形成单位（ＣＦＵ－ＧＭ）增加５．１倍，红系爆式集落形成单位（ＢＦＵ－Ｅ）增加４．５倍。Ｇ－ＣＳＦ还可使ＣＦＵ－ＧＭ＞１００／ｍｌ和ＢＦＵ－Ｅ＞２００／ｍｌ的持续时间延长；化疗后ＣＦＵ－ＧＭ的最高值提早出现，而不影响ＢＦＵ－Ｅ／ＣＦＵ－ＧＭ比值。结果表明，化疗后加用Ｇ－ＣＳＦ可明显提高ＰＢＳＣ的收集效率，Ｇ－ＣＳＦ是一种有效的ＰＢＳＣ动员剂。

关键词：外周血干细胞白血病 G-CSF

Evaluation of an oral moisture-checking device for screening dry mouth

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Open Journal of Stomatology 2013年第8期3卷 440-446页

作者： Yosuke Fukushima Tetsuya Yoda Shoichiro Kokabu Ryuichiro Araki Tsubasa Murata Yoshimasa Kitagawa Ken Omura Shuji Toya Kayoko Ito Saori Funayama Hiroshi Iwabuchi Kazuhiro Asano Yutaka Imai Akihide Negishi Satoshi Yokoo Goichi Matsumoto Eiro Kubota Hideki Watanabe Mikio Kusama Kojiro Onizawa Takuya Goto Seiji Nakamura Ryuichi Nakazawa Kiyoshi harada Takashi Fujibayashi Community Health Science Center Saitama Medical University Saitama Japan Department of Dentistry and Oral Surgery Tochigi National Hospital Tochigi Japan Department of Oral and Maxillofacial Surgery Division of Medicine Interdisciplinary Graduate School of Medicine and Engi- neering Univer-sity of Yamanashi Kofu and Tamaho Japan Department of Oral and Maxillofacial Surgery Dokkyo Medical University School of Medicine Tochigi Japan Department of Oral and Maxillofacial Surgery Faculty of Medicine Sai-tama Medical University Saitama Japan Department of Oral and Maxillofacial Surgery Institute of Clinical Medicine University of Tsukuba Tsukuba Japan Department of Oral and Maxillofacial Surgery Jichi Medical University Tochigi Japan Department of Oral and Maxillofacial Surgery Kanagawa Dental College Yokosuka Japan Department of Stomatology and Oral Surgery Gunma University Graduate School of Medicine Maebashi Japan Division of Gereatric Dentistry Niigata University Medical & Dental Hospital Niigata Japan Oral and Maxillofacial Surgery Dry Mouth Clinic The Nippon Dental University Niigata Hospital Niigata Japan Oral Diagnosis and Medicine Department of Oral Pathobiological Science Graduate School of Dental Medicine Hokkaido University Sapporo Japan Oral Surgery Department of Oral Restitution Division of Oral Health Sciences Graduate School Tokyo Medical and Dental University Tokyo Japan Section of Oral and Maxillofacial Oncology Division of Maxillofacial Diagnostic and Surgical Sciences Faculty of Dental Science Kyushu University Fukuoka Japan

Objective: This multicenter clinical study was to assess the clinical usability of an oral moisture-checking device in detecting the dry mouth patients and evaluating the optimal measurement site. Materials and Methods: The study group comprised 250 patients with dry mouth and 241 healthy volunteer subjects at 13 medical centers. This device was used to measure the moisture degrees of the lingual mucosa and the buccal mucosa. Subjective oral dryness, objective oral dryness, and saliva flow rates were also compared between the two groups. For statistical analysis, receiver-operating characteristic analysis was performed to calculate the area under the curve (AUC). Results: The moisture degree of the lingual mucosa was significantly lower in the dry mouth group (27.2 ± 4.9) than that in the healthy group (29.5 ± 3.1, AUC = 0.653). When a lingual mucosa moisture degree of 31.0 or higher was defined as normal, less than 27.0 as dry mouth, and 27.0 to less than 31.0 as borderline zone of dry mouth, both the sensitivity and the specificity for the diagnosis of dry mouth were close to 80%. Conclusion: These results suggest that the oral moisture-checking device is a usable screening device for dry mouth.

关键词： Dry Mouth Oral Moisture-Checking Device ROC Analysis