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Significance of preoperatively observed detrusor overactivity as a predictor of continence status early after robot-assisted radical prostatectomy

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Asian Journal of Andrology 2014年第6期16卷 869-872页

作者： Akihiro Yanagiuchi hideaki Miyake Kazushi Tanaka Masato Fujisawa Division of Urology Kobe University Graduate School of Medicine 7-5-1 Kusunoki-Cho Chuo-Ku Kobe Japan.

Several recent studies have reported the involvement of bladder dysfunction in the delayed recovery of urinary continence following radical prostatectomy （RP）. The objective of this study was to investigate the significance of detrusor overactivity （DO） as a predictor of the early continence status following robot-assisted RP （RARP）. This study included 84 consecutive patients with prostate cancer undergoing RARP. Urodynamic studies, including filling cystometry, pressure flow study, electromyogram of the external urethral sphincter and urethral pressure profile, were performed in these patients before surgery. Urinary continence was defined as the use of either no or one pad per day as a precaution only. DO was preoperatively observed in 30 patients （35.7%）, and 55 （65.5%） and 34 （40.5%） were judged to be incontinent 1 and 3 months after RARP, respectively. At both 1 and 3 months after RARP, the incidences of incontinence in patients with DO were significantly higher than in those without DO. Of several demographic and urodynamic parameters, univariate analyses identified DO and maximal urethral closure pressure （MUCP） as significant predictors of the continence status at both 1 and 3 months after RARP. Furthermore, DO and MUCP appeared to be independently associated with the continence at both I and 3 months after RARP on multivariate analysis. These findings suggest that preoperatively observed DO could be a significant predictor of urinary incontinence early after RARP; therefore, it is recommended to perform urodynamic studies for patients who are scheduled to undergo RARP in order to comprehensively evaluate their preoperative vesicourethral functions.

关键词： detrusor overactivity robot-assisted radical prostatectomy urinary incontinence

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A potential new tool to enhance translational success rate in stroke research by backcrossing techniques in transgenic mice

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Neural Regeneration Research 2023年第1期18卷 107-108页

作者： Takayuki Nakagomi hideaki Nishie Toshinori Sawano Akiko Nakano-Doi Institute for Advanced Medical Sciences Hyogo College of MedicineHyogoJapan Department of Therapeutic Progress in Brain Diseases Hyogo College of MedicineHyogoJapan Department of Biomedical Sciences Ritsumeikan UniversityShigaJapan

Ischemic stroke is a leading disease of the central nervous system,frequently coupled to severe damage and dysfunction in *** models mimicking human stroke provide useful tools for studying the pathomechanisms(e.g.,inflammation,neuroprotection,and neural regeneration),the treatment efficiency of various materials(e.g.,bioactive molecules or drugs),and transplantation usefulness by various cell types[e.g.,neural stem/progenitor cells(NSPCs),and mesenchymal or hematopoietic stem cells]under ischemic stroke.

关键词： inflammation damage neural

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Infrequent p53 gene mutation and expression of the cardia adenocarcinomas from a high-incidence area of Southwest China

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World Journal of Gastroenterology 2000年第5期6卷 750-753页

作者： Naoko lida hideaki Oda Shigetoshi Aiso Takatoshi Ishikawa Department of Molecular Pathology Faculty of Medicinethe University of TokyoHongoTokyo 113Japan

INTRODUCTIONAdenocarcinomas of the cardia are the lesionsarising from the proximal stomach or within 3 cm ofthe gastroesophageal *** cancerstended to be advanced at the time of presentation,usually with poor *** recent decade,the incidence of adenocarcinoma of gastric eardiaand esophagus are increasing steadily,while therehas been a decrease in the proportion of the cancersarising from the distal ***

关键词： cardia adenocarcinoma/etiology protein P53 gene expression mutation genes p53 polymerase chain reaction DNA risk factors

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Numerical simulations for describing generation of excavation damaged zone: Important case study at Horonobe underground research laboratory

Rock Mechanics Bulletin

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Rock Mechanics Bulletin 2023年第3期2卷 57-65页

作者： Sho Ogata hideaki Yasuhara Osaka University Suita565-0871Japan Kyoto University Kyoto615-8540Japan

The aim of the present research was to establish a case study for the prediction of the unknown EDZ(Excavation Damaged Zone)distribution using a numerical analysis calibrated by replicating the trends in the EDZ observed from one of the representative underground research fields in Japan(Horonobe URL).In this study,a 2D numerical analysis using a damage model,which can determine rock deformation and fracturing simultaneously,is *** was calibrated to reproduce the excavation of the gallery at the Horonobe URL at a depth of 350 *** results show an excellent agreement with the extent of the measured EDZ and capture the failure modes of EDZ fractures suggested by the in-situ ***,the calibrated numerical analysis was used to realistically estimate the EDZ formation for the geological disposal of high-level radioactive waste(HLW)under the same environment as that of the above-mentioned galley at the Horonobe ***,it was shown that the tensile/shear hybrid fractures dominantly constituted the EDZ and propagated to a maximum extent of about 0.3 m from the cavity wall during the cavity excavation for the HLW ***,the calibrated numerical analysis and resulting estimations,targeted for the environment at the depth of 350 m at the Horonobe URL,where mudstone is located,should be useful for predicting the trends in the EDZ distribution expected in the implementation of HLW disposal projects under deep geological conditions,such as those that exist in Japan,which are dominated by sedimentary rocks,including mudstone。

关键词： Generation of rock fracture Excavation damaged zone Mudstone Horonobe underground research laboratory Damage model

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Effect of bent inlet pipe on the flow instability behavior of centrifugal compressors

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Chinese Journal of Aeronautics 2020年第8期33卷 2099-2109页

作者： Zhenzhong SUN Baotong WANG Xinqian ZHENG Tomoki KAWAKUBO hideaki TAMAKI Ryuusuke NUMAKURA Department of Aerodynamics and Thermodynamics Institute for Aero EngineTsinghua UniversityBeijing 100084China Corporate Research&Development IHI CorporationYokohama 235-8501Japan State Key Laboratory of Automotive Safety and Energy School of Vehicle and MobilityTsinghua UniversityBeijing 100084China

Bent inlet pipes are often used in centrifugal compressors due to limited installation space,and an understanding of the effect on compressor stability is essential for safety and *** paper firstly investigates flow instability behaviors in two compressors,one with a straight inlet pipe and the other with an S-shaped bent *** detail,it analyzes the resulting flow fields,instability evolution paths and surge *** results show that the S-shaped pipe obviously affects the flow field at high mass flow rates,while reverse flow mainly influences the flow field at low mass flow *** flow first occurs at certain flow passages with a high pressure difference that is predominantly decided by the volute rather than the S-shaped bent *** addition,centrifugal compressors can tolerate reverse flow to some extent so that surge would not occur immediately if reverse flow occurs unless the reverse flow region extends circumferentially and radially to a sufficiently large *** the S-shaped pipe is not dominant in the creation and extension of reverse flow,it does not exacerbate the stability of the central compressor to a great *** but not least,the S-shaped pipe is noted to delay the occurrence of surge at 90%rotating speed,which suggests the possibility of improving compressor stability with bent inlet *** result differs from the conventional understanding that inlet distortion usually deteriorates compressor stability and emphasizes the particularity of centrifugal compressors.

关键词： Bent pipe Centrifugal compressor Flow field Flow instability Surge boundary

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Coordinated control between a grid forming inverter and grid following inverters suppling power in a standalone microgrid

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Global Energy Interconnection 2022年第3期5卷 259-265页

作者： Junichi Arai Yasuhiro taguchi Kogakuin University 1-24-2 Nishi-ShinjukuShinjukuTokyo 163-8677Japan Energy and Environment Technology Research Institute 1-22-2 Nishi-Waseda ShinjukuNishi-Waseda East Wing 106Tokyo 169-0051Japan

Battery energy storage systems,fuel cells,and photovoltaic generators are being adopted in distribution networks to achieve CO;emission *** power sources require inverters to connect to AC ***,sub-networks,such as a microgrids containing inverter power sources,may be disconnected from the utility network and operated in a standalone mode during extended *** study focuses on a standalone microgrid supplied by inverter power sources without a synchronous generator and proposes a new microgrid inverter *** this inverter control,a single grid forming inverter is operated as a master power source to determine frequency and voltage,and other inverters,called grid following inverters,are operated as subordinate power sources with active and reactive power *** necessary functions in the energy management system are examined,and the coordinated operation of all inverters in the microgrid is demonstrated via simulation.

关键词： Inverter control Microgrid Standalone operation Energy management system Grid forming inverter Grid following inverter

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A novel experimental method to evaluate the impact of volute's asymmetry on the performance of a high pressure ratio turbocharger compressor

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Science China(Technological Sciences) 2012年第6期55卷 1695-1700页

作者： LIN Yun ZHENG XinQian JIN Lei TAMAKI hideaki KAWAKUBO Tomoki State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China IHI Corporation TokyoJapan

All components of a turbocharger compressor are axisymmetric except for the spiral-shaped,gas-collecting overhung *** this paper,a novel experimental method to evaluate the impact of the volute's asymmetry on centrifugal compressor performance is proposed and applied to a high pressure-ratio turbocharger *** method can isolate the impact of the volute's asymmetry on the compressor performance for the first *** prove the considerable impact of the volute's asymmetry on the compressor performance,especially the stability and *** impact of the volute's asymmetry on compressor stability correlates with rotational speed and thus with the pressure ratio,constricting the stable flow range by up to 47 percent and decreasing the maximum efficiency by 4.8 percent at the design *** results provide evidence to exploit the potential of intrinsic non-axisymmetric flow induced by asymmetric volute to improve the performance of turbocharger compressor with a high pressure ratio.

关键词： high pressure-ratio turbocharger centrifugal compressor volute IC engine

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Quantitative Analysis of the Removal Ratio of Fine Particles in Water by Gas Bubbling

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Journal of Iron and Steel Research International 2011年第S2期18卷 331-334页

作者： Masafumi Miyazaki hideaki Yamamura Satoru Mineta Takehiko Toh Environment & Process Technology Center Technical Development Bureau Nippon Steel Corp. Japan Advanced Technology Research Lab. Technical Development Bureau Nippon Steel Corp. Japan

Removal of non-metallic inclusions in molten steel is important from the viewpoint of improvement of quality, property and yield of the products. As a removal method of inclusions from molten metal, gas bubble flotation adhering inclusions is well known. Gas bubbling is particularly effective for the removal of fine inclusions. Water model experiment is reported the quantitative analysis of the removal ratio of dispersed particles removed from water by gas bubbles.

关键词： inclusion gas bubble water model experiment removal constant collision attachment

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Control of Snow Falling Flow around NACA0015 Blade using a Plasma Electrode with Weather Resistant Design

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Journal of Thermal Science 2022年第1期31卷 72-81页

作者： MATSUDA Hisashi CHIBA Takahiro YAGAMI Masaki TAJIMA Yusuke WATANABE Nobuyoshi SATO hideaki TAKEYAMA Masafumi Hokkaido University of Science Hokkaido 006-8585Japan Asahi Rubber Inc. Saitama 330-0801Japan

The plasma actuation (PA) effect on the snow falling flow was investigated using a plasma electrode with weather resistant design and the natural snow wind facility of the Hokkaido University of Science. NACA0015 test blade with chord length c of 300 mm was used. Wind tunnel tests were carried out under the angle of the attack of the blade was fixed at 15 degrees, and the main flow velocity is U=5 m/s. PIV (Particle image velocimetry) measurements were conducted on various PA conditions using natural dry snowflakes as a tracer. When the actuator was driven under the condition of the fundamental frequency of F=50 kHz, and the pulsed modulated frequency f of fc/U=1 and Duty ratio (Ratio of plasma ON time to pulse duration time) =1%, movement of snowflakes was controlled the most effectively tested. It was clarified that the fundamental frequency of PA also affects the control of snow flow. Under snowfall conditions, the weather resistant designed plasma electrode has suffered no damage and operated successfully.

关键词： plasma actuator weather resistant design snow falling flow control experiment PIV

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STING palmitoylation as a therapeutic target

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Cellular & Molecular Immunology 2019年第3期16卷 236-241页

作者： Anne Louise Hansen Kojiro Mukai Francisco J.Schopfer Tomohiko taguchi Christian K.Holm Department of Biomedicine Aarhus University8000 Aarhus CDenmark Laboratory of Organelle Pathophysiology Department of Integrative Life SciencesGraduate School of Life SciencesTohoku UniversitySendai 980-8578 MiyagiJapan Department of Pharmacology and Chemical Biology University of PittsburghPittsburghPA 15213USA

Gain-of-function mutations in the STING-encoding gene TMEM173 are central to the pathology of the autoinflammatory disorder STING-associated vasculopathy with onset in infancy(SAVI).Furthermore,excessive activity of the STING signaling pathway is associated with autoinflammatory diseases,including systemic lupus erythematosus and Aicardi–Goutières syndrome(AGS).Two independent studies recently identified pharmacological inhibitors of ***,both types of compounds are reactive nitrocontaining electrophiles that target STING palmitoylation,a posttranslational modification necessary for STING *** a consequence,the activation of downstream signaling molecules and the induction of type I interferons were *** compounds were effective at ameliorating inflammation in a mouse model of AGS and in blocking the production of type I interferons in primary fibroblasts from SAVI *** mini-review focuses on the roles of palmitoylation in STING activation and signaling and as a pharmaceutical target for drug development.

关键词： STING Palmitoylation Inflammation SAVI Interferonopathies

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