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Ecological surveys of the Cryptococcus species complex in China

Chinese Medical Journal 2012年第3期000卷 511-516页

作者： Li An-sheng Pan Wei-hua Wu Shao-xi hideaki, taguchi Guo Ning-ru Shen Yong-nian Lu Gui-xia Pan Ru-gui Zhu Miao-chang Chen Min Shi Wei-ming Liao Wan-qing Chinese Acad Med Sci Inst Dermatol Nanjing 210042 Jiangsu Peoples R China Second Mil Med Univ Shanghai Key Lab Mol Med Mycol Inst Dermatol & Mycosis Changzheng Hosp Shanghai 200003 Peoples R China Chiba Univ Med Mycol Res Ctr Chiba Japan Chinese Acad Sci Nanjing 210014 Jiangsu Peoples R China Jiangxi Guixi Forest Bur Guixi 335400 Jiangxi Peoples R China Shanghai Jiao Tong Univ Dept Dermatol Peoples Hosp 1 Shanghai 200080 Peoples R China

Background Despite recent reports on the molecular epidemiology of cryptococcal infections in China,clinical isolates have been mostly reported from human immunodeficiency virus （HIV）-negative patients,and environmental isolates from China have rarely been *** aim of this study was to investigate the ecological profile of Cryptococcus （C.）neoformans and *** in *** A survey was performed in 10 cities from 20°N （North latitude） to 50°N and in a Eucalyptus （E.） camaldulensis forestry farm at the Guixi forestry center,*** Six hundred and twenty samples of pigeon droppings from 10 cities and 819 *** tree samples were collected and inoculated on caffeic acid cornmeal agar （CACA）.The brown-colored colonies were recultured to observe their morphology,growth on canavanine-glycine-bromothymol-blue （CGB） medium,phenol oxidase and urease activities,serotype and mating *** were obvious differences in the positive sample rates of *** in pigeon droppings collected from the different cities,ranging from 50% in the cities located at latitudes from 30°N-40°N,29% at 20°N-30°N and 13% at 40°N-50°*** There were no differences in positive bevy rates （approximately 80%） among the three grouped *** tests of 101 isolates purified from pigeon droppings revealed that they were *** *** also observed variable capsular size around the *** cells in colonies with variable melanin production and the bio-adhesion of the natural *** cells with other *** urease-negative *** isolatewas isolated from pigeon droppings in Jinan *** *** isolated in this study.

关键词： Cryptococcus neoformans Cryptococcus gattii ecology

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<i>Rhizopus oryzae</i>Retro-Orbital Abscess: Comparison of Spores and Hyphae Antifungal Susceptibility and Clinical Outcome

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Open Journal of Medical Microbiology 2018年第1期8卷 1-11页

作者： Adenilza Cristina S. Fonseca Ana Beatriz A. Teixeira-Loyola Luzia Lyra Ariane F. Busso Yasunori Muraosa hideaki taguchi Maria Luiza Moretti Angélica Z. Schreiber Clinical Pathology Department School of Medical Sciences University of Campinas Campinas Brazil Sapucai Valley University Pouso Alegre Brazil Infectious Diseases Division School of Medical Sciences University of Campinas S&atilde o Paulo Brazil Medical Mycology Research Chiba University Chiba Japan

Rhizopus is fungus of the order Mucorales, responsible for invasive diseases called mucormycosis. The correct identification of these fungi is one of the main questions raised in the literature since the diagnosis is not simple, being the necessary detection in biopsies of infected tissues and isolation of the microorganism for identification by morphological and molecular methods. In vitro susceptibility testing results are not fully clear since there are reports showing that in vitro resistance does not always mean therapeutic failure. This paper describes a case of rhino-orbito-cerebral mucormycosis in a patient with alcoholic chronic pancreatitis and secondary mellitus diabetes involving microbiological diagnostic, antifungal susceptibility tests for conidia and hypha and clinical correlation. The causative agent was identified by morphological characteristics and DNA sequencing. Minimal Inhibitory Concentration (MIC) for amphotericin B (AMB), itraconazole (ITZ) and terbinafine (TERB) was determined by broth microdilution method. Standardization of the dynamic growth evaluation patterns using the automated system BCT (BioCell-Tracer?) was obtained allowing to determining hyphae growth control and evaluating the effect of different concentrations of amphotericin B, itraconazole and terbinafine directly on growing hyphae. The fractional inhibitory concentration (FIC) for the combination of the two antifungals that the patient received at the same time, terbinafine and itraconazole, was also determined trying to correlate with clinical outcome. Strains isolated of retro-orbital abscess were identified as Rhizopus oryzae. MIC results (MIC) testing conidia showed high sensibility to amphotericin B and itraconazole in comparison to the obtained for terbinafine. The tests in the automated system BCT using hyphae showed sensibility to all tested antifungal agents and the FIC results for combination in vitro between terbinafine and itraconazole showed synergism consisten

关键词： Antifungal Susceptibility Testing Mucorales Terbinafine Amphotericin B Itraconazole

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Optical Wavelength Filter Using Mode Conversion in Multimode Waveguide

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光学学报 2003年第S1期23卷 291-292页

作者： Toru taguchi hideaki Okayama Kohji Furuhashi Hirochika Nakajima School of Science and Technology Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 JapanSchool of Science and Technology Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 JapanOCC Oki Electric Industry Co. Ltd.School of Science and Technology Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 JapanSchool of Science and Technology Waseda University 3-4-1 Ohkubo Shinjyuku-ku Tokyo 169-8555 Japan

A wavelength filter with simple structure using multimode waveguide is proposed. The device uses mode conversion by a grating structure fabricated simultaneously with the multimode waveguide.

关键词： mode on length Optical Wavelength Filter Using Mode Conversion in Multimode Waveguide in BPM for high

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Designer enzyme for green materials innovation： Lactatepolymerizing enzyme as a key catalyst

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Frontiers of Chemical Science and Engineering 2017年第1期11卷 139-142页

作者： Seiichi taguchi Graduate School of Engineering Hokkaido University Hokkaido 060-0808 Japan JST CREST 5 Sanbancho Chiyoda-ku Tokyo 102-0075 Japan

Establishment of the regeneratable whole-cell catalyst platform for the production ofbiobased polymeric materials is a typical topic of synthetic biology. In this commentary, discovery story of a ＂lactate-polymerizing enzyme＂（LPE） and LPE-based achievements for creating a new variety of polyesters with incorporated unnatural monomers are presented. Besides the importance of microbial platform itself is discussed referring to the ＂ballooning＂-Escherichia coli.

关键词： synthetic biology enzyme evolutionary engi-neering polyhydroxyalkanoate

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Verification of Subseasonal-to-Seasonal Forecasts for Major Stratospheric Sudden Warmings in Northern Winter from 1998/99 to 2012/13

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Advances in Atmospheric Sciences 2020年第3期37卷 250-258页

作者： Masakazu taguchi Department of Earth Science Aichi University of Education

This study reports verification results of hindcast data of four systems in the subseasonal-to-seasonal(S2S)prediction project for major stratospheric sudden warmings(MSSWs)in northern winter from 1998/99 to 2012/*** report deals with average features across all MSSWs,and possible differences between two MSSW types(vortex displacement and split types).Results for the average features show that stratospheric forecast verifications,when further averaged among the four systems,are judged to be successful for lead times around 10 d or *** systems are skillful for lead times around 5 d,whereas the results vary among the systems for longer lead times.A comparison between the MSSW types overall suggests larger forecast errors or lower skill for MSSWs of the vortex split type,although the differences do not have strong statistical significance for almost all *** limitation is likely to at least partly reflect the small sample size of the MSSWs available.

关键词： major stratospheric sudden warmings forecast verification subseasonal-to-seasonal prediction project vortex displacement and split warmings

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An extended computational approach for point-defect equilibria in semiconductor materials

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npj Computational Materials 2022年第1期8卷 746-756页

作者： Takafumi Ogawa Ayako taguchi Akihide Kuwabara Nanostructures Research Laboratory Japan Fine Ceramics Center2-4-1 MutsunoAtsuta-kuNagoya456-8587Japan

Concentrations of intrinsic and extrinsic point defects in crystalline materials with a bandgap are typically calculated in a constant-μapproach from defect formation energies based on density functional *** this work,calculations of thermal and charge equilibria among point defects are extended to a constant-N *** two approaches for point-defect equilibria are comparatively demonstrated in the application to Mg_(2)Si doped with Li,Na,and Ag,which is a lightweight and environmentally friendly thermoelectric candidate *** results reveal the systematic behavior of defect and carrier *** dopant atoms form interstitial defects at similar concentrations to substitutional defects at the Mg sites,resulting in significantly reduced free-carrier concentrations compared to the expected *** developed procedures could be utilized to find an optimal avenue for achieving higher carrier concentrations,e.g.,with regard to annealing temperature and the concentration of dopant atoms,in various semiconductors and insulators.

关键词： defect equilibria point

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Yield of OH radicals in water under heavy ion *** on mass,specific energy,and elapsed time

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Nuclear Science and Techniques 2007年第1期18卷 35-38页

作者： Mitsumasa taguchi Takuji KOJIMA Organic Pollutant Removal Technology Group Japan Atomic Energy Agency1233 WatanukiTakasakiGunma370-1292 Japan

Dependence of yields of OH (hydroxyl) radicals on the mass and specific energy of heavy ions and elapsed time after irradiation was investigated,to understand chemical reactions of aqueous *** yields of irradiation products of phenol,super-linearly increased with the incident energy of He,C,and Ne ions ranging from 2 to 18 MeV/*** yields of the OH radicals were estimated by analyzing the yields of the irradiation products of phenol. The yields of the OH radicals increased with the specific energy for each ion,but decreased both with the mass of each ion at the same specific energy and elapsed time after irradiation.

关键词：重离子辐射水辐射分解羟自由基产率质量耗用时间

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Comparative Gene Expression Analysis of Mouse and Human Cardiac Maturation

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 207-215页

作者： Hideki Uosaki Y-h taguchi Division of Cardiology The Johns Hopkins University School of Medicine Department of Physics Chuo University

Understanding how human cardiomyocytes mature is crucial to realizing stem cell-based heart regeneration, modeling adult heart diseases, and facilitating drug discovery. However, it is not feasible to analyze human samples for maturation due to inaccessibility to samples while cardiomyocytes mature during fetal development and childhood, as well as difficulty in avoiding variations among individuals. Using model animals such as mice can be a useful strategy; nonetheless, it is not well-understood whether and to what degree gene expression profiles during maturation are shared between humans and mice. Therefore, we performed a comparative gene expression analysis of mice and human samples. First, we examined two distinct mice microarray platforms for shared gene expression profiles, aiming to increase reliability of the analysis. We identified a set of genes displaying progressive changes during maturation based on principal component analysis. Second, we demonstrated that the genes identified had a differential expression pattern between adult and earlier stages （e.g., fetus） common in mice and humans. Our findings provide a foundation for further genetic studies of cardiomyocyte maturation.

关键词： Cardiac maturation Comparative gene expressionanalysis Microarray meta analysis Principal component analysis Feature selection

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PROFESSOR BRITTON CHANCE AND THE EARLY TIMES HE LIVED

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 215-219页

作者： hideaki KOIZUMI Hitachi Ltd.

*** Professor Britton Chance passed away on November 16,*** on July 24,1913,he was 97 years old when he died.I was honored to have had the opportunity to meet Professor Chance and have friendly conversation at the ear... 详细信息

关键词： Chance passed conversation

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Rebuilding insight into the pathophysiology of Alzheimer’s disease through new blood-brain barrier models

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Neural Regeneration Research 2024年第9期19卷 1954-1960页

作者： Kinya Matsuo hideaki Nshihara Yamaguchi University Graduate School of Medicine YamaguchiJapan Department of Neurotherapeutics Yamaguchi UniversityUbeJapan

The blood-brain barrier is a unique function of the microvasculature in the brain parenchyma that maintains homeostasis in the central nervous ***-brain barrier breakdown is a common pathology in various neurological diseases,such as Alzheimer’s disease,stroke,multiple sclerosis,and Parkinson’s ***,it has been considered a consequence of neuroinflammation or neurodegeneration,but recent advanced imaging techniques and detailed studies in animal models show that blood-brain barrier breakdown occurs early in the disease process and may precede neuronal ***,the blood-brain barrier is attractive as a potential therapeutic target for neurological diseases that lack effective *** elucidate the molecular mechanism underlying blood-brain barrier breakdown and translate them into therapeutic strategies for neurological diseases,there is a growing demand for experimental models of human origin that allow for functional ***,several human induced pluripotent stem cell-derived blood-brain barrier models have been established and various in vitro blood-brain barrier models using microdevices have been *** in the Alzheimer’s disease field,the human evidence for blood-brain barrier dysfunction has been demonstrated and human induced pluripotent stem cell-derived blood-brain barrier models have suggested the putative molecular mechanisms of pathological blood-brain *** this review,we summarize recent evidence of blood-brain barrier dysfunction in Alzheimer’s disease from pathological analyses,imaging studies,animal models,and stem cell ***,we discuss the potential future directions for blood-brain barrier research.

关键词： Alzheimer’s disease blood-brain barrier human induced pluripotent stem cells

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