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Autonomic Dysreflexia Severity between Urodynamics and Cystoscopy in Patients with Spinal Cord Injury above T6

International Journal of Clinical Medicine 2021年第8期12卷 351-356页

作者： heyi Zhen Tianhai Huang Xiaoyi Yang Qiuling liu Qingqing li Maping Huang Hui Chen Department of Traumatic Brain Injury Rehabilitation Guangdong Province Work Injury Rehabilitation Hospital Guangzhou China Department of Urology Guangdong Provincial Work Injury Rehabilitation Hospital Guangzhou China

Objective: The objective is to evaluate autonomic dysreflexia (AD) severity between urodynamics and cystoscopy in patients with spinal cord injury (SCI) above thoracic 6 (T6). Design: It is a cross-sectional survey. Subject and methods: The study was carried out in 22 patients with SCI above T6 who underwent both procedures of urodynamics and cystoscopy;all patients developed episodes of AD. The systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured and recorded at the beginning and during the various stages of the two examinations. AD was defined as a rise in SBP above 20 mm Hg. Results: There was no significant difference in SBP and DBP at baseline before urodynamics and cystoscopy. Both urodynamics and cystoscopy triggered episodes of AD. The volume of water instilled during cystoscopy was typically standard and smaller (150 mL) in comparison with urodynamics, where volume varied depending on cystometric bladder capacity (the mean bladder volume in our study was 234.86 ± 139.06 mL). The SBP was significantly different between cystoscopy and urodynamics (49.23 ± 23.07 mm Hg and 35.14 ± 15.75 mm Hg, respectively;P = 0.023). Conclusions: Although bladder distension during cystoscopy was less than that in urodynamics, the severity of AD was more pronounced during cystoscopy. It is recommended that monitoring of cardiovascular parameters during these procedures should be routinely performed.

关键词： Autonomic Dysreflexi Spinal Cord Injury Urodynamics Cystoscopy

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Combined Detrusor and External Urethral Sphincter BTX-A Injections for Detrusor Overactivity and Detrusor External Sphincter Dyssynergia Secondary to Spinal Cord Injury

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Open Journal of Urology 2021年第2期11卷 45-51页

作者： Maping Huang heyi Zhen Tianhai Huang Xiaoyi Yang Qiuling liu Qingqing li Hui Chen Department of Urology Guangdong Provincial Work Injury Rehabilitation Hospital Guangzhou China Department of Traumatic Brain Injury Rehabilitation Guangdong Province Work Injury Rehabilitation Hospital Guangzhou China

Objective: To evaluate the efficacy and safety of Combined detrusor and external urethral sphincter BTX-A injections for detrusor overactivity (DO) and detrusor external sphincter dyssynergia (DESD) secondary to spinal cord injury. Study Design: Prospective study. Methods: The study was carried out in 18 SCI patients with detrusor overactivity (DO) and detrusor external sphincter dyssynergia (DESD) receiving Combined detrusor and external urethral sphincter BTX-A injections treatment. Contain 200 U botulinum toxin intradetrusor and 100 U external urethral sphincter injections. The effective outcomes included maximum detrusor pressure at first DO and DESD (PdetmaxDO-DESD), volume at first DO and DESD (VDO-DESD), maximum urethral closure pressure (MUCP), and Incontinence-Specific Quality-of-life Instrument (I-QoL). Adverse events were recorded. Results: All patients experienced a significant mean reduction in PdetmaxDO-DESD (50.75%), maximum urethral closure pressure (26.34%) and a significant mean increase in VDO-DESD (63.00%) 12-weeks post-injection. Significant (p lity-of-life Instrument was also found. No obvious adverse event and toxic effect was observed. Conclusion: Combined detrusor and external urethral sphincter BTX-A injections is a good choice for patients with DO and DESD secondary to spinal cord injury. It could not only protect the upper urinary tract but also improve quality of life.

关键词： Detrusor Overactivity Detrusor External Sphincter Dyssynergia BTX-A Spinal Cord Injury

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食管癌新辅助放化疗现有问题探讨

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中华放射肿瘤学杂志 2021年第8期30卷 759-763页

作者：巩合义李宝生山东省肿瘤防治研究院山东省放射肿瘤学重点实验室山东第一医科大学附属肿瘤医院放疗科济南250117

新辅助放化疗是局部晚期可手术食管癌多家指南推荐的首选治疗模式,但仍有一些问题需要进一步探讨。本文就目前困扰临床的多个问题进行了梳理,期望能为今后的食管癌新辅助放化疗的顺利进行提供建设性建议。

关键词：食管肿瘤/新辅助放化疗法问题探讨

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The Great Imitator:Atypical Cutaneous Manifestations of Primary Syphilitic Chancre

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Chinese Medical Sciences Journal 2021年第4期36卷 279-283页

作者： Huizi Gong Mengyin Wu Jun li heyi Zheng Department of Dermatology and Venereology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

Objective To analyze the reasons of misdiagnosis of primary syphilitic chancre and strengthen the understanding of atypical features of this *** A case series of twenty-seven challenging primary syphilis patients who were not immediately recognized as chancre was included in our *** clinical data including the patients’age,sex,skin lesions,HIV status,syphilis serologic test results,treatment,and follow-up results were ***-eosin and immunohistochemistry staining of skin biopsy sections were *** Four female cases with extragenital chancres presenting as erythema or erosive skin lesions on the nipple were misdiagnosed as Paget’s disease or *** disorder of missed or misdiagnosed male cases manifested as syphilitic balanitis or multiple chancres on the penis root and adjacent pubis rather than coronal sulcus or *** with nonreactive nontreponemal tests at initial presentation were also easily missed or *** Primary syphilis presenting as multiple lesions rather than a single chancre,at atypical locations,or with a nonreactive nontreponemal test result,tends to be missed or misdiagnosed.

关键词： primary syphilis chancre misdiagnosis

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Initial Experience with Mirabegron for the Treatment of Neurogenic Lower Urinary Tract Dysfunction

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Open Journal of Urology 2021年第8期11卷 305-311页

Background: Though anticholinergic drugs are considered the standard treatment for neurogenic detrusor overactivity, it is far from an ideal tool, because of their adverse effects such as Constipation or not respond sufficiently for a substantial proportion of patients. Recently mirabegron has become a commonly used overactive bladder medication in the general population, but few studies about mirabegron for the treatment of neurogenic detrusor overactivity. Objective: To evaluate the efficacy and safety of mirabegron for the treatment of neurogenic lower urinary tract dysfunction. Study Design: Prospective study. Methods: This prospective study included 13 adult patients with neurogenic lower urinary tract dysfunction as a result of spinal cord injury. All patients receiving mirabegron treatment (50 mg once daily) at least 6 weeks. The effective outcomes included the mean urine volume per catheterization, urinary incontinence episodes and Incontinence Specific Quality of life Instrument. We monitored the blood pressure and heart rate to assess the cardiovascular safety, other adverse events were also recorded. Results: A total of 13 patients were included. After 6 weeks of treatment, all patients experienced a significant increase in the mean volume of per catheterization from 238.46 ± 65.43 ml to 327.69 ± 59.04 ml (p = 0.001). There is a significant reduction in the volume of urine leakage (463.85 ± 247.98 ml VS 180.00 ± 190.96 ml, p = 0.003) and incontinence episodes per 24 h (4.46 ± 2.03 VS 1.92 ± 1.50, p = 0.001). Significant improvement in mean Incontinence Specific Quality of life Instrument was also found (p = 0.001). No patients reported dry mouth during the study, and the cardiovascular safety were acceptable. Conclusion: Mirabegron is safe and effective in the treatment of neurogenic lower urinary tract dysfunction. It might be a good choice for reducing

关键词： Neurogenic Lower Urinary Tract Mirabegron Detrusor Overactivity Spinal Cord Injury

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基于生成对抗网络与随机森林组合模型的地震与地脉动区分研究

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振动与冲击 2022年第15期41卷 312-318页

作者：刘赫奕宋晋东李山有中国地震局工程力学研究所地震工程与工程振动重点实验室哈尔滨150080 地震灾害防治应急管理部重点实验室哈尔滨150080

地震事件识别是地震监测业务的基础性工作,特别是随着大规模地震台站建设、海量地震数据汇聚以及地震预警的发展,从连续波形记录中自动区分地震与地脉动噪声显得更加重要。以准确识别地震事件为目标,提出了一种基于生成对抗网络(generat... 详细信息

地震事件识别是地震监测业务的基础性工作,特别是随着大规模地震台站建设、海量地震数据汇聚以及地震预警的发展,从连续波形记录中自动区分地震与地脉动噪声显得更加重要。以准确识别地震事件为目标,提出了一种基于生成对抗网络(generative adversarial network,GAN)与随机森林(random forest,RF)的地震事件识别组合模型,该模型先利用生成对抗网络提取波形信号特征、再利用随机森林基于提取的波形信号特征将地震事件识别转化为地震与地脉动的分类问题。地震与地脉动各5378条数据的测试集研究结果表明,该模型对地震事件与地脉动的分类准确率均可以达到99%以上,地震事件识别率比较传统的长短时窗方法(short term averaging/long term averaging,STA/LTA)提高了23.56个百分点,表明该模型可以从地脉动中准确识别地震事件,并在地震监测与地震预警中具有应用前景。

关键词：生成对抗网络(GAN) 随机森林(RF) 地震地脉动地震预警

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Prospective study of stage l non-small-cell lung cancer treated with hypofractionated-simultaneous integrated boost-intensity modulated radiation therapy

Prospective study of stage l non-small-cell lung cancer trea...

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第八届中国肿瘤学术大会暨第十三届海峡两岸肿瘤学术会议

作者： Wei Zhang Baosheng li Yipeng Song heyi Gong Tao Zhou Hongsheng li Zhenying Wu Qiang Wang Department of Radiation Oncology VI Shandong Cancer Hospital Department of Radiation Oncology Yantai Yuhuangding Hospital Department of Radiation Oncology Dezhou Cancer Hospital Department of Radiation Oncology Linzi People's Hospital

＜正＞Purpose To analyze the effects of hypofractionated-simultaneous integrated boost-intensity modulated radiation therapy（Hypo-SIB-IMRT）on medically inoperable patients with stage I non-small-cell lung cancer（NS...

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软土深基坑的空间变形特性分析及危险性评估

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中国安全生产科学技术 2021年第1期17卷 116-121页

作者：李常茂祝和意陕西铁路工程职业技术学院陕西渭南714000

为准确掌握软土深基坑的变形特性,并合理评价其危险性,基于现场监测成果,进行基坑重要监测项目的空间变形特征分析;通过变形分级和发展趋势判据计算得到相应特征指标,从而开展基坑危险性评估。结果表明:支护结构的空间变形近似呈“驼峰... 详细信息

为准确掌握软土深基坑的变形特性,并合理评价其危险性,基于现场监测成果,进行基坑重要监测项目的空间变形特征分析;通过变形分级和发展趋势判据计算得到相应特征指标,从而开展基坑危险性评估。结果表明:支护结构的空间变形近似呈“驼峰”特征,即基坑两端头的变形值相对较小,而基坑中部的变形值相对较大;周边土体沉降相对较小,随着与基坑距离的增加,地表沉降呈下降趋势,且随基坑持续施工,不同深度处的土体侧位移也随之增加,侧位移最大值均明显大于其他监测项目的变形值;通过变形分级判据得到深层侧位移的危险性等级相对最高,其次是墙顶变形和地表沉降,危险性等级为Ⅲ级;通过发展趋势判据,得到基坑趋势等级相对较低,仅为2级;根据不利原则叠加,确定安元西路站基坑的危险性评估等级为Ⅲ级,属预警状态。

关键词：地铁基坑空间变形支护结构危险性等级变形趋势

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Synthesis of TiC by Self-propagating High-temperature Synthesis with Reduction Stage

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Rare Metals 1993年第2期12卷 137-141页

作者：缪曙霞殷声李建勇赖和怡 University of Science and Technology Beijing Beijing 100083P.R.China

Fine power of TiC was prepared by self-propagating high-temperature synthesis (SHS) method with reduction stage. The influence of diluent and relative density of the sample on both combustion rate and combustion temperature has been studied. The combustion reaction in the system of TiO2-Mg-C begins at the melting of Mg. The propagation of combustion wave is related to the gasifying of Mg. The activation energy of the process has an approximate linear dependence on the porosity of the sample.

关键词： Chemical reactions Combustion Reduction Synthesis (chemical)

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实型铸造槽邦钢的工艺设计及凝固模拟

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热加工工艺 2016年第9期45卷 101-102,104页

作者：李思彭和宜贵州大学机械工程学院贵州贵阳550025

通过综合分析槽邦铸钢件的结构并考虑铸造工艺要求后,确定采用实型铸造的工艺方案。在此基础上,确定了该槽邦钢的相应铸造工艺参数、浇冒口系统等,并采用CAE软件对其进行铸造过程模拟和分析。

关键词：槽邦钢铸钢实型铸造铸造模拟

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