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Exploiting the point spread function for optical imaging through a scattering medium based on deconvolution method

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Journal of Innovative Optical health Sciences 2019年第4期12卷 21-31页

作者： hexiang he Xiangsheng Xie Yikun Liu Haowen Liang Jianying Zhou School of Physics and Optoelectronic Engineering Foshan University Foshan 528000 P.R.China Department of Physics College of Science Shantou University Shantou 515063P.R.China School of Physics Sun Yat-sen University Guangzhou 510275 P.R.China

Visual perception of humans penetrating turbid medium is hampered by scattering.Various techniques have been prompted recently to recover optical imaging through turbid materials.Among them,speckle correlation based on deconvolution is one of the most attractive methods taking advantage of high imaging quality,robustness,eas-of-use,and ease-of-integration.By exploiting the point spread function(PSF)of the scattering system,large Field-of-View,extended Depth-of-Field,noninvasiveness and spectral resoluation are now available as successful solutions for high quality and multifunctional image reconstruction.In this paper,we review the progress of imaging through a scattering medium based on deconvolution method,including the principle,the breakthrough of the limitation of the optical memory ffect,the improvement of the deconvolution algorithm and innovative applications.

关键词： Speckle correlation deconvolution scattering medium imaging through turbid media

Geometric and defects engineering collaboration for enhanced cascade enzymatic nanoreactors

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Nano Research 2024年第4期17卷 2451-2461页

作者： Zhichao Yu Ruijin Zeng hexiang Gong Yuan Gao Shuyun Chen Yunsen Wang Dianping Tang Key Laboratory for Analytical Science of Food Safety and Biology(MOE&Fujian Province) Department of ChemistryFuzhou UniversityFuzhou 350108China

Highly evolved multi-enzyme cascade catalytic reactions in organisms facilitate rapid transfer of substrates and efficient conversion of intermediates in the catalytic unit,thus rationalizing their efficient biocatalysis.In this study,pore-ordered mesoporous single-atom(Fe)nitrogen-doped carbon nanoreactors(Mp-Fe-CN)were designed,in which a reasonable pore size was designed as a natural enzyme trap coupled to a simulated enzyme center.A polarity-mediated strategy was developed to obtain atomically dispersed nanoporous substrates,with the finding that polarity-guided engineering of the nitrogen-ligand environment and vacancy cluster defects clearly affects nanoporous activity,accompanied by appreciable mesoporous pore size elevation.The active center and distal N atom coordination of Fe-N_(4) affect the catalytic process of the nanozyme exposed by density functional theory(DFT),determining the contribution of hybridized orbitals to electron transfer and the decisive step.A cascade nanoreactor-based domain-limited sarcosine oxidase developed for non-invasive monitoring of sarcosine levels in urine for evaluation of potential prostate carcinogenesis as a proof of concept.Based on the design of surface mesoporous channels of nanocatalytic units,a bridge was built for the interaction between nanozymes and natural enzymes to achieve cascade nanocatalysis of natural enzymatic products.

关键词： nanozyme single-atom catalyst bioreactor cascade catalysis non-Invasive sensing

基于相位共轭实现散射成像及光学幻像的双功能散射光调控方法(特邀)

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红外与激光工程 2022年第8期51卷 88-99页

作者：和河向黎永耀黄锦圣佛山科学技术学院物理与光电工程学院广东佛山528225 粤港澳智能微纳光电技术联合实验室广东佛山528225 香港科技大学物理学系中国香港九龙

近年来,人们对散射光调控的研究取得了极大的进展,产生了许多有趣的应用。其中透过散射介质的成像和光学幻像是两个极为引人注目的方向,但它们不经常同时被研究。文中将深入探索散射光成像和光学幻像的内在联系,在此基础上提出一种新颖... 详细信息

近年来,人们对散射光调控的研究取得了极大的进展,产生了许多有趣的应用。其中透过散射介质的成像和光学幻像是两个极为引人注目的方向,但它们不经常同时被研究。文中将深入探索散射光成像和光学幻像的内在联系,在此基础上提出一种新颖的双功能散射光调控方法以在同一实验装置中根据需求实现散射成像和光学幻像。通过优化光路,结合相位恢复技术检测散射波前,利用相位共轭技术和高分辨率的纯相位液晶空间光调制器可以实现补偿散射的影响或实现特定衍射波前的产生。该系统只需要数秒即可完成散射光调控,因此可以对变化缓慢的散射环境实现动态散射成像或对缓慢变化的物体实现稳定的动态光学幻像。理论分析和实验演示证实了该调控方法的可行性。这一散射光调控方法有望在浑浊介质中的光学成像、光学伪装、反侦察、复杂光场调控等领域找到潜在的应用。

关键词：散射光调控散射成像光学幻像相位恢复相位共轭

Screening and identifying natural products with SARS-CoV-2 infection inhibitory activity from medicinal fungi

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Biosafety and health 2024年第1期6卷 12-20页

作者： Shuang Zhao Amelia Siqi Huang Weibo Zhang Lili Ren hexiang Wang Jianbin Wang Xinyang Shao Guanbo Wang Institute of Agri-Food Processing and Nutrition Institute of Plant ProtectionBeijing Academy of Agriculture and Forestry SciencesBejing 100097China Bejing Key Laboratory of Fruits and Vegetable Storage and Processing Key Laboratory of Vegetable Postharvest ProcessingMinistry of AgricultureBejing 100097China Dalton Academy The Affliated High School of Peking UniversityBeijing 100190China NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory National Institute of Pathogen BiologyBejing 100730China Key Laboratory of Respiratory Disease Pathogenomics Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China College of Biological Sciences China Agricultural UniversityBejing 100193China School of Life Sciences Tsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Institute for Cell Analysis Shenzhen Bay LaboratoryShenzhen 518132China

The coronavirus disease of 2019(COVID‐19),a global pandemic caused by the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2),can result in severe health complications.In addition to physical preventative measures,pharmaceutical intervention is also crucial.Numerous natural products from medicinal fungi have shown promise as potential antiviral drugs and may serve as a source of effective components with antiviral activity against SARS‐CoV‐2 and other coronaviruses.In this study,we developed a workflow that integrates viral infection inhibition assays at both cellular and molecular levels,as well as molecular separation and characterization,to screen and identify natural products with antiviral activity.Using this workflow,we screened 167 extracts extracted from 36 medicinal fungi using optimized extraction methods.We assessed the antiviral effects of these extracts by measuring their ability to inhibit SARS‐CoV‐2 infection and receptor binding domain‐human angiotensin‐converting enzyme 2(RBD‐hACE2)binding in vitro.Following charge‐and size‐based characterization of the active compounds through filtration and chromatographic fractionation,mass spectrometry characterization of the fractionated compounds revealed that the active components are polysaccharides and determined their monosaccharide residue composition.Our findings provide new insights into the antiviral potential of natural products and their screening strategies and may contribute to the development of effective antiviral therapeutics against COVID‐19 and other diseases.

关键词： Medicinal fungi Natural products Antiviral activity COVID‐19 Polysaccharides

Modification of food protein fibrils: During and after fibrillization

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Food Science and Human Wellness 2024年

作者： Kefan Ouyang hexiang Xie Hua Xiong Qiang Zhao Wenjun Wang State Key Laboratory of Food Science and Resources Nanchang University Jiangxi Key Laboratory of Natural Products and Functional Food College of Food Science and Engineering Jiangxi Agricultural University

Fibrillization endows food proteins with anisotropic nanostructures， significantly enhancing their functional properties. The resultant food protein fibrils (FPFs) have garnered attention for their diverse applications across the food industry. However， the full potential of FPFs is hindered by inherent challenges， particularly their limited stability. This review critically examines the formation of FPFs in food processing， the new protein sources， and on the modification strategies of FPFs， thereby unlocking new avenues for FPF utilization in food processing. In particular， the strategies during and after fibrillization are highlighted. The first strategy is to modify the structure and function of protein fibrils by influencing fibrillization， such as through pretreatment， incubation conditions， nuclei induction， and ingredient interactions. The second strategy is to modify the mature FPFs by regulating their properties and interactions with other components. The review also discusses the potential applications and challenges of FPFs in food systems， such as food preservation， functional food design， and novel delivery carriers.

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Method for the extraction of circulating nucleic acids based on MOF reveals cell-free RNA signatures in liver cancer

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National Science Review 2024年第1期11卷 94-106页

作者： Yuqing Sun Haixin Yu Shaoqing Han Ruoxi Ran Ying Yang Yongling Tang Yuhao Wang Wenhao Zhang heng Tang Boqiao Fu Boshi Fu Xiaocheng Weng Song-Mei Liu hexiang Deng Shuang Peng Xiang Zhou College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers-Ministry of Education Wuhan University Department of Digestive Surgical Oncology Union Hospital Tongji Medical College Huazhong University of Science and Technology Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Clinical Laboratory Center for Gene Diagnosis and Program of Clinical Laboratory Zhongnan Hospital of Wuhan University College of Chemistry and Materials Science Hubei Engineering University Department of Pharmacology School of Pharmacy China Medical University Taikang Center for Life and Medical Sciences Wuhan University Department of hematology Zhongnan Hospital of Wuhan University

Cell-free RNA(cf RNA) allows assessment of health, status, and phenotype of a variety of human organs and is a potential biomarker to non-invasively diagnose numerous diseases. Nevertheless, there is a lack of highly efficient and bias-free cf RNA isolation technologies due to the low abundance and instability of cf RNA.here, we developed a reproducible and high-efficiency isolation technology for different types of cell-free nucleic acids(containing cf RNA and viral RNA) in serum/plasma based on the inclusion of nucleic acids by metal-organic framework(MOF) materials, which greatly improved the isolation efficiency and was able to preserve RNA integrity compared with the most widely used research kit method. Importantly, the quality of cf RNA extracted by the MOF method is about 10-fold that of the kit method, and the MOF method isolates more than three times as many different RNA types as the kit method. The whole transcriptome mapping characteristics of cf RNA in serum from patients with liver cancer was described and a cf RNA signature with six cf RNAs was identified to diagnose liver cancer with high diagnostic efficiency(area under curve = 0.905 in the independent validation cohort) using this MOF method. Thus, this new MOF isolation technique will advance the field of liquid biopsy, with the potential to diagnose liver cancer.

关键词： MOF circulating cell-free RNA biomarker liver cancer diagnosis

多尺度深层特征加强的CME小样本目标检测模型

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计算机工程与应用 2024年第6期60卷 222-229页

作者：丁政伟白鹤翔胡深山西大学计算机与信息技术学院太原030006

针对现有的小样本目标检测模型存在对图像全局语义信息考虑不足、输入图像大小不一而导致检测器性能下降的问题,提出了多尺度深层特征加强的CME小样本目标检测模型。利用大量有标签的基类数据和基于残差跳跃的多层卷积神经网络及多尺度... 详细信息

针对现有的小样本目标检测模型存在对图像全局语义信息考虑不足、输入图像大小不一而导致检测器性能下降的问题,提出了多尺度深层特征加强的CME小样本目标检测模型。利用大量有标签的基类数据和基于残差跳跃的多层卷积神经网络及多尺度特征增强模块训练一个泛化性良好的模型,经过少量有标签的新类数据和基类数据对模型微调,利用微调后的模型进行目标检测。为验证模型的有效性,使用VOC2007和VOC2012数据集对模型进行训练和评估,相关消融实验证明了引入残差跳跃结构的多层卷积神经网络和多尺度特征增强模块的单独使用和组合使用均可进一步增加模型的准确率。在与6个具有代表性的小样本目标检测模型的对比实验中表明,多尺度深层特征加深的CME比最先进的检测器得分平均提高4.75个百分点。

关键词：小样本学习目标检测残差跳跃多尺度特征深层特征

艾司氯胺酮对大鼠内毒素性急性肺损伤时TLR4/NF-κB信号通路的影响

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中华麻醉学杂志 2024年第6期44卷 729-732页

作者：何旋陈鹤翔孔倩袁敏肖兴鹏吴晓静武汉大学人民医院麻醉科武汉430060

目的:评价艾司氯胺酮对大鼠内毒素性急性肺损伤时Toll样受体4(TLR4)/NF-κB信号通路的影响。方法:SPF级健康成年雄性SD大鼠30只,体质量200~220 g,8周龄,采用随机数字表法分为3组( n=10):对照组(Con组)、内毒素性急性肺损伤组(ALI组)和... 详细信息

目的:评价艾司氯胺酮对大鼠内毒素性急性肺损伤时Toll样受体4(TLR4)/NF-κB信号通路的影响。方法:SPF级健康成年雄性SD大鼠30只,体质量200~220 g,8周龄,采用随机数字表法分为3组( n=10):对照组(Con组)、内毒素性急性肺损伤组(ALI组)和艾司氯胺酮组(AK组)。采用腹腔注射LPS 10 mg/kg的方法制备大鼠内毒素性急性肺损伤模型。Con组腹腔注射等容量0.9%氯化钠注射液,AK组注射LPS 30 min和12 h时分别腹腔注射艾司氯胺酮10 mg/kg。模型制备后24 h时麻醉大鼠,采集颈动脉血样后处死大鼠取肺组织,测定PaO_(2)并计算PaO_(2)/FiO_(2),he染色光镜下观察肺组织病理学结果并行肺损伤评分,电镜下观察肺组织细胞超微结构,计数支气管肺泡灌洗液(BALF)多形核白细胞(PMN),计算肺组织湿质量/干质量(W/D)比值,比色法测定髓过氧化物酶(MPO)活性,采用Western blot法检测TLR4和NF-κB p65的表达。结果:与Con组比较,ALI组大鼠PaO_(2)和PaO_(2)/FiO_(2)降低,肺组织损伤评分、BALF PMN计数、肺W/D比值、MPO活性、肺组织TLR4和NF-κB p65表达水平升高( P<0.05);与ALI组比较,AK组大鼠PaO_(2)和PaO_(2)/FiO_(2)升高,肺组织损伤评分、BALF PMN计数、肺W/D比值、MPO活性、肺组织TLR4和NF-κB p65表达水平降低( P<0.05),肺组织细胞超微结构改善。结论:艾司氯胺酮减轻大鼠内毒素性急性肺损伤的机制与阻断TLR4/NF-κB信号通路有关。

关键词：环己烷类内毒素类急性肺损伤 Toll样受体4 NF-κB

论数字化时代的社会公权力及数字立法范式转变

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科技与法律（中英文） 2024年第4期 20-29页

作者：马忠法赵鹤翔复旦大学法学院上海200438

自创生系统论指出,社会公权力具有主体的社会性、内容的公共性、来源的事实性,并为数字立法范式转变提供了理论基础。数字化时代社会公权力具有利维坦式权力风险,数据在其形成过程中具有决定性作用。数字化时代社会公权力的本质在于数... 详细信息

自创生系统论指出,社会公权力具有主体的社会性、内容的公共性、来源的事实性,并为数字立法范式转变提供了理论基础。数字化时代社会公权力具有利维坦式权力风险,数据在其形成过程中具有决定性作用。数字化时代社会公权力的本质在于数据成为形构数字社会的基本构成要素。通过风险探究与本质考察发现,除具备工业化时代社会公权力的一般特质外,数字化时代社会公权力还具有权力产生上的数据化,权力表现形式上的场域化、多元化、去中心化,权力运行方式上的监视性与规训性之特点。对数字化时代社会公权力的规制还是要回到自创生系统论的思路,根据其上述特点,推动数字立法范式的转变。

关键词：数字权力社会公权力数据立法范式自创生系统论