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Favorable surgical treatment outcomes for chronic constipation with features of colonic pseudo-obstruction

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World Journal of Gastroenterology 2012年第32期18卷 4441-4446页

作者： Eon Chul Han heung-kwon oh Heon-Kyun Ha Eun Kyung Choe Sang Hui Moon Seung-Bum Ryoo Kyu Joo Park Department of Surgery Seoul National University College of MedicineSeoul 110-744South Korea Seoul National University Hospital Gangnam Center Seoul 110-744South Korea

AIM:To determine long-term outcomes of surgical treatments for patients with constipation and features of colonic ***:Consecutive 42 patients who underwent surgery for chronic constipation within the last 13 years were prospectively *** identified a subgroup with colonic pseudo-obstruction(CPO) features,with dilatation of the colon proximal to the narrowed transitional zone,in contrast to typical slowtransit constipation(STC),without any dilated colonic *** outcomes of surgical treatments for chronic constipation with features of CPO were analyzed and compared with outcomes for ***:Of the 42 patients who underwent surgery for constipation,33 patients had CPO with dilatation of the colon proximal to the narrowed transitional *** were 16 males and 17 females with a mean age of 51.2 ± 16.1 *** had symptoms of chronic intestinal obstruction,including abdominal distension,pain,nausea,or vomiting,and the mean duration of symptoms was 67 mo(range:6-252 mo).Preoperative defecation frequency was 1.5 ± 0.6 times/wk(range:1-2 times/wk).Thirty-two patients underwent total colectomy,and one patient underwent diverting transverse *** was no surgery-related *** histologic examination showed hypoganglionosis or agangliosis in 23 patients and hypoganglionosis combined with visceral neuropathy or myopathy in 10 *** contrast,histology of STC group revealed intestinal neuronal dysplasia type B(n = 6) and visceral myopathy(n = 3).Early postoperative complications developed in six patients with CPO;wound infection(n = 3),paralytic ileus(n = 2),and intraabdominal abscess(n = 1).Defecation frequencies 3 mo after surgery improved to 4.2 ± 3.2 times/d(range:1-15 times/d).Long-term follow-up(median:39.7 mo) was available in 32 patients;all patients had improvements in constipation symptoms,but two patients needed intermittent medication for management of *** 32 patients had distinct

关键词： Constipation Total colectomy Pseudoobstruction Surgical outcome Hypoganglionosis

Complications after ileal pouch-anal anastomosis in Korean patients with ulcerative colitis

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World Journal of Gastroenterology 2014年第23期20卷 7488-7496页

作者： Seung-Bum Ryoo heung-kwon oh Eon Chul Han Heon-Kyun Ha Sang Hui Moon Eun Kyung Choe Kyu Joo Park Division of Colorectal Surgery Department of SurgerySeoul National University College of MedicineSeoul 110-744South Korea Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM: To investigate the outcomes of treatments for complications after ileal pouch-anal anastomosis (IPAA) in Korean patients with ulcerative colitis.

关键词： Ulcerative colitis Ileal pouch-anal anastomosis Complications Pouch failure Pouch function

Surgical management of colonic diverticular disease:Discrepancy between right- and left-sided diseases

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World Journal of Gastroenterology 2014年第29期20卷 10115-10120页

作者： heung-kwon oh Eon Chul Han Heon-Kyun Ha Eun Kyung Choe Sang Hui Moon Seung-Bum Ryoo Seung-Yong Jeong Kyu Joo Park Division of Colorectal Surgery Department of SurgerySeoul National University College of Medicine

AIM:To compare the outcome of the surgical management of left-sided and right-sided diverticular ***:The medical records of 77 patients who were surgically treated for diverticular disease between 1999 and 2010 in a tertiary referral hospital were retrospectively *** study population was limited to cases wherein the surgical specimen was confirmed as diverticulosis by *** diverticula were classified as those arising from the cecum,ascending colon,and transverse colon,and those from the descending colon,sigmoid colon,and rectum were classified as left-sided *** assess the changing trend of occurrence of diverticulosis,data were compared with two previous studies of 51 ***:The proportion of left-sided disease cases was significantly increased compared to the results of our previous studies in 1994 and 2001,(27.5%vs48.1%,P<0.05).Moreover,no differences in gender,body mass index,multiplicity of the diverticula,fever,or leukocytosis were noted between patients with rightsided and left-sided ***,patients with right-sided disease were significantly younger(50.9year vs 64.0 year,P<0.01).Furthermore,left-sided disease was significantly associated with a higher incidence of complicated diverticulitis(89.2%vs 57.5%,P<0.01),combined resection due to extensive inflammation(21.6%vs 5.0%,P<0.05),operative complications(51.4%vs 27.5%,P<0.05),and in-hospital mortality(10.8%vs 0%,P<0.05),along with longer post-operative hospitalization duration(21.3±10.2 d vs 10.6±8.1 d,P<0.05).CONCLUSION:Compared with right-sided diverticular disease,the incidence of left-sided disease in Korea has increased since 2001 and is associated with worse surgical outcomes.

关键词： Colonic diverticulosis Diverticular bleeding Diverticulitis Poor surgical outcome Left-sided diverticulitis

Different oncological features of colorectal cancer codon-specific KRAS mutations:Not codon 13 but codon 12 have prognostic value

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World Journal of Gastroenterology 2023年第32期29卷 4883-4899页

作者： Hong-Min Ahn Duck-Woo Kim Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh heung-kwon oh Sung-Bum Kang Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University HospitalSeoul 03080South Korea

BACKGROUND Approximately 40%of colorectal cancer(CRC)cases are linked to Kirsten rat sarcoma viral oncogene homolog(KRAS)*** mutations are associated with poor CRC prognosis,especially KRAS codon 12 mutation,which is associated with metastasis and poorer ***,the clinicopathological characteristics and prognosis of KRAS codon 13 mutation in CRC remain *** To evaluate the clinicopathological characteristics and prognostic value of codonspecific KRAS mutations,especially in codon *** This retrospective,single-center,observational cohort study included patients who underwent surgery for stage I-III CRC between January 2009 and December *** with KRAS mutation status confirmed by molecular pathology reports were *** relationships between clinicopathological characteristics and individual codon-specific KRAS mutations were *** data were analyzed to identify codon-specific KRAS mutations as recurrence-related factors using the Cox proportional hazards regression *** Among the 2203 patients,the incidence of KRAS codons 12,13,and 61 mutations was 27.7%,9.1%,and 1.3%,*** KARS codons 12 and 13 mutations showed a tendency to be associated with clinical characteristics,but only codon 12 was associated with pathological features,such as stage of primary tumor(T stage),lymph node involvement(N stage),vascular invasion,perineural invasion,tumor size,and microsatellite *** codon 13 mutation showed no associations(77.2%vs 85.3%,P=0.159),whereas codon 12 was associated with a lower 5-year recurrence-free survival rate(78.9%vs 75.5%,P=0.025).In multivariable analysis,along with T and N stages and vascular and perineural invasion,only codon 12(hazard ratio:1.399;95%confidence interval:1.034-1.894;P=0.030)among KRAS mutations was an independent risk factor for *** This study provides evidence that KRAS codon 13 mutation is less likely to serve as a prognostic biom

关键词： Genes Ras Codon Colonic neoplasms Rectal neoplasms

Naturalization of Landscaping Woody Plant, Magnolia obovata Potentially Invasive Species

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Journal of Mountain Science 2015年第1期12卷 30-38页

作者： kwon oh Jung oh Choong Hyeon Graduate School Department of Biological and Environmental Science Dongguk University Department of Biological and Environmental Science Dongguk University

Magnolia obovata, a tree species native to Japan, is a traditional landscaping tree that has also been introduced to various countries. M. obovata individuals have recently emerged in non-planting areas in Korea, prompting us to investigate its distribution by establishing Dosolsan in an urban forest of Daejeon City as the target site. In order to determine its naturalization, the study explored the status of population growth by examining the diameter at breast height of the individuals, and diameter diminution quotient was calculated. Cores of the trees were collected, and the age distribution was estimated by regression analysis. Reproduction possibility was analyzed by verifying the flowerblooming and fruit-bearing. Spontaneous colonization was investigated in the other potential sites which have different location and environment, *** diameter distribution showed a reverse J-shaped curve, and the diminution quotient was ≥ 1.8. The population was composed of different generations,thus confirming the growth of the population. The distributed M. obovata grew and flowered normally,and followed a normal life cycle. The same phenomenon was observed in other planting areas,residual forests in urban or rural areas, alluvial islands, and mountain forests. The continuous spread of M. obovata in new ecosystems may be attributable to its long-term distribution by birds, relatively fast growth, and maturity time. Investigations on the naturalization and spread of M. obovata in Korea, as well as in various countries, are warranted.

关键词： Magnolia obovata Diameterdistribution Diminution quotient Invasive plant Naturalized plant

Small-scale multi-axial hybrid simulation of a shear-critical reinforced concrete frame

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Earthquake Engineering and Engineering Vibration 2017年第4期16卷 727-743页

作者： Vahid Sadeghian oh-Sung kwon Frank Vecchio Department of Civil Engineering University of Toronto35 St.George St.TorontoONCanada

This study presents a numerical multi-scale simulation framework which is extended to accommodate hybrid simulation （numerical-experimental integration）. The framework is enhanced with a standardized data exchange format and connected to a generalized controller interface program which facilitates communication with various types of laboratory equipment and testing configurations. A small-scale experimental program was conducted using a six degree-of-freedom hydraulic testing equipment to verify the proposed framework and provide additional data for small-scale testing of shear- critical reinforced concrete structures. The specimens were tested in a multi-axial hybrid simulation manner under a reversed cyclic loading condition simulating earthquake forces. The physical models were 1/3.23-scale representations of a beam and two columns. A mixed-type modelling technique was employed to analyze the remainder of the structures. The hybrid simulation results were compared against those obtained from a large-scale test and finite element analyses. The study found that if precautions are taken in preparing model materials and if the shear-related mechanisms are accurately considered in the numerical model, small-scale hybrid simulations can adequately simulate the behaviour of shear-critical structures. Although the findings of the study are promising, to draw general conclusions additional test data are required.

关键词： hybrid simulation small-scale testing reinforced concrete structures, shear behaviour multi-scale modelling

Experimental Analyses of Moderately High-Temperature Heat Pump Systems with R245fa and R1233zd(E)

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Energy Engineering 2022年第6期119卷 2231-2242页

作者： Ting Chen oh Kyung kwon State Key Laboratory of Fluid Power&Mechatronic Systems Zhejiang UniversityHangzhou310027China Clean Energy R&D Department Korea Institute of Industrial TechnologyCheonan31056Republic of Korea

With the limited production and use of R245fa,environmentally friendly refrigerant has attracted the attention of *** to the similar thermal characteristics,R1233zd(E)is considered to be an ideal substitute for R245fa in heat pump *** this study,the performance and economic analysis of heat pump systems with R245fa and R1233zd(E)as refrigerants are carried *** results show that the total cost of R1233zd(E)system is more than 10%higher than that of R245fa system under the same heating *** the increase of condensation temperature,the heating capacity of both systems decreases,and with the increase of evaporation temperature,the heating capacity *** variation trend of coefficient of performance(COP)of the two systems is similar to that of heating *** the same operating conditions,the COP of R1233zd(E)system is 19.2%higher than that of R245fa system,and the volumetric heat capacity of R1233zd(E)is 9.0%–13.9%lower than that of *** economic analysis results show that the investment cost of R1233zd(E)system is low under the same heat load.

关键词： Heat pump R1233zd(E) R245fa performance comparison economic analysis

Recent aspects of ketogenic diet in neurological disorders

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Acta Epileptologica 2021年第1期3卷 134-140页

作者： Hye Eun kwon heung Dong Kim Department of Pediatrics International St.Mary’s HospitalCatholic Kwandong UniversityCollege of MedicineIncheonSouth Korea Division of Pediatric Neurology Severance Children’s HospitalYonsei University College of Medicine50 Yonsei-roSinchon-dongSeodaemun-guSeoulSouth Korea

The ketogenic diet(KD)is a high-fat,low-carbohydrate diet,in which fat is used as the primary energy source through the production of ketone bodies(KBs)in place of *** KD was formally introduced in 1921 to mimic the biochemical changes associated with fasting and gained recognition as a potent treatment for pediatric epilepsy in the *** clinical and basic scientific knowledge that supports the anti-seizure efficacy,safety,and feasibility of using the KD in patients with epilepsy is ***,the International Ketogenic Diet Study Group’s consensus guidelines provide practical information in 2009 and *** KD is a broad-spectrum therapy for drug resistant epilepsy and is gaining attention as a potential therapy for other neurological *** article will review recent aspects on the use of the KD,including its mechanisms of action,KD alternatives,expanding its use across different age groups and regions,its use as a treatment for other neurologic disorders,and future research subjects.

关键词： epilepsy disorders neurological

Information Extraction Based on Multi-turn Question Answering for Analyzing Korean Research Trends

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Computers, Materials & Continua 2023年第2期74卷 2967-2980页

作者： Seongung Jo heung-Seon oh Sanghun Im Gibaeg Kim Seonho Kim School of Computer Science and Engineering KOREATECHCheonan31253Korea Korea Institute of Science and Technology Information KISTIDaejeon34141Korea

Analyzing Research and Development(R&D)trends is important because it can influence future decisions regarding R&D *** typical trend analysis,topic or technology taxonomies are employed to compute the popularities of the topics or codes over *** it is simple and effective,the taxonomies are difficult to manage because new technologies are introduced ***,recent studies exploit deep learning to extract pre-defined targets such as problems and *** on the recent advances in question answering(QA)using deep learning,we adopt a multi-turn QA model to extract problems and solutions from Korean R&D *** the previous research,we use the reports directly and analyze the difficulties in handling them using QA style on Information Extraction(IE)for sentence-level benchmark *** investigating the characteristics of Korean R&D,we propose a model to deal with multiple and repeated appearances of targets in the ***,we propose a model that includes an algorithm with two novel modules and a prompt.A newly proposed methodology focuses on reformulating a question without a static template or pre-defined *** show the effectiveness of the proposed model using a Korean R&D report dataset that we constructed and presented an in-depth analysis of the benefits of the multi-turn QA model.

关键词： Natural language processing information extraction question answering multi-turn Korean research trends