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Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 170-188页

作者： Hyunkyung Mo juryun kim Jennifer Yejean kim Jang Woon kim Heeju Han Si Hwa Choi Yeri Alice Rim Ji Hyeon ju Present Address:CiSTEM Laboratory Catholic iPSC Research CenterCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea Department of Biomedicine and Health Science College of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea YiPSCELL IncOmnibus ParkBanpo-daero 222Seocho-guSeoul 06591Republic of Korea Department of Biology Georgetown University3700 O St NWWashingtonDC 20057USA Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalInstitute of Medical ScienceCollege of MedicineThe Catholic University of KoreaSeoul 06591Republic of Korea

Background Alzheimer’s disease(AD)is the most common neurodegenerative disorder in the elderly,resulting in gradual destruction of cognitive *** on the development of various AD treatments is underway;however,no definitive treatment has been developed ***,we present induced pluripotent stem cell(iPSC)-derived cortical neural stem cell secretome(CNSC-SE)as a new treatment candidate for AD and explore its *** We first assessed the effects of CNSC-SE treatment on neural maturation and electromagnetic signal during cortical nerve cell *** to confirm the efficacy in vivo,CNSC-SE was administered to the 5×FAD mouse model through the nasal cavity(5μg/g,once a week,4 weeks).The cell-mediated effects on nerve recovery,amyloid beta(Aβ)plaque aggregation,microglial and astrocyte detection in the brain,and neuroinflammatory responses were *** analysis of iPSC-derived CNSC-SE revealed that it contained components that could exert neuro-protective effects or amplify cognitive restorative *** Human iPSC-derived CNSC-SE increased neuronal proliferation and dendritic structure formation in ***,CNSC-SE-treated iPSC-derived cortical neurons acquired electrical network activity and action potential *** 5×FAD mice treated with CNSC-SE showed memory restoration and reduced Aβplaque *** Our findings suggest that the iPSC-derived CNSC-SE may serve as a potential,non-invasive therapeutic option for AD in reducing amyloid infiltration and restoring memory.

关键词： Induced pluripotent stem cells Alzheimer’s disease Cortical neural stem cells Secretome Intranasal administration Memory disorders Neuroprotective agents

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Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43

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Acta Pharmaceutica Sinica B 2015年第6期5卷 544-553页

作者： Yuri Cho jung-Hwan Yoon Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Eun ju Cho Jeong-Hoon Lee Su Jong Yu Yoon jun kim Chung Yong kim Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine

Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor *** this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal *** ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary *** was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 *** also significantly decreased liver metastasis in *** regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling *** summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on *** results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects.

关键词： Fucoidan Hepatocellular carcinoma Invasion Hypoxia Hepatoprotective Cultured hepatocyte NDRG-1/CAP43 VMP-1

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Bile acid increases expression of the histamine-producing enzyme,histidine decarboxylase,in gastric cells

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World Journal of Gastroenterology 2014年第1期20卷 175-182页

作者： Hye Jin Ku Hye Young kim Hyeong Hoe kim Hee ju Park Jae Hun Cheong Department of Pediatrics College of MedicinePusan National UniversityBusan 601-721South Korea Department of Molecular Biology College of Natural SciencesPusan National UniversityBusan 609-735South Korea Department of Experimental Medicine College of MedicinePusan National UniversityBusan 601-721South Korea

AIM: To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon coope... 详细信息

关键词： Histamine Histidine decarboxylase Bile acid Farnesoid X receptor

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Morbidity analysis of left hepatic trisectionectomy for hepatobiliary disease and live donor

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 362-369页

作者： Young-In Yoon Sung-Gyu Lee Deok-Bog Moon Shin Hwang Ki-Hun kim Hui-ju kim Ki-Hoon Choi Division of Hepatobiliary Surgery and Liver Transplantation Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine388-1 Poongnap-dongSongpa-guSeoul 138-736Korea Department of Surgery Gold Coast University HospitalSouthportQLD 4215Australia

Background:Despite remarkable advances in surgical techniques and perioperative management,left hepatic trisectionectomy(LHT)remains a challenging procedure with a somewhat high postoperative morbidity rate compared with less-extensive *** study aimed to analyze the short-and long-term outcomes of LHT and identify factors associated with the postoperative morbidity of this technically demanding surgical ***:The medical records of 53 patients who underwent LHT between june 2005 and October 2019 at a single institution were retrospectively *** independent prognostic factor of postoperative morbidity was analyzed using the logistic regression ***:Hepatocellular carcinoma was the most common indication for surgery(n=21),followed by hilar cholangiocarcinoma(n=14),intrahepatic cholangiocarcinoma(n=10),and other pathologies(including colorectal liver metastasis,hepatolithiasis,gallbladder cancer,living donor,hemangioma,and multilocular biliary cyst;n=8).The rates of postoperative morbidities of Clavien-Dindo grade 3 or higher and 90-day mortality were 39.6% and 1.9%,*** 1-,3-,and 5-year overall survival rates were 81.1%,61.4%,and 44.6%,*** analysis revealed that preoperative jaundice[hazard ratio(HR)=6.15,95%confidence interval(CI):1.57-24.17,P=0.009]and operative time>420 min(HR=4.66,95%CI:1.27–17.17,P=0.021)were independent predictors of postoperative ***:The in-hospital mortality of LHT surgery can be minimalized by a reliable preoperative evaluation of liver function and selection of the dominant anatomic features of right posterior sector,active and appropriate preoperative management for obstructive cholangitis and compensatory hypertrophy of the future remnant posterior sector,and the experience of the surgeon.

关键词： Left hepatic trisectionectomy Major hepatectomy Liver neoplasms Survival rate Morbidity

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On the stacking fault forming probability and stacking fault energy in carbon-doped 17 at%Mn steels via transmission electron microscopy and atom probe tomography

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Journal of Materials Science & Technology 2022年第20期115卷 177-188页

作者： Hyo ju Bae Kwang Kyu Ko Muhammad Ishtiaq jung Gi kim Hyokyung Sung Jae Bok Seol Department of Materials Engineering and Convergence Technology Center for K-metalGyeongsang National University(GNU)Jinju 52828South Korea

Assessing the stacking fault forming probability(P_(sf)) and stacking fault energy(SFE)in medium-or highMn base structural materials can anticipate and elucidate the microstructural evolution before and after ***,these two parameters have been determined from theoretical calculations and empirical ***,the estimation of SFE values in Fe–Mn–C ternary systems is a longstanding debate due to the complicated nature of carbon:that is,whether the carbon doping indeed plays an important role in the formation of stacking faults;and how the amount of carbon atoms exist at grain boundaries or at internal grains with respect to the nominal carbon doping ***,the use of atom probe tomography and transmission electron microscopy(TEM)unveils the influence of carbondoping contents on the structural properties of dual-phase Fe–17 Mn–x C(x=0–1.56 at%)steels,such as carbon segregation free energy at grain boundaries,carbon concentration in grain interior,interplanar D-spacings,and mean width of intrinsic stacking faults,which are essential for SFE *** next determined the Psfvalues by two different methods,viz.,reciprocal-space electron diffraction measurements and stacking fault width measurements in real-space TEM ***,SFEs in the Fe–17 Mn–x C systems were calculated on the basis of the generally-known SFE *** found that the high amount of carbon doping gives rise to the increased SFE from 8.6 to 13.5 m J/m^(2)with non-linear *** SFE trend varies inversely with the mean width of localized stacking faults,which pass through both other stacking faults and pre-existingε-martensite plates without much difficulty at their intersecting *** high amount of carbon doping acts twofold,through increasing the segregation free energy(due to more carbon at grain boundaries)and large lattice expansion(due to increased soluble carbon at internal grains).The experimental data obtained here strengthens the composition-

关键词： Stacking fault formation probability Stacking fault energy High-Mn steel Electron diffraction

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Totally laparoscopic total gastrectomy using the modified overlap method and conventional open total gastrectomy:A comparative study

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World Journal of Gastroenterology 2021年第18期27卷 2193-2204页

作者： Chang Seok Ko Nam Ryong Choi Byung Sik kim Jeong Hwan Yook Min-ju kim Beom Su kim Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Clinical Epidemiology and Biostatistics Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although several methods of totally laparoscopic total gastrectomy(TLTG)have been *** best anastomosis technique for LTG has not been *** To investigate the effectiveness and surgical outcomes of TLTG using the modified overlap method compared with open total gastrectomy(OTG)using the circular stapled *** We performed 151 and 131 surgeries using TLTG with the modified overlap method and OTG for gastric cancer between March 2012 and December *** and oncological outcomes were compared between groups using propensity score *** addition,we analyzed the risk factors associated with postoperative *** Patients who underwent TLTG were discharged earlier than those who underwent OTG[TLTG(9.62±5.32)vs OTG(13.51±10.67),Pjunostomy(EJ)-related complications or 5-year recurrence free and overall survival between *** analysis demonstrated that body mass index[odds ratio(OR),1.824;95%confidence interval(CI):1.029-3.234,P=0.040]and American Society of Anaesthesiologists(ASA)score(OR,3.154;95%CI:1.084-9.174,P=0.035)were independent risk factors of early ***,age was associated with≥3 Clavien-Dindo classification and EJrelated *** Although TLTG with the modified overlap method showed similar complication rate and oncological outcome with OTG,it yields lower pain score,earlier bowel recovery,and *** should perform total gastrectomy cautiously and delicately in patients with obesity,high ASA scores,and older ages.

关键词： Laparoscopic surgery Gastrectomy Anastomosis Stomach neoplasms Totally laparoscopic total gastrectomy

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Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats

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World Journal of Gastroenterology 2008年第5期14卷 731-736页

作者： jun-Ho La Tae-Sik Sung Hyun-ju kim Tae-Wan kim Tong Mook Kang Il-Suk Yang Department of Physiology College of Veterinary Medicine SeoulNational University Seoul 151-742 Republic of Korea Department of Physiology College of VeterinaryMedicine Kyungpuk National University Daegu 702-701Republic of Korea Department of Physiology SungkyunkwanUniversity School of Medicine Suwon 440-746 Republic ofKorea

AIM:To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis. METHODS:We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid. RESULTS:Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 μg/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 μg/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats. CONCLUSION:These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis.

关键词： Corticotropin releasing hormone Visceral hypersensitivity Colitis

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Biochar improves soil properties and corn productivity under drought conditions in South Korea

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Biochar 2023年第1期5卷 1148-1158页

作者： Jae-Hyuk Park Jin-ju Yun Seong-Heon kim Jong-Hwan Park Bharat Sharma Acharya ju-Sik Cho Se-Won Kang Department of Agricultural Chemistry Sunchon National UniversitySuncheon 57922Republic of Korea Division of Soil and Fertilizer National Institute of Agricultural SciencesRDAWanju 55365Republic of Korea Department of Life Resources Industry Dong-A UniversityBusan 49315Republic of Korea Rodale Institute Southeast Organic CenterChattahoochee HillsGA 30268USA Department of Agricultural Life Sciences Sunchon National UniversitySuncheon 57922Republic of Korea

Biochar has been shown to improve soil properties and plant productivity in soils with inherently low ***,little has been reported for upland corns under dry and wet precipitation *** study investigates the effect of biochar addition on a range of soil physicochemical,biological,and hydrological properties,and corn growth and productivity under agrometeorological drought and wet ***,experiments were laid out in a randomized complete block design with three replications at two sites during 2017 and 2018 in South *** included(i)CN:control(ii)IF:inorganic fertilizer(N-P-K)at 145-30-60 kg ha^(−1);(iii)BS:barley straw at 5 t ha^(−1);(iv)CWBC:corn waste biochar at 5 t ha^(−1);(v)CWBC+IF:corn waste biochar+inorganic fertilizer;(vi)CWBC+BS:corn waste biochar+barley *** year 2017 was relatively dry,whereas the year 2018 was *** drought conditions in the year 2017,biochar facilitated soil water ***,higher precipitation in 2018 increased the quantity and distribution of soil water and nutrients in the top 15 *** reduced soil bulk density,and increased porosity,cation exchange capacity and total organic carbon in both years but increased total bacterial counts during the dry year *** population was generally higher under wet ***,more soil CO_(2) was emitted in the wet year than in the dry *** further indicated that biochar can enhance corn biomass and grain yield regardless of precipitation *** grain index was,however,affected by rainfall and was significantly different across treatments in the year 2018 *** biomass,grain yield,and grain index were highest in CWBC+IF treatment and lowest under CN ***,biochar addition appeared to improve soil quality and soil conditioning effects in the drought and wet years,ameliorating soil and plant ***,biochar can improve water and nutrients storage,availability,and uptake,and

关键词： Biochar Drought Precipitation Soil CO_(2)

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Dietary intake of bamboo vinegar and charcoal powder(BVC)enhances resistance of African catfi sh Clarias gariepinus to bacterial pathogen

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Journal of Oceanology and Limnology 2022年第1期40卷 336-346页

作者： Kwangjin ju Moyngsuk KIL Sanghyok RI Tongchol kim Lining ZHANG Maocang YAN Guangxu LIU College of Animal Sciences Zhejiang UniversityHangzhou 310058China College of Aquaculture Wonsan Fisheries UniversityWonsan 999093DPR Korea College of Life Science Kim Hyong Jik University of EducationPyongyang 99903DPR Korea Zhejiang Mariculture Research Institute Wenzhou 325005China

Although the immunomodulatory activity of bamboo vinegar and charcoal powder(BVC)has been increasingly documented in domestic animals,the use of BVC as immunostimulant in fi sh aquaculture awaits verifi *** the present study,the immunostimulatory impacts of dietary BVC intake were investigated in an important aquaculture fi sh species,the African catfi sh Clarias *** show that the pathogen resistance of African catfi sh was signifi cantly improved by dietary BVC intake at the tested levels(0.5%-2%),as indicated by higher survival rates(approximately 1.52-1.85 times that without BVC supplementation)upon intraperitoneally injection of bacterial pathogen Aeromonas *** addition,both the count and phagocytic activity of blood cells were signifi cantly up-regulated by a 45-day dietary supplementation of ***,compared to that of the control,fi sh individuals fed BVC containing diets exhibited signifi cant higher activities of superoxide dismutase(SOD),myeloperoxidase(MPO),and lysozyme(LYZ).The content of immunoglobulin M(IgM)in serum of African catfi sh was also induced by dietary BVC ***,the expression levels of interleukin-8(IL-8),toll-like receptor 1 and 5(TLR1 and TLR5),myeloid diff erentiation factor 88(MyD88),and nuclear factor kappa B(NFκB)in the head kidney were signifi cantly *** fi ndings indicate BVC could be an eff ective immunostimulant in teleost species,which may enhance fi sh immunity through improving hematic parameters,activating bioactive humoral molecules,and up-regulating immune related molecular pathways.

关键词： bamboo vinegar and charcoal powder(BVC) African catfi sh immunostimulant pathogen resistance

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Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis

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World Journal of Gastroenterology 2006年第2期12卷 302-305页

作者： Tae Woon kim Jae Nam Seo Young Ho Suh Hyo Jin Park ju Hyun kim Ji Young kim Kwon Ik Oh Department of Pathology Hallym University College of MedicineChuncheonKorea Division of Metabolic Diseases Department of Biomedical SciencesNational Institute of HealthSeoulKorea Graduate Program of Immunology and Department of Pathology Seoul National University College of MedicineSeoulKorea

AIM： To investigate the roles of lymphocytes in the development of dextran sulfate sodium-induced colitis. METHODS： Using various doses of dextran sulfate sodium （DSS）, we induced colitis in wild-type B6 control and Rag-1 knockout （H-2b haplotype） mice, and evaluated the colitis in terms of symptomatic and histologic parameters, such as weight loss, survival, severity of diarrhea, shortage of colon length and histological changes. Symptomatic parameters were checked daily and histological changes were scored. RESULTS： Although development of colitis in Rag-1 knockout mice treated with high dose （5%） of DSS was comparable to that in B6 control mice, colitis progression was much more tolerable in Rag-1 knockout mice compared to than in B6 mice treated with low dose （1.5%） DSS. Symptomatic parameters as well as histopathologic changes were improved in Rag-1 knockout mice. CONCLUSION： These results indicate that the presence of lymphoo/tes contributes to colitis progression at low dose of DSS stimulation. Lymphoo/tes may play roles as an aggravating factor in DSS-induced colitis.

关键词： Dextran sulfate sodium Colitis Lymphocyte Rag-1 Knockout

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