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Association between preoperative high sensitive troponin I levels and cardiovascular events after hip fracture surgery in the elderly

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Journal of Geriatric Cardiology 2018年第3期15卷 215-221页

作者： Bum Sung Kim Tae-Hoon Kim Jeong-Hwan Oh Chang Hee Kwon Sung Hea Kim Hyun-Joong Kim heung kon hwang Sang-Man Chung in-gu Seoul Republic of Korea Department of Orthopedic surgery Konkuk University Medical Center 120-1 Neungdong-ro Hwayang-dong Gwangjin-guSeoulRepublic of Korea

Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery （HFS）. We used high sensitive troponin I （hs-TnI） assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events （MACE） in elderly hip frac^u＇e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure （HF）, new-onset atrial fibrillation （AF）, myocardial infarction （MI） and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 （24.8%）. Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide （NT-proBNP） and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio （HR）： 1.79, 95% confident interval （CI）： 1.03-3.13, P = 0.04], left ventricular ejection fraction （LVEF）〈 50% （adjusted HR： 3.17, 95% CI： 1.47-5.82, P 〈 0.01） and hs-TnI 〉 6.5 ng/L （adjusted HR： 3.75, 95% CI： 2.09~5.17, P 〈 0.01）. Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.

关键词： Cardiovascular complication High sensitive troponin I Hip fracture surgery

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Phenol content,antioxidant and tyrosinase inhibitory activity of mangrove plants in Micronesia

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Asian Pacific Journal of Tropical Medicine 2014年第7期7卷 531-535页

作者： Sung-Suk Suh Jinik hwang Mirye Park heung-Sik Park Taek-Kyun Lee South Sea Environment Research Department.Korea Institute of Ocean Science and Technology Korea South Pacific Ocean Research Center Korea Institute of Ocean Science and Technology

Objective:To find out and compare the in vitro antioxidant and tyrosinase inhibitory activities of two species of mangrove ***:Mangrove samples were harvested at the shoreline on the island of Weno,Chuuk State in *** phenol content,antioxidant activity(based on DPPH-free radical scavenging)and tyrosinase inhibitory activity in different tissues(leaves,barks and roots)of Rhizophora stylosa(***)and Sonneratia alba(***),collected from the island of ***:Total phenol content ranged from 4.87 to 11.96 mg per g of freeze dried *** highest antioxidant activity was observed in *** bark(85.5%).The highest tyrosinase inhibitory activity was found in *** ***,total phenol content and antioxidant activity were higher in methanol extracts than in aqueous ***:Taken together,the results of this study proved that mangroves can be excellent sources of antioxidant compounds.

关键词： Rhizophora stylosa Sonneratia alba Phebolics Antioxidant activity Tyrosinase inhibitory activity

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Inhibition of Proliferation of Prostate Cancer Cell Line DU-145 in vitro and in vivo Using Salvia miltiorrhiza Bunge

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Chinese Journal of Integrative Medicine 2020年第7期26卷 533-538页

作者： Woong Jin Bae Jin Bong Choi Kang Sup Kim U Syn Ha Sung Hoo Hong Ji Youl Lee Tae-kon hwang Sung Yeoun hwang WANG Zhi-ping Sae Woong Kim Department of Urology The Catholic University of KoreaCollege of MedicineSeoul(06591)Republic of Korea Catholic Integrative Medicine Research Institute College of MedicineThe Catholic University of KoreaSeoul(06591)Republic of Korea Korea Bio-Medical Science Institute Seoul(06106)Republic of Korea Department of Urology Second Hospital of Lanzhou UniversityLanzhou(730030)China

Objective:To investigate the antiproliferative activity of Salvia miltiorrhiza Bunge.(SM)on the castration-resistant prostate cancer(CRPC)cell line DU-145 in vitro and in ***:Prostate cancer cell line(DU-145)and normal prostate cell line(RWPE-1)were treated with SM at different concentrations(3.125,12.5,25 and 50μg/mL)to investigate the antiproliferative *** laddering analysis was performed to investigate the apoptosis of DU-145 *** mechanism was investigated by Western blot analysis of p53,Bcl-2,prostate specific antigen(PSA),and androgen receptor(AR).Six-week-old male BALB/c nude mice were randomly divided into normal control group(n=101)and treated group(n=101)which administered 500 mg/kg SM for 2 *** volumes were ***:Treatment with SM resulted in a dose-dependent decrease in cell number of DU-145 cells in comparison with *** laddering analysis indicated the apoptosis of DU-145 *** with SM increased the expression of p53 and reduced the expression of Bcl-2 *** levels of PSA were considerably reduced in SM-treated group compared to the controls,and a decrease in AR expression was observed when cells were treated with SM in the same pattern as a reduction in *** the tumour xenograft study,SM given once a day for 2 weeks significantly inhibited tumour ***:SM might contribute to the anticancer actions such as induction of apoptosis and inhibition of proliferation of prostate cancer cells.

关键词： apoptosis prostate cancer Salvia miltiorrhiza Bunge Chinese medicine

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Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 636-642页

作者： Jongkyoung Choi Ji kon Ryu Sang Hyub Lee Dong-Won Ahn Jin-Hyeok hwang Yong-Tae Kim Yong Bum Yoon Joon Koo Han Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea Department of Internal Medicine National Medical Center Seoul Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Korea Department of Internal Medicine Seoul National University Boramae Medical Center Seoul Korea Department of Radiology Seoul National University College of Medicine Seoul Korea

BACKGROUND: For palliative treatment of the obstructive jaundice associated with unresectable hepatocellular carcinoma (HCC), percutaneous transhepatic biliary drainage (PTBD) or endoscopic retrograde biliary drainage (ERBD) has been performed. PTBD is preferred as an initial procedure. Little is known about the better option for patients with obstructive jaundice caused by unresectable HCC. METHODS: Sixty patients who had received ERBD or PTBD for the palliative treatment of obstructive jaundice caused by unresectable HCC between January 2006 and May 2010 were included in this retrospective study. Successful drainage, drainage patency, and the overall survival of patients were evaluated. RESULTS: Univariate analysis revealed that the overall frequency of successful drainage was higher in the ERBD group (22/29, 75.9%) than in the PTBD group (15/31, 48.4%) (P=0.029); but multivariate analysis showed marginal significance (P=0.057). The duration of drainage patency was longer in the ERBD group than in the PTBD group (82 vs 37 days, respectively, P=0.020). Regardless of what procedure was performed, the median survival time of patients who had a successful drainage was much longer than that of the patients who did not have a successful drainage (143 vs 38 days, respectively, P<0.001).CONCLUSION: Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage.

关键词： hepatocellular carcinoma obstructive jaundice endoscopic retrograde biliary drainage percutaneous transhepatic biliary drainage

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A left-sided periappendiceal abscess in an adult with intestinal malrotation

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World Journal of Gastroenterology 2006年第33期12卷 5399-5400页

作者： Min Ro Lee Jong Hun Kim Yong hwang Young kon Kim Department of Surgery Chonbuk National University Medical School San 2-20Geumam-dong Deokjin-gu Jeonju 561-756 South Korea Research Institute of ClinicalMedicine Chonbuk National University Medical School San2-20 Geumam-dong Deokjin-gu Jeonju 561-756 South Korea Department of Surgery Chonbuk National University Medical School San 2-20Geumam-dong Deokjin-gu Jeonju 561-756 South Korea Department of Diagnostic Radiology ChonbukNational University Medical School San 2-20 Geumam-dongDeokjin-gu Jeonju 561-756 South Korea

Left-sided periappendiceal abscesses occur in association with two types of congenital anomaly: intestinal malrotation and situs inversus. It is diffi cult to obtain an accurate preoperative diagnosis of these abscesses due to the abnormal position of the appendix. We present an unusual case of a left-sided periappendiceal abscess in an adult with intestinal malrotation, the diagnosis of which was a challenge.

关键词： Left-sided periappendiceal abscess intestinalmalrotation Diagnosis

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Major Issues in Information Technology and Challenges against Proactive Logistics/SCM System

Major Issues in Information Technology and Challenges agains...

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The Fifth International Conference on Information and Management Sciences

作者： heung Suk hwang Gyu-Sung Cho Department of Business Management Kainan University No.1 Kainan Rd.Lu-jhuTaoyuan338TaiwanChina Academy of Port ＆ Logisitics EducationTongMyong University Busan 535Yongdang-DongNam-GuBusanKorea 608-711 Korea

＜正＞The emergence of ubiquitous autonomic computing and network environment will change the service architecture of SCM/logistics information system which will be a new application area. In this study we surveyed the technical trend map of ubiquitous and its application in SCM/logistics support system. We described the evolutional model of ubiquitous computing community for SCM/logistics system. It is consisted of three view points;self-growing, autonomic, and context-aware, which will allow the decision makers to be benefited from web and mobile technology and are useful for proactive SCM/logistics support system. Finally, we suggested a cooperative research planning for the research of proactive IT technology. Ubiquitous between the government research center, university, and industry research activities.

关键词： Ubiquitous computing Logistics support system RFID

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Non-surgical treatment of post-surgical bile duct injury: Clinical implications and outcomes

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World Journal of Gastroenterology 2014年第22期20卷 6924-6931页

作者： Young Ook Eum Joo Kyung Park Jaeyoung Chun Sang-Hyub Lee Ji kon Ryu Yong-Tae Kim Yong-Bum Yoon Chang Jin Yoon Ho-Seong Han Jin-Hyeok hwang Department of Internal medicine Cheongju St. Mary's HospitalChungcheongbuk-do 360-568South Korea Department of Internal Medicine Seoul National University Hospital Seoul National University College of Medicine Seoul 110-744South Korea Department of Internal Medicine Seoul National University College of Medicine Seoul National University Bundang Hospital Gyeonggi-do 463-707South Korea Department of Radiology Seoul National University Bundang HospitalGyeonggi-do 463-707South Korea Department of Surgery Seoul National University Bundang HospitalGyeonggi-do 463-707South Korea

AIM: To investigate the prognostic factors determining the success rate of non-surgical treatment in the management of post-operative bile duct injuries (BDIs).

关键词： Endoscopic retrograde cholangiography Percutaneous transhepatic cholangiography Percutaneous transhepatic biliary drainage Bile duct Biliary stricture.

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Inhibiting scar formation via wearable multilayer stacked electret patch:Self-creation of persistent and customizable DC electric field for fibrogenic activity restriction

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InfoMat 2024年第3期6卷 66-80页

作者： Sung-Won Kim Sumin Cho Donghan Lee Jiyu Hyun Sunmin Jang Inwoo Seo Hyun Su Park Hee Jae hwang Hyung-Seop Han Dae Hyeok Yang heung Jae Chun Suk Ho Bhang Dongwhi Choi School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee UniversityYonginGyeonggiRepublic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Department of Medical Life Sciences College of MedicineInstitute of Cell and Tissue EngineeringThe Catholic University of KoreaSeoulRepublic of Korea

Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical ***,the complexity of equipment for applying appropriate electrical stimulation remains an ongoing ***,we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret(MS-electret),which can generate direct current(DC)electric field(EF)without any power supply *** addition,the MS-electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret *** confirmed inhibition of type 1 collagen andα-SMA expression of human dermal fibroblasts(hDFs)by 90%and 44%in vitro,indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical *** further revealed a 20%significant decrease in the ratio of myofibroblasts caused by the MS-electret in *** findings present that the MS-electret is an outstanding candidate for effective skin scar inhibition with a battery-free,physiological electrical microenvironment,and noninvasive treatment that allows it to prevent external infection.

关键词： DC electric field dermal fibroblasts electret scar formation restriction self-creation of electrical stimulation

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Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue

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Molecular Plant 2016年第6期9卷 870-884页

作者： Shin Ae Lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-heung Ko Yong-Sic hwang Jun Lim Department of Systems Biotechnology Konkuk University Seour 05029 Korea Department of Molecular Biotechnology Dong-A University Busan 49201 Korea Department of Molecular Biology Dankook University Yongin 16890 Korea Department of Plant and Environmental New Resources Kyung Hee University Yongin 17104 Korea These authors contributed equally to this article. Present address: The Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Present address: Department of Life Science Research Institute for Natural Sciences Hanyang University Seoul 04763 Korea

In multicellular organisms, controlling the timing and extent of asymmetric cell divisions （ACDs） is crucial for correct patterning. During post-embryonic root development in Arabidopsis thaliana, ground tissue （GT） maturation involves an additional ACD of the endodermis, which generates two different tissues： the endo- dermis （inner） and the middle cortex （outer）. It has been reported that the abscisic acid （ABA） and gibberellin （GA） pathways are involved in middle cortex （MC） formation. However, the molecular mechanisms under- lying the interaction between ABA and GA during GT maturation remain largely unknown. Through transcriptome analyses, we identified a previously uncharacterized C2H2-type zinc finger gene, whose expression is regulated by GA and ABA, thus named GAZ （GA- AND ABA-RESPONSIVE ZINC FINGER）. Seedlings ectopically overexpressing GAZ （GAZ-OX） were sensitive to ABA and GA during MC formation, whereas GAZ-SRDX and RNAi seedlings displayed opposite phenotypes. In addition, our results indicated that GAZ was involved in the transcriptional regulation of ABA and GA homeostasis. In agreement with pre- vious studies that ABA and GA coordinate to control the timing of MC formation, we also confirmed the unique interplay between ABA and GA and identified factors and regulatory networks bridging the two hor- mone pathways during GT maturation of the Arabidopsis root.

关键词： ABA GA GRAS ground tissue root development transcription factor

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Antiproliferative Effects of Zinc-Citrate Compound on Hormone Refractory Prostate Cancer

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Chinese Journal of Cancer Research 2012年第2期24卷 124-129页

作者： Hoo Hong Yong Sun Choi Hyuk Jin Cho Ji Youl Lee Joon Chul Kim Tae kon hwang Sae Woong Kim Department of Urology College of Medicine the Catholic University of Korea

Objective： To investigate the antiproliferative effects of zinc-citrate compound on hormone refractory prostate cancer （HRPC）. Methods： HRPC cell line （DU145） and normal prostate cell line （RWPE-1） were treated with zinc, citrate and zinc-citrate compound at different time intervals and concentrations to investigate the effect of zinc-citrate compound. Mitochondrial （m）-aconitase activity was determined using aconitase assay. DNA laddering analysis was performed to investigate apoptosis of DU145 cells. Molecular mechanism of apoptosis was investigated by Western blot analysis of P53, P21w^fl, Bcl-2, Bcl-xL and Bax, and also caspase-3 activity analysis. Results： Treatment with zinc-citrate compound resulted in a time- and dose-dependent decrease in cell number of DU145 cells in comparison with RWPE-1. M-aconitase activity was significantly decreased. DNA laddering analysis indicated apoptosis of DU145 cells. Zinc-citrate compound increased the expression of P21wall and P53, and reduced the expression of Bcl-2 and Bcl-xL proteins but induced the expression of Bax protein. Zinc-citrate compound induced apoptosis of DU145 cells by activation of the caspase-3 pathway. Conclusion： Zinc-citrate compound can induce apoptotic cell death in DU145, by caspase-3 activation through up-regulation of apoptotic proteins and down-regulation of antiapoptotic proteins.

关键词： Prostatic neoplasm Zinc Apoptosis

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