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Thrombotic Thrombocytopenic Purpura in a Parturient Leading to Life-Threatening Thrombocytopenia and Neonatal Demise—A Case Report

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Maternal-Fetal Medicine 2023年第2期5卷 119-122页

作者： Amnon A.Berger John J.Kowalczyk Philip e.hess Yunping Li Department of Anesthesia Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMA 02215USA

Thrombocytopenia is common (up to 12%) in pregnancy;thrombotic thrombocytopenia is a rare cause of thrombocytopenia;however,it is immediately life-threatening to both mother and fetus and requires immediate *** is compounded by the need to act on a presumptive diagnosis with high level of suspicion given the relatively long laboratory confirmation time.A 31-year-old gravida 3,para 1 parturient at 26 weeks of gestation presented to outside hospital with recent onset of easy bruising and blurry vision.A blood count was drawn and showed a platelet count of 19,000/μ*** was transferred to our institution for management where an initial diagnosis of preeclampsia with severe features was made based on thrombocytopenia and fetal growth restriction (elet count nadired at 14,000/μL and a blood smear showed schistocytes,suggesting microangiopathic hemolysis,prompting discussion of urgent cesarean delivery and anesthesia *** urgent hematology consult led to presumptively diagnosing thrombotic thrombocytopenic purpura and cesarean delivery was deferred after discussion with the patient and *** exchange and steroid therapy were started promptly,and her platelet count improved within 12 ***,the patient experienced neonatal *** ADAMTS13 levels confirmed diagnosis of thrombotic *** was transitioned to rituximab,platelets recovered to baseline,and she continues to do *** thrombocytopenia is a rare,life-threatening cause of thrombocytopenia in *** grim fetal prognosis,especially in early pregnancy,low threshold of suspicion,early anesthesia involvement,and multi-disciplinary approach can facilitate diagnosis and timely *** our case,it was likely lifesaving.

关键词： Thrombocytopenia Pregnancy Plasma exchange Preeclampsia Fetal death von Willebrand factor Purpura thrombocytopenic idiopathic HeLLP syndrome.

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Keeping Pregnant Patients Safe During COVID-19 Pandemic

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Maternal-Fetal Medicine 2021年第1期3卷 2-6页

作者： Philip e.hess Blair J.Wylie Toni Golen Scott A.Shainker Chloe Zera Yunping Li Department of Anesthesia Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusetts 02215USA Department of Obstetrics and Gynecology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMassachusetts 02215USA.

During a crisis such as the coronavirus disease 2019(COVID-19)pandemic,a hospital can suspend all elective surgery to expand capacity for intensive care;1 however,the clinical care on the Labor and Delivery Unit(L&D)cannot be *** patients must come to the hospital for their obstetric care and delivery,and patients may express concerns and fear regarding the risk of nosocomial *** CO VID-19 pandemic poses multiple challenges specifically for L&D Units around the world,such as:(1)caring for CO VID-19 and non COVID-19 pregnant patients simultaneously on the same unit;and(2)the mode of delivery cannot be pre-determined and emergent cesarean delivery is sometimes ***,strategies and guidelines are desperately needed to protect pregnant patients and health care workers(HCWs)from viral transmission while at the same time ensuring safe and swift responses to obstetric *** the CO VID-19 pandemic,we have learned an enormous amount about how to provide safe obstetric *** we report and share our strategies and experience as the CO VID-19 pandemic is accelerating and global peak is still to come.

关键词： demic COV Pregnant

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复合载荷作用下正交各向异性圆柱壳体的稳定性

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力学季刊 1965年第1期 6-17页

作者： T.e.hess 朱頤龄

日益增长地使用纤维和须状增强的材料促使需要有对于正交各向异性材料组成的圆筒与锥体的分析方法。本文处理了这类壳体在轴向载荷与均布外压联合作用下的翘曲问题。文中应用弗留格(Flügge)的微分方程式处理法,而其最终的翘曲方程式并... 详细信息

日益增长地使用纤维和须状增强的材料促使需要有对于正交各向异性材料组成的圆筒与锥体的分析方法。本文处理了这类壳体在轴向载荷与均布外压联合作用下的翘曲问题。文中应用弗留格(Flügge)的微分方程式处理法,而其最终的翘曲方程式并以轴向和周向弯曲刚度、剪切刚度、波桑此、几何参数和翘曲形式表示。列出之设计使用曲线能便于迅速确定圆筒的临界载荷,同时利用相当圆筒的概念并可用于小锥角的锥体。曲线尚能用于选制材料以适应结构的承载要求。

关键词：方程式方程复合载荷翘曲轴向弹性模量圆柱壳体正交各向异性圆柱壳波桑正交各向异性材料

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高比例万用比例仪器

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电测与仪表 1967年第5期 20-21页

作者： Alfred e·hess 庆琦

万用（Uersatile）比例仪器的准确度直接依赖于公共点结的设计和调节,所述仪器的结的传递电阻*小于10-8欧。这个传递电阻是引起在小于1/10～7比例时最坏情况下的不确定度的原因。图2是一个万用比例仪器的简图。它由一

关键词：惠斯登电桥装置固定电阻器

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产科麻醉袖珍手册

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中华围产医学杂志 2007年第2期10卷 141-142页

作者： Philip e hess Yunping Li Nancy e Oriol 闫婕（译）杨慧霞（译）美国哈佛医学院医疗中心急症护理和疼痛医学麻醉科北京大学第一医院妇产科 100034

此袖珍手册的内容系临床经验之总结，来自我们的临床实践，旨在与各位同仁交流经验，并非指南加以推广。手册中的麻醉处方可根据临床实际加以调整应用。特别指出的是所有腰麻和硬膜外麻醉使用药品均不得含防腐剂。

关键词：手册产科麻醉袖珍临床经验硬膜外麻醉临床实践麻醉处方防腐剂

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All-electron basis sets for H to Xe specific for ZORA calculations:Applications in atoms and molecules

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Chinese Physics B 2024年第8期33卷 238-246页

作者： C.S.Gomes F.e.Jorge A.Canal Neto Departamento de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Departamento de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segmented basis set of quadruple zeta valence quality plus polarization functions(QZP)for H through Xe was developed to be used in conjunction with the ZORA *** set was augmented with diffuse functions to describe electrons farther away from the nuclei *** the ZORA-CCSD(T)/QZP-ZORA theoretical model,atomic ionization energies and bond lengths,harmonic vibrational frequencies,and atomization energies of some molecules were *** addition of core-valence corrections has been shown to improve the agreement between theoretical and experimental results for molecular *** atomization energies,a similar observation emerges when considering spin-orbit *** the augmented QZP-ZORA set,static mean dipole polarizabilities of a set of atoms were calculated and compared with previously published recommended and experimental *** evaluations of the ZORA and Douglas–Kroll–hess Hamiltonians were made for each property studied.

关键词： QZP-ZORA and AQZP-ZORA basis sets elements from H to Xe CCSD(T)method atomic and molecular properties

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基于人工智能的全自动算法检测和示踪透视影像的肩关节解剖标志

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国际医学放射学杂志 2024年第2期 249-249页

作者： e.Croci H.hess F.Warmuth M.Künzler S.B?rlin D.Baumgartner 侯唯姝

摘要目的肩袖撕裂病人通常伴有肩关节不稳定。从X线摄影影像中评估解剖角度和肩关节运动需要在每张影像上标记特定的解剖标志。该研究旨在开发一种从X线影像中

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大型患者队列人群中肺高血压前期和死亡率、住院率的关系

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中华高血压杂志 2016年第2期24卷 157-157页

作者：刘莉叶鹏 Maron BA hess e Maddox TM Opotowsky AR Tedford RJ Lahm T Joynt Ke Kass DJ Stephens T Stanislawski MA Swenson eR Goldstein RH Leopold JA Zamanian RT elwing JM Plomondon Me Grunwald GK Barón Ae Rumsfeld J Choudhary G

肺高血压与所有心肺疾病死亡率增加相关。肺高血压定义为平均肺动脉压（mean pulmonary artery pressure,mPAP）≥25mm Hg（1mm Hg=0.133kPa）,而mPAP〈25mm Hg与临床预后的相关性尚未知。方法：研究人员回顾性分析美国退伍军人事务部... 详细信息

肺高血压与所有心肺疾病死亡率增加相关。肺高血压定义为平均肺动脉压（mean pulmonary artery pressure,mPAP）≥25mm Hg（1mm Hg=0.133kPa）,而mPAP〈25mm Hg与临床预后的相关性尚未知。方法：研究人员回顾性分析美国退伍军人事务部医疗系统中行右心导管插入术（right heart catheterization,RHC）（2007-2012年）的退伍军人资料（n=21 727;随访时间中位数为908d）。

关键词：高血压前期疾病死亡率心肺住院率 pulmonary 右心导管插入术人群队列

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Regulation of RNase e during the UV stress response in the cyanobacterium Synechocystis *** 6803

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mLife 2023年第1期2卷 43-57页

作者： Satoru Watanabe Damir Stazic Jens Georg Shota Ohtake Yutaka Sakamaki Megumi Numakura Munehiko Asayama Taku Chibazakura Annegret Wilde Claudia Steglich Wolfgang R.hess Faculty of Biology Genetics and Experimental BioinformaticsUniversity of FreiburgFreiburgGermany Department of Bioscience Tokyo University of AgricultureSetagayakuTokyoJapan School of Agriculture Molecular GeneticsIbaraki UniversityIbarakiJapan Faculty of Biology Molecular GeneticsUniversity of FreiburgFreiburgGermany Nexxiot Prime Tower(Hardstrasse 201)ZurichSwitzerland.

endoribonucleases govern the maturation and degradation of RNA and are indispensable in the posttranscriptional regulation of gene expression.A key endoribonuclease in Gram-negative bacteria is RNase *** ensure an appropriate supply of RNase e,some bacteria,such as escherichia coli,feedback-regulate RNase e expression via the rne 5′-untranslated region(5′UTR)in ***,the mechanisms involved in the control of RNase e in other bacteria largely remain *** rely on solar light as an energy source for photosynthesis,despite the inherent ultraviolet(UV)*** this study,we first investigated globally the changes in gene expression in the cyanobacterium Synechocystis *** ^(6)803 after a brief exposure to *** the 407 responding genes 2 h after UV exposure was a prominent upregulation of rne mRNA ***,the enzymatic activity of RNase e rapidly increased as well,although the protein stability *** unique response was underpinned by the increased accumulation of full-length rne mRNA caused by the stabilization of its 5′UTR and suppression of premature transcriptional termination,but not by an increased transcription *** of RNA 3′ends and in vitro cleavage assays revealed that RNase e cleaves within a stretch of six consecutive uridine residues within the rne 5′UTR,indicating *** observations suggest that RNase e in cyanobacteria contributes to reshaping the transcriptome during the UV stress response and that its required activity level is secured at the RNA level despite the enhanced turnover of the protein.

关键词： cyanobacteria protein turnover ribonuclease stress response

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Female Carriers of the Met Allele of the BDNF Val66Met Polymorphism Develop Weaker Fear Memories in a Fear-Potentiated Startle Paradigm

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Journal of Behavioral and Brain Science 2022年第5期12卷 211-235页

作者： Phillip R. Zoladz Mackenzie R. Riggenbach Jordan N. Weiser Jennifer J. Hipskind Leighton e. Wireman Kelsey L. hess Tessa J. Duffy Julie K. Handel MacKenzie G. Kaschalk Kassidy e. Reneau Brianne e. Mosley Psychology Program The School of Health and Behavioral Sciences Ohio Northern University Ada USA

The val66met polymorphism of the bdnf gene, which is associated with compromised brain-derived neurotrophic factor (BDNF) signaling, impaired synaptic plasticity, and impaired learning, may increase one’s susceptibility to stress- and anxiety-related disorders. Indeed, previous work has reported greater anxiety-related behaviors and impairments of fear conditioning and extinction in individuals who carry the met allele that results from this polymorphism. Nevertheless, findings in this area of research have been equivocal. Thus, we examined the influence of the val66met polymorphism on fear conditioning, extinction, and extinction memory testing. One hundred and twenty healthy participants completed differential fear conditioning in a fear-potentiated startle paradigm, followed by extinction and extinction memory testing 24 and 48 hr later, respectively. Participants were genotyped for the val66met polymorphism and divided into met allele carriers and non-carriers. Results revealed that, although both met-carriers and non-carriers developed conditioned fear, met-carriers exhibited significantly weaker fear acquisition than non-carriers. This difference persisted throughout extinction and extinction memory testing and, during these last two days of testing, was primarily evident in females. These results are consistent with previous work demonstrating that this polymorphism is associated with impaired amygdala-dependent fear learning and extend such findings by demonstrating that females may be more sensitive to such effects.

关键词： Fear Conditioning extinction Polymorphism BDNF Val66Met Startle

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