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SPACE BIOMEDICAL STUDIES IN CHINA

丛书名： de viva voz

2010年

作者： Gil de Biedma Jaime

来源：畅想之星图书光盘版（南... 评论

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空间科学学报 1998年第S1期18卷 87-93页

作者： YANG Tian-de(Institute of Space Medico-Engineering, Beijing 100094)

Chinese scientists paid great attention to the study about space life science in *** biomedical experiments in this field were completed in Chinese recoverable satellites or in a Russian biosatellite. The effect of microgravity and space radiation on Chinese silkworm eggs, plants, seeds and tomato DNA mutation was investigated in space. Head down bed rest of human body was applied to simulate weightlessness to study cardiovascular function, electrogastrogram,thermoregulation on the ground. Space motion sickness was also studied by means of swinging, optokinetic stimulation on the ground.

关键词： Microgravity Simulated weightlessness Space medicine Animal model Space motion sickness

Preparation and Characterization of InAs/Si Composite Film

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Chinese Physics Letters 2000年第8期17卷 592-594页

作者： YANG Lin LI Guang-hai ZHENG Mao-Jun ZHANG Li-de Institute of Solid State Physics Chinese Academy of SciencesHefei 230031

Composite thin films consisting of nanosized InAs particles embedded in amorphous Si matrices were prepared by radio frequency co-sputtering of InAs and Si.X-ray diffraction spectra show that the particle size of InAs increases with the increasing annealing temperature,while the particle sizes of In and As reach their maximum values at the temperature of 200℃,and decrease with the further increase of the annealing *** and As can not exist in the 500℃sample due to the sublimation of In and As and the reaction In+As→*** composition of the film in different levels was *** found that only in the deep level,the mole contents of As and In conform to the stoichiometric ratio and the oxidation occurs only a few nanometers from the *** believe that the scarcity of In and As near the surface is due to the sublimation of In and the oxide of As.

关键词： temperature. annealing sizes

Amyotrophic lateral sclerosis,a neurodegenerative motor neuron disease with retinal involvement

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Neural Regeneration Research 2022年第5期17卷 1011-1012页

作者： Ana I.Ramírez Rosa de Hoz Pilar Rojas Juan J.Salazar Instituto de Investigaciones Oftalmológicas Ramón Castroviejo.Universidad Complutense de Madrid MadridSpain Facultad deÓptica y Optometría.departamento de Inmunología Oftalmología y ORL.Universidad Complutense de MadridMadridSpain Hospital General Universitario Gregorio Marañón Instituto Oftálmico de MadridMadridSpain

Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease that damages the motor neurons,the spinal cord,the cerebellum,and some areas of the ***,more recent studies show that it can also affect the visual syst... 详细信息

关键词： visual problems involvement

development of a short duration method to assess the envelope thermal performance of multi-family housings

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Building Simulation 2023年第4期16卷 527-545页

作者： Lorena de Carvalho Araujo Simon Thébault Laurent Mora Thomas Recht Alain Sempey Patrick Schalbart Michae Cohen CSTB 84 Av.Jean JauresChamps-sur-Marne77420France Bordeaux University 351 Cours de la LiberationTalence33405France MINES ParisTech Centre for Energy Efficiency of Systems5 rue Léon BlumPalaiseau91120France

Building energy efficiency is a key factor in reducing CO_(2) *** this reason,European Union(EU)member states have developed thermal regulations to ensure building thermal *** results are often based on results achieved with building simulation software during the design ***,the actual thermal performance can deviate significantly from the predicted one,and this difference is known as the energy performance *** indicators of the actual thermal performance are a valuable tool to guarantee building *** indicators,including the heat transfer coefficient(HTC)and the heat loss coefficient(HLC),can be estimated by the application of in situ *** multi-family housing and tertiary sector buildings are an important part of the building stock,mature methods to measure their thermal performance are *** paper presents a short-duration method for assessing the HTC in large building typologies using a sampling *** method was applied in a four-storey building model under different conditions to study the limits of the method and to improve indicator bias and *** quality was strongly influenced by the external weather conditions,the temperature variation during the protocol and the heat exchange with the adjacent *** winter conditions and with stable indoor temperatures,the method had a high accuracy when the protocol was applied for half a *** is recommended that the protocol be used over two days to improve indicator quality under less favorable test conditions.

关键词： building envelope thermal performance HTC estimation multi-family housing

Ab initio molecular dynamics simulations of nano-crystallization of Fe-based amorphous alloys with early transition metals

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Chinese Physics B 2018年第11期27卷 300-304页

作者： Yao-Cen Wang Yah Zhang Yoshiyuki Kawazoe Jun Shen Chong-de School of Natural and Applied Sciences Northwestern Polytechnical UniversityXi'an 710072China Research&development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China Institute for Materials Research Tohoku UniversitySendal 980-8577Japan New Industry Creation Hatchery Center Tohoku UniversitySendai 980-8577Japan School of Materials Science and Engineering Tongji UniversityShanghai 201804China

The addition of early transition metals(ETMs)into Fe-based amorphous alloys is practically found to be effective in reducing theα-Fe grain size in crystallization *** this paper,by using ab initio molecular dynamics simulations,the mechanism of the effect of two typical ETMs(Nb and W)on nano-crystallization is *** is found that the diffusion ability in amorphous alloy is mainly determined by the bonding energy of the atom rather than the size or weight of the *** alloying of B dramatically reduces the diffusion ability of the ETM atoms,which prevents the supply of Fe near the grain surface and consequently suppresses the growth ofα-Fe ***,the difference in grain refining effectiveness between Nb and W could be attributed to the larger bonding energy between Nb and B than that between W and B.

关键词： ab initio molecular dynamics Fe-based amorphous alloys nano-crystallization atomic diffusion

Convergence Rate of Empirical Bayes for Two-parameter Exponential Distribution with Replicated Data

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Communications in Mathematical Research 2010年第3期26卷 211-218页

作者： Wang de-hui LI NAI-YI 不详 Faculty of Science Guangdong Ocean University Zhanjiang Guangdong 524088

In this paper, empirical Bayes test for a parameter θ of two-parameter exponential distribution is investigated with replicated past data. Under some conditions, the asymptotically optimal property is obtained. It is indicated that the rate of convergence can be very close to O（N-2^-1） in this case that a parameter μ is known.

关键词： replicated data empirical Bayes asymptotic optimality

Antibacterial activity and inhibition against Staphylococcus aureus NorA efflux pump by ferulic acid and its esterified derivatives

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Asian Pacific Journal of Tropical Biomedicine 2021年第9期11卷 405-413页

作者： Patrícia Gonçalves Pinheiro Gilvandete Maria Pinheiro Santiago Francisco Erivaldo Freitas da Silva Ana Carolina Justino de Araújo Cícera Rejane Tavares de Oliveira Priscilla Ramos Freitas Janaína Esmeraldo Rocha JoséBezerra de Araújo Neto Maria Milene Costa da Silva Saulo Relison Tintino Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho JoséGalberto Martins da Costa departamento de Química Biológica Programa de Pos-Graduação em Química BiológicaUniversidade Regional do Cariri–URCACrato–CEBrazil Programa de Pós-Graduação em Química Centro de CiênciasUniversidade Federal do Ceará–UFCFortaleza–CEBrazil

Objective:To evaluate the inhibitory activity of ferulic acid and four of its esterified derivatives(methyl,ethyl,propyl,and butyl)against resistance mechanisms in Staphylococcus aureus ***:Ferulic acid derivatives were obtained by esterification with methanol,ethanol,propanol,and butanol,and then characterized by hydrogen and carbon-13 nuclear magnetic resonance *** minimum inhibitory concentrations(MIC)of ferulic acid and its esterified derivatives,ethidium bromide,and norfloxacin were obtained using the microdilution test,while the efflux pump inhibition test was conducted by examining reduction in the MICs of norfloxacin and ethidium *** docking was also carried out using the Schrodinger Suite 2015 molecular modeling software.A three-dimensional model of NorA efflux pump was generated using *** best scoring model was used as a receptor for ligand-receptor ***:The methyl and butyl ester derivatives did not demonstrate significant antimicrobial ***,a significant synergic effect was evidenced when norfloxacin was combined with the ethyl and propyl esterified *** docking study demonstrated favorable energy of interaction between ferulate derivatives and NorA,and amino acid residues TYR57,TYR58,and LEU255 were present commonly in stabilizing all *** PCA analysis corroborated the docking hypothesis that the lipophilic character and hydrogen bond interactions were the most relevant characteristics involved with NorA *** pharmacokinetic parameters of ferulic acid derivatives showed good ADMET properties,demonstrating that they can be easily absorbed and have no effect or inhibit the cytochrome P450 enzyme complex,revealing their potential as drug ***:This study provides strong evidence that the molecular basis for this activity is potentially due to the NorA efflux pump.

关键词： Ferulic acid Esterified derivatives Efflux pump Staphylococcus aureus Resistance mechanisms

UPLC-Q-TOF-MS/MS法分析鉴定鸡血藤中药复方提取物的化学成分

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分析测试学报 2024年第4期43卷 511-522页

作者：谢灿辉贾德政胥爱丽邬旻珊肖观林毕晓黎张素中曹颖男广州中医药大学第五临床医学院广东广州510405 广东省中医药工程技术研究院广东省中医药研究开发重点实验室广东广州510095 广州新华学院药学院广东广州510520

应用超高效液相色谱-四极杆-飞行时间串联质谱(UPLC-Q-TOF-MS/MS)技术定性鉴别鸡血藤中药复方提取物的化学成分。采用Waters ACQUITY UPLC BEH C18色谱柱(100 mm×2.1 mm,1.7µm),以0.1%甲酸水溶液-乙腈为流动相进行梯度洗脱,电喷雾离... 详细信息

应用超高效液相色谱-四极杆-飞行时间串联质谱(UPLC-Q-TOF-MS/MS)技术定性鉴别鸡血藤中药复方提取物的化学成分。采用Waters ACQUITY UPLC BEH C18色谱柱(100 mm×2.1 mm,1.7µm),以0.1%甲酸水溶液-乙腈为流动相进行梯度洗脱,电喷雾离子源正、负离子模式扫描。通过质谱数据库、化合物裂解规律,并结合相关文献进行鉴别。共鉴别出82种化合物,以黄酮类、苯丙素类、萜类化合物为主,包括黄酮类22种、苯丙素类24种、萜类25种、酚酸类4种、甾体类6种、氨基酸类1种,各药材组成复方后首次发现的新化学成分有10种。UPLC-Q-TOF-MS/MS技术为鉴别鸡血藤中药复方中化学成分提供了简便、快速、准确的方法,鉴定得到的各个化学成分涵盖了组方中各味药材的主要成分,可为该复方的质量标准及药效物质研究提供实验依据和理论基础。

关键词： UPLC-Q-TOF-MS/MS 鸡血藤中药复方提取物化学成分裂解规律

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