检索结果-南通市图书馆

IL28B polymorphism and cytomegalovirus predict response to treatment in Egyptian HCV type 4 patients

World Journal of Gastroenterology 2013年第2期19卷 290-298页

作者： Mostafa K el Awady Noha G Bader el Din Ashraf Tabll Yaser el Hosary Ashraf O Abdel Aziz hesham el Khayat Mohsen Salama Tawfeek H Abdelhafez Department of Microbial Biotechnology National Research CenterCairoGiza 12622Egypt Department of Internal Medicin National Research CenterCairoGiza 12622Egypt Department of Tropical Medicine Cairo UniversityGiza 12622Egypt Theodor Bilharz Research Institute Giza 12622Egypt National Liver Institute Shebeen El Kom 32512Egypt

AIM:To test whether the status of positive cytomegalovirus(CMV) DNA detection adds to the predictive value of IL28B and to further categorize C/T allele ***:This study included 166 chronic hepatitis C(CHC) patients who received combined interferon and ribavirin therapy for 48 wk,84 spontaneous hepatitis C virus(HCV) resolvers who were positive for IgG anti-HCV antibody and negative for HCV RNA,and 100 healthy subjects who were negative for both HCV antibodies and RNA as *** DNA from peripheral blood was used for IL28B rs.12979860 single nucleotide polymorphism(SNP) and CMV DNA detection.A 139 bp fragment containing IL28B SNP was amplified in all subjects by polymerase chain reaction using a specifically designed *** the IL28B rs.12979860 SNP was detected by restriction fragment length polymorphism(RFLP) *** presence of CMV DNA was tested by amplification of the gB1 gene using nested polymerase chain *** role of CMV and IL28B rs.12979860 SNP genotypes in determining the response rate to combined interferon therapy and clinical status of patients were statistically ***:Current data showed that 67% of patients carrying the IL28B 12979860 C/C allele had a sustained viral response(SVR) while the genotypes C/T and TT were associated with lower SVR rates,50% and 48%,*** rates for the C/C allele were lower than other HCV genotypes and/or other *** CC was associated with the response to interferon(P = 0.025).Genotype C/C was reduced from 48% in controls to 14% in CHC patients suggesting its protective role against progression to *** majority of spontaneously cleared subjects(86%) were C/C,confirming its protective *** C/T allele was present in 71% of CHC patients compared with 38% of controls,so the use of IL28B SNP genotyping only in these patients may be of little value as a predictor of *** reactivation occurred in 40% of CHC ***-infection with

关键词： Hepatitis C Interleukin 28B Genetic polymorphisms Human cytomegalovirus Spontaneous clearance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance Evaluation of One-Way Concrete Slabs Reinforced with New Developed GFRP Bars

引用

Materials Sciences and Applications 2015年第5期6卷 420-435页

作者： Ahmed H. Ali Mohammad Z. Afifi Bahira Abdulsalam hesham Haggag Awad el Hashimy Tarek el-Sayed Hamdy M. Mohamed Department of Civil Engineering Helwan University Cairo Egypt Department of Civil and Environmental Engineering Western University London Canada

The incorporation of fiber-reinforced-polymer (FRP) bars in construction as a replacement to steel bars provides a superior material which is capable to overcome corrosion problems. However, serviceability requirements are important issues to be considered in the design of concrete elements reinforced with glass-FRP (GFRP) bars which are known to have larger deflections and wider crack widths as well as weaker bond compared with steel reinforced concrete. As a solution to this problem, square GFRP bars are proposed. This paper presents the results of an experimental investigation that was performed, in which newly developed square and circular GFRP bars were fabricated in the lab. Also, the GFRP bars were tested and used to reinforce concrete slabs. A total of nine full-scale GFRP-reinforced concrete (RC) one-way slabs were constructed, tested and analyzed, considering the most influencing parameters such as the cross sectional shape of GFRP bars, reinforcement ratio, the concrete characteristics strength, and adding polypropylene fibers to the concrete mixture. The test results were showed that, the tested slabs with GFRP square bars improved the deflection and cracking behavior as well as the ultimate load.

关键词： Square and Circular Bars GFRP Reinforcement Bars Polypropylene Fibers Concrete Slabs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Risk Factors Associated with Cholelithiasis during Pregnancy and Postpartum

引用

Open Journal of Obstetrics and Gynecology 2022年第11期12卷 1166-1175页

作者： Shaimaa Belal hesham Mohammed Hamed Abdelrahman Kamal Manal Abdel-Wanees Al-Sayed Hany Mahmoud Abd el Hamid Department of Obstetrics and Gynecology Faculty of Medicine Helwan University Helwan Egypt Department of Obstetrics and Gynecology El-Sahel Teaching Hospital Cairo Egypt Department of General Surgery Sahel Teaching Hospital Cairo Egypt

Gallbladder disease is the most common non-obstetrical cause of maternal hospitalization in the first year postpartum. Many risk factors have been associated with gallbladder disease in pregnancy including body mass index, prenatal weight gain, prenatal physical activity, dietary fat, age, parity, a history of gallbladder disease and the number of previous pregnancies were significant factors related to new gallstones and biliary sludge formation in the pregnant group. The aim of this study is to evaluate the risk factors for gallstones formation in pregnancy and one year after labour. The study included 328 female patients (pregnant or postpartum) divided into two groups;patient group (164 patient) that are pregnant or postpartum patient have gallstones and control group (164 patient) that are pregnant or postpartum patient does not have gallstones. All patients were subjected to full history taking;especially about risk factors predisposing for gallstones, physical examination and pre-operative routine laboratory investigations and imaging as abdominal ultrasound study (U/S). Obesity, young age, history of gallbladder disease and use of estrogen and progesterone are the main risk factors that increase incidence of gallstones during pregnancy or one year postpartum. Use of vit C, iron, drinking coffee and practicing regular physical activity are considered protective factors.

关键词： Cholelithiasis Pregnancy Postpartum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Administration of Zinc with Paroxetine Improved the Forced Swim Test Behavioral Pattern of Treated Mice in Acute and Sub-Acute Study

引用

Journal of Behavioral and Brain Science 2015年第7期5卷 213-220页

作者： hesham el Refaey Hasan S. Al Amri Abdelkader E. Ashour Atallah F. Ahmed Pharmacology Department College of Pharmacy King Khalid University Abha Saudi Arabia Psychiatry Department College of Medicine King Khalid University Abha Saudi Arabia Department of Pharmacology and Toxicology College of Pharmacy King Saud University Abha Saudi Arabia Department of Pharmacognosy College of Pharmacy King Saud University Abha Saudi Arabia

Despite progressive improvement in treating major depressive disorder (MDD), it remains mostly unresponsive to one antidepressant medication. Zinc is a brain highly abundant trace metal, a brain derived neurotrophic factor (BDNF) inducer, a modulator of synaptic plasticity and potent suppressor of the NMDA receptors. We proposed that co-administration of zinc with the antide-pressants may represent a valuable regimen to improve the efficacy of these drugs. This work has been implemented to evaluate the behavioral changes of acute and sub-acute co-administration of zinc with Paroxtine in mice. Methods: The animals were injected intra-peritoneal with either Paroxtine (20 mg/kg) which was a selective serotonin reuptake inhibitor (SSRI), zinc sulfate (30 mg/kg) or Paroxtine in combination with zinc for one day and one week (once daily). The pattern of the animal behavior was assessed in the forced swim test (FST). Results and Discussion: The behavioral patterns of the animals in the FST include immobility, swimming and climbing. Successful antidepressant should decrease the immobility time with either increase in swimming and/or climbing behavior based on the drug pharmacological activity. Our results revealed a significant decrease of immobility and increase of swimming behavior indicating serotonin-dependent pharmacological activity of Paroxtine or zinc alone as well as in the animals treated with zinc in combination with Paroxtine. There was no significant difference in the animals’ behavior between acute and sub-acute treatment with zinc or even upon its addition to paroxetine. Our data support the concept that co-administration of zinc may provide further antidepressant activity. Zinc may offer additional clinical value particularly in geriatric patients or other populations where zinc level has shown dramatic decrease.

关键词： Depression Antidepressants Paroxetine Zinc

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural, Magnetic and Dielectric Properties of Fe-Co Co-Doped Ba0.9Sr0.1TiO3Prepared by Sol Gel Technique

引用

New Journal of Glass and Ceramics 2014年第2期4卷 19-28页

作者： Inas Kamal Batttisha Ibrahim Sayed Ahmed Farag Mostafa Kamal Mohamed Ali Ahmed Emad Girgis hesham Azmi el Meleegi Fawzi Gooda el Desouky Materials Science Lab (1) Physics Department Faculty of Science Cairo University Giza Egypt Metal Physics Laboratory Physics Department Faculty of Science Mansoura University Mansoura Egypt National Research Center (NRC) Solid State Physics Department Dokki Giza Egypt National Research Centre (NRC) Thin Film Lab Electron Microscope Department Dokki Giza Egypt

The structural, dielectric and magnetic properties of pure and Fe-Co co-doped Ba0.9Sr0.1TiO3, (Ba(1-x)SrxTiO3, where (x = 0.10) and (Ba0.9Sr0.1Ti(1-x-y)FexCoyO3), where (x = 0.1, y = 0) and (x = 0 and y = 0.10) and (x = 0.5, y = 0.5) in powder form, abbreviated as (BST) and (BST10FO), (BST10CO) and (BST5F5CO), respectively were prepared by a modified sol gel technique. Crystallization, surface morphology and electrical behavior of BST are improved by Fe3+ and Co2+ ions with optimized grain size. Phase identification by using X-ray diffraction and surface morphology will be studied by using transmission electron microscope (TEM) and scanning electron microscope imaging (SEM). Phase identification by using X-ray diffraction and surface morphology evaluation by using transmission electron microscope (TEM) and scanning electron microscope imaging (SEM) will be studied. The nano-scale presence and the formation of the tetragonal perovskite phase as well as the crystallinity were detected using the mentioned techniques. The dielectric properties of the prepared samples have been investigated as a function of temperature and frequency. The dielectric measurements are carried out in the frequency range of 42 Hz - 1 MHz, at temperature ranging between 25°C and 250°C. The results showed an abrupt decrease in the dielectric permittivity by increasing the frequency range. The magnetic hysteresis loop confirmed enhancement in the magnetization properties by co-doping with Fe3+-Co2+ ions. An increase in the saturation of the magnetization at room temperature was detected by decreasing the crystallite sizes of the prepared samples.

关键词： Sol Gel Nano-Structure Magnetic Hysteresis Loop Dielectric Permittivity Nano-Composite BaSrTiO3 (BST) TEM XRD SEM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrating Remote Sensing and Field Survey to Map Shallow Water Benthic Habitat for the Kingdom of Bahrain

引用

Journal of Environmental Science and Engineering(B) 2017年第4期6卷 176-200页

作者： sabah Aljenaid Eman Ghoneim Mohammed Abido Khalil AlWedhai Ghadeer Khadim Saeed Mansoor Wisam el-Deen Mohd Nadir Abd Hameed Department of Geoinformatics College of Graduate Studies Arabian Gulf University Manama 22979 Bahrain Department of Earth and Ocean Sciences University of North Carolina Wilmington-UNCW Wilmington North Carolina 28403 USA Department of Natural Resources and Enviro. College of Graduate Studies Arabian Gulf University Manama 22979 Bahrain Department of Biology University of Bahrain Sakheer 32038 Bahrain Department of Student Affairs University of Bahrain Sakheer 32038 Bahrain Department of Landscape Architecture University of Dammam Dammam 31441 Saudi Arabia

Identification and classification, as well as mapping of marine habitats, are of primary importance to plan management activities, especially in disturbed ecosystems like the ones in the marine areas of Bahrain. Remotely sensed Landsat-8 imagery coupled with field survey was used to identify, classify and map the benthic habitats in Bahrain marine area. The used geospatial techniques include advanced image processing procedures, which comprise of radiometric and atmospheric corrections, sun glint removal, water depth correction and image classification. Extensive ground-truthing analyses through in-situ field surveys by a team of scuba divers were conducted in October 2014 and June 2015 to inform and refine the classifications. The variables collected from this survey included physical and chemical characteristics of the water, habitat type, substrata, fauna and flora. A total of 176 field points were collected and utilized to perform an accurate assessment of the image classification. Initial habitat classification resulted in 20 habitat categories. However, due to the inability of the Landsat-8 sensors to accurately discriminate that level of classification, categories were merged into seven classes. The derived map shows that the benthic marine habitats of Bahrain consist of deep water （2,523 km2）, rock （1,738 km2）, sand （1,191 km2）, deep water/sand （1,006 km2）, algae （922 km2）, seagrass （591 km2） and corals （275.50 km2）. Although limited by the spatial and spectral resolutions of Landsat 8, the used methods produced a suitable map of the benthic habitats within the marine area of Bahrain with an overall accuracy of 84.1%. The use of very high spatial resolution satellite imagery will most likely increase such accuracy significantly.

关键词： Landsat 8 marine water column correction scuba diving GIS (Geographic Information System)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Theoretical, Experimental and Numerical Investigations of the Effect of Inlet Blade Angle on the Performance of Regenerative Blowers

引用

Open Journal of Fluid Dynamics 2015年第3期5卷 224-237页

作者： Tarek Abdel-Malak Mekhail Omar Mohamed Dahab Mohamed Fathy Sadik Mahmoud Mohamed el-Gendi hesham Sayed Abdel-Mohsen Faculty of Energy Engineering Mechanical Power Department Aswan University Aswan Egypt Faculty of Engineering Mechanical Power Department Aswan University Aswan Egypt Faculty of Engineering Mechanical Power and Energy Department Minia University Minia Egypt

Regenerative machines allow high heads at small flow rates and present performance curves with very stable features. This research includes a study of the effect of four inlet flow angles (90°, 115°, 125° and 135°) of the blade at outlet flow angle of 90° on the performance of regenerative blower at rotation speed of 3000 rpm and at different flow rates. Investigation and comparison of the experimental results with both one-dimensional theoretical model and numerical CFD technique using CFX-ANSYS 16.1 are done. The numerical CFD analysis show that the flow enters the impeller from the blade side (about 65% of the blade side area) and leaves from the blade tip and blade side (the remaining 35% from the blade side area). According to this observation, a mathematical model that is based on momentum exchange theory to handle one inlet angle and two exit angles for the regenerative blower impeller blades is proposed. Consequently, the experimental work is carried out by two steps. The first step is done by studying the effect of inlet blade angle of 90° and analyzing the results by using the CFD analysis. The CFD results show shock losses and vortices behind each blade at the inlet flow regions. To reduce these losses, an increase of the inlet blade angle in a range between 25° to 45° is proposed. The second step is the splitting of this angle range to three inlet blade angles of 115°, 125° and 135° in order to study and analyze the CFD results for these angels. The CFD analysis shows the disappearance of the shock losses and vortices that are formed behind the blade of angle 90°. The experimental results show that the pressure head and the efficiency depend strongly on the blade inlet and outlet flow angles as well as on the blade geometry. The results also show that the best blower performance can be obtained at an inlet flow angle of 125°, and this is confirmed by CFD simulation analysis. Finally, it is shown that the proposed one-dimensional model yield results that

关键词： Regenerative Blower Circulatory Flow CFD Shock Losses Vortices Impeller Angles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Major clinical and angiographic outcome of drug eluting stents in native ostial coronary artery disease

引用

World Journal of Cardiovascular Diseases 2013年第3期3卷 320-327页

作者： Khaled R. Abd el Meguid hesham B. Mahmoud Fouad R. Amin Jonathan R. Clague Division of Cardiology Beni-Suef University Hospital Beni-Suef Egypt Division of Cardiology Heatherwood & Wexham Park Hospitals London UK Division of Cardiology Royal Brompton Hospital Imperial College London UK

Objectives: The study was designed to evaluate the efficacy and safety of drug eluting stents (DESs) in aorto-ostial (A-O) coronary artery lesions, in terms of early and late restenosis rate;including clinical assessment, non-invasive stress testing and angiographic follow-up. Also, the study was aimed to compare the results of implantation of drug eluting stents (DES) to that of bare metal stents (BMS) in aortoostial lesions done over a previous 5 years in Royal Brompton Hospital. Background: The safety and effectiveness of DESs for the treatment of aortoostial lesions. Methods: We included 161 consecutive patients with symptoms subjective of angina pectoris or objective evidence of myocardial ischemia;who underwent percutaneous coronary interventions (PCI) in coronary ostial lesions using DES. The patients were divided into two groups based on the site of ostial lesion. The control group consisted of 125 consecutive patients who underwent percutaneous coronary intervention for ostial lesions using bare metal stents (BMS) implantation in the period immediately before the introduction of DES. The incidence of major adverse cardiac events (MACE), including death or Q-wave myocardial infarction (MI), need for repeated revascularization procedure CABG or angioplasty, were recorded in-hospital and at twelve months ± 3 months. Follow-up angiography was only performed in case of recurrent symptoms subjective of myocardial ischemia or if there was objective evidence of myocardial ischemia by stress testing. Results: The initial procedure was successful in 149 patients (92.5%) in the DES arm. There were no statistically significant major in-hospital complications in the DES group, compared to BMS group which showed 4 cases of in-hospital deaths (p = 0.017). At Twelve months ± 3 months follow-up, MACE were significantly less frequent in the DES group compared to the BMS group, including death (0.8% vs. 6.4%, p = 0.004) and need for CABG (1.7% vs. 10%, p = 0.012). Conclusions

关键词： Bare Metal Stent DRUG eluting Stent Ostial Coronary Lesions

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Patterns and Changes in the Treatment of Patients with Type II Diabetes Mellitus in Egypt: The DISCOVER Program

引用

International Journal of Clinical Medicine 2020年第12期11卷 731-742页

作者： Salah Shelbaya Mohamed Khattab Khalifa Abdallah Yehia Ghanem hesham el Hefnawy Enas Shaltout Eman Roshdy Emad R. Issak Endocrinology Department Ain Shams University Cairo Egypt Internal Medicine Department Cairo University Giza Egypt Internal Medicine Department Alexandria University Alexandria Egypt Endocrinology Department National Institute of Diabetes & Endocrinology Cairo Egypt Internal Medicine Department Diabetes Unit Cairo University Giza Egypt Internal Medicine Department Ain Shams University Cairo Egypt

The DISCOVER study is a three-year, non-interventional prospective study conducted in 37 countries, including Egypt, to assess the treatment patterns and outcomes in patients with type 2 diabetes mellitus initiating a second-line antidiabetic therapy (add-on or switch). In this report of the Egyptian cohort of DISCOVER, baseline data were collected according to routine clinical practice at 38 study sites, using a standardized electronic case report form, in the period from December-2014 to November-2019. We enrolled 583 patients (mean age: 52.9 ± 9.8 years and median duration since diagnosis: median 36.5, IQR 18.1, 70.4 months). The mean HbA1c value at baseline was 8.6 ± 1.4%, indicating poor glycemic control. The most commonly prescribed first-line medications were metformin or sulfonylurea monotherapy. For second line-therapy, the majority of patients switched to dual therapy with metformin plus sulfonylureas or DPP-4 inhibitors. Fewer patients switched to triple therapy, treatment by four or more medications, or insulin treatment (15, 12, and 35 patients, respectively). The most commonly cited reasons for switching to second-line therapy were lack of efficacy, weight gain, hypoglycemic events, and side effects (549, 54, 25, and 21 patients, respectively). The set treatment target of enrolled patients at the initiation of second-line therapy was an HbA1c level of 6.9%. Follow-up data will assess the outcomes of such changes in the Egyptian population.

关键词： Diabetes Mellitus Glucose Control Metformin Patient-Reported Outcomes Egypt HbA1c Medication

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Moderate Secondary Tricuspid Regurgitation: Does It Worth More Time to Conserve?

引用

Open Journal of Thoracic Surgery 2021年第3期11卷 59-68页

作者： Montaser elsawy Abd elaziz Ahmed Labib Dokhan Awny Gamal Shalaby hesham Hassan Ahmed Mohammed Ahmed el-Hag-Aly Mohammed Fawzy eltaweel Cardithoracic Surgery Department Faculty of Medicine Menoufia University Menoufia Egypt Faculty of Medicine Jazan University Jazan KSA Cardiology Department Faculty of Medicine Menoufia University Menoufia Egypt

Background: Concomitant repair of moderate secondary tricuspid regurgitation (STR) during mitral valve surgery is still subject of controverse. This research aims to study the early and mid-term postoperative influence of tricuspid repair on the clinical outcomes and right ventricular functions. Methods: This is a retrospective cohort study of 92 patients with moderate STR who underwent tricuspid valve repair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：