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Targets and molecular mechanisms of a citrus flavonoid, hesperidin, against luminal breast cancer cells: an integrative bioinformatics analysis

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Asian Pacific Journal of Tropical Biomedicine 2019年第12期9卷 531-538页

作者： Adam Hermawan herwandhani putri Department of Pharmaceutical Chemistry Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ55281 YogyakartaIndonesia Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ55281 YogyakartaIndonesia

Objective:To identify the potential target and mechanisms of hesperidin in MCF-7 estrogen receptor-positive breast cancer cells using bioinformatics ***:Gene expression profiles were accessed from public database *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis was carried out with Database for Annotation,Visualization and Integrated *** protein-protein interaction network was analyzed by STRING-DB and visualized by *** factor regulatory networks were constructed from TRED,TRRUST,Reg Network and visualized by *** association analysis was conducted by Web ***:GO and KEGG pathway enrichment analysis revealed biological processes,cellular components and molecular functions that were related to cancer and estrogen signaling *** pathway enrichment analysis of the genes in transcription factor-differential expression genes regulatory network showed regulation of cancer,estrogen signaling pathways,epidermal growth factor receptor tyrosine kinase inhibitor resistance,and endocrine ***,drug association analysis revealed that hesperidin affected the expression of the same gene as ***:Hesperidin targets estrogen receptor signaling in estrogen receptor-positive breast cancer *** of this study could trace the molecular mechanism of hesperidin in estrogen receptor-positive breast cancer cells and integrative bioinformatics analysis could accelerate drug discovery and development.

关键词： Hesperidin Breast cancer Bioinformatics Estrogen receptor Signaling pathway

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Cardioprotective and hepatoprotective effects of Citrus hystrix peels extract on rats model

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Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 371-375页

作者： herwandhani putri Standie Nagadi Yonika Arum Larasati Nindi Wulandari Adam Hermawan Cancer Chemoprevention Research Center Faculty of PharmacyUniversitas Gadjah MadaSekip Utara Ⅱ

Objective:To observe the combination effect of doxorubicin and Citrus hystrix(kaffir lime's)peel ethanolic extract(ChEE)on blood serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)activity and cardio-hepato-histopathology of female Sprague Dawley ***:Doxorubicin and ChEE(5 rats per group)were administered in five groups of 3 rats each for 11 *** I:doxorubicin(dox)4.67 mg/kg body weight;Group II:dox+ChEE 500 mg/kg body weight;Group HI:dox+ChEE 1000 mg/kg body weight;Group IV:ChEE 1000 mg/kg body weight;Group V:untreated(control).Results:ChEE repaired cardiohistopathology profile of doxorubicin induced cardiotoxicity and hepatotoxicity rats,but did not repair neither hepatohistopathology profile nor reduce serum activity of ALT and ***:ChEE has potency to be developed as cardioprotector agent in chemotherapy.

关键词： Citrus hystrix D.C. Cardiohepatoprotector Histopathology Chemoterapy

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