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The transcriptomic signature of responses to larval crowding in Drosophila melanogaster

Insect Science 2023年第2期30卷 539-554页

作者： Juliano Morimoto Marius Wenzel Davina Derous Youn Henry herve Colinet School of Biological Sciences University of AberdeenAberdeenUnited Kingdom Programa de Pos-graduacao em ecologia e Conservacao Universidade Federal do ParanaCuritibaBrazil Institute of Mathematics King's CollegeUniversity of AberdeenAberdeenUnited Kingdom CNRS ECOBIO(Ecosystemesbiodiversiteévolution)—UMR 6553University of RennesRennesFrance Department of ecology and evolution University of LausanneLausanneSwitzerland

Intraspecific competition at the larval stage is an important ecological factor affecting life-history,adaptation and evolutionary trajectory in holometabolous ***,the molecular pathways underpinning these ecological processes are poorly *** reared Drosophila melanogaster at three egg densities(5,60,and 300 eggs/mL)and sequenced the transcriptomes of pooled third-instar *** also examined emergence time,egg-to-adult viability,adult mass,and adult sex-ratio at each *** crowding had minor detrimental effects on adult phenotypes compared to low density and yielded 24 differentially expressed genes(DeGs),including several chitinase *** contrast,high crowding had substantial detrimental effects on adult phenotypes and yielded 2107 *** these,upregulated gene sets were enriched in sugar,steroid and amino acid metabolism as well as DNA replication pathways,whereas downregulated gene sets were enriched in ABC transporters,taurine,Toll/Imd signaling,and P450 xenobiotics metabolism ***,our findings show that larval crowding has a large consistent effect on several molecular pathways(i.e.,core responses)with few pathways displaying density-specific regulation(i.e.,idiosyncratic responses).This provides important insights into how holometabolous insects respond to intraspecific competition during development.

关键词： intraspecific competition larval crowding life-history trade-offs transcriptomics

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Animal phylogeny and large-scale sequencing： progress and pitfalls

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植物分类学报 2008年第3期46卷 274-286页

作者： Henner BRINKMANN herve PHILIPPe Centre Robert Cedergren Departement de Biochimie Universite de Montreal 2900 Boulevard Edouard-Montpetit Montreal Quebec H3TIJ4 Canada

Phylogenomics, the inference of phylogenetic trees using genome-scale data, is becoming the rule for resolving difficult parts of the tree of life. Its promise resides in the large amount of information available, which should eliminate stochastic error. However, systematic error, which is due to limitations of reconstruction meth-ods, is becoming more apparent. We will illustrate, using animal phylogeny as a case study, the three most effi-cient approaches to avoid the pitfalls of phylogenomics: (1) using a dense taxon sampling, (2) using probabilistic methods with complex models of sequence evolution that more accurately detect multiple substitutions, and (3) removing the fastest evolving part of the data (e.g., species and positions). The analysis of a dataset of 55 animal species and 102 proteins (25712 amino acid positions) shows that standard site-homogeneous model inference is sensitive to long-branch attraction artifact, whereas the site-heterogeneous CAT model is less so. The latter model correctly locates three very fast evolving species, the appendicularian tunicate Oikopleura, the acoel Convoluta and the myxozoan Buddenbrockia. Overall, the resulting tree is in excellent agreement with the new animal phylogeny, confirming that "simple" organisms like platyhelminths and nematodes are not necessarily of basal emergence. This further emphasizes the importance of secondary simplification in animals, and for organismal evolution in general.

关键词：动物发展史测序方法缺陷改进措施

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The Impact of Credit Risk Management on Commercial Panks Performance in Democratic Republic of the Congo. Case of BCDC,eCOBANK,RAWBANK and TMB

The Impact of Credit Risk Management on Commercial Panks Per...

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作者： KINKANI BATeKeLe herve LANDRY 华中师范大学

学位级别：硕士

Credit risk is a major concern for banks,bond issuers and *** may be due to an economic recession,thus putting the borrowers in the impossibility of meeting their commitments,but it is all the more crucial for the banker to find effective ways to protect themselves,if not to master this risk of Non-reimbursement of the customer,synonymous with loss or *** is utopian for a company to have the goal of losing *** all companies,the bank is a commercial company,which also seeks to maximize its *** therefore has to be profitable in its *** is an anticipation of future revenue,so its good management is crucial to the performance and sustainability of the *** performance of a bank implies a good management of credit risks by effective techniques *** of the biggest activities of commercial banks in the Democratic Republic of the Congo is the granting of bank *** credit-granting activity creates risks and the credit risk is the most *** is therefore important that this credit risk be managed prudently to avoid its negative effects on the profitability of *** main objective of this study was to find the impact of credit risk management on the financial profitability of the Congo’s commercial *** specific objectives were to find the effects of CAR and NPLR on the performance of commercial *** this study,we considered independent variables the CAR and NPLR while the dependent variables were ROe and *** used commercial banks in the Democratic Republic of the Congo as a study population,and as a sample the four largest banks in the period from 2009 to *** was diagnosed for and treated,where necessary,of the problems of panel *** a fixed effects model specification a panel estimate Generalized Least Squares regression was done on the data using e views *** a 5%non-directional test of hypothesis,the study found a capital adequacy ratio has statistica

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Lukasiewicz and Lorenzen as Interpreters of Aristotle＇s Syllogistic

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Journal of Philosophy Study 2012年第3期2卷 185-194页

作者： herve Barreau Archives H.Poincare-LHSP-UMR 7117 du CNRS

Jan Lukasiewicz acknowledged that Aristotle＇s syllogistic does not admit singular terms and presents syllogism as an implication. But he failed to recognize syllogistic necessity, reducing this necessity to ＂formal implication＂ as introduced by Russell, when Aristotle shows it as binding relations between three terms. On the contrary, Paul Lorenzen directly recognized syllogistic necessity as the typical example of his own logical implication. His reconstruction of syllogistic differs from the original by his interpretation of particular propositions as the determination of classes which are specified by predicates. The result is the representation of valid moods as the board of all multiplications of relations which are permitted. These relations are not only the Aristotelian ,4, e,I, O, but also the new converse asymmetrical relations of A and O：（a） and （o）.

关键词： syllogism implication syllogistic necessity valid moods converse relation

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重金属在氧化铝微粒上吸附的实验研究

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哈尔滨工业大学学报 2005年第5期37卷 713-716页

作者：鄂勇福兹利.赫尔维东北农业大学资源与环境学院黑龙江哈尔滨150030 法国萨瓦大学环境与分子化学实验室萨瓦尚贝里73000

对溶液中重金属Cu、Zn、Cd和Pb随pH值变化(3Cu>Zn>Cd.这种顺序同离子极性力以及金属的水解常数的大小基本相符.

关键词： Cu Zn Cd Pb 复合物吸附 Al2O3微粒

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Human endogenous Retrovirus Type W envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics

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Virologica Sinica 2021年第5期36卷 1006-1026页

作者： Benjamin Charvet Justine Pierquin Joanna Brunel Rianne Gorter Christophe Que´tard Branka Horvat Sandra Amor Jacques Portoukalian herve´Perron GeNeuro Innovation Lyon 69008France CIRI International Center for Infectiology ResearchINSERM U1111CNRS UMR5308University of LyonENS LyonFrance Universite´Claude Bernard Lyon 1 Lyon 69000France Department of Pathology Amsterdam UMCLocation VUMC1007 MB AmsterdamThe Netherlands ProteinSimple Abingdon OX143NBUK Centre for Neuroscience and Trauma Blizard InstituteBarts and London School of Medicine and DentistryQueen Mary University of LondonLondon E12ATUK

In multiple sclerosis(MS),human endogenous retrovirus W family(HeRV-W)envelope protein,pHeRV-W eNV,limits remyelination and induces microglia-mediated *** better understand its role,we examined the soluble pHeRV-W antigen from MS brain lesions detected by specific ***-chemical and antigenic characteristics confirmed differences between pHeRV-W eNV and ***-W eNV monomers and trimers remained associated with membranes,while hexamers self-assembled from monomers into a soluble macrostructure involving sulfatides in MS *** hexamers are stabilized by internal hydrophobic bonds and external hydrophilic ***-W studies in MS also suggest that this diffusible antigen may correspond to a previously described highmolecular-weight neurotoxic factor secreted by MS B-cells and thus represents a major agonist in MS *** methods are now needed to identify encoding HeRV provirus(es)in affected cells *** properties and origin of MS brain pHeRV-W eNV soluble antigen will allow a better understanding of the role of HeRVs in MS *** present results anyhow pave the way to an accurate detection of the different forms of pHeRV-W eNV antigen with appropriate conditions that remained unseen until now.

关键词： Multiple sclerosis(MS) Brain Antigen HeRV-W envelope endogenous retrovirus MSRV-eNV Syncytin Demyelination Lipids Glycolipids Sulfatides Oligomer Hexamer

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连续氧化铝纤维增强铝基复合材料的新进展

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材料导报 2001年第6期15卷 7-9,6页

作者：张文龙陈嘉颐张帆顾明元 herve e.Deve 上海交通大学金属基复合材料国家重点实验室 3M Center St.PaulMinnesota 55144-1000USA

从制备、性能和应用几个方面概述了近几年新兴的连续高强氧化铝纤维增强铝基复合材料的特点,以及该类复合材料所具有的良好应用价值和应用前景。

关键词：铝基复合材料氧化铝纤维制备应用力学性能

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Two Highly Variable Vpr<sub>84</sub>and Vpr<sub>85</sub>Residues within the HIV-1-Vpr C-Terminal Protein Transduction Domain Control Transductionnal Activity and Define a Clade Specific Polymorphism

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World Journal of AIDS 2014年第2期4卷 148-155页

作者： Jean-herve Colle Thiery Rose Christine Rouzioux Alphonse Garcia eA 3620 Universite Paris Descartes AP-HP Laboratoire de Virologie Hopital Necker Paris France Laboratoire e3 Phosphatases Unite Signalisation Moleculaire et Activation Cellulaire Institut Pasteur Paris France Unite d’Immunogenetique Cellulaire Institut Pasteur Paris France Unite de Biologie des Populations Lymphocytaires Institut Pasteur Paris France

The virally encoded HIV-1 viral protein R (VPR) is a multifunctional factor that is required for induced HIV-1 pathogenesis. VPR is also a cell-penetrating protein found in biological fluids from HIV-1 infected individuals. In this regard, we previously published that the C-terminal VPR77-92 sequence from HIV-1 89.6, but not from pNL4.3 strain, is a new pro-apoptotic and protein transduction domain (PTD). Here we report on a sequence analysis of VPR77-92 domain using the Los Alamos HIV-1 sequence database. The analysis showed that the two residues of the domain VPR84 and VPR85 are highly variable and differently biased in HIV-1 clade B and HIV-1 clade C. Furthermore, when Jurkat lymphoblastoid cells or PBMC were incubated with chemically synthesized peptides containing distinct VPR77-92 C-terminal sequences from clades B or C, we found that a clade-dependent polymorphism in VPR84 and VPR85 residues controlled the transducing activity of the C-terminal HIV-1 VPR77-92 domain. Together our data indicate that clade-dependent polymorphism in the VPR84 and VPR85?residues defines the transducing properties mediated by the C-terminal domain of HIV-1 VPR. Identification of this VPR polymorphism suggests new approaches to understand the HIV-1 biology and/or pathogenesis.

关键词： VPR HIV-1 Subtypes Polymorphism Transduction

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Compact Z-pinch radiation source dedicated to broadband absorption measurements

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Matter and Radiation at extremes 2016年第3期1卷 179-186页

作者： Dunpin Hong herve Rabat erwan Le Menn Clement Zaepffel Jean-Marc Bauchire Univ.of Orleans CNRSGREMIUMR 704414 Rue d'IssoudunBP674445067OrleansFrance CNRS LPGUMR 61122 rue de la HoussinereBP 9220844322NantesFrance Onera-The French Aerospace Lab F-91761PalaiseauFrance

In order to acquire a broadband absorption spectrum in a single shot,a compact radiation source was developed by using a Z-pinch type electric *** paper presents the mechanical and electrical construction of the source,as well as its electrical and optical characteristics,including the intense continuum of radiation emitted by the source in the UV and visible spectral *** also shows that the compactness of the source allows direct coupling with the probed medium,enabling broadband absorption measurement in the spectral range of 200e300 nm without use of an optical fiber which strongly attenuates the light in the short wavelength ***,thanks to this source,broadband spectral absorption of NO molecules around 210 nm and that of OH molecules around 310 nm were recorded in this direct coupling *** atom spectral absorption around 325 nm of the peripheral cold zones of an intense transient arc was also recorded.

关键词： Z-pinch Broadband radiation source Broadband absorption spectrum

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体外模式人工氧合法治疗产后出血引起的循环骤停

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世界核心医学期刊文摘（妇产科学分册） 2006年第10期2卷 61-62页

作者： Reyftmann L. Morau e. herve D. 柳蕴 Department of Obstetrics and Gynecology A. de Villeneuve University Hospital 371 Ave. Doyen G. Giraud 34295 Montpellier Cedex 5 France Dr.

BACKGROUND: Cardiac arrest after postpartum hemorrhage may not respond to advanced life support. Various resuscitation methods have been proposed, including sternotomy and direct cardiac massage. extracorporeal membrane oxygenation (eCMO) might be an alternative. CASe:We report the case of a woman who suffered atonic uterine hemorrhage perioperatively after cesarean delivery of twins. During initial conservative treatment using pros taglandin analog(sulprostone), cardiac decompensation developed andwas followed by cardiopulmonary arrest. Circulatory failure remained unresponsive after 2 hours of resuscitation, when eCMO was initiated. The ensuing recoverywas favorable. CONCLUSION: Aggressive mechanical circulatory support, such as eCMO, should be considered in a case of potentially reversible cardiocirculatory failure in a young obstetric patient.

关键词：产后出血循环骤停子宫收缩乏力前列腺素类似物双胎妊娠剖宫产术胸骨切开术心脏按压反应状态

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