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Influence of an ALD TiN capping layer on the PBTI characteristics of n-FinFET with ALD HfO2/TiN-capping/tia. gate stacks

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Science China(Information Sciences) 2020年第2期63卷 248-250页

作者： Hong YANG Luwei QI Yanbo ZHANG bo TANG Qianqian LIU Hao XU Xueli ma Xiaolei WANG Yongliang LI Huaxiang YIN Junfeng LI Huilong ZHU Chao ZHAO Wenwu WANG tia.chun YE Key Laboratory of Microelectronics Devices & Integrated Technology Institute of MicroelectronicsChinese Academy of Sciences National Space Science Center Chinese Academy of Sciences School of Microelectronics University of Chinese Academy of Sciences

Dear editor,High k/metal gate (HKMG) stacks with fully gatelast processing have become the primary solution for sub-22-nm volume manufacturing with the development of complementary oxide semiconductor(CMOS) technology [1]. In the HKMG stack, titanium nitride (TiN) is observed to play an important role as a work-function metal and an HK

关键词： red Influence of an ALD TiN capping layer on the PBTI characteristics of n-FinFET with ALD HfO2/TiN-capping/tia. gate stacks ALD FinFET

Catheter ablation for atrial fibrillation is associated with reduced risk of mortality in the elderly:a prospective cohort study and propensity score analysis

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Journal of Geriatric Cardiology 2020年第12期17卷 740-749页

作者： Xin SU Xin DU Shang-Xin LU Chao JIANG Jing DU Shi-Jun XIA Zhao-Jie DONG Zhao-Xu JIA De-Yong LONG Cai-Hua SANG Ri-bo TANG Nian LIU Song-Nan LI Rong BAI Jian-Zeng DONG Chang-Sheng ma Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Centre for Cardiovascular DiseasesBeijingChina Heart Health Research Center BeijingChina The George Institute for Global Health Faculty of MedicineUniversity of New South WalesSydneyAustralia Beijing Centre for Disease Prevention and Control BeijingChina

Background It is unclear whether catheter ablation(CA)for atrial fibrillation(AF)affects the long-term prognosis in the *** study aims to evaluate the relationship between CA and long-term outcomes in elderly patients with *** Patients more than 75 years old with non-valvular AF were prospectively enrolled between August 2011 and December 2017 in the Chinese Atrial Fibrillation Registry *** who underwent CA at baseline were propensity score matched(1:1)with those who did not receive *** outcome events included all-cause mortality,cardiovascular mortality,stroke/transient ischemic attack(tia.,and cardiovascular *** Overall,this cohort included 571 ablated patients and 571 non-ablated patients with similar characteristics on 18 *** a mean follow-up of 39.75±19.98 months(minimum six months),24 patients died in the ablation group,compared with 60 deaths in the non-ablation group[hazard ratio(HR)=0.49,95%confidence interval(CI):0.30-0.79,P=0.0024].Besides,6 ablated and 29 non-ablated subjects died of cardiovascular disease(HR=0.25,95%CI:0.11-0.61,P=0.0022).A total of 27 ablated and 40 non-ablated patients suffered stroke/tia.HR=0.79,95%CI:0.48-1.28,P=0.3431).In addition,140 ablated and 194 non-ablated participants suffered cardiovascular hospitalization(HR=0.84,95%CI:0.67-1.04,P=0.1084).Subgroup analyses according to gender,type of AF,time since onset of AF,and anticoagulants exposure in initia.ion did not show significant *** In elderly patients with AF,CA may be associated with a lower incidence of all-cause and cardiovascular mortality.

关键词： Atrial fibrillation Catheter ablation Mortality Stroke The elderly

Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population： Results from a Nationally Representative Survey

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Chinese Medical Journal 2015年第21期128卷 2843-2850页

作者： De-Wei Zhao mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao tia. Fan Yang Nan Wang Shi-bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng tia.Zong-Sheng Li Yong Cao Li ma Orthopedic Medical Research Center Dalian University Dalian Liaoning 116001 China Department of Orthopaedics Affiliated Zhongshan Hospital of Dalian University Dalian Liaoning 116001 China Department of Pathology Stanford University School of Medicine Stanford CA USA Medical Clinic I University Hospital Wurzburg Worzburg Germany Department of Epidemiology and Statistics School of Public Health Dalian Medical University Oalian Liaoning 116044 China Department of Orthopaedics Xi'an 521 Hospital Xi'an Shaanxi 710065 China Department of Orthopaedics Kunming General Hospital of Chengdu Military Region Kunming Yunnan 650032 China Department of Clinical Laboratory Affiliated Zhongshan Hospital of Dalian University Dalian Liaoning 116001 China Department of Orthopaedics The First People's Hospital of Horqin District Tongliao Inner Mongolia 028000 China Department of Orthopaedics The People's Hospital of Changhai County Dalian Liaoning 116500 China Department of Health Kunming Kun Lu Hospital Kunming Yunnan 650217 China Department of Orthopaedics The People's Hospital of Haikou Haikou Hainan 570208 China Department of Orthopaedics Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Orthopaedics The People's Hospital of Fangzheng County Harbin Heilongjiang 150800 China Department of Orthopaedics The People's Hospital of Qionghai Qionghai Hainan 571400 China Department of Imaging Traditional Chinese Medicine Orthopedics Hospital of Xiaoshan Hangzhou Zhejiang 311261 China Department of Imaging Red Star Hospital of Agricultural Thirteen Division of Hami Hami Xinjiang 839000 China

Background： Nontraumatic osteonecrosis of the femoral head （NONFH） is a debilitating disease that represents a significant financial burden for both individuals and healthcare systems. Despite its significance, however, its prevalence in the Chinese general population remains unknown. This study aimed to investigate the prevalence of NONFH and its associated risk factors in the Chinese population. Methods： A nationally representative survey of 30,030 respondents was undertaken from June 2012 to August 2013. All participants underwent a questionnaire investigation, physical examination of hip, and bilateral hip joint X-ray and/or magnetic resonance imaging exalnination. Blood samples were taken after overnight fasting to test serum total cholesterol, triglyceride, and high-density lipoprotein （HDL） and low-density lipoprotein （LDL） levels. We then used multivariate logistic regression analysis to investigate the associations between various metabolic, demographic, and lifestyle-related variables and NONFH. Results： NONFH was diagnosed in 218 subjects （0.725%） and the estimated NONFH cases were 8.12 million among Chinesepeople aged 15 years and over. The prevalence of NONFH was significantly higher in males than in females （1.02% vs. 0.51%, x^2 = 24.997, P 〈 0.001 ）. Among NONFH patients, North residents were subjected to higher prevalence of NONFH than that of South residents （0.85% vs. 0.61%,x^2= 5.847, P = 0.016）. Our multivariate regression analysis showed that high blood levels oftriglycerides, total cholesterol, LDL-cholesterol, and non-H DL-cholesterol, male, urban residence, family history of osteonecrosis of the femoral head. heavy smoking, alcohol abuse and glucocorticoid intake, overweight, and obesity were all significantly associated with an increased risk of NONFH. Conclusions： Our findings highlight that NONFH is a significantpublic health challenge in China and underscore the need for policy measures on the national level. Furthermore, NONFH shares a n

关键词： Nontraumatic Osteonecrosis of the Femoral Head Prevalence Risk Factors

Surgical management of monomorphic epitheliotropic intestinal Tcell lymphoma followed by chemotherapy and stem-cell transplant:A case report and review of the literature

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2273-2287页

作者： Abdul Saad Bissessur Ji-Chun Zhou Ling Xu Zhao-Qing Li Si-Wei Ju Yun-Lu Jia Lin-bo Wang Department of Surgical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Medical Oncology First Affiliated HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is a rare and rapidly progressive intestinal T-cell non-Hodgkin lymphoma associated with a very poor prognosis and a median survival of 7 *** in the identification of MEITL over the last two decades have led to its recognition as a separate *** patients,predominantly male,typically present with vague and nonspecific symptoms and diagnosis is predominantly confirmed at ***,there are no standardized treatment protocols,and the optimal therapy remains *** SUMmaRY We report a case of MEITL that was initia.ly considered to be gastrointestinal stromal tumor(GIST)and Imatinib was administered for one *** 62-yearold man presented with abdominal pain,abdominal distension,and weight loss of 20 *** 2 wk,the size of the mass considerably increased on computed tomography *** patient underwent surgery followed by chemotherapy with CHOP(cyclophosphamide,doxorubicin,vincristine,and prednisone)and stem-cell transplant.A correct diagnosis of MEITL was established based on postoperative ***,the neoplastic cells fulfilled the diagnostic criteria for MEITL as they were CD3+,CD4+,CD8+,CD56+,and tia.1+.CONCLUSION Given that MEITL has no predisposing factor and presents with vague symptoms with rapid progression,the concomitant presence of abdominal symptoms and B symptoms(weight loss,fever,and night sweats)with hypoalbuminemia,anemia,low lymphocytic count and endoscopic findings of diffuse infiltrating type lesions should alert physicians to this rare disease,especially when it comes to Asian *** laparotomy should then be carried out followed by chemotherapy and stem-cell transplant.

关键词： Monomorphic epitheliotropic intestinal T-cell lymphoma Gastrointestinal stromal tumor Immunophenotypically Chemotherapy Stem-cell transplant Case report

沉积时间和靶电流比例对磁控溅射tia.N涂层耐磨性的影响（英文）

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稀有金属材料与工程 2016年第12期45卷 3057-3061页

作者：汤勇马博刘彬袁伟余彬海陆龙生华南理工大学表面功能结构先进制造广东省普通高校重点实验室广东广州510640

采用磁控溅射工艺在WC-8Co硬质合金基体表面制备了一层厚度分别为2.5、3和3.5μm的tia.N涂层,并制备了不同Ti、Al比例的tia.N涂层,利用摩擦磨损机考察了涂层的承载能力和摩擦学性能,通过扫描电子显微镜观察了磨损试件的表面形貌,通过摩... 详细信息

采用磁控溅射工艺在WC-8Co硬质合金基体表面制备了一层厚度分别为2.5、3和3.5μm的tia.N涂层,并制备了不同Ti、Al比例的tia.N涂层,利用摩擦磨损机考察了涂层的承载能力和摩擦学性能,通过扫描电子显微镜观察了磨损试件的表面形貌,通过摩擦系数和显微组织的演变来评价不同成分和不同厚度tia.N涂层的摩擦学性能。结果表明,随着涂层厚度的增加,涂层的摩擦系数降低,涂层更不易被磨穿,表明在一定范围内增加涂层厚度有利于提高涂层的耐磨损性能;涂层的成分发生改变时,由于Ti、Al元素的共同作用,呈现不同的摩擦性能,当Ti/Al比为50:50时,涂层的耐磨性最好。

关键词：耐磨性涂层 tia.N

Research on Influence of Clopidogrel on Life Quality in Patients with Transient Ischemic Attack and its Influencing Factors

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Journal of Advances in Medicine Science 2018年第1期1卷 16-21页

作者： Lanbo Chen Xiaohong Gu bo Dong Department of Health management Institute of Field SurgeryDaping HospitalThird Military Medical UniversityChongqing MunicipalityChongqing400042China

Purpose:To analyze the basic situation and health related quality of life(HRQOL)results of patients with transient ischemic attack(tia.,and to study the influencing factors of health related quality of life in patients receiving ***:Divide the tia.patients into clopidogrel group,aspirin group and untreated *** HRQOL scores of tia.patients using the short form 36 questionnaire(SF-36)scale and analyze influencing factors of HRQOL with one-way ANOVA and multivariate stepwise linear regression statistical ***:The differences of HRQOL scores among three groups are of statistical significance(F=4.29,P=0.00).There is no difference in HRQOL score between clopidogrel group and aspirin group(t=5.35,P=0.00),but HRQOL scores of clopidogrel group and aspirin group are higher than those of the untreated group(t=6.14,P=0.00;t=5.16,P=0.00).The HRQOL scores of clopidogrel group are positively correlated with diet,exercise,gender and family harmony(Ptia.patients who received secondary prevention with clopidogrel and aspirin show better life quality results than those who did *** were many factors influencing clopidogrel's treatment *** attention to middle-aged and elderly,the obese,mental workers and female tia.patients,teach tia.patients to quit smoking,drinking and eating low-salt and low-fat food,actively treating their hypertension,hyperlipidemia and diabetes and laying emphasis on psychological counseling and exercise can significantly improve the treatment effect of clopidogrel.

关键词： Transient ischemic attack Clopidogrel Life quality Influencing factors

海藻酸钙纳米羟基磷灰石胶原复合材料与兔骨髓基质干细胞的体外细胞相容性

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中国组织工程研究与临床康复 2008年第36期12卷 7022-7026页

作者：兰小勇周初松田京于博张力徐启飞冯庆玲黄智南方医科大学珠江医院骨科中心广东省广州市510282 清华大学材料科学与工程系北京市100084

背景：采用仿生学原理，利用海藻酸钙、纳米羟基磷灰石及胶原按一定比例复合，制成一种可注射、可任意塑形且具有良好骨传导、骨诱导性的组织工程骨，其应用在微创外科技术中，具有组织损伤小、不破坏修复区血供、操作简便易行等优点。... 详细信息

背景：采用仿生学原理，利用海藻酸钙、纳米羟基磷灰石及胶原按一定比例复合，制成一种可注射、可任意塑形且具有良好骨传导、骨诱导性的组织工程骨，其应用在微创外科技术中，具有组织损伤小、不破坏修复区血供、操作简便易行等优点。目的：验证海藻酸钙纳米羟基磷灰石胶原复合材料与兔骨髓基质干细胞的相容性。设计、时间及地点：对比观察实验，于2008-02／05在南方医科大学珠江医院中心实验室完成。材料：2周龄健康新西兰大白兔用于骨髓基质干细胞的分离培养。海藻酸钙纳米羟基磷灰石胶原复合材料由清华大学材料系研制提供，孔隙率90％，孔径50～200μm。方法：选取生长良好的第5代兔骨髓基质干细胞与海藻酸钙纳米羟基磷灰石胶原复合材料体外复合培养。主要观察指标：共培养5d后倒置显微镜下观察细胞在材料表面、孔隙内的生长情况，扫描电镜下观察细胞在材料上附着情况。细胞和支架共培养后CCK-8法测定细胞活性。结果：骨髓基质干细胞能在海藻酸钙纳米羟基磷灰石胶原复合材料上良好地黏附、增殖、生长，细胞活性未受到海藻酸钙纳米羟基磷灰石胶原复合材料的影响。结论：海藻酸钙纳米羟基磷灰石胶原复合材料与兔骨髓基质干细胞有良好的细胞相容性。

关键词：羟基磷灰石类骨髓干细胞生物相容性生物材料

Remote ischemic conditioning prevents ischemic cerebrovascular events in children with moyamoya disease:a randomized controlled trial

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World Journal of Pediatrics 2024年第9期20卷 925-934页

作者： Shuang-Feng Huang Jia-Li Xu Chang-Hong Ren Nathan Sim Cong Han Yi-Qin Han Wen-bo Zhao Yu-Chuan Ding Xun-Ming Ji Si-Jie Li Department of Neurology Xuanwu HospitalCapital Medical UniversityNo 45Changchun StreetXicheng DistrictBeijing100053China Department of Rehabilitation Medicine Beijing Shijitan Hospital Affiliated to Capital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Capital Medical UniversityNo.10XitoutiaoYou’anmenwaiFengtai DistrictBeijing100053China Beijing Key Laboratory of Hypoxic Conditioning Translational Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery Wayne State UniversityDetroitMIUSA Department of Neurosurgery The Fifth Medical CentreChinese PLA General HospitalBeijingChina Department of Emergency Xuanwu HospitalCapital Medical UniversityBeijingChina

Background Moyamoya disease(MMD)is a significant cause of childhood stroke and transient ischemic attacks(tia.).This study aimed to assess the safety and efficacy of remote ischemic conditioning(RIC)in children with *** In a single-center pilot study,46 MMD patients aged 4 to 14 years,with no history of reconstructive surgery,were randomly assigned to receive either RIC or sham RIC treatment twice daily for a *** primary outcome measured was the cumulative incidence of major adverse cerebrovascular events(maCEs).Secondary outcomes included ischemic stroke,recurrent tia.hemorrhagic stroke,revascularization rates,and clinical improvement assessed using the patient global impression of change(PGIC)scale during ***-related adverse events were also recorded,and cerebral hemodynamics were evaluated using transcranial *** All 46 patients completed the final follow-up(23 each in the RIC and sham RIC groups).No severe adverse events associated with RIC were ***-Meier analysis indicated a significant reduction in maCEs frequency after RIC treatment[log-rank test(mantel-Cox),P=0.021].At 3-year follow-up,two(4.35%)patients had an ischemic stroke,four(8.70%)experienced tia.,and two(4.35%)underwent revascularization as the qualifying *** clinical improvement rate in the RIC group was higher than the sham RIC group on the PGIC scale(65.2%vs.26.1%,Pmatic children with *** was largely due to the reduced incidence of ischemic cerebrovascular events.

关键词： Asymptomatic moyamoya disease Children Remote ischemic conditioning Stroke

White matter Lesions Predict Recurrent Vascular Events in Patients with Transient Ischemic Attacks

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Chinese Medical Journal 2018年第2期131卷 130-136页

作者： Xiao-Mei Ren Shu-Wei Qiu Ren-Yuan Liu Wen-bo Wu Yun Xu Hong Zhou Department of Neurology Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University Nanjing Jiangsu 210008 China Department of Neurology Yizheng People's Hospital Yangzhou Jiangsu 211400 China Jiangsu Key Laboratory for Molecular Medicine Nanjing Jiangsu 210008 China Department of Radiology Affiliated Drum Tower Hospital Nanjing University Medica/School Nanjing Jiangsu 210008 China~Department of Neurology Affiliated Drum Tower Hospital Nanjing University Medical School Nanling Jiangsu 210008 China Department of Neurology Affiliated Drum Tower Hospital Nanjing University Medical School Nanjing Jiangsu 210008 China Department of Immunology Nanjing Medical University Nanjing Jiangsu 211166 China

Background： White matter lesions （WMLs） are common findings in brain magnetic resonance imaging （MRI） and are strongly associated with stroke incidence, recurrence, and prognosis. However, the relationship between WMLs and transient ischemic attacks （tia.） is not well established. This study aimed to determine the clinical significance of WMLs in patients with tia. Methods： A total of 181 consecutive inpatients with first-ever tia.were enrolled. Brain MRls within 2 days of symptom onset were used to measure WML volumes. Recurrent vascular events within 1 year of tia.onset were assessed. The relationship between WMLs and recurrent risk of vascular events was determined by a multivariate logistic regression. Results： WMLs were identified in 104 patients （57.5%）. Age and ratio of hypertension were significantly different between patients with and without WMLs. The incidence of vascular events in patients with WMLs significantly increased in comparison to those without WMLs （21.15% vs. 5.19%, 95% confidence interval [CI]： 1.18-[ 5.20, P = 0.027） after controlling for cont／~unders. Furthermore, distributions of WML loads were found to be different between patients who developed vascular events and those who did not. WML volumes were demonstrated to be correlated with recurrent risks, and the fourth quartile of WML volumes led to an 8.5-fold elevation of recurrent risk of vascular events compared with the first quartile （95% CI： 1.52-47.65, P = 0.015） alier adjusting for hyperlipidemia. Conclusion： WMLs occur frequently in patients with T1A and are associated wiila the high risk of recurrent vascular events, suggesting a predictive neuroimaging marker for tia.outcomes.

关键词： Recurrent Vascular Events Risk factors Transient lschemic Attack Volumetric Measurement White matter Lesion