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Chemotherapy for cholangiocarcinoma:An update

World Journal of Gastrointestinal Oncology 2013年第7期5卷 171-176页

作者： natalia Ramírez-Merino santiago Ponce Aix hernán cortés-funes Department of Medical Oncology Clinica La Luz28003 MadridSpain

Cholangiocarcinomas(bile duct cancers) are a heterogeneous group of malignancies arising from the epithelial cells of the intrahepatic,perihilar and extrahepatic bile *** diagnosed with cholangiocarcinoma must be evaluated by a multidisciplinary team and be treated with individualized *** of all,it is very important to define the potential resectability of the tumor because surgery is the main therapeutic option for these ***,cholangiocarcinomas have a very poor *** 5 year survival rate is 5%-10%.In cases with a potentially curative surgery,5 year survival rates of 25%-30% are ***,it is necessary to increase the cure rate from surgery,exploring the survival benefit of any adjuvant *** is difficult to clarify the role of adjuvant treatment in localized and locally advanced *** are limited data and the role of adjuvant chemotherapy/chemoradiation in patients with resected biliary tract cancer is poorly *** most relevant studies in the adjuvant setting are one from Japan,the well known EsPAC-3 and BILCAP from the United Kingdom and a *** show the results of these *** to medical oncology guidelines,postoperative adjuvant therapy is widely recommended for all patients with intrahepatic or extrahepatic cholangiocarcinoma who have microscopically positive resection margins,as well as for those with a complete resection but node-positive *** trials are *** locally advanced cholangiocarcinoma setting includes a heterogeneous mix of patients:(1) patients who have had surgery but with macroscopic residual disease;(2) patients with locally recurrent disease after potentially curative treatment;and(3) patients with locally unresectable disease at *** these patients,surgery is not an option and chemoradiation therapy can prolong overall survival and provide control of symptoms due to local tumor ***,no neoadjuv

关键词： Chemotherapy Cholangiocarcinoma Review Oncology Gemcitabine

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