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Clinical relevance of the use of Dentoxol® for oral mucositis induced by radiotherapy: A phase II clinical trial

World Journal of Clinical Oncology 2022年第10期13卷 813-821页

作者： Sebastián Solé Sergio Becerra Claudia Carvajal Piero Bettolli hernán letelier Alejandro Santini Lorena Vargas Alexander Cifuentes Francisco Larsen natalia Jara Jorge Oyarzún Eva Bustamante Benjamín Martínez David Rosenberg Tomas Galván Department of Radiotherapy Radiomedicine InstituteAmérico Vespucio Norte 1314 Vitacura7630370SantiagoChile national Institute of Cancer SantiagoServicio de Salud Metropolitano NorteAv Profesor Zañartu 1010Independencia8380455SantiagoChile Oncologic Institute Arturo López Pérez Foundation JoséManuel Infante 805Providencia7500691SantiagoChile Hospital Base Valdivia Bueras 1003 s/n XIV Región5100238ValdiviaChile Oncologic Center of Antofagasta Los Pumas 10255Antofagasta1267348AntofagastaChile Universidad Mayor SantiagoAv Libertador Bernardo O´Higgins 20138340585SantiagoChile Ingalfarma Dr Manuel Barros Borgoño 71Oficina 1308Providencia7500593SantiagoChile

BACKGROUnD Severe oral mucositis associated with cancer therapy is a frequent complication that may affect a patient's systemic condition,resulting in interruption and/or prolongation of cancer ***®is a medical solution in the form of a mouthwash that has been shown to result in statistically significant improvement in the prevention of severe oral ***,knowing the measures of the clinical significance of this therapy is important for accurate *** describe the clinical impact of Dentoxol®use in severe oral *** Clinical significance was measured using the results obtained in a randomized controlled clinical trial previously conducted by the same group of *** measures of clinical significance evaluated were the absolute risk or incidence,relative risk,absolute risk reduction,relative risk reduction,number needed to treat,and odds *** The data obtained show that the impact of Dentoxol®on reducing the severity of oral mucositis has important clinical *** The results of this study justify the incorporation of Dentoxol®mouth rinse into clinical protocols as a complement to cancer therapy to prevent and/or treat oral mucositis secondary to radiotherapy.

关键词： Clinical trial Dentoxol Oral mucositis Prevention Radiotherapy Treatment

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On Poincaré Series of Unicritical Polynomials at the Critical Point

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Communications in Mathematics and Statistics 2013年第1期1卷 1-17页

作者： Juan Rivera-letelier Weixiao Shen Facultad de Matemáticas Pontificia Universidad Católica de ChileAvenida Vicuña Mackenna 4860SantiagoChile Block S17 10 Lower Kent Ridge RoadSingapore 119076Singapore

In this paper,we show that for a unicritical polynomial having a priori bounds,the unique conformal measure of minimal exponent has no atom at the critical *** a conformal measure of higher exponent,we give a necessary and sufficient condition for the critical point to be an atom,in terms of the growth rate of the derivatives at the critical value.

关键词： Complex dynamics Julia sets Poincaréseries Summability condition

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北极巨石阵上空的极光

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华东科技 2023年第4期 6-7页

作者： Cari letelier

发生强烈日闪（太阳耀斑）的报导，让摄影者开启了北行7小时的任务，以拍摄现代纪念碑上空满是极光的天空。位于冰岛北部Raufarh?fn村的标志性北极巨石阵（Arctic Henge）之尖顶，与恒星的方位对齐：它的一侧指向正北，另一侧指向正南...

发生强烈日闪（太阳耀斑）的报导，让摄影者开启了北行7小时的任务，以拍摄现代纪念碑上空满是极光的天空。位于冰岛北部Raufarh?fn村的标志性北极巨石阵（Arctic Henge）之尖顶，与恒星的方位对齐：它的一侧指向正北，另一侧指向正南。在这幅摄于3月下旬日落后的南眺主题图像里，由于组合图像涵盖了极为广阔的天空，因此北极星实际上位于图像的顶缘。除此之外，

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Validation of a novel imaging approach using multi-slice CT and cone-beam CT to follow-up on condylar remodeling after bimaxillary surgery

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International Journal of Oral Science 2017年第3期9卷 139-144页

作者： laura ferreira pinheiro nicolielo jeroen van dessel eman shaheen carolina letelier marina codari constantinus politis ivo lambrichts reinhilde jacobs omfs-impath research group department of imaging and pathologyfaculty of medicineuniversity of leuven and maxillofacial surgery departmentuniversity hospitals leuvenLeuvenBelgium department of oral and maxillofacial radiology university of los andessantiagochileSantiagoChile unit of radiology irccs policlinico san donato MilaneseMilanItaly department of morphology faculty of medicineuniversity of hasseltcampusDiepenbeekBelgium department of dental medicine karolinska institutetHuddingeSweden

The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography （MSCT） and postoperative cone-beam computed tomography （CBCT） images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients （11 female and 9 male） who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure. A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter- and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant （P〈O.05） mean bone volume decrease of 26.4%_ 11.4% （502.9 mm3＋ 268.1 mm3）. no significant effects of side, sex or age were found. Good to excellent （ICC〉 0.6） intra- and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel （0.4 mm） for MSCT （0.3 mm __. 0.2 mm） and CBCT （0.4 mm _ 0.3 mm）, thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption.

关键词： condylar resorption Cone-beam computed tomography mandibular condyle multi-slice computed tomography three-dimensional imaging

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Impact of Temperature on Absorption Coefficient of Pure Seawater in the Blue Wavelengths Inferred from Satellite and In Situ Measurements

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Journal of Remote Sensing 2021年第1期2021卷 289-301页

作者： Guomei Wei Zhongping Lee Xiuling Wu Xiaolong Yu Shaoling Shang Ricardo letelier State Key Laboratory of Marine Environmental Science College of Ocean and Earth SciencesXiamen UniversityXiamen 361102China Research and Development Center for Ocean Observation Technologies Xiamen UniversityXiamen 361102China School for the Environment University of Massachusetts BostonBostonMA 02125USA College of Earth Ocean&Atmospheric SciencesOregon State UniversityCorvallisOR 97331USA

There has been a long history of interest on how(if)the absorption coefficient of“pure”fresh water(a_(fw)(λ))and“pure”seawater(a_(sw)(λ))changes with temperature(T),yet the impact of T reported in the literature differs significantly in the blue *** the previous studies based on laboratory measurements,we took an approach based on~18 years(2002–2020)of MODIS ocean color and temperature measurements in the oligotrophic oceans,along with field measured chlorophyll concentration and phytoplankton absorption coefficient,to examine the relationship between T and the total absorption coefficient(a(λ))at 412 and 443 *** found that the values of a(412)and a(443)in the summer are nearly flat(slightly decreasing)for the observed T range of~19–27℃.Since there are no detectable changes of chlorophyll during this period,the results suggest that T has a negligible impact on a_(sw)(412) and a_(sw)(443)in this T *** a complement,the impact of salinity on a_(fw)(λ) was also evaluated using three independent determinations of a_(sw)(λ) and a_(fw)(λ),where good agreements were found from these observations.

关键词： salinity ocean coefficient

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