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Green extraction of phenolic compounds from Perle Hallertau and Nuggets hop pellets

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Food Bioscience 2022年第6期50卷 474-481页

作者： Vanesa Sanz Maria Dolores Torres Jose M.Lopez Vilarino herminia Dominguez Chemical Engineering Department Faculty of ScienceCampus OurenseUniversity of VigoSpain R&D Department Hijos de RiveraS.A.U.c/ José Maria Riveranº6A CoruñaSpain

Operation conditions to recover and quantify active compounds from Perle Hallertau (PH) and Nuggets (N) hops, following a sequential combination of ultrasound and microwave assisted ethanolic extraction were studied. Ultrasound treatment (55 °C, 60% ethanol, 30 minutes) allowed extracts with phenolic contents of 160.43 mg GAE/g extract and ABTS radical scavenging capacity equivalent to 400.24 mg Trolox/g extract for PH. Optimal conditions for N were found at 55 °C, using 60% ethanol for 120 minutes (98.80 mg GAE/g extract) and 55 °C, 40% ethanol for 180 min (370.00 mg Trolox/g extract). The remaining solids were further processed under ethanolic microwave extraction (130–190 °C, 5 minutes) with the optimal results obtained at 190 °C for PH (77.11 and 98.67 mg GAE/g extract) and N (226.96 and 368.72 mg Trolox/g extract). Results obtained provided hops pellets as a rich source of active compounds that could be suitable for food and no food industry applications.

关键词： Humulus lupulus Cascade extraction Environmentally friendly technologies Ultrasound microwave Antioxidants

Kinetics of Desolvation of the Glycation of Hemoglobin Catalyzed by Buffer Phosphate and Arsenate

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Journal of Chemistry and Chemical Engineering 2012年第5期6卷 410-416页

作者： herminia Gil Johanna Pefia Daniel Salcedo Department of Chemistry University of Andes Merida 5251 Venezuela

The glycation of hemoglobin is catalyzed by buffer phosphate and arsenate. The catalytic constant （kB） for aqueous arsenate is two-fold larger than for aqueous phosphate. The catalytic constant （ks） of phosphate in sorbitol mixtures increase from （1.67 ± 0.11） × 10-10 s-1·M-1 to （5.78 ± 0.39） × 10-10 s-1·M-1 and the catalytic constant is enhanced 3.5 times, relative to that in water; the catalytic constant （kB） of arsenate in sorbitol mixtures increase from （2.98±0.07）× 10-10 s-1·M-1 to （6.62 ± 0.53） × 10-10 s-1·M-1 and the catalytic constant is enhanced 2 times, relative to that in water. The spontaneous rate constants are independent of sorbitol concentration for phosphate and arsenate. The catalytic power of phosphate and arsenate in sorbitol are the same. Desolvation of strongly hydrated species such as HPO42 and HAsO42 should make a contribution to the energy cost of the formation of anion-hemoglobin complexes and can be a possible explanation for higher catalytic potential of HAsO42 in water. The same catalytic constant （ksB） for phosphate and arsenate in sorbitol indicates that the same catalyst base group on the hemoglobin molecule may be involved in the abstraction of proton in the Amadori rearrangement.

关键词： Glycation hemoglobin catalysis desolvation phosphate arsenate.

Expression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis

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World Journal of Gastroenterology 2012年第44期18卷 6387-6397页

作者： Anabel Brandoni María herminia Hazelhoff Romina Paula Bulacio Adriana Mónica Torres Pharmacology Unit Department of Physiological SciencesFaculty of Biochemical and Pharmaceutical SciencesNational University of Rosariothe National Scientific and Technical Research Council2000 RosarioArgentine

Obstructive jaundice occurs in patients suffering from cholelithiasis and from neoplasms affecting the pancreas and the common bile *** absorption,distribution and elimination of drugs are impaired during this *** cholestasis may alter both liver and kidney *** antibiotics,diuretics,non-steroidal anti-inflammatory drugs,several antiviral drugs as well as endogenous compounds are classified as organic *** hepatic and renal organic anion transport pathways play a key role in the pharmacokinetics of these *** has been demonstrated that acute extrahepatic cholestasis is associated with increased renal elimination of organic *** present work describes the molecular mechanisms involved in the regulation of the expression and function of the renal and hepatic organic anion transporters in extrahepatic cholestasis,such as multidrug resistanceassociated protein 2,organic anion transporting polypeptide 1,organic anion transporter 3,bilitranslocase,bromosulfophthalein/bilirubin binding protein,organic anion transporter 1 and sodium dependent bile salt *** modulation in the expression of renal organic anion transporters constitutes a compensatory mechanism to overcome the hepatic dysfunction in the elimination of organic anions.

关键词： Organic anions Liver Kidney Multidrugresistance-associated protein 2 Organic anion trans-porting polypeptide 1 Organic anion transporter 3 Bilitranslocase Bromosulfophthalein/bilirubin bindingprotein Organic anion transporter 1 Sodium depend-ent bile salt transporter

Influence of cirrhosis in cardiac surgery outcomes

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World Journal of Hepatology 2015年第5期7卷 753-760页

作者： Juan C Lopez-Delgado Francisco Esteve Casimiro Javierre Josep L Ventura Rafael Maez Elisabet Farrero herminia Torrado David Rodríguez-Castro Maria L Carrio Intensive Care Department Hospital Universitari de BellvitgeIDIBELL (Institut d’Investigació Biomèdica BellvitgeBiomedical Investigation Institute of Bellvitge) Physiological Sciences Ⅱ Department Universitat de BarcelonaIDIBELL (Institut d’Investigació Biomèdica BellvitgeBiomedical Investigation Institute of Bellvitge)

Liver cirrhosis has evolved an important risk factor for cardiac surgery due to the higher morbidity and mortality that these patients may suffer compared with general cardiac surgery *** presence of contributing factors for a poor outcome,such as coagulopathy,a poor nutritional status,an adaptive immune dysfunction,a degree of cirrhotic cardiomyopathy,and a degree of renal and pulmonary dysfunction,have to be taken into account for surgical evaluation when cardiac surgery is needed,together with the degree of liver disease and its primary *** associated pathophysiological characteristics that liver cirrhosis represents have a great influence in the development of complications during cardiac surgery and the postoperative *** the population of cirrhotic patients who are referred for cardiac surgery is small and recommendations come from small series,since liver cirrhotic patients have increased their chance of survival in the last 20 years due to the advances in their medical care,which includes liver transplantation,they have been increasingly considered for cardiac ***,there is an expected rise of cirrhotic patients within the cardiac surgical population due to the increasing rates of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis,especially in western *** consequence,a more specific approach is needed in the assessment of care of these patients if we want to improve their *** this article,we review the pathophysiology and outcome prediction of cirrhotic patients who underwent cardiac surgery.

关键词： Liver cirrhosis Cardiac surgery Outcomes Coagulopathy Nutritional status Adaptive immunedysfunction Cirrhotic cardiomyopathy

Evaluation of Differential Item Functioning of the Center of Epidemiological Scale Depression Revisited for Gender in Mexican Adolescents

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Psychology Research 2013年第4期3卷 232-241页

作者： Jesus Rafael Osomo Mungula herminia Beatriz Segura Celis Ochoa Alma Gloria Vallejo Casarin Patricia Andrade Palos Universidad Veracruzana Veracruz Mexico Universidad Nacional Autenoma de Mexico Mexico Mexico

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逆向管理

作者： (美)埃米尼亚·伊贝拉(herminia Ibarra)

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能力陷阱

作者： (美)埃米尼亚·伊贝拉(herminia Ibarra)

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逆向管理

Multispecies Multistrain Probiotic Effects on Calves Development and Health

作者： (美)埃米尼亚·伊贝拉(herminia Ibarra)

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Open Journal of Veterinary Medicine 2012年第4期2卷 225-229页

作者： mirentxu Indart Silvia Cerone Eduardo Néstor Esteban Guadalupe de Yaniz Ana Graciela Inza herminia Landi Silvina Mogni Leticia Igarza Department of Animal Health Faculty of Veterinary Science Universidad Nacional del Centro de la Provincia de Buenos Aires Buenos Aires Argentine Department of Animal Production Faculty of Veterinary Science Universidad Nacional del Centro de la Provincia de Buenos Aires Buenos Aires Argentine Department of Physiology and Pathology Faculty of Veterinary Medicine Universidad Nacional del Centro de la Provincia de Buenos Aires Buenos Aires Argentine

Experiment was designed to assess alimentary security or any beneficial effect on calve of a multispecies multistrain probiotic (MMP). An experiment with 36 calves, two day old, was conducted to assess the influence of probiotic on growth and health indicators. The treatment period was extended to 45 d. Group 1 received one daily dose of MMP (1.1 × 109 CFU per calf) during 20 d. Group 2 was the untreated control. On a weekly basis, every calf in each group was weighed to determine weight gain. Forty five days after the beginning of the experiment, blood samples were obtained from seven animals from Group 1 and six from Group 2, and peripheral blood neutrophils separated in order to determine metabolic and microbicidal activity. There was a significant increase in H2O2 production and NBT reduction test in MMP treated calves. The MMP not only lacks adverse effects when supplied as food additive, but showed health benefits. The prevention of infection and the highly significant increase of phagocytic activity in peripheral blood leukocytes seen in calves strongly suggest an efficient connection between the MMP and the immune system.

关键词： Probiotic Growth Health Immunology Calves