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Astrocyte in prion disease: a double-edged sword

Neural Regeneration Research 2022年第8期17卷 1659-1665页

作者： Waqas Tahir Simrika Thapa hermann m.schatzl Department of Comparative Biology&Experimental medicine Faculty of Veterinary MedicineUniversity of CalgaryCalgaryABCanada Calgary Prion Research Unit University of CalgaryCalgaryABCanada Hotchkiss Brain Institute University of CalgaryCalgaryABCanada

Prion diseases are infectious protein misfolding disorders of the central nervous system that result from misfolding of the cellular prion protein(PrPC)into the pathologic isoform *** hallmarks of prion disease are depositions of pathological prion protein PrPSc,neuronal loss,spongiform degeneration and astrogliosis in the *** diseases affect human and animals,there is no effective therapy,and they invariably remain *** a long time,neuronal loss was considered the sole reason for neurodegeneration in prion pathogenesis,and the contribution of non-neuronal cells like microglia and astrocytes was considered less *** evidence suggests that neurodegeneration during prion pathogenesis is a consequence of a complex interplay between neuronal and non-neuronal cells in the brain,but the exact role of these non-neuronal cells during prion pathology is still *** are non-neuronal cells that regulate brain homeostasis under physiological ***,astrocytes can deposit PrPSc aggregates and propagate prions in prion-infected ***,sub-populations of reactive astrocytes that include neurotrophic and neurotoxic species have been identified,differentially expressed in the brain during prion *** the exact role of astrocytes in prion disease is hampered by the lack of in vitro models of prion-infected ***,we established a murine astrocyte cell line persistently infected with mouse-adapted prions,and showed how such astrocytes differentially process various prion *** the complexity of the role of astrocytes in prion pathogenesis,we need more in vitro and in vivo models for exploring the contribution of sub-populations of reactive astrocytes,their differential regulation of signaling cascades,and the interaction with neurons and microglia during prion *** will help to establish novel in vivo models and define new therapeutic targets against prion

关键词： Alzheimer’s disease astrocytes central nervous system Creutzfeldt-Jakob disease glial cells neurodegeneration prion prion disease prion protein scrapie

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CO_(2)capture costs of chemical looping combustion of biomass:A comparison of natural and synthetic oxygen carrier

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Journal of Energy Chemistry 2024年第5期92卷 296-310页

作者： Benjamin Fleiß Juraj Priscak martin Hammerschmid Josef Fuchs Stefan müller hermann Hofbauer Institute of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BEST–Bioenergy and Sustainable Technologies GmbH Graz8010 StyriaAustria

Chemical looping combustion has the potential to be an efficient and low-cost technology capable of contributing to the reduction of the atmospheric concentration of CO_(2) in order to reach the 1.5/2°C goal and mitigate climate *** this process,a metal oxide is used as oxygen carrier in a dual fluidized bed to generate clean CO_(2) via combustion of *** commonly,natural ores or synthetic materials are used as oxygen carrier whereas both must meet special requirements for the conversion of solid *** oxygen carriers are characterized by higher reactivity at the expense of higher costs versus the lower-cost natural *** determine the viability of both possibilities,a techno-economic comparison of a synthetic material based on manganese,iron,and copper to the natural ore ilmenite was *** synthetic oxygen carrier was characterized and tested in a pilot plant,where high combustion efficiencies up to 98.4%and carbon capture rates up to 98.5%were *** techno-economic assessment resulted in CO_(2) capture costs of 75 and 40€/tCO_(2) for the synthetic and natural ore route respectively,whereas a sensitivity analysis showed the high impact of production costs and attrition rates of the synthetic *** synthetic oxygen carrier could break even with the natural ore in case of lower production costs and attrition rates,which could be reached by adapting the production process and recycling *** comparison to state-of-the-art technologies,it is demonstrated that both routes are viable and the capture cost of CO_(2) could be reduced by implementing the chemical looping combustion technology.

关键词： Chemical looping combustion BECCS Techno-economic assessment CO_(2)capture costs Oxygen carrier development Synthetic materials Ilmenite

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Influence of lithospheric thickness distribution on oil and gas basins,China seas and adjacent areas

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Acta Oceanologica Sinica 2024年第4期43卷 1-14页

作者： Jing ma Wanyin Wang hermann Zeyen Yimi Zhang Zhongsheng Li Tao He Dingding Wang School of Geology Engineering and Geomatics Key Laboratory of Western China’s Mineral Resources and Geological Engineering of Ministry of EducationChang’an UniversityXi’an 710054China UmR8148 GEOPS CNRS/UniversitéParis-SaclayDépartement des Sciences de la TerreBât.50491405France CNOOC Research Institute Co. Ltd.Beijing 100027China Qingdao Institute of marine geology Qingdao 266071China Department of Earth Sciences Memorial University of NewfoundlandSt.John’sNewfoundland AlB3X5Canada University of Naples Federico Ⅱ Department of Earth SciencesNaples80138Italy

The distribution of oil and gas resources is intricately connected to the underlying structure of the ***,investigating the characteristics of lithospheric thickness and its correlation with oil and gas basins is highly *** research utilizes recently enhanced geological–geophysical data,including topographic,geoid,rock layer thickness,variable rock layer density,and interface depth *** the principles of lithospheric isostasy and heat conduction,we compute the laterally varying lithospheric thickness in the China seas and adjacent *** these results,two pivotal parameters for different types of oil and gas basins were statistically analyzed:the minimum lithospheric thickness and the relative fluctuation in lithospheric thickness.A semiquantitative analysis was used to explore the connection between these parameters and the hydrocarbon abundance within the oil and gas *** study unveils distinct variations in lithospheric thickness among basins,with oil and gas rich basins exhibiting a thicker lithosphere in the superimposed basins of central China and a thinner lithosphere in the rift basins of eastern ***,the relative fluctuations in lithospheric thickness in basins demonstrate significant disparities:basins rich in oil and gas often exhibit greater thickness ***,in the offshore basins of China,a conspicuous negative linear correlation is observed between the minimum lithospheric thickness and the relative fluctuation in lithospheric *** study posits that deep-seated thermal upwelling results in lithospheric undulations and extensional thinning in oil and gas ***,sustained deep-seated heat influences sedimentary materials in basins,creating favorable conditions for oil and gas *** insights derived from this study contribute to a quantitative understanding of the intricate relationships between deep lithospheric structures and oil and gas basins.

关键词： China seas and adjacent areas lithospheric thickness oil and gas basins

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Reciprocity Relation between Alternative Gravity Formulas

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Journal of Applied mathematics and Physics 2024年第4期12卷 1432-1440页

作者： Hans hermann Otto Department of materials Science and Crystallography Clausthal University of Technology Clausthal-Zellerfeld Germany

We compare Newton’s force law of universal gravitation with a corrected simple approach based on Bhandari’s recently presented work, where the gravitation constant G is maintained. A reciprocity relation exists between both alternative gravity formulas with respect to the distances between mass centers. We conclude a one-to-one mapping of the two gravitational formulas. We don’t need Einstein’s construct of spacetime bending by matter.

关键词： Gravity Formulas Reciprocity Distance Relation Newton Einstein Bhandari Higgs Field Dirac’s Large Number

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Petrographic and Geochemical Characters of Granites of the Banfora Belt, Burkina Faso (West Africa)

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International Journal of Geosciences 2024年第9期15卷 682-697页

作者： Abdoulaye Ouedraogo Seta Naba hermann Ilboudo Laboratoire Gosciences et Environnement (LaGE) Dpartement des Sciences de la Terre Unit de Formation et de Recherche en Sciences de la Vie et de la Terre Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Bureau des mines et de la Gologie du Burkina (BUmIGEB) Ouagadougou Burkina Faso

The Banfora’s birimian greenstones belt is located in the western part of Burkina Faso (west Africa). Recent petrographic and lithogeochemical studies have highlighted plutons intruding the metasedimentary and metavolcanic series. These plutonic rocks are composed of leucogranites belonging to the so-called Ferkessedougou’s or Ferké’s batholith, granites, granodiorites, monzodiorites and quartz monzonites. From the lithogeochemical studies, these plutonic rocks have a calc-alkaline and peraluminous character. The rare earth elements spectra of the Ferké’s leucogranites let distinguished two sub-facies. One of the sub-facies is composed of quartz monzonite to granite, while the other is granitic sensu stricto. However, all these plutonic rocks were emplaced in a geodynamic context of subduction followed by collision.

关键词： Burkina Faso Banfora Greenstones Belt Plutons Geodynamic Context Subduction

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晚发性结直肠癌患者亲属的结肠镜筛查时间间隔:一项全国性匹配队列研究

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Science Bulletin 2024年第6期69卷 732-736页

作者：梁群风 Kristina Sundquist Jan Sundquist hermann Brenner Elham Kharazmi mahdi Fallah Division of Preventive Oncology National Center for Tumor DiseasesGerman Cancer Research CenterHeidelberg 69120Germany medical Faculty Heidelberg Heidelberg UniversityHeidelberg 69120Germany Center for Primary Health Care Research Lund UniversityMalmö20213Sweden Department of Family medicine and Community Health Department of Population Health Science and PolicyIcahn School of Medicine at Mount SinaiNew YorkNY10029USA Center for Community-based Healthcare Research and Education Department of Functional PathologySchool of MedicineShimane UniversityIzumo 693-8501Japan Division of Clinical Epidemiology and Aging Research German Cancer Research CenterHeidelberg 69120Germany German Cancer Consortium German Cancer Research CenterHeidelberg 69120Germany Institute of Primary Health Care University of BernBern 3012Switzerland

Colorectal cancer(CRC)is a major global cancer burden,ranking third in terms of incidence,but second in terms of mortality[1].Early detection of CRC through screening combined with subsequent removal of polyps remains a predominant strategy for CRC *** history is a known risk factor for CRC[2-4].However,only a few screening guidelines provide recommendations for individuals with familial CRC risk[5].

关键词：队列研究时间间隔晚发性

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Experimental Study of the Thermal Behavior of a Bioclimatic Building Prototype in a Sahelian Zone

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Smart Grid and Renewable Energy 2024年第8期15卷 187-199页

作者： Arouna Kaboré Boukaré Ouédraogo Sayouba Sandwidi Vincent Zoma hermann Kaboré Kalifa Palm Laboratoire des Energies Thermiques et Renouvelables (LETRE) Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Laboratoire de Chimie Analytique Physique Spatiale et Energtique (LACAPSE) Universit Norbert ZONGO Koudougou Burkina Faso Laboratoire de Physique et Chimie de lEnvironnement Universit Joseph KI-ZERBO Ouagadougou Burkina Faso Laboratoire des Systmes dEnergie Renouvelable et Environnement Institut de Recherche en Sciences Appliques et Technologies (IRSAT) Centre National de la Recherche Scientifique et Technologique (CNRST) Ouagadougou Burkina Faso

Buildings constructed with modern materials (cement blocks, sheet metal, reinforced concrete, etc.) in the Sahelian zone often generate excessive electricity consumption and consequently very high electricity bills. This study is a contribution to the development of new building types based on the principle of bioclimatic construction. The aim is to find materials suited to the Sahelian climate and improve thermal comfort. To this end, an experimental study of the hygrothermal behavior of a bioclimatic building prototype with a domed roof is being carried out. Site meteorological data, air temperature and relative humidity of the building’s internal environment were measured for three climatic seasons in Burkina Faso. The data acquisition system consists of thermocouples, solarimeters and humidity meters, and the data are processed using Excel and Origin Pro software. The results show that, despite the high temperature values (between 36˚C and 39˚C) of the internal environment measured in the hot season, good thermal performance is achieved, in particular an average phase shift of 7.17 h and an average damping of 10.81˚C. The dome-roofed building could therefore contribute to limiting heat transmission to the building interior, improving thermal comfort all year round. Analysis of humidity profiles shows that indoor humidity varies between 66% and 80% for the September period, and between 44% and 69% for the January period. The high values of internal ambient humidity could be reduced by very good ventilation of the building. This study shows that the proposed bioclimatic building prototype with domed roof could be integrated into the Sahelian habitat.

关键词： Thermal Comfort Hygrothermal Behavior Bioclimatic Building Thermal Inertia Domed Roof

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德米安

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英语画刊(高中版) 2024年第16期 15-18页

作者： hermann Hesse

《德米安》是德国作家赫尔曼·黑塞于1919年创作的中篇小说。读者将跟随少年埃米尔·辛克莱经历复杂世界的诱惑,品尝孤独、胆怯、彷徨、叛逆,渴望爱情与友谊,陷入对着我与外部世界的怀疑,直到遇见同龄人德米安,在他的影响下,一步步寻得...

《德米安》是德国作家赫尔曼·黑塞于1919年创作的中篇小说。读者将跟随少年埃米尔·辛克莱经历复杂世界的诱惑,品尝孤独、胆怯、彷徨、叛逆,渴望爱情与友谊,陷入对着我与外部世界的怀疑,直到遇见同龄人德米安,在他的影响下,一步步寻得答案,走向成熟。本文节选自***的英译版本。

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Evaluation of Particle Properties of mgO/TiO₂ material by monte Carlo Simulation method

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Journal of materials Science and Chemical Engineering 2024年第2期12卷 49-60页

作者： Koffi N’guessan Placide Gabin Allangba Yves Kily Hervé Fagnidi hermann N’guessan Zié Traoré Koffi Arnaud Kamenan Physics Pedagogical Unit Laboratory of Environmental Science and Technology University Jean Lorougnon Guédé Daloa C&#244te d’Ivoire Laboratory of Fundamental and Applied Physics University Nangui Abrogoua Abidjan C&#244te d’Ivoire Department of medical Physics University of Trieste and International Centre for Theoretical Physics (ICTP) Trieste Italy Department of Science and Technology University Alassane Ouattara Bouaké C&#244te d’Ivoire Nuclear Physics and Radiation Protection Team Laboratory of Material Sciences Environment and Solar Energy University Felix Houphouet-Boigny Abidjan C&#244te d’Ivoire Department of mathematics Physics and Chemistry UFR Biological Sciences University Peleforo Gon Coulibaly Korhogo C&#244te d’Ivoire

The simulation by the monte Carlo method executed by the software PyPENELOPE proved effective to specify the particle propagation characteristics by calculating the absorption fractions, backscattering and transmission of electrons and secondary photons under the incidence of 0.5 to 20 KeV range of primary electrons. more than 99.9% of the primary electrons were transmitted in the 125 nm thick mgO/TiO2 material at 20 KeV. This occurred because several interactions took place in the transmitted primary irradiation such as characteristic, fluorescence, and bremsstrahlung produced when of the occupation of the KL3, KL2, Km3, and Km2 shell and sub-shell of titanium and magnesium which are the elements with a high atomic number in the material. The transmission particle characteristic of this material is therefore an indicator capable of improving the electrical performance and properties of the sensor.

关键词： monte Carlo PyPENELOPE Primary Electrons Transmission mgO/TiO2

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Optimized Adsorption of Small and medium molecules by a Biosorbent Based on Hevea Hulls

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Journal of materials Science and Chemical Engineering 2024年第9期12卷 69-83页

作者： Djedjess Essoh Jules César meledje Yapo hermann Aristide Yapi David Léonce Kouadio Djamatchè Paul Valéry Akesse Kolo Yeo Laboratoire des Sciences Physiques Fondamentales et appliques Ecole Normale Suprieure dAbidjan Abidjan Cte dIvoire mathmatiques physiques Chimie Physique UFR Environnement Universit Jean Lorougnon Gud Daloa Cte dIvoire

In the context of the recovery of agricultural waste, many researches have focused on the preparation of adsorbents from natural waste from fruit trees, egg shells, palm waste or sawdust. This work aims to optimize the preparation of a biosorbent from rubber hulls by studying its ability to adsorb small and medium molecules. The influence of parameters such as drying temperature (X1), particle size (X2), stirring time (X3) and sodium hypochloride mass (X4) was studied. The results indicate that the model used for biosorbent optimization on methylene blue and iodine index is significant. In addition, this model has greater adsorption capabilities on small molecules than with large molecules. Statistical analysis of the data shows that temperature is the most influential factor in the adsorption of small molecules. On the other hand, particle size has a significant influence on the adsorption of large molecules. The optimum biosorbent preparation values are 1.0 for drying temperature (X1), −1.0 for biosorbent grain size (X2), 1.0 for stirring time (X3) and 1.0 for sodium hypochloride mass (X4).

关键词： Optimization Biosorbent methylene Blue Index Iodine Index Rubber Hulls

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