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Methemoglobinemia—A biomarker and a link to ferric iron accumulation in Alzheimer’s disease

Advances in Bioscience and Biotechnology 2014年第1期5卷 12-18页

作者： Lucijan Mohorovic Anna M. Lavezzi Sanja Stifter George Perry Djulija Malatestinic Vladimir Micovic Eris Materljan herman haller Oleg Petrovic “Lino Rossi” Research Center Department of Biomedical Sur-gical and Dental Science University of Milan Milan Italy Department of Biology University of Texas at San Antonio San Antonio USA Department of Environmental Medicine University of Rijeka School of Medicine Rijeka Croatia Department of Family Medicine University of Rijeka School of Medicine Rijeka Croatia Department of Gynecology and Obstetrics University of Rijeka School of Medicine Rijeka Croatia Department of Pathology University of Rijeka School of Medi-cine Rijeka Croatia Department of Social Medicine and Epidemiology University of Rijeka School of Medicine Rijeka Croatia

Understanding the mechanism of oxidative stress is likely to yield new insights regarding the pathogenesis of Alzheimer’s disease (AD). Our earlier work focused on the difference between hemoglobin and methemoglobin degradation, respectively leading to ferrous (Fe2+) iron, or ferric (Fe3+) iron. Methemoglobin has the role of carrier, the donor of cytotoxic and redox-active ferric (Fe3+) iron, which can directly accumulate and increase the rate of capillary endothelial cell apoptosis, and may cross into the brain parenchyma, to the astrocytes, glia, neurons, and other neuronal cells (neurovascular unit). This supposition helps us to understand the transport and neuronal accumulation process of ferric iron, and determine how iron is transported and accumulated intracellularly, identifiable as “Brain rust”. Earlier research found that the incidences of neonatal jaundice (p = 0.034), heart murmur (p = 0.011) and disorders such as dyslalia and learning/memory impairments (p = 0.002) were significantly higher in those children born from mothers with methemoglobinemia. Our hypothesis suggests that prenatal iron abnormalities could lead to greater neuronal death, the disease ageing process, and neurodegenerative disorders such as AD and other neurodegenerative diseases.

关键词： Alzheimer’s Disease (AD) Apoptosis Blood-Brain Barrier (BBB) Brain Capillary Ferric Iron Deposition Hemoglobin and Methemoglobin Catabolism Neurodegenerative Brain Disease SIDS

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Exploiting viral vectors to deliver genome editing reagents in plants

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aBIOTECH 2024年第2期5卷 247-261页

作者： Yilin Shen Tao Ye Zihan Li Torotwa herman Kimutai Hao Song Xiaoou Dong Jianmin Wan State Key Laboratory of Crop Genetics and Germplasm Enhancement and Utilization Jiangsu Collaborative Innovation Centre for Modern Crop ProductionJiangsu Engineering Research Center for Plant Genome EditingNanjing Agricultural UniversityNanjing 210095China Zhongshan Biological Breeding Laboratory Nanjing 210014China Hainan Seed Industry Laboratory Sanya 572025China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

Genome editing holds great promise for the molecular breeding of plants,yet its application is hindered by the shortage of simple and effective means of delivering genome editing reagents into *** plant transformation-based methods for delivery of genome editing reagents into plants often involve prolonged tissue culture,a labor-intensive and technically challenging process for many elite crop *** this review,we describe various virus-based methods that have been employed to deliver genome editing reagents,including components of the CRISPR/Cas machinery and donor DNA for precision editing in *** update the progress in these methods with recent successful examples of genome editing achieved through virus-based delivery in different plant species,highlight the advantages and limitations of these delivery approaches,and discuss the remaining challenges.

关键词： Plant genome engineering Genome editing CRISPR/Cas Virus-based delivery

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Preparation of Regenerated Silk Fibroin Hybrid Fibers with Hydrogen Peroxide Sensing Properties by Wet Spinning

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Journal of Renewable Materials 2024年第6期12卷 1043-1055页

作者： Song Lu Jianjun Guo Richard Ansah herman Xinyi Wu Lin Ma Guohua Wu College of Biotechnology Jiangsu University of Science and TechnologyZhenjiang212100China College of Agriculture Anshun UniversityAnshun561000China

Silk is widely used in the production of high-quality *** the same time,the amount of silk textiles no longer in use and discarded is increasing,resulting in significant waste and *** issue is of great concern in many countries where silk is *** peroxide as a naturally occurring compound is an important indicator of detection in both biology and the *** study aims to develop a composite fiber with hydrogen peroxide-sensing properties using discarded silk *** achieve this goal,firstly,polydopamine(PDA)was used to encapsulate the ZnFe_(2)O_(4) NPs to achieve the improvement of dispersion,and then regenerated silk fibroin(RSF)and PDA@ZnFe_(2)O_(4)/RSF hybrid fibers are prepared by wet *** has shown that PDA@ZnFe_(2)O_(4)/RSF demonstrates exceptional sensitivity,selectivity,and stability in detecting hydrogen peroxide,while maintaining high mechanical ***,the complete hybridization of PDA@ZnFe_(2)O_(4) with silk fibroin not only results in the combination of the durability of silk fibroin and PDA@ZnFe_(2)O_(4)’s rigidity,ensuring a reliable service life,but also makes PDA@ZnFe_(2)O_(4)/RSF exhibit excellent catalytic activity and ***,the composite fiber exhibits exceptional mechanical properties and reliable hydrogen peroxide sensing capabilities,making it a promising material for biological and medical applications.

关键词： Regenerated silk fibroin modified zinc ferrite nanoparticles composite fiber hydrogen peroxide sensor wet spinning

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Introducing a 2^nd Universal Space-Time Constant Can Explain the Observed Age of the Universe and Dark Energy

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World Journal of Mechanics 2024年第2期14卷 9-22页

作者： herman A. van Hoeve Hulst Netherlands

The purpose of this paper is to introduce new theoretical concepts as opposed to accepting the existence of dark entities, such as dark energy. This research sought to introduce a 2nd universal space-time constant, besides having a finite speed constant (speed of light in vacuum c). A finite universal age constant b is introduced. Namely, this paper shows that the changes in the Earth’s anomalistic year duration over time support the hypothesis of the age of the universe correlating with a maximum number of orbital revolutions constant. Neglecting the gravitational influence of other cosmological entities in the proximity of the Earth, the constant maximum number of revolutions is herewith determined solely by the Earth’s orbital revolutions around the Sun. The value of the universal age constant b is calculated to be around 13.8 billion orbital revolutions, derived out of an equation related to the changes in the Earth’s anomalistic year duration over time and the so-called Hubble tension. The above-mentioned calculated value b correlates well with the best fit to measured data of the cosmic microwave background radiation (CMBR) by the Planck spacecraft, the age of the observed universe is measured to be approximately 13.787 ± 0.020 billion years (2018 final data release). Developing a theory with this 2nd universal space-time constant b, being covariant with respect to the Lorentz transformations when time spans are large, gives results such as: A confirmation of the measured CMBR value of 13.787 ± 0.020 billion years. Correlating well with the observed expansion rate of the universe (dark energy). The universe’s expansion accelerating over the last four to five billion years.

关键词： Anomalistic Year Orbital Revolution Hubble Tension Age of the Universe Cosmological Constant Dark Energy Cosmic Microwave Background

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Epigenetic silencing schlafen-11 sensitizes esophageal cancer to ATM inhibitor

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2060-2073页

作者： Jing Zhou Mei-Ying Zhang Ai-Ai Gao Cheng Zhu Tao He James G herman Ming-Zhou Guo School of Medicine NanKai UniversityTianjin 300071China Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Departments of Pathology Characteristic Medical Center of The Chinese People’s Armed Police ForceTianjin 300162China The Hillman Cancer Center University of Pittsburgh Cancer InstitutePittsburghPA 15213United States National Key Laboratory of Kidney Diseases Chinese PLA General HospitalBeijing 100853China

BACKGROUND Targeting DNA damage response(DDR)pathway is a cutting-edge *** has been reported that Schlafen-11(SLFN11)contributes to increase chemosensitivity by participating in ***,the detailed mechanism is *** To investigate the role of SLFN11 in DDR and the application of synthetic lethal in esophageal cancer with SLFN11 *** To reach the purpose,eight esophageal squamous carcinoma cell lines,142 esophageal dysplasia(ED)and 1007 primary esophageal squamous cell carcinoma(ESCC)samples and various techniques were utilized,including methylationspecific polymerase chain reaction,CRISPR/Cas9 technique,Western blot,colony formation assay,and xenograft mouse *** Methylation of SLFN11 was exhibited in 9.15%of(13/142)ED and 25.62%of primary(258/1007)ESCC cases,and its expression was regulated by promoter region ***11 methylation was significantly associated with tumor differentiation and tumor size(both P<0.05).However,no significant associations were observed between promoter region methylation and age,gender,smoking,alcohol consumption,TNM stage,or lymph node *** DNA damaged model induced by low dose cisplatin,SLFN11 was found to activate non-homologous end-joining and ATR/CHK1 signaling pathways,while inhibiting the ATM/CHK2 signaling *** silencing of SLFN11 was found to sensitize the ESCC cells to ATM inhibitor(AZD0156),both in vitro and in *** SLFN11 is frequently methylated in human *** of SLFN11 is sensitive marker of ATM inhibitor in ESCC.

关键词： Schlafen-11 Esophageal squamous cell carcinoma DNA methylation Synthetic lethality AZD0156

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Assessment of the effectiveness of weight-adjusted antibiotic administration,for reduced duration,in surgical prophylaxis of primary hip and knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 170-179页

作者： Tosan Okoro Michael Wan Takura Darlington Mukabeta Ella Malev Marketa Gross Claudia Williams Muhammad Manjra Jan herman Kuiper John Murnaghan Department of Arthroplasty Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation TrustOswestry SY107AGUnited Kingdom School of Medicine Keele UniversityStaffordshire ST55BGUnited Kingdom St Joseph’s Health Centre Unity Health TorontoToronto M6R 1B5Canada Department of Arthroplasty The Royal London HospitalBarts Health NHS TrustLondon E11BBUnited Kingdom Department of Arthroplasty Sunnybrook Holland Orthopaedic and Arthritis CentreToronto M4Y 1H1Canada Institute for Science and Technology in Medicine Keele UniversityStaffordshire ST51BGUnited Kingdom

BACKGROUND Prophylactic antibiotics have significantly led to a reduction in the risk of postoperative surgical site infections(SSI)in orthopaedic *** aim of using antibiotics for this purpose is to achieve serum and tissue drug levels that exceed,for the duration of the operation,the minimum inhibitory concentration of the likely organisms that are *** antibiotics reduce the rate of SSIs in lower limb arthroplasty from between 4%and 8%to between 1%and 3%.Controversy,however,still surrounds the optimal frequency and dosing of antibiotic *** To evaluate the impact of introduction of a weight-adjusted antibiotic prophylaxis regime,combined with a reduction in the duration of administration of post-operative antibiotics on SSI incidence during the 2 years following primary elective total hip and knee arthroplasty METHODS Following ethical approval,patients undergoing primary total hip arthroplasty(THA)/total knee arthroplasty(TKA)with the old regime(OR)of a preoperative dose[cefazolin 2 g intravenously(IV)],and two subsequent doses(2 h and 8 h),were compared to those after a change to a new regime(NR)of a weight-adjusted preoperative dose(cefazolin 2 g IV for patients120 kg)and a post-operative dose at 2 *** primary outcome in both groups was SSI rates during the 2 years *** A total of n=1273 operations(THA n=534,TKA n=739)were performed in n=1264 *** was no statistically significant difference in the rate of deep(OR 0.74%(5/675)vs NR 0.50%(3/598);fishers exact test P=0.72),nor superficial SSIs(OR 2.07%(14/675)vs NR 1.50%(9/598);chi-squared test P=0.44)at 2 years *** propensity score weighting and an interrupted time series analysis,there was also no difference in SSI rates between both groups[RR 0.88(95%CI 0.61 to 1.30)P=0.46].CONCLUSION A weight-adjusted regime,with a reduction in number of post-operative doses had no adverse impact on S

关键词： Antibiotics Weight-adjusted Hip and knee arthroplasty Surgical site infection

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Lab results of COVID-19 patients:Omicron vs delta variants

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World Journal of Virology 2024年第2期13卷 71-77页

作者： Dana Avraham Amir herman Gal Shaham Arkady Shklyar Elina Sulim Maria Oulianski Orthopedic Department Kaplan Medical CenterRehovot 7661041Israel Department of Medicine Lithuanian University of Health SciencesKaunas 44307Lithuania Emergency Department Kaplan Medical CenterRehovot 7661041Israel

BACKGROUND The coronavirus disease 2019(COVID-19)virus has been a world-known pan-demic since February *** variances had been established;the most common variants in Israel were omicron and *** To analyze and compare laboratory values in the"omicron"and"delta"variants of the coronavirus by conducting follow-up examinations and laboratory audits on COVID-19 patients admitted to our *** A retrospective study,two groups,50 patients in each *** examined positive for COVID-19 were divided into groups according to the common variant at the given *** reviewed demographic data and laboratory results such as complete blood count and full chemistry,including electrolytes and coagulation *** The mean age was 52%,66.53±21.7 were *** significance was found comparing laboratory results in the following disciplines:Blood count,hemo-globin,and lymphocytes(P=0.41,P=0.87,P=0.97).Omicron and delta variants have higher neutrophil counts,though they are not significantly different(P=0.38).Coagulation tests:Activated paritial thromoplastin test and international normalized ratio(P=0.72,P=0.68).We found no significance of abnormality for all *** The study compares laboratory results of blood tests between two variants of the COVID-19 virus–omicron and *** found no significance between the *** results show the need for further research with larger data as well as the need to compare all COVID-19 variants.

关键词： COVID-19 Coronavirus Omicron variant Delta variant

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白鲸

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英语画刊(高中版) 2024年第23期 3-5页

作者： herman Melville 成时

《白鲸》是19世纪美国小说家赫尔曼·梅尔维尔的代表作，曾被英国作家毛姆列入“世界文学十大最佳小说”。小说从讲述者以实玛利的角度出发，描写了一场惊险万分的海洋冒险，对现代主义小说和后现代主义小说产生了重大影响。本文节选自...

《白鲸》是19世纪美国小说家赫尔曼·梅尔维尔的代表作，曾被英国作家毛姆列入“世界文学十大最佳小说”。小说从讲述者以实玛利的角度出发，描写了一场惊险万分的海洋冒险，对现代主义小说和后现代主义小说产生了重大影响。本文节选自第三章，讲述了以实玛利出海前的经历。

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Male factor infertility and ART

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Asian Journal of Andrology 2012年第1期14卷 103-108,178页

作者： herman Tournaye Centre for Reproductive Medicine University Hospital of the Dutch-speaking Brussels Free University Brussels B-1090 Belgium

For years, the management and treatment of male factor infertility has been ‘experience＇ and not ‘evidence＇ based. Although not evidence-based, current clinical practice involves extensive use of assisted reproductive techniques （ART）. Where specific treatments are not indicated or have failed, ART have become popular adjunctive treatments for alleviating male factor infertility. According to the limited evidence available, intrauterine insemination （IUI） may be considered as a first-line treatment in a couple in which the female partner has a normal fertility status and at least 1 × 10^6 progressively motile spermatozoa are recovered after sperm preparation. If no pregnancy is achieved after 3-6 cycles of IUI, optimized in vitro fertilization （IVF） can be proposed. When less than 0.5× 106 progressively motile spermatozoa are obtained after seminal fluid processing or sperm are recovered surgically from the testis or epididymis, intracytoplasmic sperm injection （ICSI） should be performed. Although the outcome of no other ART has ever been scrutinized as much before, no large-scale ‘macroproblems＇ have as yet been observed after ICSI. Yet, ICSI candidates should be rigorously screened before embarking on IVF or ICSI, and thoroughly informed of the limitations of our knowledge on the hereditary aspects of male infertility and the safety aspects of ART.

关键词： artificial intracytoplasmic sperm injection insemination in vitro fertilization male infertility sperm

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Epidemiological and Clinical Profile of Children Exposed to SARS-CoV-2 at the COVID-19 Treatment Center at the ISIRO Hospital and WATSA in the Democratic Republic of the Congo

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Journal of Biosciences and Medicines 2024年第9期12卷 73-81页

作者： Hilaire Lisimo Abwa David Azako Michel Ngbatala Bienvenu Apenya Jolie Mambeizidra Julbert Malangu Eugene Kumbodimo George Mutuale herman Luhavo Jean Claude Gbundu Fiston Bolanda François Enze Marie Tasile Yvette Kpakpo Nyange Nicholas Katembo Clinics Universitaires Uele Department of Pediatrics Faculty of Medicine University of Uele Isiro Democratic Republic of the Congo General Hospital of Isiro Isiro Democratic Republic of the Congo Division Provinciale de la Sant du Haut Ul Isiro Democratic Republic of the Congo Additional Vaccination Program for Watsa Watsa Democratic Republic of the Congo Center Hospitalier KIBALI Durba Democratic Republic of the Congo Hospital General of Watsa Watsa Democratic Republic of the Congo

Introduction: COVID-19, an emerging infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), typically presents with mild clinical manifestations in pediatric populations. As in many other regions of the Democratic Republic of the Congo (DRC), the COVID-19 pandemic affected children in Haut-Uélé, a province bordering South Sudan and Uganda. This study aimed to describe the epidemiological profile of COVID-19 in pediatric population in this area. Materials and Methods: This descriptive cross-sectional study was conducted over a 6-month period from August 1, 2021 to February 7, 2022. It included all patients aged 0 to 19 years with confirmed COVID-19 using RT-PCR and managed at the COVID-19 Treatment Centers (CTCO) in ISIRO and WATSA. Data were collected from patient records supplemented by the dataset from the service of Health Information System (SNIS) and the Epidemiological Surveillance Commission of the Provincial Health Division (DPS). Epidemiological and clinical profiles were analyzed. All statistical analyses were performed using SPSS software, Version 18. Results: During the 4th wave of the pandemic, 5 out of 13 health zones in Haut-Uélé province were affected, with a total of 569 recorded cases;45 of them were children aged 0 to 19 years (7.9%). Asymptomatic cases accounted for 33.3% (15 cases). The mean age was 9.88 ± 5.49 years, with the most affected age group being 10 - 14 years (44.45%). There was a predominance of males (73.3%), with a male-to-female sex ratio of 2.75. Half of the patients (53.3%) were from Watsa Health Zone. A seasonal peak was observed between December and January. Comorbidities were present in 10% of infected patients, and nearly half of participants were contacts of infected individuals. The primary reasons for admission were fever (66.66%), followed by rhinorrhea (57.77%) and cough (31.11%). All patients responded favorably to treatment. Conclusion: The proportion of pediatric COVID-19 cases at t

关键词： COVID-19 Morbi-Mortal Emergency Haut-Uélé

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