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Male factor infertility and ART

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Asian Journal of Andrology 2012年第1期14卷 103-108,178页

作者： herman Tournaye Centre for Reproductive Medicine University Hospital of the Dutch-speaking Brussels Free University Brussels B-1090 Belgium

For years, the management and treatment of male factor infertility has been ‘experience＇ and not ‘evidence＇ based. Although not evidence-based, current clinical practice involves extensive use of assisted reproductive techniques （ART）. Where specific treatments are not indicated or have failed, ART have become popular adjunctive treatments for alleviating male factor infertility. According to the limited evidence available, intrauterine insemination （IUI） may be considered as a first-line treatment in a couple in which the female partner has a normal fertility status and at least 1 × 10^6 progressively motile spermatozoa are recovered after sperm preparation. If no pregnancy is achieved after 3-6 cycles of IUI, optimized in vitro fertilization （IVF） can be proposed. When less than 0.5× 106 progressively motile spermatozoa are obtained after seminal fluid processing or sperm are recovered surgically from the testis or epididymis, intracytoplasmic sperm injection （ICSI） should be performed. Although the outcome of no other ART has ever been scrutinized as much before, no large-scale ‘macroproblems＇ have as yet been observed after ICSI. Yet, ICSI candidates should be rigorously screened before embarking on IVF or ICSI, and thoroughly informed of the limitations of our knowledge on the hereditary aspects of male infertility and the safety aspects of ART.

关键词： artificial intracytoplasmic sperm injection insemination in vitro fertilization male infertility sperm

Herpesviruses and the TypeⅢInterferon System

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Virologica Sinica 2021年第4期36卷 577-587页

作者： Yue Yin herman W.Favoreel Department of Virology Parasitology and ImmunologyFaculty of Veterinary MedicineGhent University9820 MerelbekeBelgium

TypeⅢinterferons(IFNs)represent the most recently discovered group of *** with typeⅠIFNs(***-α/β),typeⅢIFNs(IFN-λ)are produced as part of the innate immune response to virus infection,and elicit an anti-viral state by inducing expression of interferon stimulated genes(ISGs).It was initially thought that typeⅠIFNs and typeⅢIFNs perform largely redundant ***,it has become evident that typeⅢIFNs particularly play a major role in antiviral protection of mucosal epithelial barriers,thereby serving an important role in the first-line defense against virus infection and invasion at contact areas with the outside world,versus the generally more broad,potent and systemic antiviral effects of typeⅠ*** are large DNA viruses,which enter their host via mucosal surfaces and establish lifelong,latent *** the importance of mucosal epithelial cells in the pathogenesis of herpesviruses,our current knowledge on the interaction of herpesviruses with typeⅢIFN is limited and largely restricted to studies on the alphaherpesvirus herpes simplex virus(HSV).This review summarizes the current understanding about the role of IFN-λin the immune response against herpesvirus infections.

关键词： TypeⅢinterferon(IFN-λ) Herpesvirus Innate immunity Herpes simplex virus(HSV)

Altered leukocyte gene expression after traumatic spinal cord injury:clinical implications

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Neural Regeneration Research 2018年第9期13卷 1524-1529页

作者： Paige E.herman Ona Bloom The Feinstein Institute for Medical Research Northwell Health Departments of Physical Medicine and Rehabilitation Molecular MedicineDonald and Barbara Zucker School of Medicine at Hofstra Northwell

In addition to changes in motor and sensory function, individuals with spinal cord injury （SCI） experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardio- vascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to im- prove immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genom- ics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.

关键词： traumatic spinal cord injury inflammation immune cells functional genomics gene expression autoimmunity microarray chronic spinal cord injury

Functional sperm produced after spermatogonial stem ：ell transplantation into rhesus

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Asian Journal of Andrology 2013年第2期15卷 216-217页

作者： Ellen Goossens herman Tournaye Research Group Biology of the testis (BITE) Research Department Embryology and Genetics Vrije Universiteit Brussel Laarbeeklaan 103 Jette 1090 Belgium Centre for Reproductive Medicine UZ Brussel Laarbeeklaan 101 Brussels 1090 Belgium

Spermatogonial stem cell （SSC） transplantation is a promising technique to circumvent sterility in prepubertal boys undergoing gonadotoxic treatments. While the cryopreservation of spermatogonial stem cells is being introduced in clinical practices worldwide, a lot of unanswered questions remain regarding their eventual transplantation. In this paper autologous and allogeneic SSC transplantations in the testes of sterilized macaques were performed and spermatogenesis could be restored from donor SSCs. The spermatozoa obtained were competent to fertilize oocytes. This report proves the feasability of SSC transplantation in a primate model, hence reinforcing the hope that this strategy will eventually find its way into clinical practice.

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The Ethical Break:Marguerite Duras,Jorie Graham,and *** Philip

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Journal of Foreign Languages and Cultures 2020年第1期4卷 86-98页

作者： herman Rapaport Wake Forest University

In addition to positing a historical,traumatic,and representational break relative to the end of World War II in Europe,this essay posits the idea of an ethical break concerning the abrogation of the right to life as figured in three texts:La Douleur,a memoir by Marguerite Duras;Overlord,lyrical poetry by Jorie Graham;and Zong!,a conceptual poem by *** *** all four breaks converge synchronically as the instantiation of an event everyone has experienced as catastrophic,but diachronically history,trauma,representation,and ethics may not be recognized simultaneously,since it may take years for society to accept social trauma or ethical fault,not to mention finding adequate means of representing catastrophe,or accepting the verdicts of history and the changes they have *** three literary works that concern a historical break inherently reveal both the simultaneity and asymmetry of ethics,representation,and trauma.

关键词： trauma history representation ethics

China’s Party Training Programs in South Africa:A Quest for Political Alignment

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Fudan Journal of the Humanities and Social Sciences 2020年第3期13卷 437-451页

作者： Fanie herman Department of Political Studies and Governance University of the Free StateBloemfonteinSouth Africa

South Africa's contemporary political relations with China shows a resemblance in political thinking and beliefs that forms the basis for solidarity and draws the two countries closer on ideological *** literature points out that when states shares similar characteristics,certain hypotheses exists that can provide an analytical explanation of alignment *** ideological push by China aims to promote the political like-mindedness of the Chinese Communist Party(CCP)and African National Congress(ANC)and manifests in the launching of party training *** with Chinese characteristics forms the core of the training programs,which is used to strengthen party structures,advance solidarity and maintain official party-to-party *** with an ANC party official provide a first-hand account of the beliefs of the current South African president and also what the stance of the South African Communist party(SACP)is.A major difference is that the ANC leader regards the Chinese way of governance as important,while the SACP focus on solidifying party *** light of this,the impact party training programs can have in testing the alignment hypotheses is examined in the *** findings reflect on the similar traits both parties share and the significance of the alignment to strengthen the political ideological relationship.

关键词： Sino-South African relationship The Chinese Communist Party The African National Congress Ideological alignment Party training programs

Conservative Residual Distribution Method for Viscous Double Cone Flows in Thermochemical Nonequilibrium

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Communications in Computational Physics 2013年第2期13卷 479-501页

作者： Andrea Lani Marco Panesi herman Deconinck Von Karman Institute for Fluid Dynamics Waterloosesteenweg 721640Sint Genesius RodeBelgium Institute for Computational Engineering and Sciences University of TexasAustinTexas 78712USA

Amulti-dimensionally upwind conservative ResidualDistribution algorithm for simulating viscous axisymmetric hypersonic flows in thermo-chemical nonequilibrium on unstructured grids is presented and validated in the case of the complex flowfield over a double cone *** resulting numerical discretization combines a state-of-the-art nonlinear quasi-monotone second order blended scheme for distributing the convective residual and a standard Galerkin formulation for the diffusive *** physical source terms are upwinded together with the convective *** results show an excellent agreement with experimental measurements and available literature.

关键词： Unstructured mesh hypersonic flows thermo-chemical nonequilibrium residual distribution schemes double cone

Genetic causes of spermatogenic failure

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Asian Journal of Andrology 2012年第1期14卷 40-48,175页

作者： Annelien Massart Willy Lissens herman Tournaye Katrien Stouffs Center for Medical Genetics Universitair Ziekenhuis Brussel 1090 Brussels Belgium Reproduction and Genetics （REGE） Vrije Universiteit Brussel 1090 Brussels Belgium Center for Reproductive Medicine Universitair Ziekenhuis Brussel 1090 Brussels Belgium Biology of the Testis （BITE） Vrije Universiteit Brussel 1090 Brussels Belgium

Approximately 10%-15% of couples are infertile, and a male factor is involved in almost half of these cases. This observation is due in part to defects in spermatogenesis, and the underlying causes, including genetic abnormalities, remain largely unknown. Until recently, the only genetic tests used in the diagnosis of male infertility were aimed at detecting the presence of microdeletions of the long arm of the Y chromosome and/or chromosomal abnormalities. Various other single-gene or polygenic defects have been proposed to be involved in male fertility. However, their causative effects often remain unproven. The recent evolution in the development of whole-genome-based techniques and the large-scale analysis of mouse models might help in this process. Through knockout mouse models, at least 388 genes have been shown to be associated with spermatogenesis in mice. However, problems often arise when translating this information from mice to humans.

关键词： genetic causes gene male infertility spermatogenesis

Quo vadis? Bioengineered polysaccharide-based hydrogel scaffolds for damaged central nervous system recovery and regeneration

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Neural Regeneration Research 2022年第7期17卷 1478-1480页

作者： Isadora C.Carvalho herman S.Mansur Center of Nanoscience Nanotechnology and Innovation-CeNano2IDepartment of Metallurgical and Materials EngineeringFederal University of Minas GeraisBelo HorizonteMGBrazil

Impairments in the central nervous system(CNS)are a prevalent cause of life-long disabilities worldwide,representing serious health,social,and economic concerns(Doblado et al.,2021).During the last decades,with the population eldering and the increase in the life span,we have experienced an increase in CNS-related disorders,like stroke and neurodegenerative diseases(Jarrin et al.,2021).

关键词： al. diseases system