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Live and Inactivated Salmonella Enteritidis Vaccines:Immune Mechanisms in Broiler Breeders

World Journal of Vaccines 2015年第4期5卷 155-164页

作者： Letícia Dal Bérto Breno C. B. Beirao Tobias Fernandes Filho Max Ingberman Celso Favaro Jr. Rosangela Tavella Rebeca Buest de Mesquita Silva Luiz Felipe Caron Campus UP Universidade PositivoCuritibaBrazil Imunova Análises Biologicas CuritibaBrazil Departamento de Patologia Basica Universidade Federal do ParanaCuritibaBrazil

Salmonella is a ubiquitous pathogen which, in addition to causing poultry diseases, has a growing zoonotic impact. It has demanded the implementation of diverse control strategies, in which vaccines play a major role. The understanding of the immune pathways elicited by the different vaccines is important, contributing for the establishment of strong immune correlates of protection, for instance. With the purpose of determining the dynamics of the humoral and cellular immune responses to vaccination, broiler breeders (Cobb Slow) were immunized with live or inactivated vaccines against Salmonella Enteritidis. Lymphocyte and macrophage subsets were analyzed in the peripheral blood by flow cytometry and antigen-specific circulating IgY and mucosal IgA were quantified. The markers analyzed by flow cytometry were CD8/CD28, CD4/TCRVβ1, Kul/ MHC II and Bu-1. Both live and inactivated vaccines induced an increase in the proportion of circulating monocytes (Kul+MHCII+) in some time points compared to non-vaccinated controls. However, whereas the live vaccine leads to an increase in CD8-CD28+ and Bu-1+ lymphocytescompared to the control group, the inactivated vaccine prompteda reduction in the percentage of severalleucocyte subsets (Kul-MHCII+, Bu-1+, CD8+CD28+, CD8-CD28+, CD4+TCRVβ1-, CD4+TCRVβ1+, CD4-TCRVβ1+) after the boost dose. Both vaccines induced specific serum IgY and mucosal IgA production;however, the inactivated vaccine stimulated higher titers in a shorter period. These results contribute to the understanding of mechanisms of action of live and inactivated Salmonella vaccines in chickens.

关键词： Salmonella Enteritidis Humoral and Cellular Immunity Live Vaccine Bacterin Broiler Breeders

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Ex-Patients with COVID-19: Observations after Healing and Its Consequences*

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Open Journal of Epidemiology 2021年第1期11卷 31-36页

作者： José Humberto Cardoso Resende Aline Correia Barbosa Arley Braz Gomides Daniel Asafe Ferreira Rocha Gabriela Costa Santos Helena Beatriz Gonç alves Pô rto Mariana Palmeira Dias De Souza Rainy da Silva Rogério Tágara Alessandra Oliveira Kamimura Emí dio Silva Falcã o Brasileiro Alfredo Nasser University Aparecida de Goi&#226 nia GO Brazil

During the SARS-Cov-2 or COVID-19 clinical course pandemic of the coronavirus family, we observed symptoms of the respiratory tract, fever, cough, sore throat, and fatigue. The most common symptoms were loss of smell and taste and, when aggravated, it could develop into pneumonia and even death. We selected 40 former COVID-19 patients, who answered a questionnaire with questions about the symptoms and complications after they were cured and which symptoms remained or appeared after the total isolation quarantine for a specific time. Among the answers, the most cited was about “forgetting”. Another observation noted was the number of cases in children, which surprised us, considering that, at the beginning of the pandemic, the danger was more related to the elderly population and those with comorbidities.

关键词： Corona COVID Disease Infection Pandemic Pneumonia Thrombosis

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Ex-Patients with COVID-19: Observations after Healing and Its Consequences

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Open Journal of Epidemiology（流行病学期刊） 2021年第1期

作者： José Humberto Cardoso Resende Aline Correia Barbosa Arley Braz Gomides Daniel Asafe Ferreira Rocha Gabriela Costa Santos Helena Beatriz Gonçalves Pôrto Mariana Palmeira Dias De Souza Rainy da Silva Rogério Tágara Alessandra Oliveira Kamimura Emídio Silva Falcão Brasileiro

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