检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

钓鱼比赛

初中生 2023年第29期 48-51页

作者： dolores Kleinholz 潘麟之(编译) 不详

“Derby”(德比),指同一城市或区域内两支球队之间的体育比赛,也指同一范围内两种力量的竞争。在下面这个故事中,它就是指“钓鱼比赛”。期盼了一整年的路易斯,有没有在今年的钓鱼比赛中如愿以偿地获得大奖呢?

关键词：体育比赛钓鱼比赛 Derby

HLA-DQ:Celiac disease vs inflammatory bowel disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2018年第1期24卷 96-103页

作者： Marta Maia Bosca-Watts Miguel Minguez dolores Planelles Samuel Navarro Alejandro Rodriguez Jesus Santiago Joan Tosca Francisco Mora Disease Department of the University Clinic Hospital of Valencia University of ValenciaValencia 46017Spain Histocompatibility Department of the Transfusion Center of the Valencian Community Valencia 46014Spain Pathology Department of the University Clinic Hospital of Valencia University of ValenciaValencia 46017Spain Digestive Disease Department of the Hospital Virgen del Castillo of Yecla Yecla 30510Spain Digestive Disease Department of the Hospital de Manises Valencia 46940Spain Digestive Disease Department of the University Clinic Hospital of Valencia University of ValenciaValencia 46017Spain

AIM To determine the genetic predisposition to celiacdisease(Ce D) in inflammatory bowel disease(IBD) patients by quantifying the frequency of Ce D-related human leucocyte antigen(HLA)(HLA-Ce D: HLA-DQ2 and-DQ8) in IBD patients globally, by type of IBD and gender, and by calculating the protective/risk contribution of these haplotypes in the development of the IBD *** We conducted a prospective study with IBD patients from our Unit. Clinical information was gathered and blood was tested for HLA-CeD. The control group was made up of unrelated Valencian organ ***1034 subjects were analyzed: 457 IBD [207 ulcerative coliti(UC) and 250 Crohn's disease(CD)] patients and 577 healthy controls. 39% of the controls and 34% of the patients had HLA-Ce D(P = 0.0852). HLA-DQ2 was less frequent in UC patients(P = 0.0287), and HLA-DQ8 in CD(P = 0.0217). In women with UC, the frequency of DQ2.5 cis(DQB1*02:01-DQA1*05:01) was reduced ≥ 50% [P = 0.0344; preventive fraction(PF) = 13%]. PFs(7%-14%) were obtained with all HLACe D haplotypes. HLA DQB1*02:02-DQA1*02:01(HLADQ2.2) was more frequent in CD patients with respect to controls(P = 0.001) and UC patients(etiological fraction = 15%).CONCLUSION HLA-CeD is not more frequent in IBD patients, with an even lower frequency of HLA-DQ2 and-DQ8 in UC and CD respectively. HLA-DQ2.5 confers protection from the development of UC, especially in women, and HLADQ8 does so for the appearance of CD. HLA-DQ2.2 is present in 34% of the CD patients and may constitute a genetic risk factor for CD development.

关键词： Genetic predisposition Celiac disease Inflammatory bowel disease Crohn's disease Human leucocyte antigen Ulcerative colitis

Is there a relationship between dopamine and rhegmatogenous retinal detachment?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第2期15卷 311-314页

作者： Alessio Martucci Massimo Cesareo Maria dolores Pinazo-Durán Michela Di Pierro Matteo Di Marino Carlo Nucci Massimiliano Coletta Raffaele Mancino Ophthalmology Unit Department of Experimental MedicineUniversity of Rome Tor VergataRomeItaly Ophthalmic Research Unit "Santiago Grisolia"/FISABIO and Cellular-Molecular Ophthalmobiology Group/University of Valencia ValenciaSpain Department of Clinical Sciences and Translational Medicine University of Rome Tor VergataRomeItaly

Dopamine and its receptors have been widely studied in the neurological conditions and in the retina. In this study, we evaluated the possible role of dopamine in rhegmatogenous retinal detachment(RRD) by comparing the amount of 3,4-dihydroxyphenylacetic acid(DOPAC), a surrogate index of retinal dopamin levels, in the vitreous sample of patients affected by RRD with those affected by macular pucker and vitre ous hemorrhage. Our results showed that significantly higher levels of DOPAC were found in the vitreou sample of patients affected by RRD compared with those affected by vitreous hemorrhage and macula pucker(P = 0.002). Specifically, no trace of the substance was found in vitreous hemorrhage and macula pucker samples. A slightly significant positive correlation was found among DOPAC and post-operativ best corrected visual acuity(r = 0.470, P = 0.049). No correlation was found between DOPAC and the day elapsed between diagnosis and surgery(P = 0.317). For the first time our findings suggest that DOPAC i released in RRD, but not in other retinal diseases such as vitreous hemorrhage and macular pucker. More over, we showed a correlation between visual acuity outcome and the amount of DOPAC in the vitreous This might have a potential, although still unknown, implication in the pathogenesis of the disease and/o in the associated photoreceptors loss. This study was approved by the Ethics Committee of Rome Tor Ver gata University Hospital(R.S.92.10) on September 24, 2010.

关键词： 3,4-dihydroxyphenylacetic acid DOPAC dopamine dopaminergic amacrine cells dopaminergic neurotoxicity macular pucker oxidative stress photoreceptor degeneration rhegmatogenous retinal detachment vitreous hemorrhage

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

马努·维布·廷托雷内心的景观

苏州工艺美术职业技术学院学报 2024年第1期 100-100页

作者：玛丽亚·多洛雷斯·希门尼斯-布兰科马德里康普顿斯大学

马努·维布·廷托雷的作品是对风景的再现,还是对所见、所知、所感、所想之地的回忆?这些风景本身是否是实际存在的地方,是否遵循自己的规则、外形和纹理?又或者,它们最终是他自我世界的精神地图,勾勒出了他自己的内心世界?实际上,很难... 详细信息

马努·维布·廷托雷的作品是对风景的再现,还是对所见、所知、所感、所想之地的回忆?这些风景本身是否是实际存在的地方,是否遵循自己的规则、外形和纹理?又或者,它们最终是他自我世界的精神地图,勾勒出了他自己的内心世界?实际上,很难区分这些可能性,因为正如经常强调的那样,风景的概念本身就包含了这些元素:比如观察自然的视角,或者更确切地说,是从一种特定文化的角度理解自然。也许比起呈现观察到的外部世界,廷托雷更多地呈现了他的个人世界,那是一种内在的风景,是他在许多方面对周围环境做出的回应。廷托雷的作品中所呈现的世界反映了他对大自然长期而深刻的体验,这大概归功于当初他在非洲、拉丁美洲和亚马逊等地作为农业工程师时的思索,工作使得这种思考得以放大。但最近几年,这种思考在另一个完全不同的地方生根发芽:也就是他现在所居住的加泰罗尼亚。

关键词：周围环境加泰罗尼亚外部世界托雷马努亚马逊生根发芽工程师

Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2016年第48期22卷 10545-10556页

作者： Gloria Segarra Belén Cortina María dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina Department of Physiology University of Valencia and Institute of Health Research INCLIVAHospital Clínico Universitario Valencia Department of Gastroenterology and Hepatology and Institute of Health Research INCLIVA Hospital Clínico Universitario Valencia

AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic *** Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney.

关键词： Portal hypertension Cirrhosis Nitric oxide Asymmetric dimethylarginine Nitric oxide inhibitors Dimethylarginine dimethylaminohydrolase

Angle-to-angle and spur-to-spur distance analysis with high-resolution optical coherence tomography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2020年第1期7卷 399-411页

作者： Robert Montés-Micó Pedro Tañá-Rivero Salvador Aguilar-Córcoles María Ruiz-Santos María dolores Rodríguez-Carrillo Ramón Ruiz-Mesa Oftalvist Alicante and Jerez de la FronteraAlicanteSpain University of Valencia ValenciaSpain

Background:To measure angle-to-angle(ATA)and spur-to-spur(STS)distances along six meridians using highresolution swept-source optical coherence tomography(SS-OCT)and to compare those values with horizontal white-to-white(WTW)***:68 eyes from 68 patients were quantitatively assessed with the Anterion SS-OCT(Heidelberg Engineering,Heidelberg,Germany).ATA and STS distances were measured with the SS-OCT’s B-Scan in six cross-sectional images corresponding to the vertical(6-12 o’clock),1-7 o’clock,2-8 o’clock,horizontal(3-9 o’clock),4-10 o’clock and 5-11 o’clock *** was measured horizontally with the device’s infrared camera.A Pearson correlation analysis was carried out to compare ATA and STS distances with ***:The largest values were found for the vertical meridian and the shortest for the 2-8 o’clock meridian,both for ATA and STS *** statistically significant differences were found between WTW,ATA and STS along the horizontal meridian(p>0.1).However,ATA and STS showed statistically significant differences elsewhere,except for the horizontal and the 2-8 o’clock meridians(p>0.05).Moreover,we found that ATA and STS varied significantly depending on the meridian being assessed,except for ATA at 4-10 versus 3-9 o’clock and for STS at 4-10 versus 3-9 o’clock and at 3-9 versus 2-8 o’clock(p>0.1).R^(2) values ranged from 0.49 to 0.75 for ATA and STS at the different meridians,showing the best correlation at 3-9 o’clock meridian(0.64 and 0.75,respectively)and the worst at 6-12 o’clock meridian(R^(2)=0.49 for both ATA and STS).Conclusions:ATA and STS distances vary radially,thus showing that the anterior chamber is vertically ***,it is advisable to measure these two distances along the meridian to be used.

关键词： Angle-to-angle Spur-to-spur White-to-white Optical coherence tomography Swept-source Fourier domain

Role of T cell death in maintaining immune tolerance during persistent viral hepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第12期19卷 1877-1889页

作者： Juan Ramón Larrubia Megha Uttam Lokhande Silvia García-Garzón Joaquín Miquel dolores Subirá Eduardo Sanz-de-Villalobos Translational Hepatology Unit Guadalajara University Hospital University of Alcalá

Virus-specific T cells play an important role in the resolution of hepatic infection. However, during chronic hepatitis infection these cells lack their effector functions and fail to control the virus. Hepatitis B virus and hepatitis C virus have developed several mechanisms to generate immune tolerance. One of these strategies is the depletion of virus-specific T cells by apoptosis. The immunotolerogenic liver has unique property to retain and activate na ve T cell to avoid the over reactivation of immune response against antigens which is exploited by hepatotropic viruses to persist. The deletion of the virus-specific T cells occurs by intrinsic (passive) apoptotic mechanism. The pro-apoptotic molecule Bcl-2 interacting mediator (Bim) has attracted increasing attention as a pivotal involvement in apoptosis, as a regulator of tissue homeostasis and an enhancer for the viral persistence. Here, we reviewed our current knowledge on the evidence showing critical role of Bim in viral-specific T cell death by apoptotic pathways and helps in the immune tolerance.

关键词： T cell death Specific cytotoxic T lymphocytes Hepatitis C virus immune tolerance Apoptosis Bcl-2 interacting mediator Liver tolerance Apoptotic pathways Viral hepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于蒸散平衡的封闭式温室节水效果分析

农业工程学报 2010年第12期26卷 259-264页

作者：张诚贺超兴 Guillermo Zaragoza 严登华 dolores Buendia 赵志轩中国水利水电科学研究院水资源研究所北京100038 中国农业科学院蔬菜花卉研究所北京100081 卡雅玛尔基金会科学研究院西班牙阿尔梅利亚天津大学建筑工程学院天津300072

为了更好地提高温室的节水潜力,以西班牙的封闭式温室(Watergy项目)为研究对象,系统介绍了温室的闭路结构、节水节能与水处理等特点;以蒸散为基本原理设计2套水平衡公式,评估了温室的内外2套水平衡系统,论证了温室提高纯净水的可能性。... 详细信息

为了更好地提高温室的节水潜力,以西班牙的封闭式温室(Watergy项目)为研究对象,系统介绍了温室的闭路结构、节水节能与水处理等特点;以蒸散为基本原理设计2套水平衡公式,评估了温室的内外2套水平衡系统,论证了温室提高纯净水的可能性。结合试验期内的农作物产量,综合评价了封闭式温室的节水与农业生产能力。以2个月为试验周期,计算出总输入水量与总输出水量之差为244L,节水效果明显。农作物产量方面,同一时期种植的四季豆的水分生产效率要比同期在开放温室中生长的类似作物高出5倍(51kg/m3)。最后提出了提高纯净水产量的几点建议并分析了封闭式温室的应用前景与问题。

关键词：温室蒸散效率水分生产节水节能 Watergy项目

Mitochondrial-triggered immune responses mechanistically connect drug-induced steatohepatitis and cardiomyopathy associated with nonalcoholic steatohepatitis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2021年第8期18卷 2078-2080页

作者： Haoran Wang Sananda Pai Shun Ishiyama Xin Guo Wei Dong Gao Lakshmi Santhanam Kathy Gabrielson dolores B.Njoku Department of Anesthesiology and Critical Care Medicine Johns Hopkins UniversityBaltimoreMDUSA Molecular and Comparative Pathobiology Johns Hopkins UniversityBaltimoreMDUSA Department of Pathology Johns Hopkins UniversityBaltimoreMDUSA Department of Pediatrics Johns Hopkins UniversityBaltimoreMDUSA

In our prior publication[1],we elucidated IL-33-dependent mechanisms that regulate drug-induced liver *** this commentary,we mechanistically connected IL-33-dependent drug-induced steatohepatitis with nonalcoholic ***-induced steatohepatitis(DISH)is a rare form of drug-induced liver injury caused by drugs that are capable of inducing metabolic injury,steatosis or steatohepatitis[2].

关键词： drug hepatitis drugs