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Visual perception alterations in COVID-19:a preliminary study

International Journal of Ophthalmology(English edition) 2023年第1期16卷 1-9页

作者： María Begoña Coco-Martín Luis Leal-Vega Irene Alcoceba-Herrero Ainhoa Molina-Martín dolores de-Fez María JoséLuque Carlos Dueñas-Gutiérrez Juan Francisco Arenillas-Lara David PPiñero Group of Applied Clinical Neurosciences and Advanced Data Analysis Department of MedicineDermatology and ToxicologyUniversity of ValladolidValladolid 47005Spain Group of Optics and Visual Perception Department of OpticsPharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain Department of Optics and Optometry and Vision SciencesUniversity of ValenciaValencia 46100Spain COVID-19 Unit Department of Internal MedicineUniversity Clinical Hospital of ValladolidValladolid 47003Spain Stroke Unit Department of NeurologyUniversity Clinical Hospital of ValladolidValladolid 47003Spain Clinical Optometry Unit Department of OphthalmologyVithas Medimar International HospitalAlicante 03016Spain

AIM:To compare the visual perception(color and chromatic-achromatic contrast vision)of a small cohort of COVID-19 patients at the time of infection and after 6mo with that of a healthy population matched for sex and ***:A total of 25 patients(9 females,16 males,mean age:54±10y)with COVID-19 hospitalized in the COVID-19 Unit of the University Clinical Hospital of Valladolid were recruited for this preliminary *** perception,as determined by monocular measurement of contrast sensitivity function(CSF)and color vision was assessed in each patient using the Optopad *** results obtained were then compared with those of a sample of 16 age-and sex-matched healthy controls(5 females,11 males,mean age:50±6y)in which the same measurement procedure was *** significant differences between groups were assessed using the Mann-Whitney U *** were repeated after a minimum follow-up period of 6mo and statistically significant differences between the two time points in each group were assessed using the Wilcoxon signed rank ***:Discrimination thresholds(color and chromatic-achromatic contrast vision)and their corresponding sensitivity,calculated as the inverse of the discrimination threshold,were *** of the data revealed higher contrast threshold results(i.e.,worse contrast sensitivity)in the COVID-19 group than in the control group for all spatial frequencies studied in the Optopad-CSF achromatic test and most of the spatial frequencies studied in the Optopad-CSF chromatic test for the red-green and blue-yellow *** addition,color threshold results in the COVID-19 group were also significantly higher(i.e.,worse color sensitivity)for almost all color mechanisms studied in the Optopad-Color *** 6mo,most of the differences found between the groups were maintained despite COVID-19 ***:The present results provide preliminary evidence that visual perception may be impaired in COVID-19

关键词： SARS-CoV-2 COVID-19 visual perception contrast sensitivity function color vision

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Sperm counts and sperm sex ratio in male infertility patients

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Asian Journal of Andrology 2012年第5期14卷 683-686页

作者： Michael L Eisenberg Lata Murthy Kathleen Hwang dolores J Lamb Larry I Lipshultz Department of Urology Stanford University School of Medicine Stanford CA 94305 USA Scott Department of Urology Baylor College of Medicine Houston TX 77030 USA Department of Urology Brown University Providence RI 02912 USA

In recent years, investigators have noted a trend toward a declining proportion of male births in many industrialized nations. While men bear the sex-determining chromosome, the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio. We attempted to determine a man＇s secondary sex ratio （F1 generation） by directly examining the sex chromosomes of his sperm. We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization （FISH）. Patient demographic and semen parameters were recorded. Chi-squared analysis was used to compare gender ratios （Y chromosomes/total chromosomes）. Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters. A total of 185 men underwent sperm FISH. For the entire cohort, the proportion of Y chromosome-bearing sperm was 51.5%. Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm （50.8%） compared to men with higher sperm counts （51.6%; P= 0.02）. After multivariable adjustment, a higher sperm concentration, total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm （P〈0.01）. As a man＇s sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man＇s reproductive potential may predict his ability to sire male offspring.

关键词： infertility sex ratio spermatogenesis sperm chromosomes

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Crop phenotyping in a context of global change:What to measure and how to do it

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Journal of Integrative Plant Biology 2022年第2期64卷 592-618页

作者： Jose Luis Araus Shawn Carlisle Kefauver Omar Vergara-Díaz Adrian Gracia-Romero Fatima Zahra Rezzouk Joel Segarra Maria Luisa Buchaillot Melissa Chang-Espino Thomas Vatter Rut Sanchez-Bragado JoséArmando Fernandez-Gallego Maria dolores Serret Jordi Bort Integrative Crop Ecophysiology Group Plant Physiology SectionFaculty of BiologyUniversity of BarcelonaBarcelonaSpain AGROTECNIO Center LleidaSpain Plant Ecophysiology and Metabolism Lab ITQB NovaPlant Sciences DivisionOeirasPortugal Programa de Ingeniería Electrónica Facultad de IngenieríaUniversidad de IbaguéIbaguéColombia

High-throughput crop phenotyping,particularly under field conditions,is nowadays perceived as a key factor limiting crop genetic *** not only facilitates conventional breeding,but it is necessary to fully exploit the capabilities of molecular breeding,and it can be exploited to predict breeding targets for the years ahead at the regional level through more advanced simulation models and decision support *** terms of phenotyping,it is necessary to determined which selection traits are relevant in each situation,and which phenotyping tools/methods are available to assess such *** sensing methodologies are currently the most popular approaches,even when lab-based analyses are still relevant in many *** top of that,data processing and automation,together with machine learning/deep learning are contributing to the wide range of applications for *** review addresses spectral and red-green-blue sensing as the most popular remote sensing approaches,alongside stable isotope composition as an example of a lab-based tool,and root phenotyping,which represents one of the frontiers for field ***,we consider the two most promising forms of aerial platforms(unmanned aerial vehicle and satellites)and some of the emerging data-processing *** review includes three Boxes that examine specific case studies.

关键词： crop phenotyping deep learning models photosynthesis platforms remote sensing roots satellites sensors stable isotopes

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Gene expression and physiological responses to salinity and water stress of contrasting durum wheat genotypes

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Journal of Integrative Plant Biology 2016年第1期58卷 48-66页

作者： Salima Yousfi Antonio J.Marquez Marco Betti Jose Luis Araus Maria dolores Serret Unit of Plant Physiology Department of Plant BiologyFaculty of BiologyUniversity of Barcelona08028Spain Department of Plant Biochemistry and Molecular Biology Faculty of ChemistryUniversity of SevilleSevilla 41012Spain

Elucidating the relationships between gene expression and the physiological mechanisms remains a bottleneck in breeding for resistance to salinity and drought. This study related the expression of key target genes with the physiological performance of durum wheat under different combinations of salinity and irrigation. The candidate genes assayed included two encoding for the DREB（dehydration responsive element binding） transcription factors Ta DREB1 A and Ta DREB2 B, another two for the cytosolic and plastidic glutamine synthetase（Ta GS1 and Ta GS2）, and one for the specific Na^＋/H^＋ vacuolar antiporter（Ta NHX1）. Expression of these genes was related to growth and different trait indicators of nitrogen metabolism（nitrogen content, stable nitrogen isotope composition, and glutamine synthetase and nitrate reductase activities）, photosynthetic carbon metabolism（stable carbon isotope composition and different gas exchange traits） and ion accumulation. Significant interaction between genotype and growing conditions occurred for growth, nitrogen content, and the expression of most *** general terms, higher expression of Ta GS1, Ta GS2,Ta DREB2 B, and to a lesser extent of Ta NHX1 were associated with a better genotypic performance in growth, nitrogen, and carbon photosynthetic metabolism under salinity and water stress. However, Ta DREB1 A was increased in expression under stress compared with control conditions, with tolerant genotypes exhibiting lower expression than susceptible ones.

关键词： Durum wheat (Triticum turgidum ssp. durum) geneexpression nitrogen metabolism salinity stable isotope

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Short-term outcomes of robotic liver resection: An initial singleinstitution experience

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World Journal of Hepatology 2022年第1期14卷 224-233页

作者： Manuel Durán Javier Briceño Ana Padial Ferdinando Massimiliano Anelli Juan Manuel Sánchez-Hidalgo María dolores Ayllón Rafael Calleja-Lozano Carmen García-Gaitan Unit of Hepatobiliary Surgery and Liver Transplantation General and Digestive Surgery DepartmentReina Sofia University HospitalCordoba 14004Spain GC18 Translational Research in Surgery of Solid Organ Transplantation Maimonides Biomedical Research InstituteCórdoba 14004Spain GE09 Research in Peritoneal and Retroperitoneal Oncological Surgery Maimonides Biomedical Research InstituteCórdoba 14004Spain Department of Anesthesiology and Resuscitation Reina Sofia University HospitalCordoba 14004Spain

BACKGROUND Liver surgery has traditionally been characterized by the complexity of its procedures and potentially high rates of morbidity and mortality in inexperienced *** robotic approach has gradually been introduced in liver surgery and has increased notably in recent ***,few centers currently perform robotic liver surgery and experiences in robot-assisted surgical procedures continue to be limited compared to the laparoscopic *** To analyze the outcomes and feasibility of an initial robotic liver program implemented in an experienced laparoscopic hepatobiliary *** A total of forty consecutive patients underwent robotic liver resection(da Vinci Xi,***,United States)between June 2019 and January *** were prospectively followed and retrospectively *** characteristics and perioperative and short-term outcomes were *** are expressed as mean and standard *** study was approved by the Institutional Review *** The mean age of patients was 59.55 years,of which 18(45%)were *** mean body mass index was 29.41 kg/m^(2).Nine patients(22.5%)were *** were divided by type of resection as follows:Ten segmentectomies,three wedge resections,ten left lateral sectionectomies,six bisegmentectomies(two VVI bisegmentectomies and four IVb-V bisegmentectomies),two right anterior sectionectomies,five left hepatectomies and two right *** lesions occurred in twenty-nine(72.5%)of the *** mean operative time was 258.11 min and two patients were transfused intraoperatively(5%).Inflow occlusion was used in thirty cases(75%)and the mean total clamping time was 32.62 *** was a single conversion due to uncontrollable *** postoperative complications(Clavien–Dindo>Ⅲb)occurred in three patients(7.5%)and mortality in one(2.5%).No patient required readmission to the *** mean hospital stay was 5.6 *** Althou

关键词： Robotics Hepatectomy Minimally invasive surgery Liver surgery Da vinci

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Difficulty scores in laparoscopic liver surgery—getting closer to a powerful and necessary tool

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Hepatobiliary Surgery and Nutrition 2019年第4期8卷 428-430页

作者： Ruben Ciria Maria dolores Ayllon Javier Brice(n)o Unit of Hepatobiliary Surgery and Liver Transplantation University Hospital Reina Sofia Cordoba Spain

Obtaining standardized difficulty scores for surgical techniques is mandatory. The more accurate the scores become, the better results may be achieved in terms of patients' safety and surgical implementation. This need is especially useful when technically demanding and complex surgical procedures are performed. In this sense, liver resections are difficult procedures with high morbidity and mortality rates that should be performed by experienced surgeons. Hepatobiliary surgery has always been considered as a long-term project that needs patience, expertise and a progressive learning curve. Since the first reported laparoscopic liver resection in 1996, the adoption and implementation of minimally invasive liver surgery has been cautious. However, laparoscopic liver resections have experienced a wide expansion in recent years (1), mainly after the last Consensus Meeting held in Morioka in 2014 (2). One of the statements reported during this Consensus and in the latter European Guidelines Meeting held in Southampton in 2017 (3) is that a need for a safe expansion and control on technical procedures should be encouraged. In this context, liver surgical teams are trying to develop feasible tools that may standardize laparoscopic liver resections.

关键词： surgery closer latter

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Machine perfusion and the prevention of ischemic type biliary lesions following liver transplant:What is the evidence?

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World Journal of Gastroenterology 2023年第20期29卷 3066-3083页

作者： Manuel Durán Rafael Calleja Angus Hann George Clarke Ruben Ciria Anisa Nutu Rebeca Sanabria-Mateos María dolores Ayllón Pedro López-Cillero Hynek Mergental Javier Briceño M Thamara P R Perera Department of Liver Transplantation Reina Sofía University HospitalCórdoba 14004Spain The Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152THUnited Kingdom Centre for Liver and Gastrointestinal Research Institute of Immunology and ImmunotherapyUniversity of BirminghamBirmingham B152THUnited Kingdom

The widespread uptake of different machine perfusion(MP)strategies for liver transplant has been driven by an effort to minimize graft *** to the cholangiocytes during the liver donation,preservation,or early posttransplant period may result in stricturing of the biliary tree and inadequate biliary *** problem continues to trouble clinicians,and may have catastrophic consequences for the graft and *** injury,as a result of compromised hepatic artery flow,is a well-known cause of biliary strictures,sepsis,and graft ***,very similar lesions can appear with a patent hepatic artery and these are known as ischemic type biliary lesions(ITBL)that are attributed to microcirculatory dysfunction rather than main hepatic arterial *** the warm and cold ischemic period duration appear to influence the onset of *** of the commonly used MP techniques deliver oxygen to the graft cells,and therefore may minimize the cholangiocyte injury and subsequently reduce the incidence of *** clinical experience and published evidence grows for these modalities,the impact they have on ITBL rates is important to *** this review,the evidence for the three commonly used MP strategies(abdominal normothermic regional perfusion[A-NRP],hypothermic oxygenated perfusion[HOPE],and normothermic machine perfusion[NMP])for ITBL prevention has been critically *** with ITBL definitions used in trials,coupled with variations in techniques of MP,make interpretation ***,the evidence suggests that both HOPE and A-NRP prevent ITBL in donated after circulatory death grafts compared to cold *** evidence for ITBL prevention in donor after brain death grafts with any MP technique is weak.

关键词： Liver transplant Ischemic type biliary lesions Hypothermic oxygenated machine perfusion Normothermic machine perfusion Abdominal normothermic regional perfusion Donation after circulatory death

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Selective uptake of major and trace elements in Erica andevalensis,an endemic species to extreme habitats in the Iberian Pyrite Belt

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Journal of Environmental Sciences 2011年第3期23卷 444-452页

作者： Fabrizio Monaci Eduardo O.Leidi Maria dolores Mingorance Benito Valdés Sabina Rossini Oliva Roberto Bargagli Department of Environmental Sciences"G.Sarfatti" University of Siena Via P.A.Mattioli4Siena 53100Italy Department of Plant Biotechnology IRNAS-CSICAvda.Reina Mercedes10Sevilla 41012Spain Andalusian Institute of Earth Science CSIC-UGRProf.Albareda1Granada 18008Spain Deparment of Plant Biology and Ecology University of SevilleAvda.Reina Mercedes s/nApartado de Correo 1095Sevilla 41080Spain

To assess the ecophysiological traits and the phytoremediation potential of the endemic heather Erica andevalensis, we determined the concentrations of major and trace elements in different plant parts and in rizosphere soils from Riotinto mining district （Huelva, Spain）. The results showed that E. andevalensis may grow on substrates with very high As, Cu, Fe and Pb concentrations （up to 4114, 1050, 71900 and 15614μg/g dry weight, respectively）, very low availability of macro- and micronutrients and with pH values ranging from 3.3 to 4.9. In these harsh edaphic conditions E. andevalensis selectively absorbed and translocated essential nutrients and excludes potentially phytotoxic elements, which were accumulated in the root epidermis. The concentrations of major and trace elements in E. andevalensis aerial parts from the Riotinto mining district were in the normal range for plants; likewise other Erica species it accumulated Mn and only in a very polluted site we measured leaf concentrations of As and Pb within the excessive or toxic limits for plants. Differently from previous studies, which emphasized the soil pH and bioavailability of phytotoxic elements as the main stress factors, this study showed that in the Riotinto region, E. andevalensis can tolerate wide range of pH and toxic element concentrations; the harshest environments colonized by monospecific patches of this species were characterized above all by very low availability of nutrients. The extraordinary capability to adapt to these extreme habitats made E. andevalensis a priority species to promote the phytostabilization and the development of a self-sustaining vegetative cover on Riotinto mine tailings.

关键词： mine tailing Riotinto tolerant plants Erica andevalensis rhizosphere soils

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Men with a complete absence of normal sperm morphology exhibit high rates of success without assisted reproduction

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Asian Journal of Andrology 2017年第1期19卷 39-42页

作者： Jason R Kovac Ryan P Smith Miguel Cajipe dolores J Lamb Larry I Lipshultz Center of Reproductive Medicine and the Department of Molecular and Cellular Biology Scott Department of Urology Baylor College of Medicine Houston TX USA Department of Urology University of Virginia Charlottesville VA USA.

In couples with infertility, abnormal strict morphology of 0% normal forms （NF） is a criterion to proceed rapidly to in vitro fertilization （IVF）. Since no data currently exist, we investigated the outcomes for men with 0% NF to determine reproductive success without the use of assisted reproductive technologies （ART）. A cohort of 24 men with 0% NF were identified （2010-2013） with 27 randomly selected men with 〉4% NF as controls. Patient charts were reviewed with men contacted and administered an Institutional Review Board （IRB）-approved telephone questionnaire to ascertain outcomes. After a median follow-up time of 2.5 years, 29.2% of men with 0% NF did not require ART for their first pregnancy （controls = 55.6%, P〈 0.05）. When all pregnancies were analyzed together, men with 0% NF achieved twenty pregnancies of which 75% did not require IVF （controls - thirty pregnancies; 76.7% did not require IVF）. The average age of men and female partners was similar between men with 0% NF and 〉4% NF. All men had normal follicle-stimulating hormone （FSH）, testosterone, prolactin, sex hormone-binding globulin （SHBG）, and estradiol. Although, global semen parameters were worse in men with 0% NF, when a first pregnancy was a natural conception （NC）, 100% of men with 0% NF （n = 7/7） and 37.5% of controls in = 3/8） went on to have a subsequent pregnancy via NC. Men with 0% NF conceived without IVF in 29.2% of cases compared to 55.6% of controls. Strict morphology should not be used to predict fertilization, pregnancy, or live birth potential. In men with 0% NF, alternative modalities should be considered before immediate IVF.

关键词： conception infertility intrauterine insemination in vitro fertilization strict morphology success

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Trading in your spindles for blebs： the amoeboid tumor cell phenotype in prostate cancer

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Asian Journal of Andrology 2014年第4期16卷 530-535页

作者： Samantha Morley Martin H Hager Sara G Poilan Beatrice Knudsen dolores Di Vizio Michael R Freeman Division of Cancer Biology and Therapeutics Departments of Surgery Medicine and Biomedical Sciences and The Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles CA Urological Diseases Research Center Boston Children's Hospital Boston MA Department of Surgery Harvard Medical School Boston MA Department of Medicine David Geffen School of Medicine University of California Los Angeles CA USA.

Prostate cancer （PCa） remains a principal cause ofmortalityin developed *** no clinical interventions overcome resistance to androgen ablation therapy, management of castration resistance and metastatic disease remains largely untreatable. Metastasis is a multistep process in which tumor cells lose cell-cell contacts, egress from the primary tumor, intravasate, survive shear stress within the vasculature and extravasate into tissues to colonize ectopic sites. Tumor ceils reestablish migratory behaviors employed during nonneoplastic processes such as embryonic development, leukocyte trafficking and wound healing. While mesenchymal motility is an established paradigm of dissemination, an alternate, ＇amoeboid＇ phenotype is increasingly appreciated as relevant to human cancer.

关键词： SIGNALING COOPERATE RHO GTPASES INVASION MOTILITY MIGRATION TRANSITION PLASTICITY ROCK METASTASIS ACTIVATION

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