<正>Background:The cellular functions of DNA repair and programmed cell death are believed to play an important role in controlling the fate of tumor cells in response to chemotherapy or *** has been speculated that...
<正>Background:The cellular functions of DNA repair and programmed cell death are believed to play an important role in controlling the fate of tumor cells in response to chemotherapy or *** has been speculated that single nucleotide polymorphisms (SNPs) in related genes may alter their expression or activity,affect the functions of DNA repair and/or apoptosis,and in turn influence the effects of cancer treatment and *** assess this possibility,we genotyped four single nucleotide polymorphisms (SNPs) in ATM (A60G),ERCCl (Asn118Asn),APEl (Asn148Glu),XRCCl(Arg194Trp),XRCCl (Arg399Gln) and iASPP (A67T),and examined their associations with treatment response and overall survival among patients with advanced non-small cell lung cancer (NSCLC). Methods:Included in the study were 230 patients diagnosed with inoperable advanced *** these patients,76 received platinum-based chemotherapy,125 received chemotherapy plus radiation,and 29 received radiotherapy *** SNPs were genotyped using the TaqMan methods. Associations between clinical variables,treatment response and genotype were analyzed using the Chi-square *** unconditional logistic regression model was used to analyze the association between genotype and treatment response while adjusting for *** analysis was performed for overall survival using Kaplan-meier survival curves and Cox proportional hazards regression. Results:No significant correlation between genotype and overall survival was found,but ERCCl (Asn118Asn) and iASPP (A67T) genotype was significantly associated with treatment response separately among the patients who received chemotherapy only and the patients who were treated with both chemotherapy and *** with either one or two T alleles (T/T+C/T) at Asn118Asn of ERCCl were more likely not to respond to platinum-based chemotherapy compared to those without the T allele (OR=4.10,95% CI:1.31-12.85).Patients carrying an A allele (A/T+A/A) at A67T o
AIM: To evaluate the treatment effect of percutaneous ethanol injection (PEI) for patients with advanced, non-resectable HCC compared with combination of transarterial chemoembolisation (TACE) and repeated single...
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AIM: To evaluate the treatment effect of percutaneous ethanol injection (PEI) for patients with advanced, non-resectable HCC compared with combination of transarterial chemoembolisation (TACE) and repeated single-session PEI, repeated single-session PEI alone, repeated TACE alone, or best supportive care. METHODS: All patients who received PEI treatment during the study period were included and stratified to one of the following treatment modalities according to physical status and tumor extent: combination of TACE and repeated single-session PEI, repeated single-session PEI alone, repeated TACE alone, or best supportive care. Prognostic value of clinical parameters including Okuda-classification, presence of portal vein thrombosis, presence of ascites, number of tumors, maximum tumor diameter, and serum cholinesterase (CHE), as well as Child-Pugh stage, α-fetoprotein (AFP), fever, incidence of complications were assessed and compared between the groups. Survival was determined using Kaplan-meier and multivariate regression analyses.
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