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Harnessing and honing mesenchymal stem/stromal cells for the amelioration of graft-versus-host disease

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World Journal of Stem Cells 2023年第4期15卷 221-234页

作者： Tang-her Jaing Tsung-Yen Chang Chia-Chi Chiu Division of Hematology OncologyDepartment of PediatricsChang Gung Children’s HospitalChang Gung UniversityTaoyuan 333TaiwanChina Department of Pediatrics Chang Gung University College of MedicineTaoyuan 333TaiwanChina Department of Nursing Chang Gung Memorial HospitalTaoyuan 333TaiwanChina

Allogeneic hematopoietic stem cell transplantation is a deterministic curative procedure for various hematologic disorders and congenital *** its increased use,the mortality rate for patients undergoing this procedure remains high,mainly due to the perceived risk of exacerbating graft-versushost disease(GVHD).However,even with immunosuppressive agents,some patients still develop *** mesenchymal stem/stromal cell(MSC)strategies have been proposed to achieve better therapeutic outcomes,given their immunosuppressive ***,the efficacy and trial designs have varied among the studies,and some research findings appear contradictory due to the challenges in characterizing the in vivo effects of *** review aims to provide real insights into this clinical entity,emphasizing diagnostic,and therapeutic considerations and generating pathophysiology hypotheses to identify research *** indications and timing for the clinical application of MSCs are still subject to debate.

关键词： Mesenchymal stem/stromal cells Graft-versus-host disease Immunomodulatory Adaptive immunity Exosomes

A Multimodel Transfer-Learning-Based Car Price Prediction Model with an Automatic Fuzzy Logic Parameter Optimizer

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Computer Systems Science & Engineering 2023年第8期46卷 1577-1596页

作者： Ping-Huan Kuo Sing-Yan Chen her-Terng Yau Department of Mechanical Engineering National Chung Cheng UniversityChiayi62102TaiwanChina Advanced Institute of Manufacturing with High-Tech Innovations(AIM-HI) National Chung Cheng UniversityChiayi62102TaiwanChina

Cars are regarded as an indispensable means of transportation in *** studies have indicated that the automotive industry has witnessed remarkable advances and that the market of used cars has rapidly *** this study,a price prediction system for used BMW cars was *** parameters of used cars,including their model,registration year,and transmission style,were *** data obtained were then divided into three *** first subset was used to compare the results of each *** predicted values produced by the two algorithms with the most satisfactory results were used as the input of a fully connected neural *** second subset was used with an optimization algorithm to modify the number of hidden layers in a fully connected neural network and modify the low,medium,and high parameters of the membership function(MF)to achieve model ***,the third subset was used for the validation set during the prediction *** three subsets were divided using k-fold cross-validation to avoid overfitting and selection *** conclusion,in this study,a model combining two optimal algorithms(i.e.,random forest and k-nearest neighbors)with several optimization algorithms(i.e.,gray wolf optimizer,multilayer perceptron,and MF)was successfully *** prediction results obtained indicated a mean square error of 0.0978,a root-mean-square error of 0.3128,a mean absolute error of 0.1903,and a coefficient of determination of 0.9249.

关键词： Used car price prediction transfer learning fuzzy logic machine learning optimization algorithm

Effects of Plant Residue Decomposition on Soil N Availability,Microbial Biomass and β-Glucosidase Activity During Soil Fertility Improvement in Ghana

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Pedosphere 2019年第5期29卷 608-618页

作者： Samuel T. PARTEY Robert B. Z0UGM0RE Naresh V. THEVATHASAN Richard F. PREZIOSI CGI AR CCAFS West Africa ProgramInternational Crops Research Institute for the Semi-Arid Tropics (ICRISAT)Bamako B.P. Box 320 (Mali) School of Environmental Sciences University of GuelphGuelph NIG 2W1 (Canada) Faculty of Life Sciences The University of ManchesterManchester M13 9PL (UK)

With limited use of inorganic fertilizers on smallholder farms,plant residues could be viable alternatives for soil fertility *** study was conducted to determine how residue quality and decomposition of nine plant species influence soil N availability,microbial biomass,andβ-glucosidase activity during soil fertility *** differences in N concentration were found among the species,ranging from 12.2 g kg-1 in Zea mays to 39.2 g kg-1 in Baphia *** C/N ratio was the highest in ***(34.4),whereas lignin and polyphenol concentrations were the greatest in Acacia *** highest decomposition rate(0.251%per day)occurred in Tithonia diversifolia,and the lowest in ***,Albizia zygia,***,and ***,with the half-lives of 28-56 *** 80%and 89%of N,P,K,Ca,and Mg were released from *** in 7 d,compared with over 70%retention in ***,***,and *** decomposition and nutrient release half-lives of Gliricidia sepium,Leucaena leucocephala,Azadirachta indica,and Senna spectabilis were less than 14 *** mineral N,microbial biomass,andβ-glucosidase activity increased under all treatments,with *** having the greatest *** N mineralization occurred in all of the species throughout the experiment,an initial N immobilization was recorded in the ***,***,***,and *** treatments for up to 14 *** and nutrient release rates,mineral N,soil microbial biomass,andβ-glucosidase activity were dependent on residue quality,and P and lignin levels,the lignin/N ratio,and the(lignin+polyphenol)/N ratio had the most significant effects(P≤0.05).

关键词： leguminous species litter quality microbial activity N mineralization nutrient release organic matter

BASIC FORMULATION OF STATIC AND DYNAMIC BEHAVIOURS OF SOIL AND OTher POROUS MEDIA

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Applied Mathematics and Mechanics(English Edition) 1982年第4期3卷 457-468页

作者： 0.C.Zienkiewicz University of Wales. Swansea. U. K. Department of Civil Engineering

This paper treats the soil and rock or concrete as a two-phasemedium composed of a solid skeleton and an interstitial ***-der the unsaturated condition of interstitial fluid,the thirdphase is taken into consideration. In this paper. we consider theconstitutive relation,dynamic and kinematic relations,and also va-rious approximations with their limits of *** thoseof most practical engineering situations such as the consolidationproblem and the undrained behaviour. The finite element discreti-zation and the time dependent solution of various classes of soilproblem are also discussed.

关键词： BASIC FORMULATION OF STATIC AND DYNAMIC BEHAVIOURS OF SOIL AND OTher POROUS MEDIA

Modern Radical Organizations and Their Impact on National and International Security

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Modern Radical Organizations and Their Impact on National an...

作者： B0Z0R0V ABUZHABBOR 山东大学

学位级别：硕士

At the present stage,many have begun to realize that any radical extremist organizations are purposefully working to achieve their political ambitions and goals and have begun to affect the national and regional security of entire regions *** purpose of this work is to study modern radical organizations and their impact on national and regional security and its sources of *** the goal,the following research objectives were identified:Analyze global threats,modern challenges and the problem of modern radical organizations for regional security;investigate the forms of youth involvement in some terrorist organizations;analysis of sources of financing of terrorist and extremist organizations;analyze the impact of religious extremism on the national security of the Central Asian states;analysis of international terrorism as a factor in the destabilization of the situation in Central Asia;explore the specifics of international terrorism,radical religious extremism,and separatism;explore the cooperation of the Central Asian states in countering terrorism,extremism and radical organizations;analyze the main trends in the politicization of Islam in Central Asia;consider forms of manifestation of religious extremism on the security of Central Asia;to investigate the forms of manifestation of internal terrorism in the states of Central Asia;Analyze the prospects of countering religious extremism and international terrorism in the *** object of research is radical organizations,and the subject of research is the activities of these organizations and the activities of specific structures and countries to counter *** novelty of the work consists in the fact that when I studied the existing literature-scientific works,materials of international conferences and publications,I periodically made an attempt to analyze the influence of modern radical organizations on national and regional security alongside with investigation the forms of involving young peop

关键词： Modern radical organizations their impact national security international security

Synthesis and photocurrent response of porphyrin-containing conjugated polymers

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Chinese Science Bulletin 2006年第11期51卷 1287-1295页

作者： ZHAO Jinling LI Binsong B0 Zhishan State Key Laboratory of Polymer Physics and Chemistry Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

Porphyrin-containing conjugated poly- mers with fluorene or carbazole as spacer groups were prepared by Sonogashira cross-coupling reac- tions. The polymers were of high molecular weight and the flexible alkyl chains on fluorene or carbazole units made the conjugated polymers soluble in common organic solvents, such as THF and methyl- ene chloride. The polymers could form high quality durable films from solution casting. Their optical and photocurrent responsive properties were investigated. It was found that the photocurrent response was di- rectly proportional to the content of porphyrin. The incorporation of carbazole units into the polymer chains also gave positive contribution to the photo- current generation in some extent.

关键词：卟啉共轭聚合物光电流响应合成

Co-doping Effect on Microstructures and Ionic Conductivity of Aliovalent Cations Modified Ceria

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材料科学与工程学报 2007年第6期25卷 861-863页

作者： YEH Tsung-her CHOU Chen-chia Advanced Ceramics Laboratory Department of Mechanical EngineeringNational Taiwan University of Science and TechnologyTaipei-10672China

Microstructural features and ionic conductivity of divalent(Mg 2+)and trivalent(Gd 3+)cations co-doped ceria electrolyte system Ce_ 0.8-xGd_ 0.2Mg_xO_ 1.9-x were investigated by scanning electron microscopy(SEM)and AC impedance *** experimental results exhibit that addition of MgO to GDC reduces the average binding energy of GDC by decreasing the energy barrier of oxygen ion migration in ceria matrix and the ionic conductivity of 2 mol% magnesium doped GDC(0.018 S/cm)is higher than that of GDC matrix at 650℃(0.0105 S/cm).Co-doping Mg 2+ and Gd 3+ is found to increase the ionic conductivity of ceria and hence decreases the operation temperature as well as the cost of solid oxide fuel cell(SOFC).

关键词：钴掺杂离子电导性改良铈固体氧化物燃料电池结合能电解质

MOTION ERROR ESTIMATION OF 5-AXIS MACHINING CENTER USING DBB METHOD

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Chinese Journal of Mechanical Engineering 2006年第2期19卷 276-281页

作者： CHEN Huawei ZHANG Dawei TIAN Yanling ICHIR0 Hagiwara School of Mechanical Engineering Tianjin UniversityTianjin 300072 China Graduate School of Science and Engineering Tokyo Institute of TechnologyTokyo JAPAN

In order to estimate the motion errors of 5-axis machine center, the double ball bar （DBB） method is adopted to realize the diagnosis procedure. The motion error sources of rotary axes in 5-axis machining center comprise of the alignment error of rotary axes and the angular error due to various factors, e.g. the inclination of rotary axes. From sensitive viewpoints, each motion error is possible to have a particular sensitive direction in which deviation of DBB error trace arises from only some specific error sources. The model of the DBB error trace is established according to the spatial geometry theory. Accordingly, the sensitive direction of each motion error source is made clear through numerical simulation, which is used as the reference patterns for rotational error estimation. The estimation method is proposed to easily estimate the motion error sources of rotary axes in quantitative manner. To verify the proposed DBB method for rotational error estimation, the experimental tests are carried out on a 5-axis machining center M-400 （MORISEIKI）. The effect of the mismatch of the DBB is also studied to guarantee the estimation accuracy. From the experimental data, it is noted that the proposed estimation method for 5-axis machining center is feasible and effective.

关键词： 5-axis NC machine tool Double ball bar(DBB) Motion errors of rotary axes

SMALLEST g-SUPERSOLUTION WITH CONSTRAINT

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Applied Mathematics(A Journal of Chinese Universities) 2000年第3期15卷 289-296页

作者： Lin QingquanSchool of Mathematics and System Science,Shandong Univ.,Jinan 2 50 1 0 0 School of Mathematics and System Science Shandong Univ. Jinan

In this paper the existence and uniqueness of the smallest g-supersolution for BSDE is discussed in the case without Lipschitz condition imposing on both constraint function and drift coefficient in the different method from the one with Lipschitz *** by considering (ξ,g) as a parameter of BSDE,and ( ξ α,g α) as a class of parameters for BSDE,where α belongs to a set A,for every α ∈A there exists a pair of solution { Y α,Z α } for the BSDE,the properties of sup α ∈A{ Y α } which is also a solution for some BSDE is *** result may be used to discuss optimal problems with recursive utility.

关键词： Backward stochastic differential equation comparison theorem constraint Lipschitz condition.