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Efficacy of estradiol on preventing chronic kidney allograft rejection

Chinese Medical Journal 1999年第9期 18-18页

作者： heque zou and uwe heemann

hronic rejection is the main factor to result in the loss of renal allograft In order to look for a potential therapy chronic rejection, we investigated the efficacy of estradiol on preventing renal chronic rejection The kidneys of female F344 rats were orthotopically transplanted into ovatiectomized female Lewis rats and treated for 16 weeks with either estradiol or vehicle Compared with controls treated with vehicle, estradiol treatment reduced urinary protein excretion, glomerular sclerosis, interstitial infiltration and fibrosis, vascular lesions, in parallel to a reduced ICAM 1 and TGF β mRNA expression Our results suggested that estrodiol could significantly decrease the progression of chronic rejection, at least in female recipients, and the reduced adhesion molecule and TGF β gene expression may be involved in the mechanism for estradiol to prevent chronic rejection

关键词： Efficacy of estradiol on preventing chronic kidney allograft rejection

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Influence of Progesterone on Chronic Renal Allograft Dysfunction in Rat Model

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器官移植内科学杂志 2009年第3期4卷 134-138页

作者： Hequn zou Shanying Liu Yousheng Yao Erwei Song Jens Lutz uwe heemann Institute of Nephrology and Rheumatology The Third Affiliated Hospital of China Southern MedicalUniversity Guangzhou 510630 China Department of Nephrology University Hospital Essen Germany

Background It is indicated in our recent investigation that oestrogens ameliorate the progression of chronic renal allograft dysfunction. In our present study, we investigated the influence of progesterone on chronic renal allograft dysfunction. Methods The kidneys of female Fisher (F344) rats were orthotopically transplanted into ovariectomized female Lewis recipients. The recipients were divided into two groups and treated with progesterone or vehicle. Animals were harvested 24 weeks after trans- plantation for histological, immunohistological studies and molecular analysis. Results The administration of progesterone resulted in increased urinary protein excretion, profound glomerulosclerosis and mononuclear cell infiltration. Renal allograft damage paralleled intragraft mRNA expression of transforming growth factor-β1 in the two groups. Conclusions It is suggested by our results that progesterone worsened long-term renal allograft outcome.

关键词：细移植转化生长孕酮黄体酮

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