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Nano Research 2020年第4期13卷 1035-1043页

作者： Qiuqin Huang heqi gao Shuming Yang Dan Ding Zhenghuan Lin Qidan Ling Fujian Key Laboratory of Polymer Materials College of Chemistry and Materials ScienceFujian Normal UniversityFuzhou 350007China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of Educationand College of Life SciencesNankai UniversityTianjin 300071China Fujian provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering Fuzhou 350007China

Special attention has been paid to the organic afterglow materials(OAM)for their fascinating ***,poor stability at air and complicated structure design hinder the development of ***,sol-gel,a facile and simple technique,is employed to synthesize a series of organic/inorganic hybrid nanocomposites(N1/SiO2,N2/SiO2,and N3/SiO2)by covalently linking three common aryl imides with crosslinked silica *** nanomaterials show excitation wavelength-dependent and colorful(yellow,red and green)afterglow of organic imides with long lifetime up to 1.1 s at ***,the ultralong phosphorescence is ultrastable under various conditions:water,high temperature,UV irradiation and in vivo,due to the protection of inorganic *** particularly,heating to 500℃does not quench the afterglow of organic luminophore in nanocomposites,but forms new ultralong phosphorescence originated from space-conjugation of silica and *** afterglow nanomaterials display huge advantages in the applications of advanced anti-counterfeiting and bioimaging.

关键词： phosphorescence afterglow sol-gel nanocomposite bioimaging

Endoplasmic reticulum targeted AIE bioprobe as a highly efficient inducer of immunogenic cell death

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Science China Chemistry 2020年第10期63卷 1428-1434页

作者： Jun Li heqi gao Ruihua Liu Chao Chen Sheng Zeng Qian Liu Dan Ding Key Laboratory of Bioactive Materials Ministry of Education College of Life Sciencesand State Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjin 300071China Department of Urology Tianjin First Central HospitalTianjin 300192China

Focused oxidative stress of the specific organelles(e.g.,endoplasmic reticulum(ER)and mitochondrion)of cancer cells can boost the immunogenic cell death(ICD)effect for cancer ***,an ER-targeted bioprobe with aggregationinduced emission(AIE)characteristics(TPE-PR-FFKDEL)was rationally designed and synthesized by integrating a new AIE photosensitizer with ER targeting peptide,which has been demonstrated to be able to efficiently induce ER oxidative stress to evoke *** with the photosensitizer hypericin that is well-known as an ER-targeted ICD inducer,TPE-PR-FFKDEL can lead to more robust emission of immunostimulatory damage-associated molecular patterns such as surface-exposed calreticulin,ATP secretion,and high-mobility group protein B1(HMGB1)and heat shock protein 70(HSP 70)***,a range of immune responses are activated to protect mice from the attack of cancer cells in vivo.

关键词： immunogenic cell death endoplasmic reticulum oxidative stress aggregation-induced emission reactive oxygen species

β-galactosidase responsive AIE fluorogene for identification and removal of senescent cancer cells

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Science China Chemistry 2020年第3期63卷 398-403页

作者： Zhengfeng gao heqi gao Debin Zheng Tengyan Xu Yaoxia Chen Chunhui Liang Ling Wang Dan Ding Zhimou Yang State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy Nankai UniversityTianjin 300071China Key Laboratory of Bioactive Materials Ministry of EducationCollege of Life Sciencesand Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)Nankai UniversityTianjin 300060China

The selective identification and removal of senescent cells including senescent cancer cells are very important to prolong life and improve the treatment efficacy of cancer *** this study,we integrated the high selectivity of enzyme-instructed selfassembly(EISA)and efficient reactive oxygen species(ROS)generating property of a novel luminogen with aggregationinduced emission(AIE)character to selectively identify and remove senescent He La(s-He La)*** s-He La cells expressed high levels ofβ-galactosidase(β-Gal),which led to the selective accumulation and formation of nanomaterials of Comp.1 in the *** white light irradiation,the nanomaterials efficiently produced ROS and therefore killed s-He La *** study demonstrated a promising strategy to selectively remove senescent cells and improve the treatment efficacy of cancer therapy.

关键词： senescence cancer fluorescence self-assembly aggregation induced emission

Sonosensitized Aggregation-Induced Emission Dots with Capacities of Immunogenic Cell Death Induction and Multivalent Blocking of Programmed Cell Death-Ligand 1 for Amplified Antitumor Immunotherapy

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CCS Chemistry 2022年第2期4卷 501-514页

作者： Shaorui Jia Zhiyuan gao Zelin Wu heqi gao He Wang Hanlin Ou Dan Ding Key Laboratory of Bioactive Materials Ministry of Education College of Life SciencesState Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjin 300071 Department of Urology First Affiliated Hospital of Soochow UniversitySuzhou 215006

The combination of immunogenic cell death(ICD)induction and immune checkpoint blockade has emerged as a major direction of cancer *** currently available ICD inducers,sonosensitizers that produce reactive oxygen species(ROS)under an external trigger to evoke ICD of tumor cells have shown great ***,a highly efficient sonosensitizer-based ICD inducer with an aggregationinduced emission(AIE)characteristic has yet to be ***,a novel AIE sonosensitizer with a twisted molecular structure,very small energy gap between the singlet and triplet excited states(ΔE_(ST)),and efficient ROS generation ability,which can serve as an effective ICD inducer,is reported for sonodynamic processes in cancer ***,an AIE sonosensitizer-based nanosystem with surface modification of anti-PD-L1 peptide is constructed for boosting antitumor *** this system,AIE sonosensitizer-mediated sonodynamic therapy can successfully convert a hypoimmunogenic cold tumor to a hot one and further facilitate the multivalent blocking of programed death ligand(PD-L1)by anti-PD-L1 *** an advanced nanosystem could effectively initiate the activation of antitumoral immune reactions and modulation of an immunosuppressive microenvironment,contributing to systemic antitumor effects to further inhibit the growth of distant tumors.

关键词： aggregation-induced emission sonodynamic therapy immunogenic cell death PD-L1 antitumor immunotherapy

Organic/polymer photothermal nanoagents for photoacoustic imaging and photothermal therapy in vivo

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Science China Materials 2019年第11期62卷 1740-1758页

作者： Hanlin Ou Jun Li Chao Chen heqi gao Xue Xue Dan Ding Key Laboratory of Bioactive Materials Ministry of Educationand College of Life SciencesNankai UniversityTianjin 300071China State Key Laboratory of Medicinal Chemical Biology and College of PharmacyNankai UniversityTianjin 300353China Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy Cancer InstituteXuzhou Medical UniversityXuzhou 221002China

In recent years,organic/polymer photothermal nanoagents including semiconducting polymer nanoparticles and small-molecule organic photothermal agents-encapsulated nanoparticles have attracted large attention from researchers in the biomedical field,owing to their excellent optical properties,good biocompatibility,easy processability,and flexible surface functionalization,as well as their combined functions of photoacoustic(PA)imaging and photothermal therapy(PTT).In this review,we summarize the recent advances in organic/polymer photothermal nanoagents for in vivo PA imaging and PTT *** particular,we focus on the design strategies,which are composed of traditional approaches and emerging mechanisms,especially based on'intramolecular motion-induced photothermy'strategy to regulate the photophysical properties of organic/polymer photothermal nanoagents for boosted in vivo PA imaging and PTT.

关键词： photothermal agent photoacoustic imaging photothermal therapy semiconducting polymer nanoparticle

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城市供水管网水质问题

净水技术 2005年第3期24卷 59-61页

作者：高和气国家水质监测网合肥监测站安微合肥230011

根据多年来的调查和实验结果对合肥及国内其它城市供水管网水质问题产生的原因进行了总结、分析,其中造成危害较大的管网水质问题是由于用户内部二次供水及管材、配件质量问题造成的,文中同时浅析了改善管网水质的措施。

关键词：城市供水管网水质问题二次供水管网水质质量问题

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舰艇编队救护所医疗队集训课程体系评价

解放军医院管理杂志 2020年第12期27卷 1178-1182页

作者：高贺奇秦超江雷海军军医大学卫生勤务学系卫生勤务学教研室上海200433 南部战区海军第二医院三亚572000

目的探索适合舰艇编队救护所的集训课程体系,为开展医疗队集训、提升队员救治能力和医疗队整体保障效能提供支撑。方法以医疗队岗位任职需要为牵引,构建集训课程体系;对教学内容的满意度、重要性以及组织形式进行评价。结果课程体系所... 详细信息

目的探索适合舰艇编队救护所的集训课程体系,为开展医疗队集训、提升队员救治能力和医疗队整体保障效能提供支撑。方法以医疗队岗位任职需要为牵引,构建集训课程体系;对教学内容的满意度、重要性以及组织形式进行评价。结果课程体系所设置的课程教学效果较好,教学内容的重要性得到普遍认同,但部分课程仍需进行优化调整。结论课程体系基本满足医疗队队员的岗位任职需要,后续可根据此次评价和探索的结果对课程体系进行调整完善。

关键词：舰艇编队救护所集训课程体系评价

后脱贫攻坚中贵州省林下经济发展SWOT分析

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广东蚕业 2022年第5期56卷 139-141页

作者：高鹤淇黄海燕罗钰清贵州财经大学管理科学与工程学院贵州贵阳550025 贵州财经大学经济学院贵州贵阳550025

贵州省发展林下经济,对促进脱贫农户稳定就业与增收,守住不发生规模性返贫底线,实现巩固拓展脱贫攻坚成果同乡村振兴有效衔接,纵深推进农村产业革命和生态文明建设意义重大。文章基于SWOT方法分析贵州省林下经济发展的优势、劣势、机遇... 详细信息

贵州省发展林下经济,对促进脱贫农户稳定就业与增收,守住不发生规模性返贫底线,实现巩固拓展脱贫攻坚成果同乡村振兴有效衔接,纵深推进农村产业革命和生态文明建设意义重大。文章基于SWOT方法分析贵州省林下经济发展的优势、劣势、机遇和挑战,立足林下经济发展的战略选择,就如何加快推进贵州省林下经济高质量发展进行了探讨。

关键词：贵州林下经济 SWOT分析战略选择后脱贫攻坚时代

从产业扶贫到产业兴旺的特色产业发展策略研究--以纳雍县“玛瑙红”樱桃产业为例

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热带农业科技 2022年第3期45卷 43-48页

作者：罗钰清鲁静芳周丕东高鹤淇贵州财经大学贵阳550025

产业扶贫培育的特色产业在脱贫攻坚期间发挥了关键作用,其提质增效对当下乡村振兴阶段促进产业兴旺也至关重要。本文以纳雍县“玛瑙红”樱桃产业为例,运用SWOT分析,得出其产业内部优势和劣势,以及产业外部面临的机遇和威胁,并结合专家... 详细信息

产业扶贫培育的特色产业在脱贫攻坚期间发挥了关键作用,其提质增效对当下乡村振兴阶段促进产业兴旺也至关重要。本文以纳雍县“玛瑙红”樱桃产业为例,运用SWOT分析,得出其产业内部优势和劣势,以及产业外部面临的机遇和威胁,并结合专家打分法进行战略选择,指出产业要充分利用现有优势和机遇,克服产业劣势和外部威胁,实现提质增效。并提出在乡村振兴背景下,特色扶贫产业要推进基础设施建设、强化多元主体参与、完善经营体系、推进产业融合发展的建议。

关键词：樱桃 SWOT分析专家打分法发展策略

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原位生成纳米MnO_(2)胶体对Mn^(2+)的吸附机理实验研究

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环境科学与技术 2024年第4期47卷 16-25页

作者：张欣宇唐玉朝王坤黄显怀尹翠琴高和气伍昌年黄健李卫华安徽建筑大学环境污染控制与废弃物资源化利用安徽省重点实验室安徽合肥230601 合肥供水集团有限公司安徽合肥230011

该文用Mn^(2+)离子与KMnO4溶液反应,得到原位生成纳米MnO_(2)胶体,用该胶体颗粒对水中Mn^(2+)离子进行吸附。对原位生成MnO_(2)胶体采用光学显微镜、能谱分析、傅立叶变换红外光谱、粒度和Zeta电位分析仪进行表征,探究了原位生成MnO_(2... 详细信息

该文用Mn^(2+)离子与KMnO4溶液反应,得到原位生成纳米MnO_(2)胶体,用该胶体颗粒对水中Mn^(2+)离子进行吸附。对原位生成MnO_(2)胶体采用光学显微镜、能谱分析、傅立叶变换红外光谱、粒度和Zeta电位分析仪进行表征,探究了原位生成MnO_(2)胶体对Mn^(2+)离子吸附机理,考察了原位生成MnO_(2)胶体浓度、吸附温度、吸附时间以及pH对原位生成的MnO_(2)胶体对Mn^(2+)离子吸附容量的影响。结果表明,原位生成MnO_(2)胶体对Mn^(2+)离子的吸附符合Freundlich吸附模型(R^(2)>0.97),说明发生了多层次吸附,最佳吸附时间为30 min,符合伪二级动力学方程(R^(2)>0.98);低浓度原位生成的MnO_(2)胶体吸附容量相较于高浓度更大,1 mg/L原位生成的MnO_(2)胶体在25℃下吸附容量能达到2 022.19 mg/g;低温有利于原位生成的MnO_(2)胶体对Mn^(2+)离子的物理吸附,高温有利于其表面羟基与Mn^(2+)离子络合;pH=8.03时原位生成的Mn O_(2)胶体对Mn^(2+)离子的吸附容量约为p H=4.56时的4倍且表面Mn-OH和羟基增多,45 mg/L的MnO_(2)胶体吸附容量达到1 647.13 mg/g;pH=4.56和pH=8.03条件下原位生成的MnO_(2)胶体吸附Mn^(2+)离子后Zeta电势值分别为-12.6、-1.10 m V,原位生成纳米MnO_(2)胶体对水中Mn^(2+)离子的吸附实际上是物理吸附、静电吸引、表面配位的共同作用。

关键词：原位生成纳米MnO_(2) 吸附除锰影响因素吸附机制