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Risk factors and therapeutic results of early local recurrence after transcatheter arterial chemoembolization

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World Journal of Gastroenterology 2014年第22期20卷 6995-7004页

作者： Woo Sun Rou Byung Seok lee Hee Seok Moon Eaum Seok lee Seok Hyun Kim heon young lee Division of Gastroenterology Department of Internal MedicineChungnam National University College of MedicineDaejeon 301-721South Korea Division of Gastroenterology Department of Internal MedicineChungnam National University College of MedicineDaejeon 301-721South Kore

AIM: To identify factors affecting early local recurrence after transcatheter arterial chemoembolization (TACE) and investigate treatments and outcomes for local recurrence.

关键词： Chemoembolization Hepatocellular carcinoma Recurrence Survival Lipiodol

Is there correlation between pancreatic enzyme and radiological severity in acute pancreatitis?

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World Journal of Gastroenterology 2008年第15期14卷 2401-2405页

作者： Yeon Soo Kim Byung Seok lee Seok Hyun Kim Jae Kyu Seong Hyun Yong Jeong heon young lee Departments of Internal Medicine Daejeon St. Mary's Hospital Medical College of the Catholic University of Korea Korea Department of Internal Medicine Chungnam National University Hospital Daejeon 301721 Korea

AIM: To investigate the correlation between the changes of pancreatic enzyme, the biochemical markers and the clinical results according to the Balthazar computer tomography (CT) grade. METHODS: Between July 2004 and July 2005, we reviewed the charts of 119 patients who were admitted to our hospital with acute pancreatitis. RESULTS: Eighty-three patients (69.7%) were male, and the mean age of the patients was 57 ± 15.7 years. The biliary pancreatitis patients had an older mean age. Forty-nine patients (41.1%) had biliary pancreatitis and forty-six (38.6%) had alcoholic pancreatitis. Group 3 patients had a longer duration of pain (2.51 ± 1.16 vs 3.17 ± 1.30 vs 6.56 ± 6.13, P < 0.001), a longer period of fasting (7.49 ± 4.65 vs 10.65 ± 5.54 vs 21.88 ± 13.81, P < 0.001) and a longer hospital stay (9.17 ± 5.34 vs 14.63 ± 8.65 vs 24.47 ± 15.52, P < 0.001) than the other groups. On the univariate analysis, the factors that affected the radiological grade were the leukocyte count at admission (P = 0.048), the hemoglobin (P = 0.016) and total bilirubin concentrations (P = 0.023), serum lipase (P = 0.009), the APACH Ⅱ scores at admission (P = 0.017), the APACH Ⅱ scores after 24 h (P = 0.031), the C-reactive protein (CRP) titer (P = 0.0001) and the follow up CRP titer (P = 0.003). But the CRP level (P = 0.001) and follow up CRP titer (P = 0.004) were only correlated with the radiological grade on multivariate analysis. According to the ROC curve, when we set the CRP cut off value at 83 mg/L, the likelihoodratio for a positive test was 3.84 and the likelihood ratio for a negative test was 0.26 in group 3. CONCLUSION: In conclusion, our study suggests that the CRP with the radiological severity may be used to estimate the severity of acute pancreatitis.

关键词： Acute pancreatitis Computed tomography C-reactive protein

Spectrum of final pathological diagnosis of gastric adenoma after endoscopic resection

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World Journal of Gastroenterology 2011年第47期17卷 5177-5183页

作者： Kwan Woo Nam Kyu Sang Song heon young lee Byung Seok lee Jae Kyu Seong Seok Hyun Kim Hee Seok Moon Eaum Seok lee Hyun Yong Jeong Gastroenterology Center Sun Hospital Pathologic Department Chung-Nam National University Hospital Gastroenterology Unit of Internal Medicine Department Chung-Nam National University Hospital

AIM: To investigate how many discrepancies occur in patients before and after endoscopic treatment of referred adenoma and the reason for these results. METHODS: We retrospectively reviewed data from 554 cases of 534 patients who were referred from primary care centres for adenoma treatment and treated for endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD) at Chungnam National University Hospital, from July 2006 to June 2009. Reendoscopy was examined in 142 cases and biopsywas performed in 108 cases prior to treatment. Three endoscopists (1, 2 and 3) performed all EMRs or ESDs and three pathologists (1, 2 and 3) diagnosed most of the cases. Transfer notes, medical records and endoscopic pictures of these cases were retrospectively reviewed and analyzed. RESULTS: Adenocarcinoma was 72 (13.0%) cases in total 554 cases after endoscopic treatment of referred adenoma. When the grade of dysplasia was high (55.0%), biopsy number was more than three (22.7%), size was no smaller than 2.0 cm (23.2%), morphologic type was depressed (35.8%) or yamada type Ⅳ (100%), and color was red (30.9%) or mixed-or-undetermined (25.0%), it had much more malignancy rate than the others (P < 0.05). All 18 cases diagnosed as adenocarcinoma in the re-endoscopic forceps biopsy were performed by endoscopist 1. There were different malignancy rates according to the pathologist (P = 0.027). CONCLUSION: High grade dysplasia is the most important factor for predicting malignancy as a final pathologic diagnosis before treating the referred gastric adenoma. This discrepancy can occur mainly through inappropriately selecting a biopsy site where cancer cells do not exist, but it also depends on the pathologist to some extent.

关键词： Discrepancy Adenoma High grade dyspla-sia Endoscopic mucosal resection Endoscopic submu-cosal dissection

Long-term treatment outcomes of clevudine in antiviral-naive patients with chronic hepatitis B

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World Journal of Gastroenterology 2012年第47期18卷 6943-6950页

作者： Suk Bae Kim Il Han Song young Min Kim Ran Noh Ha Yan Kang Hyang Ie lee Hyeon Yoong Yang An Na Kim Hee Bok Chae Sae Hwan lee Hong Soo Kim Tae Hee lee young Woo Kang Eaum Seok lee Seok Hyun Kim Byung Seok lee heon young lee Department of Internal Medicine Dankook University College of MedicineCheonan 330-715South Korea Department of Internal Medicine Eulji University College of MedicineDaejeon 302-779South Korea Department of Internal Medicine Chungbuk University College of MedicineCheongju 362-711South Korea Department of Internal Medicine Soonchunhyang University College of MedicineCheonan 330-090South Korea Department of Internal Medicine Konyang University College of MedicineDaejeon 371-718South Korea Department of Internal Medicine Chungnam University College of MedicineDaejeon 301-721South Korea

AIM:To evaluate the treatment outcomes of clevudine compared with entecavir in antiviral-naive patients with chronic hepatitis B(CHB).METHODS:We retrospectively analyzed the clinical data of CHB patients treated with clevudine 30 mg/d and compared their clinical outcomes with patients treated with entecavir 0.5 mg/*** biochemical response,as assessed by serum alanine aminotransferase(ALT) activity,virologic response,as assessed by serum hepatitis B virus DNA(HBV DNA) titer,serologic response,as assessed by hepatitis B e antigen(HBeAg) status,and virologic breakthrough with genotypic mutations were ***:Two-hundred and fifty-four patients [clevudine(n = 118) vs entecavir(n = 136)] were *** clevudine-treated patients,the cumulative rates of serum ALT normalization were 83.9% at week 48 and 91.5% at week 96(80.9% and 91.2% in the entecavir group,respectively),the mean titer changes in serum HBV DNA were-6.03 and-6.55 log 10 copies/mL(-6.35 and-6.86 log 10 copies/mL,respectively,in the entecavir group),and the cumulative non-detection rates of serum HBV DNA were 72.6% and 83.1%(74.4% and 83.8%,respectively,in the entecavir group).These results were similar to those of entecavir-treated *** cumulative rates of HBeAg seroconversion were 21.8% at week 48 and 25.0% at week 96 in patients treated with clevudine,which was similar to patients treated with entecavir(22.8% and 27.7%,respectively).The virologic breakthrough in the clevudine group occurred in 9(7.6%) patients at weeks 48 and 15(12.7%) patients at week 96,which primarily corresponded to genotypic mutations of rtM204I and/or *** was no virologic breakthrough in the entecavir ***:In antiviral-naive CHB patients,longterm treatment outcomes of clevudine were not inferior to those of entecavir,except for virologic breakthrough.

关键词： Chronic hepatitis B Hepatitis B virus Clevudine Entecavir Treatment outcomes

Atypical onset of bicalutamide-induced liver injury

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World Journal of Gastroenterology 2016年第15期22卷 4062-4065页

作者： Gee young Yun Seok Hyun Kim Seok Won Kim Jong Seok Joo Ju Seok Kim Eaum Seok lee Byung Seok lee Sun Hyoung Kang Hee Seok Moon Jae Kyu Sung heon young lee Kyung Hee Kim Department of Internal Medicine Chungnam National University School of Medicine Chungnam National University Hospital Departments of Pathology Chungnam National University School of Medicine Chungnam National University Hospital

Anti-androgen therapy is the leading treatment for advanced prostate cancer and is commonly used for neoadjuvant or adjuvant treatment. Bicalutamide is a non-steroidal anti-androgen, used during the initiation of androgen deprivation therapy along with a luteinizing hormone-releasing hormone agonist to reduce the symptoms of tumor-related flares in patients with advanced prostate cancer. As side effects, bicalutamide can cause fatigue, gynecomastia, and decreased libido through competitive androgen receptor blockade. Additionally, although not as common, drug-induced liver injury has also been reported. Herein, we report a case of hepatotoxicity secondary to bicalutamide use. Typically, bicalutamideinduced hepatotoxicity develops after a few days; however, in this case, hepatic injury occurred 5 mo after treatment initiation. Based on this rare case of delayed liver injury, we recommend careful monitoring of liver function throughout bicalutamide treatment for prostate cancer.

关键词： Bicalutamide Drug-induced liver injury Prostate neoplasm

Reactivation of tuberculosis in hepatocellular carcinoma treated with transcatheter arterial chemoembolization: A report of 3 cases

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World Journal of Radiology 2012年第5期4卷 236-240页

作者： Yun Jeung Kim Pyung Gohn Goh Hee Seok Moon Eaum Seok lee Seok Hyun Kim Byung Seok lee heon young lee Division of Hepatology Department of Internal Medicine Chung-Nam National University Hospital 640 Daesa-Dong Jung-Gu Daejeon 301-721 South Korea

Pulmonary tuberculosis is an opportunistic infection that can be reactivated in immunocompromised conditions, for example, in malignancy or after liver transplantation. Hepatocellular carcinoma (HCC) has a high mortality rate because it is frequently diagnosed at an advanced stage. Although surgical resection is the established curative measure for HCC, it is only feasible for earlystage HCC. Transcatheter arterial chemoembolization (TACE) is the most common treatment modality for patients with unresectable HCC. However, repeated TACE sessions and, occasionally, the tumor itself can further impair the reserve hepatic function and immunity. We report 3 recent cases of HCC with reactivation of pulmonary tuberculosis after TACE.

关键词： Hepatocellular carcinoma Reactivation Transcatheter arterial chemoembolization Tuberculosis

Cloning,expression in Escherichia coli,and enzymatic properties of laccase from Aeromonas hydrophila WL-11

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Journal of Environmental Sciences 2010年第4期22卷 635-640页

作者： Jing Wu Kyoung-Sook Kim Jai-heon lee young-Choon lee Department of Biotechnology Dong-A University Busan 604-714 South Korea. Brain Korea 21 Center for Silver-Bio Industrialization Dong-A University Busan 604-714 South Korea

A strain WL-11 with high laccase activity was isolated from activated sludge collected from the effluent treatment plant of a textile and dyeing industry. It was identified as Aeromonas hydrophila by physiological test and 16S rDNA sequence analysis. A gene encoding of laccase from a newly isolated Aeromonas hydrophila WL-11 was cloned and characterized. Nucleotide sequence analysis showed an open reading frame of 1605 bp encoding a polypeptide comprised of 534 amino acids. The primary structure of the enzyme predicted the structural features characteristic of other laccases, including the conserved regions of four histidine-rich copper-binding sites. The predicted amino acid sequence showed a high homology （more than 60%） with bacterial laccases in the genome and protein databases and the highest degree of similarity （61% identity） was observed with the multicopper oxidase of KlebsieUa sp. 601. When expressed in Escherichia coli, the recombinant enzyme was overproduced in the cytoplasm as soluble and active form. The purified enzyme had an optimum pH of 2.6 and 8.0 for ABTS （2,2＇-azino-bis（3-ethylbenzthiazolinesulfonic acid） and DMP （2,6-dimethoxyphenol）, respectively. The kinetic study on ABTS revealed a higher affinity of this enzyme to this substrate than DMP.

关键词： cloning expression enzymatic properties laccase Aeromonas hydrophila

An advanced segmentation using area and boundary tracing technique in extraction of lungs region

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Journal of Central South University 2014年第10期21卷 3811-3820页

作者： Kiran THAPALIYA Sang-Woong lee Jae-young PYU heon JEONG Goo-Rak KWON Department of Information and Communication Engineering Chosun University School of Computer Engineering Chosun University Deparment of Fire Administration Chodang University

A new method is presented for the segmentation of pulmonary parenchyma. The proposed method is based on the area calculation of different objects in the image. The main purpose of the proposed algorithm is the segment of the lungs images from the computer tomography(CT) images. The original image is binarized using the bit-plane slicing technique and among the different images the best binarized image is chosen. After binarization, the labeling is done and the area of each label is calculated from which the next level of binarized image is obtained. Then, the boundary tracing algorithm is applied to get another level of binarized image. The proposed method is able to extract lung region from the original images. The experimental results show the significance of the proposed method.

关键词： bit-plane slicing technique connected component labeling area tracing boundary tracing

Assessing land use/land cover change impacts on the hydrology of Nyong River Basin, Cameroon

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Journal of Mountain Science 2020年第1期17卷 50-67页

作者： EWANE Basil Ewane heon Ho lee Department of Geography Faculty of Social and Management SciencesUniversity of BueaP.O.BOX 63 BueaCameroon Department of Forest Resources College of Natural ResourcesYeungnam University280 Daehak-roGyeongsanSouth Korea

Uncontrolled land use land cover change(LULCC) is impacting watershed hydrology,particularly in tropical watersheds in developing countries. We assessed the extent of LULCC in the southern portion of the Nyong River basin through analysis of three land use maps in 1987, 2000 and2014. LULCC impact on hydrological variables of the Mbalmayo, Olama, Pont So’o, Messam, and Nsimi sub-watersheds of the southern portion of the Nyong River basin were evaluated by using the linear regression modeling and the Mann-Kendall test. This study reveals that dense forest cover decreased by16%, young secondary forest increased by 18%,agricultural/cropland increased by 10%, and built-up area/bare soil increased by 3% from 1987 to *** decrease in dense forest cover at 0.6% per year on average was driven by indiscriminate expansion of subsistence agricultural/cropland through shifting and fallow cultivation farming systems. Nonsignificant trends in total discharge, high flows, and low flows were observed in the large sub-watersheds of Mbalmayo and Olama from 1998 to 2013 with LULCC within the watershed. In contrast, significant decreasing trends in stream discharge(up to-5.1%and-5.9%), and significant increasing trends in high flows(up to 2.1% and 6.3%), respectively, were observed in the small sub-watersheds of Pont So’o and Messam from 1998 to 2013, particularly with increase in agricultural/cropland cover and decrease in dense forest cover. However, we found nonsignificant trends in mean annual discharge and low flows for all and whole watershed with LULCC. The results reveal spatially varying trends of stream discharge, low flows and high flows among the subwatersheds with LULCC within the study *** results suggest that the impacts of LULCC on watershed hydrology are easily detected in small subwatersheds than in large sub-watersheds. Therefore,the magnitude of dense forest cover loss must be significantly greater than 16% to cause significant changes and common trends

关键词： LULCC Land cover Land use Stream discharge Linear regression modeling Nyong River basin Mann-Kendall test